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Research priorities in advanced heart failure
Objective: To determine research priorities in advanced heart failure (HF) for patients, carers and healthcare professionals. Methods: Priority setting partnership using the systematic James Lind Alliance method for ranking and...
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A guide to best practices for Gene Ontology (GO) manual annotation.
The Gene Ontology Consortium (GOC) is a community-based bioinformatics project that classifies gene product function through the use of structured controlled vocabularies. A fundamental application of the Gene Ontology (GO) is...
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Horses for courses? Assessing the potential value of a surrogate, point-of-care test for SARS-CoV-2 epidemic control.
Point-of-care tests (POCTs) offer considerable potential for improving clinical and public health management of COVID-19 by providing timely information to guide decision-making, but data on real-world performance are in short...
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Antibody response to SARS-CoV-2 infection in humans
BACKGROUND: Progress in characterising the humoral immune response to Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) has been rapid but areas of uncertainty persist. Assessment of the full range of evidence generated to date...
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Assessing awareness in severe Alzheimer's disease.
There is an urgent need to understand the nature of awareness in people with severe Alzheimer's disease (AD) to ensure effective person-centered care. Objective biomarkers of awareness validated in other clinical groups (e.g....
Understanding Alzheimer's disease as a disorder of consciousness.
People with Alzheimer's disease (AD) demonstrate a range of alterations in consciousness. Changes in awareness of cognitive deficit, self-awareness, and introspection are seen early in AD, and dysfunction of awareness and...
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Selections From the Reverend Charles Rice Memory Book: Reflections From the Ursinus Community
Selections from the Reverend Charles Rice memorial book presented to the Rice family. Included are reflections from the following Ursinus College alumni, students, staff and faculty chosen by Tonya Rice: Christian Rice...
Published by: Ursinus College
T cell response to SARS-CoV-2 infection in humans
BACKGROUND: Understanding the T cell response to SARS-CoV-2 is critical to vaccine development, epidemiological surveillance and disease control strategies. This systematic review critically evaluates and synthesises the...
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HIRA loss transforms FH-deficient cells.
Fumarate hydratase (FH) is a mitochondrial enzyme that catalyzes the reversible hydration of fumarate to malate in the tricarboxylic acid (TCA) cycle. Germline mutations of FH lead to hereditary leiomyomatosis and renal cell...
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