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Results: 78794
Peptide based drug delivery systems to the brain
Yamir Islam, Andrew G Leach, Jayden Smith, Stefano Pluchino, Christopher R Coxonl, Muttuswamy Sivakumaran, James Downing, Amos A Fatokun, Meritxell Teixidò, Touraj Ehtezazi
May 18, 2020
Abstract: With estimated worldwide cost over $1 trillion just for dementia, diseases of the central nervous system pose a major problem to health and healthcare systems, with significant socio-economic implications for sufferers...
Peptide based drug delivery systems to the brain
Yamir Islam, Andrew G Leach, Jayden Smith, Stefano Pluchino, Christopher R Coxonl, Muttuswamy Sivakumaran, James Downing, Amos A Fatokun, Meritxell Teixidò, Touraj Ehtezazi
May 20, 2021
Abstract: With estimated worldwide cost over $1 trillion just for dementia, diseases of the central nervous system pose a major problem to health and healthcare systems, with significant socio-economic implications for sufferers...
Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles.
Yamir Islam, Andrew G Leach, Jayden Smith, Stefano Pluchino, Christopher R Coxon, Muttuswamy Sivakumaran, James Downing, Amos A Fatokun, Meritxell Teixidò, Touraj Ehtezazi
Jun 09, 2021
The prevalence of neurological/neurodegenerative diseases, such as Alzheimer's disease is known to be increasing due to an aging population and is anticipated to further grow in the decades ahead. The treatment of brain diseases...
Correlated and geographically predictable Neanderthal and Denisovan legacies are difficult to reconcile with a simple model based on inter-breeding.
William Amos
Jul 28, 2021
Although the presence of archaic hominin legacies in humans is taken for granted, little attention has been given as to how the data fit with how humans colonized the world. Here, I show that Neanderthal and Denisovan legacies...
Correlated and geographically predictable Neanderthal and Denisovan legacies are difficult to reconcile with a simple model based on inter-breeding
William Amos
Jun 17, 2021
Although the presence of archaic hominin legacies in humans is taken for granted, little attention has been given as to how the data fit with how humans colonized the world. Here, I show that Neanderthal and Denisovan legacies...
A System Dynamics Model of Technology and Society
Kenya has emerged in recent times as one of the fastest growing telecom markets in the world. There is not a single, widely used paradigm which has synthesised the various schools and theories dealing with technology and...
Published by: IGI Global Scientific Publishing
The red edge excitation shift phenomenon can be used to unmask protein structural ensembles
To understand complex molecular interactions it is necessary to account for molecular flexibility and the available equilibrium of conformational states. Only a small number of experimental approaches can access such...
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Signatures of Introgression across the Allele Frequency Spectrum.
The detection of introgression from genomic data is transforming our view of species and the origins of adaptive variation. Among the most widely used approaches to detect introgression is the so-called ABBA-BABA test or...
A Dosimetric Comparison of Breast Radiotherapy Techniques to Treat Locoregional Lymph Nodes Including the Internal Mammary Chain.
A Ranger, A Dunlop, K Hutchinson, H Convery, MK Maclennan, H Chantler, N Twyman, C Rose, D McQuaid, RA Amos, C Griffin, NM deSouza, E Donovan, E Harris, CE Coles, A Kirby
Jun 05, 2018
AIMS: Radiotherapy target volumes in early breast cancer treatment increasingly include the internal mammary chain (IMC). In order to maximise survival benefits of IMC radiotherapy, doses to the heart and lung should be...
Classification of symmetry-protected topological many-body localized phases in one dimension.
We provide a classification of symmetry-protected topological (SPT) phases of many-body localized (MBL) spin and fermionic systems in one dimension. For spin systems, using tensor networks we show that all eigenstates of these...
Flanking heterozygosity influences the relative probability of different base substitutions in humans.
William Amos
Nov 26, 2019
Understanding when, where and which mutations are mostly likely to occur impacts many areas of evolutionary biology, from genetic diseases to phylogenetic reconstruction. Africans and non-African humans differ in the mutability...
Knowledge of cervical cancer risk factors and symptoms among women in a refugee settlement
Winnie Adoch, Christopher Orach Garimoi, Suzanne E. Scott, Geoffrey Goddie Okeny, Jennifer Moodley, Henry Komakech, Fiona M. Walter, Amos Deogratius Mwaka
Dec 03, 2020
Abstract: Background: There are limited data on awareness of cervical cancer risk factors and symptoms among refugee populations living in Uganda. In this study, we sought to determine the awareness and knowledge of cervical...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
The red edge excitation shift phenomenon can be used to unmask protein structural ensembles
To understand complex molecular interactions it is necessary to account for molecular flexibility and the available equilibrium of conformational states. Only a small number of experimental approaches can access such...
Women's appraisal, interpretation and help-seeking for possible symptoms of breast and cervical cancer in South Africa
BACKGROUND: In South Africa, breast cancer is the most commonly diagnosed cancer and cervical cancer the leading cause of cancer mortality. Most cancers are diagnosed at a late-stage and following symptomatic presentation. The...
Breast Cancer Cervical cancer Help-seeking Qualitative research methods South Africa symptom appraisal Adult Breast Neoplasms Cross-Sectional Studies Female Health Knowledge Attitudes practice Humans Middle Aged Patient Acceptance of Health Care qualitative research South Africa Uterine Cervical Neoplasms Young Adult
Resistance to Targeted Agents Used to Treat Paediatric ALK-Positive ALCL.
Non-Hodgkin lymphoma (NHL) is the third most common malignancy diagnosed in children. The vast majority of paediatric NHL are either Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), anaplastic large cell lymphoma...
Global demographic history of human populations inferred from whole mitochondrial genomes.
The Neolithic transition has led to marked increases in census population sizes across the world, as recorded by a rich archaeological record. However, previous attempts to detect such changes using genetic markers, especially...
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
Cranioplasty Following Decompressive Craniectomy
Corrado Iaccarino, Angelos G. Kolias, Louis-Georges Roumy, Kostas Fountas, Amos Olufemi Adeleye
Feb 12, 2020
Cranioplasty (CP) after decompressive craniectomy (DC) for trauma is a neurosurgical procedure that aims to restore esthesis, improve cerebrospinal fluid (CSF) dynamics, and provide cerebral protection. In turn, this can...
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
Knowledge of cervical cancer risk factors and symptoms among women in a refugee settlement
Winnie Adoch, Christopher Orach Garimoi, Suzanne E Scott, Geoffrey Goddie Okeny, Jennifer Moodley, Henry Komakech, Fiona M Walter, Amos Deogratius Mwaka
Dec 10, 2020
BACKGROUND: There are limited data on awareness of cervical cancer risk factors and symptoms among refugee populations living in Uganda. In this study, we sought to determine the awareness and knowledge of cervical cancer risk...
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