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Chan-Vese Reformulation for Selective Image Segmentation.
Selective segmentation involves incorporating user input to partition an image into foreground and background, by discriminating between objects of a similar type. Typically, such methods involve introducing additional...
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Classification of symmetry-protected topological many-body localized phases in one dimension.
Amos Chan, Thorsten B Wahl
May 18, 2020
We provide a classification of symmetry-protected topological (SPT) phases of many-body localized (MBL) spin and fermionic systems in one dimension. For spin systems, using tensor networks we show that all eigenstates of these...
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Validation of Performance Homogeneity of Chan-Vese Model on Selected Tumour Cells
This study aims to analyze the Chan-Vese model's performance using a variety of tumor images. The processes involve the tumors' segmentation, detecting the tumors, identifying the segmented tumor region, and extracting the...
The ‘ownership’ of science
C Rhodes, J Harris, S Chan, J Sulston
Aug 10, 2017
Dr Catherine Rhodes is a research fellow at the Institute for Science, Ethics and Innovation specialising in the international regulations relevant to control of biotechnology. Professor John Harris is director of the Institute...
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Uncovering Regulators of Whole-Body Metabolism by Chemoproteomic Profiling of the Adipocyte Secretome
Chan Hee J Choi
Jan 01, 0001
A major threat to human health, obesity is associated with increased risk of cardiometabolic complications such as cardiovascular disease, type 2 diabetes, hypertension, and many types of cancers. Whereas white adipocytes...
Published by: Rockefeller University
Tuning of Neuronal Excitation by a Brain Specific Microrna MIR-128: From Targets to Behavior
Chan Lek Tan
Jan 01, 0001
MicroRNAs constitute a vital new component of our evolving understanding of regulatory mechanisms that shape cellular gene expression. As ubiquitous regulators of protein translation, microRNAs have a unique regulatory function...
Published by: Rockefeller University
Correlated and geographically predictable Neanderthal and Denisovan legacies are difficult to reconcile with a simple model based on inter-breeding.
William Amos
Jul 28, 2021
Although the presence of archaic hominin legacies in humans is taken for granted, little attention has been given as to how the data fit with how humans colonized the world. Here, I show that Neanderthal and Denisovan legacies...
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Signatures of Introgression across the Allele Frequency Spectrum.
The detection of introgression from genomic data is transforming our view of species and the origins of adaptive variation. Among the most widely used approaches to detect introgression is the so-called ABBA-BABA test or...
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Flanking heterozygosity influences the relative probability of different base substitutions in humans.
William Amos
Nov 26, 2019
Understanding when, where and which mutations are mostly likely to occur impacts many areas of evolutionary biology, from genetic diseases to phylogenetic reconstruction. Africans and non-African humans differ in the mutability...
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Controversial Issues in Arthroscopic Surgery for Femoroacetabular Impingement.
Femoroacetabular impingement (FAI) is a common cause of painful hip in the young and middle-aged population. This condition frequently leads to a labral tear, damage of acetabular cartilage, and secondary arthritis of the hip....
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Correlated and geographically predictable Neanderthal and Denisovan legacies are difficult to reconcile with a simple model based on inter-breeding
William Amos
Jun 17, 2021
Although the presence of archaic hominin legacies in humans is taken for granted, little attention has been given as to how the data fit with how humans colonized the world. Here, I show that Neanderthal and Denisovan legacies...
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Resistance to Targeted Agents Used to Treat Paediatric ALK-Positive ALCL.
Non-Hodgkin lymphoma (NHL) is the third most common malignancy diagnosed in children. The vast majority of paediatric NHL are either Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), anaplastic large cell lymphoma...
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Global demographic history of human populations inferred from whole mitochondrial genomes.
The Neolithic transition has led to marked increases in census population sizes across the world, as recorded by a rich archaeological record. However, previous attempts to detect such changes using genetic markers, especially...
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Cranioplasty Following Decompressive Craniectomy
Cranioplasty (CP) after decompressive craniectomy (DC) for trauma is a neurosurgical procedure that aims to restore esthesis, improve cerebrospinal fluid (CSF) dynamics, and provide cerebral protection. In turn, this can...
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Prevention of radiotherapy-induced neurocognitive dysfunction in survivors of paediatric brain tumours
Neurocognitive dysfunction is the leading cause of reduced quality of life in long-term survivors of paediatric brain tumours. Radiotherapy is one of the main contributors to neurocognitive sequelae. Current approaches for...
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The red edge excitation shift phenomenon can be used to unmask protein structural ensembles

To understand complex molecular interactions it is necessary to account for molecular flexibility and the available equilibrium of conformational states. Only a small number of experimental approaches can access such...

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Consanguinity and susceptibility to infectious diseases in humans.
Studies of animal populations suggest that low genetic heterozygosity is an important risk factor for infection by a diverse range of pathogens, but relatively little research has looked to see whether similar patterns exist in...
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A System Dynamics Model of Technology and Society
Kenya has emerged in recent times as one of the fastest growing telecom markets in the world. There is not a single, widely used paradigm which has synthesised the various schools and theories dealing with technology and...
Users' Acceptance of Artificial Intelligence-Based Chatbots
This research examines the effects of factors such as perceived ease of use, perceived usefulness, perceived enjoyment, innovativeness, perceived information quality, and perceived customisation on behavioural intention to use...
Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts.
Arginase has therapeutic potential as a cytotoxic agent in some cancers, but this is unclear for precursor B acute lymphoblastic leukaemia (pre-B ALL), the commonest form of childhood leukaemia. We compared arginase cytotoxicity...
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