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Simultaneous depletion of RB, RBL1 and RBL2 affects endoderm differentiation of human embryonic stem cells.
Shota Nakanoh, Juned Kadiwala, Laetitia Pinte, Carola Maria Morell, An-Sofie Lenaerts, Ludovic Vallier
Dec 23, 2022
Simultaneous depletion of RB, RBL1 and RBL2 affects endoderm differentiation of human embryonic stem cells.
Shota Nakanoh, Juned Kadiwala, Laetitia Pinte, Carola Maria Morell, An-Sofie Lenaerts, Ludovic Vallier
Nov 22, 2022
Modeling PNPLA3-Associated NAFLD Using Human-Induced Pluripotent Stem Cells.
Samantha G Tilson, Carola M Morell, An-Sofie Lenaerts, Seung Bum Park, Zongyi Hu, Benjamin Jenkins, Albert Koulman, T Jake Liang, Ludovic Vallier
Aug 26, 2021
BACKGROUND AND AIMS: NAFLD is a growing public health burden. However, the pathogenesis of NAFLD has not yet been fully elucidated, and the importance of genetic factors has only recently been appreciated. Genomic studies have...
CRISPR-Cas Systems Cell Differentiation Cell Line Ethanol Gene Knockout Techniques Genetic Predisposition to Disease Hepatocytes Humans Induced Pluripotent Stem Cells LIPASE Lipid Metabolism Loss of Function Mutation Membrane Proteins Methotrexate non-alcoholic fatty liver disease Polymorphism Single Nucleotide Toxicity Tests Acute
The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency.
Alessandro Bertero, Stephanie Brown, Pedro Madrigal, Anna Osnato, Daniel Ortmann, Loukia Yiangou, Juned Kadiwala, Nina C Hubner, Igor Ruiz de Los Mozos, Christoph Sadée, An-Sofie Lenaerts, Shota Nakanoh, Rodrigo Grandy, Edward Farnell, Jernej Ule, Hendrik G Stunnenberg, Sasha Mendjan, Ludovic Vallier
May 15, 2018
Activins Adenosine Animals Cell Cycle Proteins Cell Differentiation Epigenesis Genetic Humans Methylation Methyltransferases Multiprotein Complexes Nanog Homeobox Protein Nodal Protein Nuclear Proteins Pluripotent Stem Cells Protein Binding RNA Splicing Factors RNA Messenger Signal Transduction Smad2 Protein Smad3 Protein Transcriptome Transforming Growth Factor beta
The novel homozygous KCNJ10 c.986T>C (p.(Leu329Pro)) variant is pathogenic for the SeSAME/EAST homologue in Malinois dogs.
Mario Van Poucke, Kimberley Stee, Sofie FM Bhatti, An Vanhaesebrouck, Leslie Bosseler, Luc J Peelman, Luc Van Ham
Aug 08, 2019
SeSAME/EAST syndrome is a multisystemic disorder in humans, characterised by seizures, sensorineural deafness, ataxia, developmental delay and electrolyte imbalance. It is exclusively caused by homozygous or compound...
Comparison of intranasal versus intravenous midazolam for management of status epilepticus in dogs
Marios Charalambous, Holger A Volk, Andrea Tipold, Johannes Erath, Enrice Huenerfauth, Antonella Gallucci, Gualtiero Gandini, Daisuke Hasegawa, Theresa Pancotto, John H Rossmeisl, Simon Platt, Luisa De Risio, Joan R Coates, Mihai Musteata, Federica Tirrito, Francesca Cozzi, Laura Porcarelli, Daniele Corlazzoli, Rodolfo Cappello, An Vanhaesebrouck, Bart JG Broeckx, Luc Van Ham, Sofie FM Bhatti
Oct 28, 2019
BACKGROUND: The intranasal (IN) route for rapid drug administration in patients with brain disorders, including status epilepticus, has been investigated. Status epilepticus is an emergency, and the IN route offers a valuable...
Stress and Coping Experiences of UK Professional Football Managers During the COVID-19 Pandemic
Guided by transactional stress theory, this study aimed to explore elite U.K. soccer coaches’ perceived stressors, the situational properties, appraisals, and coping during the COVID-19 pandemic. This study also aimed to explore...
Enhancing Car Segmentation for Thailand's Expressway Industry With an Automated Hybrid Machine Learning Framework
Car segmentation on Thailand's expressways poses challenges for traditional models due to unique characteristics, often resulting in predictive inaccuracies. Manual data analytics in this field is time-consuming and human...
Published by: IGI Global Scientific Publishing
Stress and Coping Experiences of UK Professional Football Managers During the COVID-19 Pandemic
Guided by transactional stress theory, this study aimed to explore elite U.K. soccer coaches’ perceived stressors, the situational properties, appraisals, and coping during the COVID-19 pandemic. This study also aimed to explore...
Scaling Up? Unpacking the Effect of Deliberative Mini-Publics on Legitimacy Perceptions
Deliberative mini-publics are increasingly used to try to tackle public discontent with the functioning of democracy. However, the ability of mini-publics to increase perceptions of legitimate decision-making among citizens at...
Scaling Up? Unpacking the Effect of Deliberative Mini-Publics on Legitimacy Perceptions
Deliberative mini-publics are increasingly used to try to tackle public discontent with the functioning of democracy. However, the ability of mini-publics to increase perceptions of legitimate decision-making among citizens at...
Late Latin Verb Second
AN Ledgeway
May 05, 2017
In this article we undertake a systematic study of the Itinerarium Egeriae, one of the best known late Latin texts, to determine the proper characterization of the word order of the text and to consider in particular whether the...
The association of depression with subsequent dementia diagnosis
BACKGROUND: Depression is associated with an increased risk of dementia. However, short follow-up times and lack of adjustment for familial factors in previous studies could influence this association. The purpose of the present...
Observations of Buried Lake Drainage on the Antarctic Ice Sheet.
D Dunmire, JTM Lenaerts, AF Banwell, N Wever, J Shragge, S Lhermitte, R Drews, F Pattyn, JSS Hansen, IC Willis, J Miller, E Keenan
Dec 07, 2020
Between 1992 and 2017, the Antarctic Ice Sheet (AIS) lost ice equivalent to 7.6 ± 3.9 mm of sea level rise. AIS mass loss is mitigated by ice shelves that provide a buttress by regulating ice flow from tributary glaciers....
The evolving view of the hematopoietic stem cell niche.
Hematopoietic stem cells (HSCs) reside in specialized microenvironments known as niches. The niche is essential to support HSC function and to maintain a correct balance between self-renewal and differentiation. Recent advances...
EBF1 primes B-lymphoid enhancers and limits the myeloid bias in murine multipotent progenitors.
Aurelie Lenaerts, Iwo Kucinski, Ward Deboutte, Marta Derecka, Pierre Cauchy, Thomas Manke, Berthold Göttgens, Rudolf Grosschedl
Oct 01, 2022
Reproducibility of telomere length assessment
Carmen M Martin-Ruiz, Duncan Baird, Laureline Roger, Petra Boukamp, Damir Krunic, Richard Cawthon, Martin M Dokter, Pim van der Harst, Sofie Bekaert, Tim de Meyer, Goran Roos, Ulrika Svenson, Veryan Codd, Nilesh J Samani, Liane McGlynn, Paul G Shiels, Karen A Pooley, Alison M Dunning, Rachel Cooper, Andrew Wong, Andrew Kingston, Thomas von Zglinicki
Oct 07, 2015
Perioperative management of open fractures in the lower limb.
An open fracture is a fracture which communicates with the external environment through a wound in the skin. Severe open fractures are managed by both orthopaedic and plastic surgeons to address injuries in both the bone and...
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