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Results: 383
Into the Andes
Nicolas Chazot, Keith R Willmott, Fabien L Condamine, Donna Lisa De-Silva, André VL Freitas, Gerardo Lamas, Hélène Morlon, Carlos E Giraldo, Chris D Jiggins, Mathieu Joron, James Mallet, Sandra Uribe, Marianne Elias
Mar 21, 2019
Understanding why species richness peaks along the Andes is a fundamental question in the study of Neotropical biodiversity. Several biogeographic and diversification scenarios have been proposed in the literature, but there is...
Diazaborines Are a Versatile Platform to Develop ROS-Responsive Antibody Drug Conjugates*.
João PM António, Joana Inês Carvalho, Ana S André, Joana NR Dias, Sandra I Aguiar, Hélio Faustino, Ricardo MRM Lopes, Luis F Veiros, Gonçalo JL Bernardes, Frederico A da Silva, Pedro MP Gois
Oct 08, 2021
Antibody-drug conjugates (ADCs) are a new class of therapeutics that combine the lethality of potent cytotoxic drugs with the targeting ability of antibodies to selectively deliver drugs to cancer cells. In this study we show...
Spin in the neurosurgical trauma literature
João Vitor Miranda Porto Oliveira, André Luiz Freitas Oliveira Júnior, Angelos G Kolias, Wellingson S Paiva, Davi Jorge Fontoura Solla
Jan 10, 2022
INTRODUCTION: Spin is defined as an inaccurate interpretation of results, intentionally or not, leading to equivocal conclusions and misdirecting readers to look at the data in an overly optimistic way. Previous studies have...
Accuracy of self-report of HIV viral load among people with HIV on antiretroviral treatment.
J Sewell, M Daskalopoulou, F Nakagawa, FC Lampe, S Edwards, N Perry, E Wilkins, R O'Connell, M Jones, S Collins, A Speakman, AN Phillips, AJ Rodger, Sexual Transmission Risk and Attitudes (ASTRA) Study Group Antiretrovirals
Mar 27, 2019
OBJECTIVES: The aim of the study was to assess, among people living with HIV, knowledge of their latest HIV viral load (VL) and CD4 count. METHODS: Agreement between self-report and clinic record was assessed among 2771...
CD4 count HIV knowledge HIV viral load accuracy of self-report engagement in care medical record Socioeconomic status Adult Aged Anti-Retroviral Agents CD4 Lymphocyte Count Cross-Sectional Studies Female HIV Infections Humans Male Middle Aged Self Report Surveys and Questionnaires United Kingdom Viral Load Young Adult
Hepatomegaly Associated with Non-Obstructive Sinusoidal Dilation in Experimental Visceral Leishmaniasis.
Kota Maeda, Sonya Sadoughi, Ayako Morimoto, Kazuyuki Uchida, James K Chambers, Chizu Sanjoba, Junya Yamagishi, Yasuyuki Goto
Oct 21, 2021
Visceral leishmaniasis (VL) is the most severe form of leishmaniasis caused by protozoan parasites of the genus Leishmania. Hepatomegaly is one of the most frequent clinical manifestations of VL, whereas immunopathology of the...
Integrated genomic and metabolomic profiling of ISC1, an emerging Leishmania donovani population in the Indian subcontinent.
Bart Cuypers, Maya Berg, Hideo Imamura, Franck Dumetz, Géraldine De Muylder, Malgorzata A Domagalska, Suman Rijal, Narayan Raj Bhattarai, Ilse Maes, Mandy Sanders, James A Cotton, Pieter Meysman, Kris Laukens, Jean-Claude Dujardin
Apr 12, 2019
Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in...
Understanding the Enabling and Constraining Factors in Using the Virtual Lab
It is commonly accepted that learners gain better understanding of science concepts when they perform ‘hands-on' experiments in the lab. However, the lack of lab infrastructure, particularly in most rural schools, negatively...
Published by: IGI Global Scientific Publishing
Gamification Elements in a Virtual Learning Environment (VLE)
André Pretorius
Jan 01, 2024
This paper explores the role of gamification in online courses and demonstrates three applications of gamification in a virtual learning environment (VLE). The research evaluates the effect that these gamification tools can have...
Published by: IGI Global Scientific Publishing
Cryptotephra as a dating and correlation tool in archaeology
A new development in archaeological chronology involves the use of far travelled volcanic ash which may form discrete but invisible layers within a site's stratigraphy. Known as cryptotephra, these horizons can provide isochrons...
Validation of a mixture of rK26 and rK39 antigens from Iranian strain of Leishmania infantum to detect anti-Leishmania antibodies in human and reservoir hosts.
Bibi Razieh Hosseini Farash, Mehdi Mohebali, Bahram Kazemi, Abdolmajid Fata, Homa Hajjaran, Behnaz Akhoundi, Reza Raoofian, Pietro Mastroeni, Elham Moghaddas, Azad Khaledi, Ghodratollah Salehi Sangani
Jul 22, 2022
Mediterranean type of visceral leishmaniasis (VL) is a zoonotic parasitic infection. Some provinces of Iran are endemic for VL while other parts are considered as sporadic areas. This study aimed to assess a combination of...
Validation of a mixture of rK26 and rK39 antigens from Iranian strain of Leishmania infantum to detect anti-Leishmania antibodies in human and reservoir hosts.
Bibi Razieh Hosseini Farash, Mehdi Mohebali, Bahram Kazemi, Abdolmajid Fata, Homa Hajjaran, Behnaz Akhoundi, Reza Raoofian, Pietro Mastroeni, Elham Moghaddas, Azad Khaledi, Ghodratollah Salehi Sangani
Jun 29, 2022
Mediterranean type of visceral leishmaniasis (VL) is a zoonotic parasitic infection. Some provinces of Iran are endemic for VL while other parts are considered as sporadic areas. This study aimed to assess a combination of...
Care home residents admitted to hospital through the emergency pathway
BACKGROUND: Routinely collected hospital information could help to understand the characteristics and outcomes of care home residents admitted to hospital as an emergency. METHODS: This retrospective 2-year service evaluation...
Imprints from idea origin on innovation and the development environment
This study builds on the evolutionary and organization literatures to explore how the nature of innovation outcomes was influenced by the innovation’s original idea and the environment in which it was developed. We use data from...
Imprints from idea origin on innovation and the development environment
This study builds on the evolutionary and organization literatures to explore how the nature of innovation outcomes was influenced by the innovation’s original idea and the environment in which it was developed. We use data from...
Effects of birth weight, sex and neonatal glucocorticoid overexposure on glucose-insulin dynamics in young adult horses.
Conserved ancestral tropical niche but different continental histories explain the latitudinal diversity gradient in brush-footed butterflies.
Nicolas Chazot, Fabien L Condamine, Gytis Dudas, Carlos Peña, Ullasa Kodandaramaiah, Pável Matos-Maraví, Kwaku Aduse-Poku, Marianne Elias, Andrew D Warren, David J Lohman, Carla M Penz, Phil DeVries, Zdenek F Fric, Soren Nylin, Chris Müller, Akito Y Kawahara, Karina L Silva-Brandão, Gerardo Lamas, Irena Kleckova, Anna Zubek, Elena Ortiz-Acevedo, Roger Vila, Richard I Vane-Wright, Sean P Mullen, Chris D Jiggins, Christopher W Wheat, Andre VL Freitas, Niklas Wahlberg
Nov 25, 2021
The global increase in species richness toward the tropics across continents and taxonomic groups, referred to as the latitudinal diversity gradient, stimulated the formulation of many hypotheses to explain the underlying...
Last Minute Medical Appointments No-Show Management
A no-show occurs when a client has an appointment of some sort with another entity, and voluntarily or not, the client does not show up to that appointment. A patient missing an appointment will mean that the clinic's and health...
Published by: IGI Global Scientific Publishing
The Innerworkings of Digital Storytelling
Traditionally, storytelling was used for entertainment and the transfer of know-how. The advent of digital media gave rise to new possibilities for telling stories. When the context is, for example, to relay information about...
Published by: IGI Global Scientific Publishing
PI3K inhibitors are finally coming of age.
Bart Vanhaesebroeck, Matthew WD Perry, Jennifer R Brown, Fabrice André, Klaus Okkenhaug
Jun 17, 2021
Overactive phosphoinositide 3-kinase (PI3K) in cancer and immune dysregulation has spurred extensive efforts to develop therapeutic PI3K inhibitors. Although progress has been hampered by issues such as poor drug tolerance and...
The rK39 Antigen from an Iranian Strain of Leishmania infantum
Bibi Razieh Hosseini Farash, Mehdi Mohebali, Bahram Kazemi, Homa Hajjaran, Abdolmajid Fata, Reza Raoofian, Behnaz Akhoundi, Majid Mojarrad, Pietro Mastroeni, Mohammad Kazem Sharifi-Yazdi, Mohammad Hossein Tanipour
Mar 31, 2020
BACKGROUND: Visceral leishmaniasis (VL) is the most severe form of leishmaniasis in Iran with high mortality rates in the case of inaccurate diagnosis and treatment. This study aimed to prepare and evaluate a new rk39...
Human Immunodeficiency Virus-1 Viral Load Is Elevated in Individuals With Reverse-Transcriptase Mutation M184V/I During Virological Failure of First-Line Antiretroviral Therapy and Is Associated With Compensatory Mutation L74I.
BACKGROUND: M184V/I cause high-level lamivudine (3TC) and emtricitabine (FTC) resistance and increased tenofovir disoproxil fumarate (TDF) susceptibility. Nonetheless, 3TC and FTC (collectively referred to as XTC) appear to...
HIV antiretroviral compensatory mutation Drug Resistance Lamivudine Anti-HIV Agents CD4 Lymphocyte Count Drug Resistance Viral Drug Therapy Combination Emtricitabine HIV Infections HIV Reverse Transcriptase HIV-1 Humans Lamivudine Mutation Randomized Controlled Trials as Topic Reverse Transcriptase Inhibitors Tenofovir Treatment Failure Viral Load
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