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Results: 73
Developing EasySci, a High-Throughput and Low-Cost Single-Cell Genomic Technique, to Study Aging and Alzheimer's Disease in Human and Mouse Brain
Andras Sziraki
Jan 01, 0001
Previous single-cell methods are limited by their relatively low throughput and high costs. This prevents most laboratories from performing large-scale cell profiling, complicating the understanding of rare cell type...
Published by: Rockefeller University
Divorce and infidelity are associated with skewed adult sex ratios in birds
Adult sex ratio (ASR) is a fundamental concept in population demography, and recent theory suggests that ASR plays a central role in social behavior, mating systems, and parental care [1-6]. Unbalanced ASRs are predicted to...
Integrated Systems Biology Approach Identifies Novel Maternal and Placental Pathways of Preeclampsia.
Nandor Gabor Than, Roberto Romero, Adi Laurentiu Tarca, Katalin Adrienna Kekesi, Yi Xu, Zhonghui Xu, Kata Juhasz, Gaurav Bhatti, Ron Joshua Leavitt, Zsolt Gelencser, Janos Palhalmi, Tzu Hung Chung, Balazs Andras Gyorffy, Laszlo Orosz, Amanda Demeter, Anett Szecsi, Eva Hunyadi-Gulyas, Zsuzsanna Darula, Attila Simor, Katalin Eder, Szilvia Szabo, Vanessa Topping, Haidy El-Azzamy, Christopher LaJeunesse, Andrea Balogh, Gabor Szalai, Susan Land, Olga Torok, Zhong Dong, Ilona Kovalszky, Andras Falus, Hamutal Meiri, Sorin Draghici, Sonia S Hassan, Tinnakorn Chaiworapongsa, Manuel Krispin, Martin Knöfler, Offer Erez, Graham J Burton, Chong Jai Kim, Gabor Juhasz, Zoltan Papp
Nov 21, 2018
Preeclampsia is a disease of the mother, fetus, and placenta, and the gaps in our understanding of the complex interactions among their respective disease pathways preclude successful treatment and prevention. The placenta has a...
Husserl und die „Philosophie der Philosophiegeschichte“
Peter Andras Varga
May 19, 2021
“Nichts lag Husserl ferner als Geschichte der Philosophie, denn die Wahrheit istnatürlich nicht interessiert an den Irrtümer der Vergangenheit“ – sagte HansJonas in einem Vortrag über Husserl und Heidegger. Jonas, der im SS 1921...
Published by: Memorial University of Newfoundland
Husserl und die „Philosophie der Philosophiegeschichte“
Peter Andras Varga
May 19, 2021
“Nichts lag Husserl ferner als Geschichte der Philosophie, denn die Wahrheit istnatürlich nicht interessiert an den Irrtümer der Vergangenheit“ – sagte HansJonas in einem Vortrag über Husserl und Heidegger. Jonas, der im SS 1921...
Published by: Memorial University of Newfoundland
Divorce and infidelity are associated with skewed adult sex ratios in birds
Adult sex ratio (ASR) is a fundamental concept in population demography, and recent theory suggests that ASR plays a central role in social behavior, mating systems, and parental care [1-6]. Unbalanced ASRs are predicted to...
Interplay of Structural Disorder and Short Binding Elements in the Cellular Chaperone Function of Plant Dehydrin ERD14
Nikoletta Murvai, Lajos Kalmar, Bianka Szalaine Agoston, Beata Szabo, Agnes Tantos, Gyorgy Csikos, András Micsonai, József Kardos, Didier Vertommen, Phuong N. Nguyen, Nevena Hristozova, Andras Lang, Denes Kovacs, Laszlo Buday, Kyou-Hoon Han, Andras Perczel, Peter Tompa
Aug 08, 2020
Details of the functional mechanisms of intrinsically disordered proteins (IDPs) in living cells is an area not frequently investigated. Here, we dissect the molecular mechanism of action of an IDP in cells by detailed...
Interplay of Structural Disorder and Short Binding Elements in the Cellular Chaperone Function of Plant Dehydrin ERD14.
Nikoletta Murvai, Lajos Kalmar, Bianka Szalaine Agoston, Beata Szabo, Agnes Tantos, Gyorgy Csikos, András Micsonai, József Kardos, Didier Vertommen, Phuong N Nguyen, Nevena Hristozova, Andras Lang, Denes Kovacs, Laszlo Buday, Kyou-Hoon Han, Andras Perczel, Peter Tompa
Sep 01, 2020
Details of the functional mechanisms of intrinsically disordered proteins (IDPs) in living cells is an area not frequently investigated. Here, we dissect the molecular mechanism of action of an IDP in cells by detailed...
cell protection chaperone client protein in-cell NMR intrinsic structural disorder pre-structured motif Arabidopsis Arabidopsis Proteins Escherichia coli Heat-Shock Response Intrinsically Disordered Proteins Microbial Viability Microorganisms Genetically-Modified Molecular Chaperones Protein Binding Protein Domains Proteome
Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor.
Andras S Solt, Mark J Bostock, Binesh Shrestha, Prashant Kumar, Tony Warne, Christopher G Tate, Daniel Nietlispach
Jun 08, 2018
A complex conformational energy landscape determines G-protein-coupled receptor (GPCR) signalling via intracellular binding partners (IBPs), e.g., Gs and β-arrestin. Using 13C methyl methionine NMR for the β1-adrenergic...
The relationship between eye movement and vision develops before birth.
Veronika Schöpf, Thomas Schlegl, Andras Jakab, Gregor Kasprian, Ramona Woitek, Daniela Prayer, Georg Langs
Jan 02, 2019
While the visuomotor system is known to develop rapidly after birth, studies have observed spontaneous activity in vertebrates in visually excitable cortical areas already before extrinsic stimuli are present. Resting state...
Imaging of morphological changes and phase segregation in doped polymeric semiconductors
Felix Deschler, Daniel Riedel, Andras Deák, Bernhard Ecker, Elizabeth von Hauff, Enrico Da Como
Jan 01, 2015
The electrical conductivity and morphological characteristics of two conjugated polymers, P3HT and PCPDTBT, p-doped with the strong electron acceptor tetrafluoro-tetracyanoquinodimethane (F4-TCNQ) are studied as a function of...
Imaging of morphological changes and phase segregation in doped polymeric semiconductors
Felix Deschler, Daniel Riedel, Andras Deák, Bernhard Ecker, Elizabeth von Hauff, Enrico Da Como
Jan 01, 2015
The electrical conductivity and morphological characteristics of two conjugated polymers, P3HT and PCPDTBT, p-doped with the strong electron acceptor tetrafluoro-tetracyanoquinodimethane (F4-TCNQ) are studied as a function of...
Extracellular vesicles
Stefania Mondello, Eric P Thelin, Gerry Shaw, Michel Salzet, Carmela Visalli, Dasa Cizkova, Firas Kobeissy, Andras Buki
Aug 01, 2019
Transplantation of Human Cortically-Specified Neuroepithelial Progenitor Cells Leads to Improved Functional Outcomes in a Mouse Model of Stroke.
Rehnuma Islam, Stasja Drecun, Balazs V Varga, Ilan Vonderwalde, Ricky Siu, Andras Nagy, Cindi M Morshead
Jun 25, 2021
Stroke is a leading cause of death and long-term disability worldwide. Current therapeutic options are limited in terms of their time for implementation and efficacy in promoting recovery. Cell transplantation has been shown to...
When health technology assessment is confidential and experts have no power
Marcell Csanádi, Olga Löblová, Piotr Ozieranski, Andras Harsányi, Zoltan Kalo, Martin McKee, Lawrence King
Apr 01, 2019
Health technology assessment (HTA) is not simply a mechanistic technical exercise as it takes place within a specific institutional context. Yet, we know little about how this context influences the operation of HTA and its...
When health technology assessment is confidential and experts have no power
Marcell Csanádi, Olga Löblová, Piotr Ozieranski, Andras Harsányi, Zoltan Kalo, Martin McKee, Lawrence King
Apr 01, 2019
Health technology assessment (HTA) is not simply a mechanistic technical exercise as it takes place within a specific institutional context. Yet, we know little about how this context influences the operation of HTA and its...
Incidence, predictors of success and outcome of LISA in very preterm infants.
Gergely Balazs, Andras Balajthy, Magdolna Riszter, Tamas Kovacs, Tamas Szabo, Gusztav Belteki, Gyorgy Balla
Apr 26, 2022
OBJECTIVES: The aim of this study was to examine the success rate of less invasive surfactant administration (LISA), to identify early predictive factors for the outcome of LISA, and to compare neonatal outcomes between the LISA...
Continuous Positive Airway Pressure respiratory distress syndrome in premature infants Surfactant Continuous Positive Airway Pressure Female Fetal Growth Retardation Humans Incidence Infant Infant Newborn Infant Premature Infant Premature Diseases Pulmonary Surfactants Respiratory Distress Syndrome Newborn Retrospective Studies Surface-Active Agents
Transplantation of Human Cortically-Specified Neuroepithelial Progenitor Cells Leads to Improved Functional Outcomes in a Mouse Model of Stroke
Rehnuma Islam, Stasja Drecun, Balazs V. Varga, Ilan Vonderwalde, Ricky Siu, Andras Nagy, Cindi M. Morshead
May 20, 2021
Stroke is a leading cause of death and long-term disability worldwide. Current therapeutic options are limited in terms of their time for implementation and efficacy in promoting recovery. Cell transplantation has been shown to...
Conformational plasticity of ligand-bound and ternary GPCR complexes studied by 19F NMR of the β1-adrenergic receptor.
J Niclas Frei, Richard W Broadhurst, Mark J Bostock, Andras Solt, Andrew JY Jones, Florian Gabriel, Aditi Tandale, Binesh Shrestha, Daniel Nietlispach
Jan 13, 2020
Cell autonomous regulation of herpes and influenza virus infection by the circadian clock.
Rachel S Edgar, Alessandra Stangherlin, Andras D Nagy, Michael P Nicoll, Stacey Efstathiou, John S O'Neill, Akhilesh B Reddy
Aug 12, 2016
Circadian clock herpes Influenza Virus ARNTL Transcription Factors Animals Biological Transport CLOCK Proteins Cell Line Chromatin Assembly and Disassembly Circadian Clocks Circadian Rhythm Cricetinae Epithelial Cells Female Gene Expression Regulation Genes Reporter Herpes Simplex Herpesviridae Infections Herpesvirus 1 Human Host-Pathogen Interactions Influenza A virus H1N1 Subtype Luciferases Mice Mice Knockout Orthomyxoviridae Infections Rhadinovirus Tumor Virus Infections Virus Replication
Engineering short, strong, charge-assisted hydrogen bonds in benzoic acid dimers through co-crystallisation with proton sponge
Lynne H. Thomas, Andrew O. F. Jones, Andras A. Kallay, Garry J. Mcintyre, Chick C. Wilson
Apr 06, 2016
A series of molecular complexes of the proton sponge 1,8-bis(dimethylamino)naphthalene (DMAN) with mono-substituted halobenzoic acids are reported, illustrating the designed exploitation of the characteristics of the proton...
Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells
Ana Carolina B. Sant’Anna-Silva, Juan A. Perez-Valencia, Marco Sciacovelli, Claude Lalou, Saharnaz Sarlak, Laura Tronci, Efterpi Nikitopoulou, Andras T. Meszaros, Christian Frezza, Rodrigue Rossignol, Erich Gnaiger, Helmut Klocker
Apr 07, 2021
Tumor cells display metabolic alterations when compared to non-transformed cells. These characteristics are crucial for tumor development, maintenance and survival providing energy supplies and molecular precursors. Anaplerosis...
Geometrical Effect in 2D Nanopores
Ke Liu, Martina Lihter, Aditya Sarathy, Sabina Caneva, Hu Qiu, Davide Deiana, Vasiliki Tileli, Duncan TL Alexander, Stephan Hofmann, Dumitru Dumcenco, Andras Kis, Jean-Pierre Leburton, Aleksandra Radenovic
Mar 29, 2018
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