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Results: 78820
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells.
David K Finlay, Ella Rosenzweig, Linda V Sinclair, Carmen Feijoo-Carnero, Jens L Hukelmann, Julia Rolf, Andrey A Panteleyev, Klaus Okkenhaug, Doreen A Cantrell
Jun 28, 2018
mTORC1 (mammalian target of rapamycin complex 1) controls transcriptional programs that determine CD8+ cytolytic T cell (CTL) fate. In some cell systems, mTORC1 couples phosphatidylinositol-3 kinase (PI3K) and Akt to the control...
3-Phosphoinositide-Dependent Protein Kinases Animals Aryl Hydrocarbon Receptor Nuclear Translocator CD8-Positive T-Lymphocytes Cell Differentiation Cell Movement Chemokines Gene Expression Regulation Glucose Glycolysis Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1 alpha Subunit Interleukin-2 Mechanistic Target of Rapamycin Complex 1 Mice Mice Inbred C57BL Mice Mutant Strains Mice Transgenic Multiprotein Complexes Phosphatidylinositol 3-Kinases Protein Serine-Threonine Kinases Proteins Proto-Oncogene Proteins c-akt Receptors Antigen T-Cell Receptors Chemokine TOR Serine-Threonine Kinases
Nonlinear switching with a graphene coupler
Daria A. Smirnova, Andrey V. Gorbach, Ivan V. Iorsh, Ilya V. Shadrivov, Yuri S. Kivshar
Jan 01, 0001
We study nonlinear propagation of electromagnetic waves in two closely spaced graphene layers and demonstrate that this double-layer graphene waveguide can operate as an efficient nonlinear optical coupler for both continuous...
Nonlinear switching with a graphene coupler
Daria A. Smirnova, Andrey V. Gorbach, Ivan V. Iorsh, Ilya V. Shadrivov, Yuri S. Kivshar
Jan 01, 0001
We study nonlinear propagation of electromagnetic waves in two closely spaced graphene layers and demonstrate that this double-layer graphene waveguide can operate as an efficient nonlinear optical coupler for both continuous...
Anisotropic odd viscosity via a time-modulated drive
At equilibrium, the structure and response of ordered phases are typically determined by the spontaneous breaking of spatial symmetries. Out of equilibrium, spatial order itself can become a dynamically emergent concept. In...
Graphene plasmonic waveguides for mid-infrared supercontinuum generation on a chip
Andrey V. Gorbach
Jul 23, 2015
Using perturbation expansion of Maxwell equations with the nonlinear boundary condition, a generic propagation equation is derived to describe nonlinear effects, including spectral broadening of pulses, in graphene surface...
Anisotropic odd viscosity via a time-modulated drive
At equilibrium, the structure and response of ordered phases are typically determined by the spontaneous breaking of spatial symmetries. Out of equilibrium, spatial order itself can become a dynamically emergent concept. In...
A string dual for partially topological Chern-Simons-matter theories
We consider a string dual of a partially topological $U(N)$
Chern-Simons-matter (PTCSM) theory recently introduced by Aganagic, Costello,
McNamara and Vafa. In this theory, fundamental matter fields are coupled to...
Graphene plasmonic waveguides for mid-infrared supercontinuum generation on a chip
Andrey V. Gorbach
Jul 23, 2015
Using perturbation expansion of Maxwell equations with the nonlinear boundary condition, a generic propagation equation is derived to describe nonlinear effects, including spectral broadening of pulses, in graphene surface...
Quasi-SMILES for Nano-QSAR Prediction of Toxic Effect of Al2O3 Nanoparticles
The level of malondialdehyde (MDA) in wet tissue of different organs is utilized as a measure of toxic effect. The numerical data on the concentration of MDA in wet tissue of liver, kidneys, brain, and heart of rat is examined...
Published by: IGI Global Scientific Publishing
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Testing the reproducibility and robustness of the cancer biology literature by robot.
Katherine Roper, A Abdel-Rehim, Sonya Hubbard, Martin Carpenter, Andrey Rzhetsky, Larisa Soldatova, Ross King
Apr 06, 2022
Scientific results should not just be 'repeatable' (replicable in the same laboratory under identical conditions), but also 'reproducible' (replicable in other laboratories under similar conditions). Results should also, if...
Testing the reproducibility and robustness of the cancer biology literature by robot.
Katherine Roper, A Abdel-Rehim, Sonya Hubbard, Martin Carpenter, Andrey Rzhetsky, Larisa Soldatova, Ross D King
May 09, 2022
Scientific results should not just be 'repeatable' (replicable in the same laboratory under identical conditions), but also 'reproducible' (replicable in other laboratories under similar conditions). Results should also, if...
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
Physically Triggered Morphology Changes in a Novel Acremonium Isolate Cultivated in Precisely Engineered Microfabricated Environments.
Fungi are strongly affected by their physical environment. Microfabrication offers the possibility of creating new culture environments and ecosystems with defined characteristics. Here, we report the isolation of a novel member...
Sentiment Analysis on Movie Reviews Dataset Using Support Vector Machines and Ensemble Learning
The internet makes it easier for people to connect to each other and has become a platform to express ideas and share information with the world. The growth of the internet has indirectly led to the development of social...
Published by: IGI Global Scientific Publishing
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
A Possible Submarine Landslide and Associated Tsunami at the Northwest Nile Delta, Mediterranean Sea
Ahmet C. Yalciner, Andrey Zaytsev, Betul Aytore, Isil Insel, Mohammad Heidarzadeh, Rozita Kian, Fumihiko Imamura
Jan 02, 2014
A hypothetical landslide tsunami at the Nile Delta in the Eastern Mediterranean Sea is modeled in order to study hazards it would pose to the region. The methodology used is based on numerical simulation of the generation and...
Near infrared ultrafast pump-probe spectroscopy with ZrF4-BaF2-LaF3-AlF3-NaF fiber supercontinuum
We report on the performance of a setup designed for femtosecond pump-probe spectroscopy in the near infrared (NIR) spectral region. We generate a supercontinuum (SC) probe by coupling 140 fs light pulses at 1550 nm into a...
Right sided eventration of diaphragm with clinodactyly
A. Sareen and K. Mahajan
Apr 21, 2015
Diaphragmatic hernia can be of two types-absence or deficiency of the diaphragm, or eventration resulting in elevation of a portion of the diaphragm as a result of incomplete muscularization. Complete eventration almost...
Published by: IJHS Medical Association
Sustainable Supply Chain Management Practices in Ghana
The study assessed the sustainable supply chain management (SSCM) practices of 303 manufacturing firms in Ghana with an annual turnover of not less than $1,000,000, which were purposively selected for the study. A questionnaire...
Published by: Indonesia Strategic Sustainability
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