Search
Results: 38
An arthropod cis-regulatory element functioning in sensory organ precursor development dates back to the Cambrian.
Achaete-Scute Complex Genome Region Amino Acid Sequence Animals Arthropods Base Sequence Basic Helix-Loop-Helix Transcription Factors Binding Sites Biological Evolution Conserved Sequence Gene Duplication Gene Expression Regulation Developmental Molecular Sequence Data Nervous System Neural Plate Phylogeny Regulatory Elements Transcriptional Sequence Alignment Species Specificity
Functional analysis of sense organ specification in the Tribolium castaneum larva reveals divergent mechanisms in insects.
Insects and other arthropods utilise external sensory structures for mechanosensory, olfactory, and gustatory reception. These sense organs have characteristic shapes related to their function, and in many cases are distributed...
Increased GLP-1 response to oral glucose in pre-pubertal obese children.
Cosimo Giannini, Nicoletta Pietropaoli, Nella Polidori, Francesco Chiarelli, Maria Loredana Marcovecchio, Angelika Mohn
Aug 24, 2018
BACKGROUND: Gastrointestinal hormones, such as glucagon-like peptide (GLP-1), have been hypothesized to play a role in the pathogenesis of obesity-related complications. However, few data are available in youth. The objective of...
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
Dendritic cells (DCs) undergo maturation during virus infection and thereby become potent stimulators of cell-mediated immunity. HIV-1 replicates in immature DCs, but we now find that infection is not accompanied by many...
Antigen Presentation cellular immunity cytokine production dendritic cell lysosome HIV-1 T lymphocyte
Published by: Rockefeller University
Sixteen Student-Athletes Will Face Disciplinary Action Over Alcohol
Winthrop University
Jan 01, 0001
The charges included eight for transferring alcohol to a person under 21; eight for possession of alcohol under 21, and one for resisting police. The student-athletes cited include: baseball players John Menken, Austin Lawrence...
Published by: Winthrop University
Deep carbon cycle constrained by carbonate solubility.
Stefan Farsang, Marion Louvel, Chaoshuai Zhao, Mohamed Mezouar, Angelika D Rosa, Remo N Widmer, Xiaolei Feng, Jin Liu, Simon A T Redfern
Aug 15, 2021
Earth's deep carbon cycle affects atmospheric CO2, climate, and habitability. Owing to the extreme solubility of CaCO3, aqueous fluids released from the subducting slab could extract all carbon from the...
Published by: Nature Communications
Role of THRB, ARG1, and ADRB2 Genetic Variants on Bronchodilators Response in Asthmatic Children.
Alessandra Scaparrotta, Marica Franzago, Maria Loredana Marcovecchio, Sabrina Di Pillo, Francesco Chiarelli, Angelika Mohn, Liborio Stuppia
Feb 12, 2019
Background: An interindividual variability in response to short-acting bronchodilator drugs (short-acting inhaled β2-agonists, SABA) exists and this is linked in part to genetic factors. The aim of this study was to verify the...
Asthma bronchodilator response children Genetic variants Pharmacogenetics Administration Inhalation Adrenergic beta-2 Receptor Agonists Arginase Asthma Bronchodilator Agents Child Female Forced Expiratory Volume Genes erbA genetic variation Genotype Humans Male Polymorphism Single Nucleotide Prospective Studies Receptors Adrenergic beta-2 Spirometry
Structure-Based Discovery of Lipoteichoic Acid Synthase Inhibitors.
Xavier Chee Wezen, Aneesh Chandran, Rohan Sakariah Eapen, Elaine Waters, Laura Bricio-Moreno, Tommaso Tosi, Stephen Dolan, Charlotte Millership, Aras Kadioglu, Angelika Gründling, Laura S Itzhaki, Martin Welch, Taufiq Rahman
Jun 09, 2022
Plasma from pre-pubertal obese children impairs insulin stimulated Nitric Oxide (NO) bioavailability in endothelial cells
Natalia Di Pietro, M Loredana Marcovecchio, Sara Di Silvestre, Tommaso de Giorgis, Vincenzo Giuseppe Pio Cordone, Paola Lanuti, Francesco Chiarelli, Giuseppina Bologna, Angelika Mohn, Assunta Pandolfi
Aug 01, 2018
Childhood obesity is commonly associated with early signs of endothelial dysfunction, characterized by impairment of insulin signaling and vascular Nitric Oxide (NO) availability. However, the underlying mechanisms remain to be...
ER stress Endothelial dysfunction Insulin Resistance Nitric oxide obesity Activating Transcription Factor 6 Biological Availability Biomarkers Cell Nucleus Child Cyclic GMP Endoplasmic Reticulum Chaperone BiP Endoplasmic reticulum stress Human Umbilical Vein Endothelial Cells Humans Insulin Models Biological NF-kappa B Nitric oxide Nitric Oxide Synthase Type III obesity Phosphorylation Protein Transport Proto-Oncogene Proteins c-akt Puberty
Deep carbon cycle constrained by carbonate solubility
Stefan Farsang, Marion Louvel, Chaoshuai Zhao, Mohamed Mezouar, Angelika D. Rosa, Remo N. Widmer, Xiaolei Feng, Jin Liu, Simon A. T. Redfern
Jul 28, 2021
Abstract: Earth’s deep carbon cycle affects atmospheric CO2, climate, and habitability. Owing to the extreme solubility of CaCO3, aqueous fluids released from the subducting slab could extract all carbon from the slab. However...
Distinct Trends of DNA Methylation Patterning in the Innate and Adaptive Immune Systems.
Ronald P Schuyler, Angelika Merkel, Emanuele Raineri, Lucia Altucci, Edo Vellenga, Joost HA Martens, Farzin Pourfarzad, Taco W Kuijpers, Frances Burden, Samantha Farrow, Kate Downes, Willem H Ouwehand, Laura Clarke, Avik Datta, Ernesto Lowy, Paul Flicek, Mattia Frontini, Hendrik G Stunnenberg, José I Martín-Subero, Ivo Gut, Simon Heath
Oct 10, 2018
DNA methylation and the localization and post-translational modification of nucleosomes are interdependent factors that contribute to the generation of distinct phenotypes from genetically identical cells. With 112 whole-genome...
2ʹ-Deoxyadenosine 5ʹ-diphosphoribose is an endogenous TRPM2 superagonist
Ralf Fliegert, Andreas Bauche, Adriana-Michelle Wolf Pérez, Joanna M Watt, Monika D. Rozewitz, Riekje Winzer, Mareike Janus, Feng Gu, Annette Rosche, Angelika Harneit, Marianne Flato, Christelle Moreau, Tanja Kirchberger, Valerie Wolters, Barry V. L. Potter, Andreas H Guse
Sep 01, 2017
Transient receptor potential melastatin 2 (TRPM2), is a ligand-gated Ca2+-permeable non selective cation channel. While physiological stimuli, e.g. chemotactic agents, evoke controlled Ca2+ signals via TRPM2, pathophysiological...
2ʹ-Deoxyadenosine 5ʹ-diphosphoribose is an endogenous TRPM2 superagonist
Ralf Fliegert, Andreas Bauche, Adriana-Michelle Wolf Pérez, Joanna M Watt, Monika D. Rozewitz, Riekje Winzer, Mareike Janus, Feng Gu, Annette Rosche, Angelika Harneit, Marianne Flato, Christelle Moreau, Tanja Kirchberger, Valerie Wolters, Barry V. L. Potter, Andreas H Guse
Sep 01, 2017
Transient receptor potential melastatin 2 (TRPM2), is a ligand-gated Ca2+-permeable non selective cation channel. While physiological stimuli, e.g. chemotactic agents, evoke controlled Ca2+ signals via TRPM2, pathophysiological...
Haematopoietic stem cells in perisinusoidal niches are protected from ageing.
Mehmet Saçma, Johannes Pospiech, Ruzhica Bogeska, Walter de Back, Jan-Philipp Mallm, Vadim Sakk, Karin Soller, Gina Marka, Angelika Vollmer, Rebekah Karns, Nina Cabezas-Wallscheid, Andreas Trumpp, Simón Méndez-Ferrer, Michael D Milsom, Medhanie A Mulaw, Hartmut Geiger, Maria Carolina Florian
Nov 15, 2019
With ageing, intrinsic haematopoietic stem cell (HSC) activity decreases, resulting in impaired tissue homeostasis, reduced engraftment following transplantation and increased susceptibility to diseases. However, whether ageing...
aging Animals Bone Marrow Capillaries Cell Differentiation Cell Division Cell Polarity Cell Tracking Doxycycline Fluorouracil Gene Expression Regulation Genes Reporter Green Fluorescent Proteins Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells Histones Homeostasis Jagged-2 Protein Mice Mice Inbred C57BL Mice Transgenic Myeloablative Agonists Stem Cell Niche
Intra-Tumour Heterogeneity Is One of the Main Sources of Inter-Observer Variation in Scoring Stromal Tumour Infiltrating Lymphocytes in Triple Negative Breast Cancer.
Darren Kilmartin, Mark O'Loughlin, Xavier Andreu, Zsuzsanna Bagó-Horváth, Simonetta Bianchi, Ewa Chmielik, Gábor Cserni, Paulo Figueiredo, Giuseppe Floris, Maria Pia Foschini, Anikó Kovács, Päivi Heikkilä, Janina Kulka, Anne-Vibeke Laenkholm, Inta Liepniece-Karele, Caterina Marchiò, Elena Provenzano, Peter Regitnig, Angelika Reiner, Aleš Ryška, Anna Sapino, Elisabeth Specht Stovgaard, Cecily Quinn, Vasiliki Zolota, Mark Webber, Davood Roshan, Sharon A Glynn, Grace Callagy
Oct 13, 2021
Stromal tumour infiltrating lymphocytes (sTILs) are a strong prognostic marker in triple negative breast cancer (TNBC). Consistency scoring sTILs is good and was excellent when an internet-based scoring aid developed by the...
Adjuvant Effect of Orally Applied Preparations Containing Non-Digestible Polysaccharides on Influenza Vaccination in Healthy Seniors
Christiane Laue, Yala Stevens, Monique van Erp, Ekaterina Papazova, Edlyn Soeth, Angelika Pannenbeckers, Ellen Stolte, Ruwen Böhm, Sophie Le Gall, Xavier Falourd, Simon Ballance, Svein H Knutsen, Iris Pinheiro, Sam Possemiers, Paul M Ryan, R Paul Ross, Catherine Stanton, Jerry M Wells, Sylvie van der Werf, Jurriaan J Mes, Juergen Schrezenmeir
Oct 25, 2021
Senior individuals can suffer from immunosenescence and novel strategies to bolster the immune response could contribute to healthy ageing. In this double-blind, randomised, controlled pilot trial, we investigated the ability of...
Adjuvant Arabinoxylan Cold Immunity Influenza non-digestible polysaccharide Prebiotics Vaccination β-glucan Adjuvants Immunologic Administration Oral Aged Double-Blind Method Female Healthy Volunteers Hemagglutination Inhibition Tests Humans Immunization Secondary Influenza A virus H1N1 Subtype Influenza A virus Influenza Vaccines Influenza Human Male Middle Aged Pilot Projects Polysaccharides
Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types
Simone Ecker, Lu Chen, Vera Pancaldi, Frederik O Bagger, José M Fernández, Enrique Carrillo de Santa Pau, David Juan, Alice L Mann, Stephen Watt, Francesco P Casale, Nikos Sidiropoulos, Nicolas Rapin, Angelika Merkel, Hendrik G Stunnenberg, Oliver Stegle, Mattia Frontini, Kate Downes, Tomi Pastinen, Taco W Kuijpers, Daniel Rico, Alfonso Valencia, Stephan Beck, Nicole Soranzo, Dirk S Paul
Jan 27, 2017
Abstract
Background
A healthy immune system requires immune cells that adapt rapidly to environmental challenges. This phenotypic plasticity can be mediated by transcriptional and...
Intra-Tumour Heterogeneity Is One of the Main Sources of Inter-Observer Variation in Scoring Stromal Tumour Infiltrating Lymphocytes in Triple Negative Breast Cancer
Darren Kilmartin, Mark O’Loughlin, Xavier Andreu, Zsuzsanna Bagó-Horváth, Simonetta Bianchi, Ewa Chmielik, Gábor Cserni, Paulo Figueiredo, Giuseppe Floris, Maria Pia Foschini, Anikó Kovács, Päivi Heikkilä, Janina Kulka, Anne-Vibeke Laenkholm, Inta Liepniece-Karele, Caterina Marchiò, Elena Provenzano, Peter Regitnig, Angelika Reiner, Aleš Ryška, Anna Sapino, Elisabeth Specht Stovgaard, Cecily Quinn, Vasiliki Zolota, Mark Webber, Davood Roshan, Sharon A. Glynn, Grace Callagy
Sep 02, 2021
Stromal tumour infiltrating lymphocytes (sTILs) are a strong prognostic marker in triple negative breast cancer (TNBC). Consistency scoring sTILs is good and was excellent when an internet-based scoring aid developed by the...
Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein
Mariana Sacerdoti, Lissy Gross, Andrew M. Riley, Karin Zehnder, Abhijeet Ghode, Sebastian Klinke, Ganesh Srinivasan Anand, Kristina Paris, Angelika Winkel, Amanda K. Herbrand, H. Yasmin Godage, Gyles Cozier, Evelyn Sub, Jorg O. Schulze, Daniel Pastor-Flores, Mariela Bollini, Maria Victoria Cappellari, Dmitri Svergun, Melissa A. Grawert, Pedro F. Aramendia, Alejandro E. Leroux, Barry Potter, Carlos J. Camacho, Ricardo M. Biondi
Jun 13, 2023
The activation of at least 23 different mammalian kinases requires the phosphorylation of their hydrophobic motifs by the kinase PDK1. A linker connects the phosphoinositide-binding PH domain to the catalytic domain, which...
Accelerating drug development for neuroblastoma
Lucas Moreno, Giuseppe Barone, Steven G DuBois, Jan Molenaar, Matthias Fischer, Johannes Schulte, Angelika Eggert, Gudrun Schleiermacher, Frank Speleman, Louis Chesler, Birgit Geoerger, Michael D Hogarty, Meredith S Irwin, Nick Bird, Guy B Blanchard, Sean Buckland, Hubert Caron, Susan Davis, Bram De Wilde, Hedwig E Deubzer, Emmy Dolman, Martin Eilers, Rani E George, Sally George, Štěrba Jaroslav, John M Maris, Lynley Marshall, Melinda Merchant, Peter Mortimer, Cormac Owens, Anna Philpott, Evon Poon, Jerry W Shay, Roberto Tonelli, Dominique Valteau-Couanet, Gilles Vassal, Julie R Park, Andrew DJ Pearson
Jul 29, 2020
Only one class of targeted agents (anti-GD2 antibodies) has been incorporated into front-line therapy for neuroblastoma since the 1980s. The Neuroblastoma New Drug Development Strategy (NDDS) initiative commenced in 2012 to...
Clinical Trials Drug development epigenetics MYCN Neuroblastoma phase I Preclinical testing Antineoplastic Agents Brain Neoplasms Child Congresses as Topic Drug development Drug Discovery Europe Humans Medical Oncology Molecular Targeted Therapy Neuroblastoma Pediatrics Protein Kinase Inhibitors therapies Investigational
Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein
Mariana Sacerdoti, Lissy Gross, Andrew M. Riley, Karin Zehnder, Abhijeet Ghode, Sebastian Klinke, Ganesh Srinivasan Anand, Kristina Paris, Angelika Winkel, Amanda K. Herbrand, H. Yasmin Godage, Gyles Cozier, Evelyn Sub, Jorg O. Schulze, Daniel Pastor-Flores, Mariela Bollini, Maria Victoria Cappellari, Dmitri Svergun, Melissa A. Grawert, Pedro F. Aramendia, Alejandro E. Leroux, Barry Potter, Carlos J. Camacho, Ricardo M. Biondi
Jun 13, 2023
The activation of at least 23 different mammalian kinases requires the phosphorylation of their hydrophobic motifs by the kinase PDK1. A linker connects the phosphoinositide-binding PH domain to the catalytic domain, which...
A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity.
David Wylensek, Thomas CA Hitch, Thomas Riedel, Afrizal Afrizal, Neeraj Kumar, Esther Wortmann, Tianzhe Liu, Saravanan Devendran, Till R Lesker, Sara B Hernández, Viktoria Heine, Eva M Buhl, Paul M D'Agostino, Fabio Cumbo, Thomas Fischöder, Marzena Wyschkon, Torey Looft, Valeria R Parreira, Birte Abt, Heidi L Doden, Lindsey Ly, João MP Alves, Markus Reichlin, Krzysztof Flisikowski, Laura Navarro Suarez, Anthony P Neumann, Garret Suen, Tomas de Wouters, Sascha Rohn, Ilias Lagkouvardos, Emma Allen-Vercoe, Cathrin Spröer, Boyke Bunk, Anja J Taverne-Thiele, Marcel Giesbers, Jerry M Wells, Klaus Neuhaus, Angelika Schnieke, Felipe Cava, Nicola Segata, Lothar Elling, Till Strowig, Jason M Ridlon, Tobias AM Gulder, Jörg Overmann, Thomas Clavel
Jan 25, 2021
Our knowledge about the gut microbiota of pigs is still scarce, despite the importance of these animals for biomedical research and agriculture. Here, we present a collection of cultured bacteria from the pig gut, including 110...
Towards a cancer mission in Horizon Europe
Anton Berns, Ulrik Ringborg, Julio E Celis, Manuel Heitor, Neil K Aaronson, Nancy Abou-Zeid, Hans-Olov Adami, Kathi Apostolidis, Michael Baumann, Alberto Bardelli, René Bernards, Yvonne Brandberg, Carlos Caldas, Fabien Calvo, Caroline Dive, Angelika Eggert, Alexander Eggermont, Carolina Espina, Frederik Falkenburg, Jérôme Foucaud, Douglas Hanahan, Ulrike Helbig, Bengt Jönsson, Mette Kalager, Sakari Karjalainen, Miklós Kásler, Pamela Kearns, Klas Kärre, Denis Lacombe, Francesco de Lorenzo, Françoise Meunier, Gerd Nettekoven, Simon Oberst, Péter Nagy, Thierry Philip, Richard Price, Joachim Schüz, Eric Solary, Peter Strang, Josep Tabernero, Emile Voest
Sep 04, 2020
A comprehensive translational cancer research approach focused on personalized and precision medicine, and covering the entire cancer research-care-prevention continuum has the potential to achieve in 2030 a 10-year...
European healthcare systems cancer mission cancer research/care/prevention continuum comprehensive cancer centres patient empowerment Science policy Cancer Survivors Clinical Trials as Topic Europe Humans Neoplasms Organizational Innovation Palliative Care Patient Participation specialization Translational Research Biomedical
ONEST (Observers Needed to Evaluate Subjective Tests) Analysis of Stromal Tumour-Infiltrating Lymphocytes (sTILs) in Breast Cancer and Its Limitations.
Bálint Cserni, Darren Kilmartin, Mark O'Loughlin, Xavier Andreu, Zsuzsanna Bagó-Horváth, Simonetta Bianchi, Ewa Chmielik, Paulo Figueiredo, Giuseppe Floris, Maria Pia Foschini, Anikó Kovács, Päivi Heikkilä, Janina Kulka, Anne-Vibeke Laenkholm, Inta Liepniece-Karele, Caterina Marchiò, Elena Provenzano, Peter Regitnig, Angelika Reiner, Aleš Ryška, Anna Sapino, Elisabeth Specht Stovgaard, Cecily Quinn, Vasiliki Zolota, Mark Webber, Sharon A Glynn, Rita Bori, Erika Csörgő, Orsolya Oláh-Németh, Tamás Pancsa, Anita Sejben, István Sejben, András Vörös, Tamás Zombori, Tibor Nyári, Grace Callagy, Gábor Cserni
Mar 06, 2023
|
|< |
< |
1 |