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Results: 115
The diagnostic impact of UK regional variations in age-specific prostate-specific antigen guidelines.
Alexander Light, Nicholas Burns-Cox, Angus Maccormick, Joseph John, John McGrath, Vincent J Gnanapragasam
May 04, 2021
The ideal prostate cancer diagnostic pathway would maximise detection of clinically-significant prostate cancer (csPCa) while avoiding unnecessary biopsies and other investigations. The introduction of pre-biopsy MRI has done...
Where we work determines what we eat
Food choices, including the decision to consume meat, are complex and determined by many inter-related influences. This study examined the choice of working professionals to consume meat in the context of forced changes in...
Visualisation of BioPAX Networks using BioLayout Express (3D).
BioLayout Express (3D) is a network analysis tool designed for the visualisation and analysis of graphs derived from biological data. It has proved to be powerful in the analysis of gene expression data, biological pathways and...
Competition and Dispersal in Pseudomonas aeruginosa
Dispersal plays a crucial role in a range of evolutionary and ecological processes; hence there is strong motivation to understand its evolution. One key prediction is that the relative benefits of dispersal should be greater...
Competition and Dispersal in Pseudomonas aeruginosa
Dispersal plays a crucial role in a range of evolutionary and ecological processes; hence there is strong motivation to understand its evolution. One key prediction is that the relative benefits of dispersal should be greater...
Spatial Structure Mitigates Fitness Costs in Host-Parasite Coevolution
The extent of population mixing is known to influence the coevolutionary outcomes of many host and parasite traits, including the evolution of generalism (the ability to resist or infect a broad range of genotypes). While the...
Spatial Structure Mitigates Fitness Costs in Host-Parasite Coevolution
The extent of population mixing is known to influence the coevolutionary outcomes of many host and parasite traits, including the evolution of generalism (the ability to resist or infect a broad range of genotypes). While the...
Population mixing promotes arms race host–parasite coevolution
The consequences of host–parasite coevolution are highly contingent on the qualitative coevolutionary dynamics: whether selection fluctuates (fluctuating selection dynamic; FSD), or is directional towards increasing...
Social Networking Tools for the DCC
The DCC is considering how it can engage more fully with its target communities using social media. Encouraged by the experience of other organisations in this area, the DCC has conducted surveys both internally and externally...
wikis forums Social Media collaborative writing social bookmarking Blogging Social Networking Microblogging
Published by: Digital Curation Centre
Predictive Validity of the qSOFA Score for Sepsis in Adults with Community-Onset Staphylococcal Infection in Thailand.
Supaksh Gupta, Kristina E Rudd, Sarunporn Tandhavanant, Pornpan Suntornsut, Ploenchan Chetchotisakd, Derek C Angus, Sharon J Peacock, Narisara Chantratita, Timothy Eoin West
Nov 21, 2019
The quick sequential organ failure assessment (qSOFA) score has had limited validation in lower resource settings and was developed using data from high-income countries. We sought to evaluate the predictive validity of the...
Effects of epistasis on infectivity range during host-parasite coevolution
Understanding how parasites adapt to changes in host resistance is crucial to evolutionary epidemiology. Experimental studies have demonstrated that parasites are more capable of adapting to gradual, rather than sudden changes...
Population mixing promotes arms race host–parasite coevolution
The consequences of host–parasite coevolution are highly contingent on the qualitative coevolutionary dynamics: whether selection fluctuates (fluctuating selection dynamic; FSD), or is directional towards increasing...
Dislocation interactions in olivine control postseismic creep of the upper mantle.
Changes in stress applied to mantle rocks, such as those imposed by earthquakes, commonly induce a period of transient creep, which is often modelled based on stress transfer among slip systems due to grain interactions....
Published by: Nature Communications
The diversity-generating benefits of a prokaryotic adaptive immune system
Stineke van Houte, Alice Ekroth, Jenny Broniewski, Hélène Chabas, Ben Ashby, Joseph Bondy-Denomy, Sylvain Gandon, Mike Boots, Angus Buckling, Edze Westra
Apr 21, 2016
Prokaryotic CRISPR-Cas adaptive immune systems insert spacers derived from viruses and other parasitic DNA elements into CRISPR loci to provide sequence-specific immunity. This frequently results in high within-population spacer...
Solid-State Lithium-Ion Batteries as a Method for Doping Halide Perovskites with an In Situ Optical Readout of Dopant Concentration.
Controlled doping of halide perovskites is a longstanding challenge for efficient optoelectronic applications. Here, a solid-state lithium-ion battery (LIB) inspired device is used as a method of extrinsically doping a halide...
Effects of epistasis on infectivity range during host-parasite coevolution
Understanding how parasites adapt to changes in host resistance is crucial to evolutionary epidemiology. Experimental studies have demonstrated that parasites are more capable of adapting to gradual, rather than sudden changes...
Social Networking Tools for the DCC
The DCC is considering how it can engage more fully with its target communities using social media. Encouraged by the experience of other organisations in this area, the DCC has conducted surveys both internally and externally...
wikis forums Social Media collaborative writing social bookmarking Blogging Social Networking Microblogging
Published by: Digital Curation Centre
Host-parasite fluctuating selection in the absence of specificity
Alex Best, Ben Ashby, Andy White, Roger Bowers, Angus Buckling, Britt Koskella, Mike Boots
Nov 01, 2017
Fluctuating selection driven by coevolution between hosts and parasites is important for the generation of host and parasite diversity across space and time. Theory has focused primarily on infection genetics, with highly...
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