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Results: 66
A direct role for SNX9 in the biogenesis of filopodia.
Iris K Jarsch, Jonathan R Gadsby, Annalisa Nuccitelli, Julia Mason, Hanae Shimo, Ludovic Pilloux, Bishara Marzook, Claire M Mulvey, Ulrich Dobramysl, Charles R Bradshaw, Kathryn S Lilley, Richard D Hayward, Tristan J Vaughan, Claire L Dobson, Jennifer L Gallop
May 25, 2020
Filopodia are finger-like actin-rich protrusions that extend from the cell surface and are important for cell-cell communication and pathogen internalization. The small size and transient nature of filopodia combined with shared...
Published by: The Journal of cell biology
Wind Energy, Benefit-Sharing and Indigenous Peoples
This article looks at the practice of benefit-sharing in wind energy projects in indigenous peoples’ lands in the Isthmus of Tehuantepec, Mexico. The aim is to gauge how the procedural, distributive and recognition justice...
Published by: Oil, Gas and Energy Law
Structure of As-Se glasses by neutron diffraction with isotope substitution
The method of neutron diffraction with selenium isotope substitution is used to measure the structure of glassy As0.30Se0.70, As0.35Se0.65 and As0.40Se0.60. The method delivers three difference functions for each sample in which...
Modelling circulating tumour cells for personalised survival prediction in metastatic breast cancer.
Ductal carcinoma is one of the most common cancers among women, and the main cause of death is the formation of metastases. The development of metastases is caused by cancer cells that migrate from the primary tumour site (the...
Combining Pathway Identification and Breast Cancer Survival Prediction via Screening-Network Methods.
Breast cancer is one of the most common invasive tumors causing high mortality among women. It is characterized by high heterogeneity regarding its biological and clinical characteristics. Several high-throughput assays have...
Structure of As-Se glasses by neutron diffraction with isotope substitution
The method of neutron diffraction with selenium isotope substitution is used to measure the structure of glassy As0.30Se0.70, As0.35Se0.65 and As0.40Se0.60. The method delivers three difference functions for each sample in which...
The makings of a gradient
The gibberellin phytohormones regulate growth and development throughout the plant lifecycle. Upstream regulation and downstream responses to gibberellins vary across cells and tissues, developmental stages, environmental...
Cancer Markers Selection Using Network-Based Cox Regression
International initiatives such as the Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) are collecting multiple datasets at different genome-scales with the aim of identifying novel cancer...
Understanding and predicting the impact of critical dissolution variables for nifedipine immediate release capsules by multivariate data analysis
In this study the selection of in vivo predictive in vitro dissolution experimental set-ups using a multivariate analysis approach, in line with the Quality by Design (QbD) principles, is explored. The dissolution variables...
High-pressure neutron diffraction apparatus for investigating the structure of liquids under hydrothermal conditions
A high-pressure setup is described for making neutron diffraction experiments on liquids under hydrothermal conditions. Designs are given for a modied Bridgman unsupported area seal, a fluid separator that keeps apart the liquid...
CiliateGEM
Alessio Mancini, Filmon Eyassu, Maxwell Conway, Annalisa Occhipinti, Pietro Liò, Claudio Angione, Sandra Pucciarelli
May 13, 2019
BACKGROUND: The study of cell metabolism is becoming central in several fields such as biotechnology, evolution/adaptation and human disease investigations. Here we present CiliateGEM, the first metabolic network reconstruction...
High-pressure neutron diffraction apparatus for investigating the structure of liquids under hydrothermal conditions
A high-pressure setup is described for making neutron diffraction experiments on liquids under hydrothermal conditions. Designs are given for a modied Bridgman unsupported area seal, a fluid separator that keeps apart the liquid...
Understanding and predicting the impact of critical dissolution variables for nifedipine immediate release capsules by multivariate data analysis
In this study the selection of in vivo predictive in vitro dissolution experimental set-ups using a multivariate analysis approach, in line with the Quality by Design (QbD) principles, is explored. The dissolution variables...
When Did the Swahili Become Maritime?
Jeffrey Fleisher, Paul Lane, Adria LaViolette, Mark Horton, Edward Pollard, Eréndira Quintana Morales, Thomas Vernet, Annalisa Christie, Stephanie Wynne-Jones
Apr 29, 2019
UNLABELLED: In this article, we examine an assumption about the historic Swahili of the eastern African coast: that they were a maritime society from their beginnings in the first millennium C.E. Based on historical and...
2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa.
Alyssa C McVey, Sean Bartlett, Mahmud Kajbaf, Annalisa Pellacani, Viviana Gatta, Päivi Tammela, David R Spring, Martin Welch
Apr 03, 2020
Pseudomonas aeruginosa conditionally essential target enzyme inhibitor glyoxylate shunt isocitrate lyase Isothermal titration calorimetry malate synthase G Aminopyridines Anti-Bacterial Agents Bacterial Proteins Calorimetry Cell Line Gene Expression Regulation Bacterial Glyoxylates Humans isocitrate lyase Malate Synthase Molecular Structure Pseudomonas aeruginosa
Structure and dynamics of aqueous NaCl solutions at high temperatures and pressures
Annalisa Polidori, Ruth Rowlands, Anita Zeidler, Mathieu Salanne, Henry Fischer, Burkhard Annighoefer, Stefan Klotz, Philip Salmon
Nov 21, 2021
The structure of a concentrated solution of NaCl in D2O was investigated by in situ high-pressure neutron diffraction with chlorine isotope substitution to give site-specific information on the coordination environment of the...
Structure and dynamics of aqueous NaCl solutions at high temperatures and pressures
Annalisa Polidori, Ruth Rowlands, Anita Zeidler, Mathieu Salanne, Henry Fischer, Burkhard Annighoefer, Stefan Klotz, Philip Salmon
Nov 21, 2021
The structure of a concentrated solution of NaCl in D2O was investigated by in situ high-pressure neutron diffraction with chlorine isotope substitution to give site-specific information on the coordination environment of the...
2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa.
Alyssa C McVey, Sean Bartlett, Mahmud Kajbaf, Annalisa Pellacani, Viviana Gatta, Päivi Tammela, David R Spring, Martin Welch
May 09, 2020
Pseudomonas aeruginosa enzyme inhibitor isocitrate lyase Isothermal titration calorimetry glyoxylate shunt malate synthase G conditionally essential target
Published by: International journal of molecular sciences
2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa
Alyssa C. McVey, Sean Bartlett, Mahmud Kajbaf, Annalisa Pellacani, Viviana Gatta, Päivi Tammela, David R. Spring, Martin Welch
Apr 04, 2020
Pseudomonas aeruginosa is an opportunistic pathogen responsible for many hospital-acquired infections. P. aeruginosa can thrive in diverse infection scenarios by rewiring its central metabolism. An example of this is the...
The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation.
Samuel A Lambert, Laurent Gil, Simon Jupp, Scott C Ritchie, Yu Xu, Annalisa Buniello, Aoife McMahon, Gad Abraham, Michael Chapman, Helen Parkinson, John Danesh, Jacqueline AL MacArthur, Michael Inouye
Nov 09, 2020
Differential biosynthesis and cellular permeability explain longitudinal gibberellin gradients in growing roots.
Annalisa Rizza, Bijun Tang, Claire E Stanley, Guido Grossmann, Markus R Owen, Leah R Band, Alexander M Jones
Aug 26, 2021
Control over cell growth by mobile regulators underlies much of eukaryotic morphogenesis. In plant roots, cell division and elongation are separated into distinct longitudinal zones and both division and elongation are...
Exploring regulatory networks of miR-96 in the developing inner ear.
Morag A Lewis, Annalisa Buniello, Jennifer M Hilton, Fei Zhu, William I Zhang, Stephanie Evans, Stijn van Dongen, Anton J Enright, Karen P Steel
Jan 22, 2018
Mutations in the microRNA Mir96 cause deafness in mice and humans. In the diminuendo mouse, which carries a single base pair change in the seed region of miR-96, the sensory hair cells crucial for hearing fail to develop fully...
Patient's Clinical Presentation and CPPopt Availability
Annalisa Liberti, Erta Beqiri, Ari Ercole, Manuel Cabeleira, Jeanette Tas, Frederick A Zeiler, Marek Czosnyka, Peter Smielewski, Marcel J Aries, CENTER-TBI High Resolution Substudy Participants and Investigators
Apr 17, 2020
BACKGROUND: The 'optimal' CPP (CPPopt) concept is based on the vascular pressure reactivity index (PRx). The feasibility and effectiveness of CPPopt guided therapy in severe traumatic brain injury (TBI) patients is currently...
Decreasing hospital burden of COVID-19 during the first wave in Regione Lombardia
Francesca Maria Grosso, Anne Margaret Presanis, Kevin Kunzmann, Chris Jackson, Alice Corbella, Giacomo Grasselli, Aida Andreassi, Annalisa Bodina, Maria Gramegna, Silvana Castaldi, Danilo Cereda, Daniela De Angelis, Covid-19 Lombardy Working Group
Jan 04, 2022
BACKGROUND: The aim of this study is to quantify the hospital burden of COVID-19 during the first wave and how it changed over calendar time; to interpret the results in light of the emergency measures introduced to manage the...
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