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Lessons Learned About Designing and Conducting Studies From HRI Experts.
Marlena R Fraune, Iolanda Leite, Nihan Karatas, Aida Amirova, Amélie Legeleux, Anara Sandygulova, Anouk Neerincx, Gaurav Dilip Tikas, Hatice Gunes, Mayumi Mohan, Nida Itrat Abbasi, Sudhir Shenoy, Brian Scassellati, Ewart J de Visser, Takanori Komatsu
Feb 11, 2022
The field of human-robot interaction (HRI) research is multidisciplinary and requires researchers to understand diverse fields including computer science, engineering, informatics, philosophy, psychology, and more disciplines....
Preferential interaction of MHC class I with TAPBPR in the absence of glycosylation.
We recently discovered that TAPBPR promotes reglucosylation of the N-linked glycan on MHC class I molecules, a modification that restores their recognition by calreticulin and reincorporation into the peptide-loading complex. We...
antigen processing and presentation MHC N-linked glycosylation tapasin Calreticulin Cell Line Tumor Endoplasmic Reticulum Genes MHC Class I Glycosylation HeLa Cells Histocompatibility Antigens Class I Humans Immunoglobulins Membrane Proteins Membrane Transport Proteins Peptides Protein Disulfide-Isomerases
Coincident relapsing polychondritis and IgG4-related disease
Relapsing polychondritis (RP) and immunoglobulin G4–related disease (IgG4-RD) are rare multi-organ immune-mediated diseases. Both can present with nonspecific symptoms of fatigue, weight loss, arthralgia, raised inflammatory...
Visual loss in giant cell arteritis 3 weeks after steroid initiation.
Giant cell arteritis (GCA) is the most common vasculitis in adults and blindness is a common complication if left untreated. Oral glucocorticoids are the mainstay of treatment and if started promptly, loss of vision can usually...
Utilizing TAPBPR to promote exogenous peptide loading onto cell surface MHC I molecules.
The repertoire of peptides displayed at the cell surface by MHC I molecules is shaped by two intracellular peptide editors, tapasin and TAPBPR. While cell-free assays have proven extremely useful in identifying the function of...
TAPBPR mediates peptide dissociation from MHC class I using a leucine lever.
F Tudor Ilca, Andreas Neerincx, Clemens Hermann, Ana Marcu, Stefan Stevanović, Janet E Deane, Louise H Boyle
Dec 19, 2018
Antigen Presentation Antigen processing human immunology Inflammation Major Histocompatibility Complex Amino Acid Sequence Antigen Presentation Binding Sites HLA-A Antigens HeLa Cells Histocompatibility Antigens Class I Humans Immunoglobulins Leucine Membrane Proteins Molecular Docking Simulation Mutation Peptides Protein Binding Protein Domains
Place of death and end-of-life transitions experienced by very old people with differing cognitive status
Anouk J Perrels, Jane Fleming, Jun Zhao, Stephen Barclay, Morag Farquhar, Hilde M Buiting, Carol Brayne, Cambridge City over-75s Cohort (CC75C) study collaboration
Jun 14, 2019
BACKGROUND: Despite fast-growing 'older old' populations, 'place of care' trajectories for very old people approaching death with or without dementia are poorly described and understood. AIM: To explore end-of-life transitions...
80 and over COGNITIVE IMPAIRMENT Aged Delivery of Health Care Dementia Frail Elderly Homes for the Aged Nursing Homes Patient Transfer residential characteristics Terminal Care Aged 80 and over Cognition Disorders Cohort Studies Female Hospital Mortality Humans Male Nursing Homes Terminal Care Terminally Ill United Kingdom
A Neural Network Approach to Identify the Peritumoral Invasive Areas in Glioblastoma Patients by Using MR Radiomics
Jiun-Lin Yan, Chao Li, Anouk van der Hoorn, Natalie R. Boonzaier, Tomasz Matys, Stephen J. Price
Jun 17, 2021
Abstract: The challenge in the treatment of glioblastoma is the failure to identify the cancer invasive area outside the contrast-enhancing tumour which leads to the high local progression rate. Our study aims to identify its...
A Neural Network Approach to Identify the Peritumoral Invasive Areas in Glioblastoma Patients by Using MR Radiomics
Jiun-Lin Yan, Chao Li, Anouk van der Hoorn, Natalie R. Boonzaier, Tomasz Matys, Stephen J. Price
Aug 11, 2020
Abstract: The challenge in the treatment of glioblastoma is the failure to identify the cancer invasive area outside the contrast-enhancing tumour which leads to the high local progression rate. Our study aims to identify its...
Anouk van der Hoorn, Jiun-Lin Yan, Timothy J Larkin, Natalie R Boonzaier, Tomasz Matys, Stephen J Price
May 12, 2016
Apparent diffusion coefficient Brain tumor Glioblastoma Magnetic Resonance Imaging treatment response Aged Brain Neoplasms Cohort Studies Diffusion Magnetic Resonance Imaging Female Glioblastoma Humans Image Processing Computer-Assisted Male Middle Aged Neoplasm Recurrence Local Regression Analysis Survival Analysis Treatment Outcome Tumor Burden
Validation of a semi-automatic co-registration of MRI scans in patients with brain tumors during treatment follow-up.
Anouk van der Hoorn, Jiun-Lin Yan, Timothy J Larkin, Natalie R Boonzaier, Tomasz Matys, Stephen J Price
Apr 01, 2016
MRI brain tumors high-grade gliomas linear co-registration non-linear co-registration structural similarity treatment response validation Adult Aged Algorithms Brain Neoplasms Female Follow-Up Studies Glioblastoma Humans Image Enhancement Image Interpretation Computer-Assisted Longitudinal Studies Magnetic Resonance Imaging Male Middle Aged pattern recognition Automated Sensitivity and Specificity Subtraction Technique Treatment Outcome
Ventricle contact is associated with lower survival and increased peritumoral perfusion in glioblastoma.
Bart Roelf Jan van Dijken, Peter Jan van Laar, Chao Li, Jiun-Lin Yan, Natalie Rosella Boonzaier, Stephen John Price, FCRS, Anouk van der Hoorn
Sep 05, 2018
Glioblastoma Lateral Ventricles Magnetic Resonance Imaging oncology Perfusion survival Adult Aged Brain Neoplasms Cerebral Ventricles Cerebrovascular Circulation Cohort Studies Female Glioblastoma Humans Magnetic Resonance Imaging Male Middle Aged Multimodal Imaging Survival Rate Treatment Outcome Young Adult
A Neural Network Approach to Identify the Peritumoral Invasive Areas in Glioblastoma Patients by Using MR Radiomics
Jiun-Lin Yan, Chao Li, Anouk van der Hoorn, Natalie R. Boonzaier, Tomasz Matys, Stephen J. Price
Jun 16, 2020
Abstract: The challenge in the treatment of glioblastoma is the failure to identify the cancer invasive area outside the contrast-enhancing tumour which leads to the high local progression rate. Our study aims to identify its...
A Neural Network Approach to Identify the Peritumoral Invasive Areas in Glioblastoma Patients by Using MR Radiomics.
Jiun-Lin Yan, Chao Li, Anouk van der Hoorn, Natalie R Boonzaier, Tomasz Matys, Stephen J Price
Jul 02, 2020
The challenge in the treatment of glioblastoma is the failure to identify the cancer invasive area outside the contrast-enhancing tumour which leads to the high local progression rate. Our study aims to identify its progression...
Adult Aged Aminolevulinic Acid Brain Neoplasms Cohort Studies Contrast Media Diffusion Magnetic Resonance Imaging Disease Progression Female Glioblastoma Humans Image Processing Computer-Assisted Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Middle Aged Neural Networks Computer Optical Imaging Retrospective Studies
Cardiac decompensation revealing giant cell arteritis.
Karl Emil Nelveg-Kristensen, Anouk Le Goueff, Rona M Smith, Kevin Loudon, Allyson C Egan, David RW Jayne
Nov 22, 2021
Cardiac decompensation revealing giant cell arteritis.
Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer's disease polygenic risk score.
Jori Tomassen, Anouk den Braber, Sven J van der Lee, Lianne M Reus, Elles Konijnenberg, Stephen F Carter, Maqsood Yaqub, Bart NM van Berckel, Lyduine E Collij, Dorret I Boomsma, Eco JC de Geus, Philip Scheltens, Karl Herholz, Betty M Tijms, Pieter Jelle Visser
Dec 15, 2022
BACKGROUND: What combination of risk factors for Alzheimer's disease (AD) are most predictive of cognitive decline in cognitively unimpaired individuals remains largely unclear. We studied associations between APOE genotype...
APOE genotype Amyloid-β cognitive decline Longitudinal design neuropsychology polygenic risk score Preclinical Alzheimer’s disease Female Humans Male Alzheimer Disease Amyloid beta-Peptides Cognitive Dysfunction Genotype Apolipoproteins E Memory Disorders Risk Factors Positron-Emission Tomography Apolipoprotein E4
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