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Derivatives of a PARP inhibitor TIQ-A through synthesis of 8-alkoxythieno[2,3-c]isoquinolin-5(4H)-ones
Mirko Maksimainen, Antti Nurmesjärvi, Reima Terho, Michael Threadgill, Lari Lehtiö, Juha Heiskanen
Jan 01, 0001
Thieno[2,3-c]isoquinolin-5(4H)-one is known for its potential as an anti-ischemic agent through inhibition of poly(ADP-ribose) polymerase 1 (PARP1). However, the compound also inhibits many other enzymes of the PARP family...
Derivatives of a PARP inhibitor TIQ-A through synthesis of 8-alkoxythieno[2,3-c]isoquinolin-5(4H)-ones
Mirko Maksimainen, Antti Nurmesjärvi, Reima Terho, Michael Threadgill, Lari Lehtiö, Juha Heiskanen
Jan 01, 0001
Thieno[2,3-c]isoquinolin-5(4H)-one is known for its potential as an anti-ischemic agent through inhibition of poly(ADP-ribose) polymerase 1 (PARP1). However, the compound also inhibits many other enzymes of the PARP family...
Adolescent cannabis use, baseline prodromal symptoms and the risk of psychosis.
Antti Mustonen, Solja Niemelä, Tanja Nordström, Graham K Murray, Pirjo Mäki, Erika Jääskeläinen, Jouko Miettunen
May 11, 2018
BACKGROUND: The association between cannabis use and the risk of psychosis has been studied extensively but the temporal order still remains controversial. Aims To examine the association between cannabis use in adolescence and...
Identifying targets of multiple co-regulating transcription factors from expression time-series by Bayesian model comparison.
BACKGROUND: Complete transcriptional regulatory network inference is a huge challenge because of the complexity of the network and sparsity of available data. One approach to make it more manageable is to focus on the inference...
Enantioselective remote C-H activation directed by a chiral cation
Chiral cations have been used extensively as organocatalysts but their application to rendering transition metal catalyzed processes enantioselective remains rare. This is despite the success of the analogous charge-inverted...
Global Burden of Small Vessel Disease-Related Brain Changes on MRI Predicts Cognitive and Functional Decline.
Hanna Jokinen, Juha Koikkalainen, Hanna M Laakso, Susanna Melkas, Tuomas Nieminen, Antti Brander, Antti Korvenoja, Daniel Rueckert, Frederik Barkhof, Philip Scheltens, Reinhold Schmidt, Franz Fazekas, Sofia Madureira, Ana Verdelho, Anders Wallin, Lars-Olof Wahlund, Gunhild Waldemar, Hugues Chabriat, Michael Hennerici, John O'Brien, Domenico Inzitari, Jyrki Lötjönen, Leonardo Pantoni, Timo Erkinjuntti
Oct 10, 2019
Effect of natural weathering on water absorption and pore size distribution in thermally modified wood determined by nuclear magnetic resonance
Chenyang Cai, Muhammad Asadullah Javed, Sanna Komulainen, Ville-Veikko Telkki, Antti Haapala, Henrik Heräjärvi
Jun 06, 2020
Climatology of Transient Luminous Events and Lightning Observed Above Europe and the Mediterranean Sea
Enrico Arnone, Jozsef Bor, Olivier Chanrion, Veronika Barta, Stefano Dietrich, Carl-Fredrik Enell, Thomas Farges, Martin Fullekrug, Antti Kero, Roberto Labanti, Antti Makela, Keren Mezuman, Anna Odzimek, Martin Popek, Marco Prevedelli, Marco Ridolfi, Serge Soula, Oscar van der Velde, Yoav Yair, Torsten Neubert
Mar 31, 2020
In 1999, the first sprites were observed above European thunderstorms using sensitive cameras. Since then, Eurosprite campaigns have been conducted to observe sprites and other transient luminous events (TLEs), expanding into a...
Inference of RNA polymerase II transcription dynamics from chromatin immunoprecipitation time course data.
Ciira wa Maina, Antti Honkela, Filomena Matarese, Korbinian Grote, Hendrik G Stunnenberg, George Reid, Neil D Lawrence, Magnus Rattray
Jan 14, 2020
Gene transcription mediated by RNA polymerase II (pol-II) is a key step in gene expression. The dynamics of pol-II moving along the transcribed region influence the rate and timing of gene expression. In this work, we present a...
Bayesian identification of bacterial strains from sequencing data
Aravind Sankar, Brandon Malone, Sion Bayliss, Ben Pascoe, Guillaume Méric, Matthew D. Hitchings, Samuel K. Sheppard, Edward J. Feil, Jukka Corander, Antti Honkela
Aug 01, 2016
Rapidly assaying the diversity of a bacterial species present in a sample obtained from a hospital patient or an environmental source has become possible after recent technological advances in DNA sequencing. For several...
Diagnostic metabolite biomarkers of chronic typhoid carriage.
Elin Näsström, Pär Jonsson, Anders Johansson, Sabina Dongol, Abhilasha Karkey, Buddha Basnyat, Nga Tran Vu Thieu, Tan Trinh Van, Guy E Thwaites, Henrik Antti, Stephen Baker
Apr 10, 2019
BACKGROUND: Salmonella Typhi and Salmonella Paratyphi A are the agents of enteric (typhoid) fever; both can establish chronic carriage in the gallbladder. Chronic Salmonella carriers are typically asymptomatic, intermittently...
Modulating dream experience
Valdas Noreika, Jennifer M Windt, Markus Kern, Katja Valli, Tiina Salonen, Riitta Parkkola, Antti Revonsuo, Ahmed A Karim, Tonio Ball, Bigna Lenggenhager
Jun 08, 2020
Recently, cortical correlates of specific dream contents have been reported, such as the activation of the sensorimotor cortex during dreamed hand clenching. Yet, despite a close resemblance of such activation patterns to those...
Climatology of Transient Luminous Events and Lightning Observed Above Europe and the Mediterranean Sea
Enrico Arnone, Jozsef Bor, Olivier Chanrion, Veronika Barta, Stefano Dietrich, Carl-Fredrik Enell, Thomas Farges, Martin Fullekrug, Antti Kero, Roberto Labanti, Antti Makela, Keren Mezuman, Anna Odzimek, Martin Popek, Marco Prevedelli, Marco Ridolfi, Serge Soula, Oscar van der Velde, Yoav Yair, Torsten Neubert
Mar 31, 2020
In 1999, the first sprites were observed above European thunderstorms using sensitive cameras. Since then, Eurosprite campaigns have been conducted to observe sprites and other transient luminous events (TLEs), expanding into a...
Hydrogen Atom Transfer Driven Enantioselective Minisci Reaction of Alcohols.
Avene C Colgan, Rupert SJ Proctor, David C Gibson, Padon Chuentragool, Antti SK Lahdenperä, Kristaps Ermanis, Robert J Phipps
Apr 28, 2022
Catalytic enantioselective Minisci reactions have recently been developed but all instances so far utilize α-amino radical coupling partners. We report a substantial evolution of the enantioselective Minisci reaction that...
Nicola De Franceschi, Antti Arjonen, Nadia Elkhatib, Konstantin Denessiouk, Antoni G Wrobel, Thomas A Wilson, Jeroen Pouwels, Guillaume Montagnac, David J Owen, Johanna Ivaska
Jan 08, 2016
Excited-State Lifetime Modulation by Twisted and Tilted Molecular Design in Carbene-Metal-Amide Photoemitters.
Modulating dream experience
Valdas Noreika, Jennifer M Windt, Markus Kern, Katja Valli, Tiina Salonen, Riitta Parkkola, Antti Revonsuo, Ahmed A Karim, Tonio Ball, Bigna Lenggenhager
May 23, 2020
Recently, cortical correlates of specific dream contents have been reported, such as the activation of the sensorimotor cortex during dreamed hand clenching. Yet, despite a close resemblance of such activation patterns to those...
Published by: Scientific reports
Adolescent inhalant use and psychosis risk - a prospective longitudinal study.
Antti Mustonen, Solja Niemelä, John J McGrath, Graham K Murray, Tanja Nordström, Pirjo Mäki, Jouko Miettunen, James G Scott
Nov 22, 2018
BACKGROUND: Cross-sectional studies have suggested inhalant use is associated with psychosis. This association was examined in a longitudinal study accounting for other substance use and potential confounders. METHODS: We used a...
Birth cohort Psychotic Disorders Schizophrenia Substance Abuse Adolescent Adolescent Behavior Adult Bipolar Disorder Comorbidity Depressive Disorder Major Family Follow-Up Studies Humans Incidence Inhalant Abuse Longitudinal Studies Mental Disorders Prospective Studies Psychotic Disorders Risk Factors Schizophrenia
High-resolution sweep metagenomics using fast probabilistic inference.
Tommi Mäklin, Teemu Kallonen, Sophia David, Christine J Boinett, Ben Pascoe, Guillaume Méric, David M Aanensen, Edward J Feil, Stephen Baker, Julian Parkhill, Samuel K Sheppard, Jukka Corander, Antti Honkela
Nov 17, 2021
Determining the composition of bacterial communities beyond the level of a genus or species is challenging because of the considerable overlap between genomes representing close relatives. Here, we present the mSWEEP pipeline...
Bayesian identification of bacterial strains from sequencing data
Aravind Sankar, Brandon Malone, Sion Bayliss, Ben Pascoe, Guillaume Méric, Matthew D. Hitchings, Samuel K. Sheppard, Edward J. Feil, Jukka Corander, Antti Honkela
Aug 01, 2016
Rapidly assaying the diversity of a bacterial species present in a sample obtained from a hospital patient or an environmental source has become possible after recent technological advances in DNA sequencing. For several...
Hydrogen Atom Transfer Driven Enantioselective Minisci Reaction of Alcohols
Avene C Colgan, Rupert SJ Proctor, David C Gibson, Padon Chuentragool, Antti SK Lahdenperä, Kristaps Ermanis, Robert J Phipps
Apr 28, 2022
Abstract: Catalytic enantioselective Minisci reactions have recently been developed but all instances so far utilize α‐amino radical coupling partners. We report a substantial evolution of the enantioselective Minisci reaction...
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