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Exploration of inositol 1,4,5-trisphosphate (IP3) regulated dynamics of N-terminal domain of IP3 receptor reveals early phase molecular events during receptor activation.
Inositol 1, 4, 5-trisphosphate (IP3) binding at the N-terminus (NT) of IP3 receptor (IP3R) allosterically triggers the opening of a Ca2+-conducting pore located ~100 Å away from the IP3-binding core (IBC). However, the precise...
Circulating maternal placental growth factor responses to low-molecular-weight heparin in pregnant patients at risk of placental dysfunction.
Kelsey McLaughlin, Sebastian R Hobson, Anjana Ravi Chandran, Swati Agrawal, Rory C Windrim, W Tony Parks, Adrian W Bowman, Ulla Sovio, Gordon C Smith, John C Kingdom
Sep 14, 2021
BACKGROUND: Patients at high risk of severe preeclampsia and fetal growth restriction have low circulating levels of placental growth factor and features of maternal vascular malperfusion placental pathology at delivery....
Biomarkers fetal growth restriction placental pathology preeclampsia/eclampsia treatment/management Adult Anticoagulants Biomarkers Birth Weight Cohort Studies Female Gestational Age Heparin Low-Molecular-Weight Humans Infant Newborn Pilot Projects Placenta Growth Factor pre-eclampsia Pregnancy Pregnancy High-Risk premature birth
Elucidating Pro-Inflammatory Cytokine Responses after Traumatic Brain Injury in a Human Stem Cell Model.
Eric Peter Thelin, Claire E Hall, Kunal Gupta, Keri LH Carpenter, Siddharthan Chandran, Peter J Hutchinson, Rickie Patani, Adel Helmy
Jun 05, 2018
Cytokine mediated inflammation likely plays an important role in secondary pathology after traumatic brain injury (TBI). The aim of this study was to elucidate secondary cytokine responses in an in vitro enriched (>80%) human...
Hospital admission with non-alcoholic fatty liver disease is associated with increased all-cause mortality independent of cardiovascular risk factors
Jake P. Mann, Paul Carter, Matthew J. Armstrong, Hesham K. Abdelaziz, Hardeep Uppal, Billal Patel, Suresh Chandran, Ranjit More, Philip N. Newsome, Rahul Potluri
Oct 27, 2020
Non-alcoholic fatty liver disease (NAFLD) is common and strongly associated with the metabolic syndrome. Though NAFLD may progress to end-stage liver disease, the top cause of mortality in NAFLD is cardiovascular disease (CVD)....
Psoriatic arthritis
Oliver FitzGerald, Alexis Ogdie, Vinod Chandran, Laura C. Coates, Arthur Kavanaugh, William Tillett, Ying Ying Leung, Maarten deWit, Jose U. Scher, Philip J. Mease
Aug 12, 2021
Psoriatic arthritis (PsA) is a complex inflammatory disease with heterogeneous clinical features, which complicates psoriasis in 30% of patients. There are no diagnostic criteria or tests available. Diagnosis is most commonly...
Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology
Rameen Shakur, Juan Pablo Ochoa, Alan J. Robinson, Abhishek Niroula, Aneesh Chandran, Taufiq Rahman, Mauno Vihinen, Lorenzo Monserrat
Jun 21, 2021
Abstract: The cardiac troponin T variations have often been used as an example of the application of clinical genotyping for prognostication and risk stratification measures for the management of patients with a family history...
Hospital admission with non-alcoholic fatty liver disease is associated with increased all-cause mortality independent of cardiovascular risk factors.
Jake P Mann, Paul Carter, Matthew J Armstrong, Hesham K Abdelaziz, Hardeep Uppal, Billal Patel, Suresh Chandran, Ranjit More, Philip N Newsome, Rahul Potluri
Oct 15, 2020
Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology
Rameen Shakur, Juan Pablo Ochoa, Alan J. Robinson, Abhishek Niroula, Aneesh Chandran, Taufiq Rahman, Mauno Vihinen, Lorenzo Monserrat
Jul 02, 2021
Abstract: The cardiac troponin T variations have often been used as an example of the application of clinical genotyping for prognostication and risk stratification measures for the management of patients with a family history...
Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology.
Rameen Shakur, Juan Pablo Ochoa, Alan J Robinson, Abhishek Niroula, Aneesh Chandran, Taufiq Rahman, Mauno Vihinen, Lorenzo Monserrat
Aug 09, 2021
The cardiac troponin T variations have often been used as an example of the application of clinical genotyping for prognostication and risk stratification measures for the management of patients with a family history of sudden...
Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology
Rameen Shakur, Juan Pablo Ochoa, Alan J. Robinson, Abhishek Niroula, Aneesh Chandran, Taufiq Rahman, Mauno Vihinen, Lorenzo Monserrat
Jun 14, 2021
Abstract: The cardiac troponin T variations have often been used as an example of the application of clinical genotyping for prognostication and risk stratification measures for the management of patients with a family history...
Psoriatic arthritis
Oliver FitzGerald, Alexis Ogdie, Vinod Chandran, Laura C. Coates, Arthur Kavanaugh, William Tillett, Ying Ying Leung, Maarten deWit, Jose U. Scher, Philip J. Mease
Aug 12, 2021
Psoriatic arthritis (PsA) is a complex inflammatory disease with heterogeneous clinical features, which complicates psoriasis in 30% of patients. There are no diagnostic criteria or tests available. Diagnosis is most commonly...
Quantifying preference for social stimuli in young children using two tasks on a mobile platform.
Indu Dubey, Simon Brett, Liliana Ruta, Rahul Bishain, Sharat Chandran, Supriya Bhavnani, Matthew K Belmonte, Georgia Lockwood Estrin, Mark Johnson, Teodora Gliga, Bhismadev Chakrabarti, START consortium
Jun 07, 2022
Children typically prefer to attend to social stimuli (e.g. faces, smiles) over non-social stimuli (e.g. natural scene, household objects). This preference for social stimuli is believed to be an essential building block for...
Structure-Based Discovery of Lipoteichoic Acid Synthase Inhibitors.
Xavier Chee Wezen, Aneesh Chandran, Rohan Sakariah Eapen, Elaine Waters, Laura Bricio-Moreno, Tommaso Tosi, Stephen Dolan, Charlotte Millership, Aras Kadioglu, Angelika Gründling, Laura S Itzhaki, Martin Welch, Taufiq Rahman
Jun 09, 2022
Population distribution analyses reveal a hierarchy of molecular players underlying parallel endocytic pathways.
Gagan D Gupta, Gautam Dey, MG Swetha, Balaji Ramalingam, Khader Shameer, Joseph Jose Thottacherry, Joseph Mathew Kalappurakkal, Mark T Howes, Ruma Chandran, Anupam Das, Sindhu Menon, Robert G Parton, R Sowdhamini, Mukund Thattai, Satyajit Mayor
Jan 06, 2020
Single-cell-resolved measurements reveal heterogeneous distributions of clathrin-dependent (CD) and -independent (CLIC/GEEC: CG) endocytic activity in Drosophila cell populations. dsRNA-mediated knockdown of core versus...
Quantifying preference for social stimuli in young children using two tasks on a mobile platform.
Indu Dubey, Simon Brett, Liliana Ruta, Rahul Bishain, Sharat Chandran, Supriya Bhavnani, Matthew K Belmonte, Georgia Lockwood Estrin, Mark Johnson, Teodora Gliga, Bhismadev Chakrabarti, START consortium
Jul 02, 2022
Children typically prefer to attend to social stimuli (e.g. faces, smiles) over non-social stimuli (e.g. natural scene, household objects). This preference for social stimuli is believed to be an essential building block for...
Proceedings of the 2018 GRAPPA Collaborative Research Network (CRN) Meeting
Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer.
Kadir C Akdemir, Victoria T Le, Sahaana Chandran, Yilong Li, Roel G Verhaak, Rameen Beroukhim, Peter J Campbell, Lynda Chin, Jesse R Dixon, P Andrew Futreal, PCAWG Structural Variation Working Group, PCAWG Consortium
Feb 04, 2021
Chromatin is folded into successive layers to organize linear DNA. Genes within the same topologically associating domains (TADs) demonstrate similar expression and histone-modification profiles, and boundaries separating...
Proceedings of the 2019 GRAPPA Collaborative Research Network Meeting.
Robin Waxman, Carmel Stober, Deepak R Jadon, Ana-Maria Orbai, Vinod Chandran, Alexis Ogdie, Stephen R Pennington, Maarten de Wit, Denis O'Sullivan, Philip J Mease, April W Armstrong, Kristina Callis Duffin, Philip S Helliwell, Leonieke JJ van Mens, Christopher T Ritchlin, Oliver FitzGerald
Apr 06, 2020
At the 2019 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis-Collaborative Research Network annual meeting, the group presented its progress in selecting a database platform; items to include in an...
Remyelination varies between and within lesions in multiple sclerosis following bexarotene.
J William L Brown, Ferran Prados, Daniel R Altmann, Baris Kanber, Jonathan Stutters, Nick G Cunniffe, Joanne L Jones, Zoya G Georgieva, Edward J Needham, Cyrus Daruwalla, Claudia Gandini Wheeler-Kingshott, Peter Connick, Siddharthan Chandran, Robin Franklin, David MacManus, Rebecca Samson, Alasdair Coles, Declan Chard
Oct 24, 2022
Remyelination varies between and within lesions in multiple sclerosis following bexarotene.
J William L Brown, Ferran Prados, Daniel R Altmann, Baris Kanber, Jonathan Stutters, Nick G Cunniffe, Joanne L Jones, Zoya G Georgieva, Edward J Needham, Cyrus Daruwalla, Claudia Gandini Wheeler-Kingshott, Peter Connick, Siddharthan Chandran, Robin Franklin, David MacManus, Rebecca Samson, Alasdair Coles, Declan Chard
Sep 18, 2022
Proceedings of the 2020 GRAPPA Collaborative Research Network (CRN) Meeting.
Carmel Stober, Deepak R Jadon, April W Armstrong, Vinod Chandran, Maarten de Wit, Philip S Helliwell, Philip Mease, Alexis Ogdie, Denis O'Sullivan, Stephen R Pennington, Thorvardur Löve, Alberto Cauli, Leonieke van Mens, Robin Waxman, Jose U Scher, Anne Barton, Christopher T Ritchlin, Oliver FitzGerald
Mar 03, 2021
At the 2020 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)- Collaborative Research Network (CRN) annual meeting, the GRAPPA-CRN group presented a pilot investigator-initiated study protocol to...
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