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Results: 32
Artificial pancreas treatment for outpatients with type 1 diabetes
Eleni Bekiari, Konstantinos Kitsios, Hood Thabit, Martin Tauschmann, Eleni Athanasiadou, Thomas Karagiannis, Anna-Bettina Haidich, Roman Hovorka, Apostolos Tsapas
May 29, 2018
OBJECTIVE: To evaluate the efficacy and safety of artificial pancreas treatment in non-pregnant outpatients with type 1 diabetes. DESIGN: Systematic review and meta-analysis of randomised controlled trials. DATA SOURCES...
Modal-based estimation via heterogeneity-penalized weighting
BACKGROUND: A robust method for Mendelian randomization does not require all genetic variants to be valid instruments to give consistent estimates of a causal parameter. Several such methods have been developed, including a...
Contextualizing selection bias in Mendelian randomization
Bayesian variable selection with a pleiotropic loss function in Mendelian randomization
Mendelian randomization is the use of genetic variants as instruments to assess the existence of a causal relationship between a risk factor and an outcome. A Mendelian randomization analysis requires a set of genetic variants...
RESEARCH ARTICLE RESEARCH ARTICLES general Bayesian inference instrumental variables Mendelian randomization pleiotropy VARIABLE SELECTION
Published by: Statistics in Medicine
Education and austerity in the European Union from an autism perspective
Robin van Kessel, Ines Siepmann, Luis Capucha, Apostolos Kavaliotis Paschalis, Carol Brayne, Simon Baron‐Cohen, Katarzyna Czabanowska, Andres Roman‐Urrestarazu
May 24, 2021
Abstract: This study explores how autism and education policy are affected by austerity measures in Ireland, Portugal, Italy, and Greece by using a path dependence analysis. The implementation of mixed mainstream classrooms and...
Original Article Original Articles austerity autism Education Policy special education needs 紧缩 自闭症 教育 政策 特殊教育需求 austeridad autismo educación políticas necesidades educativas especiales
Published by: European Policy Analysis
Bayesian variable selection with a pleiotropic loss function in Mendelian randomization.
Mendelian randomization is the use of genetic variants as instruments to assess the existence of a causal relationship between a risk factor and an outcome. A Mendelian randomization analysis requires a set of genetic variants...
Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn's disease
Evangelos Stournaras, Wendi Qian, Apostolos Pappas, You Yi Hong, Rasha Shawky, UK IBD BioResource Investigators, Tim Raine, Miles Parkes, UK IBD Bioresource Investigators
Jul 20, 2020
OBJECTIVE: Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date...
Genetic Determinants of Lipids and Cardiovascular Disease Outcomes
Elias Allara, Gabriele Morani, Paul Carter, Apostolos Gkatzionis, Verena Zuber, Christopher N Foley, Jessica MB Rees, Amy M Mason, Steven Bell, Dipender Gill, Sara Lindström, Adam S Butterworth, Emanuele Di Angelantonio, James Peters, Stephen Burgess, INVENT Consortium
Nov 18, 2019
BACKGROUND: Evidence from randomized trials has shown that therapies that lower LDL (low-density lipoprotein)-cholesterol and triglycerides reduce coronary artery disease (CAD) risk. However, there is still uncertainty about...
Mendelian randomization aortic valve stenosis EPIDEMIOLOGY Lipids venous thromboembolism Adult Aged Cardiovascular Diseases Cholesterol LDL Europe Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Mendelian Randomization Analysis Middle Aged Odds Ratio Risk Factors Triglycerides White People
In vivo Simulation-Based Learning for Undergraduate Medical Students
In vivo Simulation-Based Learning for Undergraduate Medical Students
Michail Sideris, Marios Nicolaides, Jade Jagiello, Kathrine S Rallis, Elif Emin, Efthymia Theodorou, John Gerrard Hanrahan, Rebecca Mallick, Funlayo Odejinmi, Nikolaos Lymperopoulos, Apostolos Papalois, George Tsoulfas
Oct 18, 2021
An increasing emphasis on simulation has become evident in the last three decades following fundamental shifts in the medical profession. Simulation-based learning (SBL) is a wide term that encompasses several means for...
Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.
Larissa S Carnevalli, Roberta Scognamiglio, Nina Cabezas-Wallscheid, Susann Rahmig, Elisa Laurenti, Kohei Masuda, Lars Jöckel, Andrea Kuck, Stefanie Sujer, Apostolos Polykratis, Miriam Erlacher, Manolis Pasparakis, Marieke AG Essers, Andreas Trumpp
Aug 28, 2020
The serine protease granzyme B (GzmB) is stored in the granules of cytotoxic T and NK cells and facilitates immune-mediated destruction of virus-infected cells. In this study, we use genetic tools to report novel roles for GzmB...
Animals Apoptosis Bone Marrow Cell Proliferation Colony-Forming Units Assay DNA Primers Drug Therapy Enzyme-Linked Immunosorbent Assay Flow Cytometry Fluorouracil Gene Expression Regulation Granzymes Hematopoietic Stem Cells Immunohistochemistry Lipopolysaccharides Mice Mice Inbred C57BL Mice Knockout Microarray Analysis Mitochondria Real-Time Polymerase Chain Reaction Signal Transduction Stress Physiological
Extracellular Vesicles Isolated from Malignant Mesothelioma Cancer-Associated Fibroblasts Induce Pro-Oncogenic Changes in Healthy Mesothelial Cells.
Tatyana Chernova, Stefano Grosso, Xiao-Ming Sun, Angela Rubio Tenor, Joaquin Zacarias Cabeza, Andrew Craxton, Emily L Self, Apostolos Nakas, Kelvin Cain, Marion MacFarlane, Anne E Willis
Nov 04, 2022
Inclusion of multiple high-risk histopathological criteria improves the prediction of adjuvant chemotherapy efficacy in lung adenocarcinoma.
Marco Sereno, Zhangyi He, Claire R Smith, Juvenal Baena, Madhumita Das, Robert K Hastings, Grace Rake, Dean A Fennell, Apostolos Nakas, David A Moore, John Le Quesne
Apr 20, 2021
AIMS: The decision to consider adjuvant chemotherapy (AC) for non-small cell lung cancer is currently governed by clinical stage. This study aims to assess other routinely collected pathological variables related to metastasis...
Adenocarcinoma of Lung Adjuvant Biomarkers Chemotherapy Histology Tumour Adenocarcinoma of Lung Aged Aged 80 and over Antineoplastic Agents Chemotherapy Adjuvant Female Humans Lung Neoplasms Male Middle Aged Neoplasm Invasiveness Neoplasm Staging Prognosis Retrospective Studies Survival Rate Treatment Outcome
Shared mechanisms between coronary heart disease and depression
Golam M. Khandaker, Verena Zuber, Jessica M. B. Rees, Livia Carvalho, Amy M. Mason, Christopher N. Foley, Apostolos Gkatzionis, Peter B. Jones, Stephen Burgess
Aug 19, 2020
Abstract: While comorbidity between coronary heart disease (CHD) and depression is evident, it is unclear whether the two diseases have shared underlying mechanisms. We performed a range of analyses in 367,703 unrelated...
MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis.
Christine Podrini, Apostolos Koffas, Shilpa Chokshi, Manlio Vinciguerra, Christopher J Lelliott, Jacqueline K White, Hibret A Adissu, Roger Williams, Azzura Greco
Apr 07, 2021
The importance of epigenetic changes in the development of hepatic steatosis is largely unknown. The histone variant macroH2A1 under alternative splicing gives rise to macroH2A1.1 and macroH2A1.2. In this study, we show that the...
bivalent promoter histone methylation histone variants Lipid uptake Animals Biomarkers Blotting Western Carcinoma Hepatocellular Cells Cultured Chromatin Immunoprecipitation Diet High-Fat Epigenomics Fatty Liver Female Fluorescent Antibody Technique Gene Expression Profiling Hepatocytes Histones Humans Immunoenzyme Techniques Lipid Peroxidation Liver Liver Neoplasms Male Mice Mice Inbred C57BL Mice Knockout Mitochondrial Proton-Translocating ATPases Oligonucleotide Array Sequence Analysis Promoter Regions Genetic Protein Isoforms RNA Messenger Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction
Shared mechanisms between coronary heart disease and depression
Golam M Khandaker, Verena Zuber, Jessica MB Rees, Livia Carvalho, Amy M Mason, Christopher N Foley, Apostolos Gkatzionis, Peter B Jones, Stephen Burgess
Feb 19, 2019
While comorbidity between coronary heart disease (CHD) and depression is evident, it is unclear whether the two diseases have shared underlying mechanisms. We performed a range of analyses in 367,703 unrelated middle-aged...
Shared mechanisms between coronary heart disease and depression
Golam M. Khandaker, Verena Zuber, Jessica M. B. Rees, Livia Carvalho, Amy M. Mason, Christopher N. Foley, Apostolos Gkatzionis, Peter B. Jones, Stephen Burgess
Jun 18, 2020
Abstract: While comorbidity between coronary heart disease (CHD) and depression is evident, it is unclear whether the two diseases have shared underlying mechanisms. We performed a range of analyses in 367,703 unrelated...
Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf).
Tatyana Chernova, Fiona A Murphy, Sara Galavotti, Xiao-Ming Sun, Ian R Powley, Stefano Grosso, Anja Schinwald, Joaquin Zacarias-Cabeza, Kate M Dudek, David Dinsdale, John Le Quesne, Jonathan Bennett, Apostolos Nakas, Peter Greaves, Craig A Poland, Ken Donaldson, Martin Bushell, Anne E Willis, Marion MacFarlane
Sep 18, 2019
Mesothelioma is a fatal tumor of the pleura and is strongly associated with asbestos exposure. The molecular mechanisms underlying the long latency period of mesothelioma and driving carcinogenesis are unknown. Moreover, late...
CDKN2A asbestos Carbon nanotubes epigenetics hypermethylation Mesothelioma toxicity tumor suppressor genes Aged Animals Asbestos Carcinogenesis Cell Proliferation Cells Cultured Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinase Inhibitor p19 Female Humans Lung Neoplasms Male Mesothelioma Mesothelioma Malignant Methylation Mice Mice Inbred C57BL Middle Aged Nanotubes Carbon
Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression.
Sara Busacca, Qi Zhang, Annabel Sharkey, Alan G Dawson, David A Moore, David A Waller, Apostolos Nakas, Carolyn Jones, Kelvin Cain, Jin-Li Luo, Adriana Salcedo, Iris Chiara Salaroglio, Chiara Riganti, John Le Quesne, Tom John, Paul C Boutros, Shu-Dong Zhang, Dean A Fennell
Apr 01, 2021
We hypothesized that small molecule transcriptional perturbation could be harnessed to target a cellular dependency involving protein arginine methyltransferase 5 (PRMT5) in the context of methylthioadenosine phosphorylase...
Biomarkers Tumor Cell Transformation Neoplastic Gene Deletion Gene Expression Regulation Neoplastic Gene Silencing Humans Kaplan-Meier Estimate Mesothelioma Malignant Prognosis Protein-Arginine N-Methyltransferases Proto-Oncogene Proteins c-jun Purine-Nucleoside Phosphorylase Quinacrine Transcription Genetic
Lipid traits and type 2 diabetes risk in African ancestry individuals
Opeyemi Soremekun, Ville Karhunen, Yiyan He, Skanda Rajasundaram, Bowen Liu, Apostolos Gkatzionis, Chisom Soremekun, Brenda Udosen, Hanan Musa, Sarah Silva, Christopher Kintu, Richard Mayanja, Mariam Nakabuye, Tafadzwa Machipisa, Amy Mason, Marijana Vujkovic, Verena Zuber, Mahmoud Soliman, Joseph Mugisha, Oyekanmi Nash, Pontiano Kaleebu, Moffat Nyirenda, Tinashe Chikowore, Dorothea Nitsch, Stephen Burgess, Dipender Gill, Segun Fatumo
Apr 24, 2022
BACKGROUND: Dyslipidaemia is highly prevalent in individuals with type 2 diabetes mellitus (T2DM). Numerous studies have sought to disentangle the causal relationship between dyslipidaemia and T2DM liability. However...
Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight.
Saira Hameed, Michael Patterson, Waljit S Dhillo, Sofia A Rahman, Yue Ma, Christopher Holton, Apostolos Gogakos, Giles SH Yeo, Brian YH Lam, Joseph Polex-Wolf, Wiebke Fenske, Jimmy Bell, Jelena Anastasovska, Jacques Samarut, Stephen R Bloom, JH Duncan Bassett, Graham R Williams, James V Gardiner
Aug 18, 2017
The obesity epidemic is a significant global health issue. Improved understanding of the mechanisms that regulate appetite and body weight will provide the rationale for the design of anti-obesity therapies. Thyroid hormones...
Cardiometabolic Traits, Sepsis, and Severe COVID-19
Mark J Ponsford, Apostolos Gkatzionis, Venexia M Walker, Andrew J Grant, Robyn E Wootton, Luke SP Moore, Segun Fatumo, Amy M Mason, Verena Zuber, Cristen Willer, Humaira Rasheed, Ben Brumpton, Kristian Hveem, Jan Kristian Damås, Neil Davies, Bjørn Olav Åsvold, Erik Solligård, Simon Jones, Stephen Burgess, Tormod Rogne, Dipender Gill
Sep 28, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic. Many patients with severe COVID-19 develop sepsis. Cardiometabolic traits have been...
Mendelian Randomization Analysis coronavirus Risk Factors Sepsis Betacoronavirus Body Mass Index covid-19 Case-Control Studies Coronavirus Infections Diabetes mellitus Type 2 Dyslipidemias Gene-Environment Interaction Genetic Association Studies Genetic Predisposition to Disease Host-Pathogen Interactions Humans Mendelian Randomization Analysis obesity Pandemics Phenotype Pneumonia Viral Polymorphism Single Nucleotide Risk Factors SARS-CoV-2 Sepsis Severity of Illness Index Smoking
Mendelian randomization for studying the effects of perturbing drug targets.
Dipender Gill, Marios K Georgakis, Venexia M Walker, A Floriaan Schmidt, Apostolos Gkatzionis, Daniel F Freitag, Chris Finan, Aroon D Hingorani, Joanna MM Howson, Stephen Burgess, Daniel I Swerdlow, George Davey Smith, Michael V Holmes, Martin Dichgans, Robert A Scott, Jie Zheng, Bruce M Psaty, Neil M Davies
Feb 26, 2021
Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be approved after clinical development. In this paper, we provide an overview of how natural sequence variation in the genes that encode...
Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia.
Esther Meyer, Keren J Carss, Julia Rankin, John ME Nichols, Detelina Grozeva, Agnel P Joseph, Niccolo E Mencacci, Apostolos Papandreou, Joanne Ng, Serena Barral, Adeline Ngoh, Hilla Ben-Pazi, Michel A Willemsen, David Arkadir, Angela Barnicoat, Hagai Bergman, Sanjay Bhate, Amber Boys, Niklas Darin, Nicola Foulds, Nicholas Gutowski, Alison Hills, Henry Houlden, Jane A Hurst, Zvi Israel, Margaret Kaminska, Patricia Limousin, Daniel Lumsden, Shane McKee, Shibalik Misra, Shekeeb S Mohammed, Vasiliki Nakou, Joost Nicolai, Magnus Nilsson, Hardev Pall, Kathryn J Peall, Gregory B Peters, Prab Prabhakar, Miriam S Reuter, Patrick Rump, Reeval Segel, Margje Sinnema, Martin Smith, Peter Turnpenny, Susan M White, Dagmar Wieczorek, Sarah Wiethoff, Brian T Wilson, Gidon Winter, Christopher Wragg, Simon Pope, Simon JH Heales, Deborah Morrogh, UK10K consortium, Deciphering Developmental Disorders Study, NIHR BioResource Rare Diseases Consortium, Alan Pittman, Lucinda J Carr, Belen Perez-Dueñas, Jean-Pierre Lin, Andre Reis, William A Gahl, Camilo Toro, Kailash P Bhatia, Nicholas W Wood, Erik-Jan Kamsteeg, Wui K Chong, Paul Gissen, Maya Topf, Russell C Dale, Jonathan R Chubb, F Lucy Raymond, Manju A Kurian
Aug 29, 2019
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