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GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth.
Leanne Li, Qiqun Zeng, Arjun Bhutkar, José A Galván, Eva Karamitopoulou, Daan Noordermeer, Mei-Wen Peng, Alessandra Piersigilli, Aurel Perren, Inti Zlobec, Hugh Robinson, M Luisa Iruela-Arispe, Douglas Hanahan
Jun 28, 2018
Genetic linkage analysis previously suggested that GKAP, a scaffold protein of the N-methyl-D-aspartate receptor (NMDAR), was a potential modifier of invasion in a mouse model of pancreatic neuroendocrine tumor (PanNET). Here...
FMRP GKAP/Dlgap1 GluN2b/NR2b/Grin2b HSF1 MK801 NMDAR RIP1Tag2 cancer modifier glutamate receptor Memantine pancreatic ductal adenocarcinoma (PDAC) Animals Antineoplastic Agents Carcinoma Neuroendocrine Carcinoma Pancreatic Ductal Cell Line Tumor Fragile X Mental Retardation Protein Gene Expression Profiling Gene Expression Regulation Neoplastic Heat Shock Transcription Factors Humans Mice Neoplasm Invasiveness Neoplasm Transplantation Pancreatic Neoplasms Prognosis Receptors N-Methyl-D-Aspartate SAP90-PSD95 Associated Proteins Sequence Analysis RNA Signal Transduction Survival Analysis
Foxm1 controls a pro-stemness microRNA network in neural stem cells.
Zein Mersini Besharat, Luana Abballe, Francesco Cicconardi, Arjun Bhutkar, Luigi Grassi, Loredana Le Pera, Marta Moretti, Mauro Chinappi, Daniel D'Andrea, Angela Mastronuzzi, Alessandra Ianari, Alessandra Vacca, Enrico De Smaele, Franco Locatelli, Agnese Po, Evelina Miele, Elisabetta Ferretti
Sep 05, 2018
Cerebellar neural stem cells (NSCs) require Hedgehog-Gli (Hh-Gli) signalling for their maintenance and Nanog expression for their self-renewal. To identify novel molecular features of this regulatory pathway, we used...
Animals Animals Newborn Cell Differentiation Cell Proliferation cerebellum Forkhead Box Protein M1 Gene Expression Regulation Developmental Hedgehog Proteins High-Throughput Nucleotide Sequencing Mice Mice Inbred C57BL MicroRNAs Nanog Homeobox Protein Neural Stem Cells Neurogenesis Primary Cell Culture Signal Transduction Spheroids Cellular Zinc Finger Protein GLI1
Visible-Light Promoted C-O Bond Formation with an Integrated Carbon Nitride-Nickel Heterogeneous Photocatalyst.
Ni-deposited mesoporous graphitic carbon nitride (Ni-mpg-CNx ) is introduced as an inexpensive, robust, easily synthesizable and recyclable material that functions as an integrated dual photocatalytic system. This material...
MANUFACTURING MULTI-MATRIX COMPOSITES:
The formation of porosity is a major challenge in any composite manufacturing process, particularly in the absence of vacuum assistance. Highly localised injection of polymer matrix into regions of interest in a dry preform is a...
Network trade-offs and homeostasis in Arabidopsis shoot architectures.
Adam Conn, Arjun Chandrasekhar, Martin van Rongen, Ottoline Leyser, Joanne Chory, Saket Navlakha
Sep 02, 2019
MANUFACTURING MULTI-MATRIX COMPOSITES:
The formation of porosity is a major challenge in any composite manufacturing process, particularly in the absence of vacuum assistance. Highly localised injection of polymer matrix into regions of interest in a dry preform is a...
The known unknowns of assisted hydration at the end of life.
Much is unknown about assisted hydration at the end of life: why rates of usage vary so highly between institutions, cultures and countries, what beneficial or burdensome effects this treatment has, whether there is a place for...
What is the impact of clinically assisted hydration in the last days of life? A systematic literature review and narrative synthesis.
BACKGROUND: Clinically assisted hydration (CAH) can be provided in the last days of life as drinking declines. The impact of this practice on quality of life or survival in the last days of life is unclear. Practice varies...
Visible-Light Flow Reactor Packed with Porous Carbon Nitride for Aerobic Substrate Oxidations.
Mark A Bajada, Arjun Vijeta, Aleksandr Savateev, Guigang Zhang, Duncan Howe, Erwin Reisner
Jan 29, 2020
A triphasic photocatalytic reactor employing a mesoporous carbon nitride photocatalyst and aerobic O2 was assembled to operate under continuous flow conditions. This reactor design allows for facile downstream processing and...
Bridging Plastic Recycling and Organic Catalysis
Tengfei Li, Arjun Vijeta, Carla Casadevall, Alexander S Gentleman, Tijmen Euser, Erwin Reisner
Aug 25, 2022
Chemical recycling of synthetic polymers represents a promising strategy to deconstruct plastic waste and make valuable products. Inspired by small-molecule C-H bond activation, a visible-light-driven reaction is developed to...
ET-traps offer a potential therapeutic tool for use in different autoimmune diseases.
Research shows that endothelin (ET)-traps are a potential therapy for diabetes. Given that type 1 diabetes mellitus (T1DM) is an autoimmune disorder, ET-traps could also have an efficacious, therapeutic effect on other...
Inter-adsorbate forces and coherent scattering in helium spin-echo experiments.
David J Ward, Arjun Raghavan, Anton Tamtögl, Andrew P Jardine, Emanuel Bahn, John Ellis, Salvador Miret-Artès, William Allison
Oct 07, 2020
In studies of dynamical systems, helium atoms scatter coherently from an ensemble of adsorbates as they diffuse on the surface. The results give information on the co-operative behaviour of interacting adsorbates and thus...
Extracting in Situ Charge Carrier Diffusion Parameters in Perovskite Solar Cells with Light Modulated Techniques.
Agustín Bou, Haralds A Boliņš, Arjun Ashoka, Héctor Cruanyes, Antonio Guerrero, Felix Deschler, Juan Bisquert
Jan 07, 2022
Frequency resolved methods are widely used to determine device properties of perovskite solar cells. However, obtaining the electronic parameters for diffusion and recombination by impedance spectroscopy has been so far elusive...
Shifting uncertainty intolerance
Abstract: Risk evaluation is a critical component of decision making. Risk tolerance is relevant in both daily decisions and pathological disorders such as attention-deficit hyperactivity disorder (ADHD), where impulsivity is a...
A neurocomputational account of reward and novelty processing and effects of psychostimulants in attention deficit hyperactivity disorder.
Computational models of reinforcement learning have helped dissect discrete components of reward-related function and characterize neurocognitive deficits in psychiatric illnesses. Stimulus novelty biases decision-making, even...
Adult Attention Deficit Disorder with Hyperactivity Case-Control Studies Central Nervous System Stimulants Choice Behavior Cross-Sectional Studies Double-Blind Method Exploratory Behavior Female Humans Imaging Three-Dimensional Magnetic Resonance Imaging Male methylphenidate Models Neurological Photic Stimulation RECOGNITION psychology Reward Surveys and Questionnaires Task Performance and Analysis
A structural role for the PHP domain in E. coli DNA polymerase III.
Tiago Barros, Joel Guenther, Brian Kelch, Jordan Anaya, Arjun Prabhakar, Mike O'Donnell, John Kuriyan, Meindert H Lamers
May 30, 2013
Direct observation of ultrafast singlet exciton fission in three dimensions.
Arjun Ashoka, Nicolas Gauriot, Aswathy V Girija, Nipun Sawhney, Alexander J Sneyd, Kenji Watanabe, Takashi Taniguchi, Jooyoung Sung, Christoph Schnedermann, Akshay Rao
Nov 15, 2022
We present quantitative ultrafast interferometric pump-probe microscopy capable of tracking of photoexcitations with sub-10 nm spatial precision in three dimensions with 15 fs temporal resolution, through retrieval of the full...
Published by: Nature Communications
Muslim Sikhs Relations
Sikhism as a syncretic movement was initiated by Baba Guru Nanak during the 15th century, which was different from pre-existing beliefs of Hinduism, Islam, Christianity, and Bhaktism. His life struggle was based on the...
Published by: Department of History, University of Karachi
Waiting Impulsivity
Valerie Voon, Yee Chien Chang-Webb, Laurel S Morris, Ella Cooper, Arjun Sethi, Kwangyeol Baek, Jon Grant, Trevor W Robbins, Neil A Harrison
Jul 07, 2015
Addiction Binge drinking Impulsivity methylphenidate Premature responding stimulant dependence Analysis of Variance Central Nervous System Stimulants Choice Behavior Cross-Over Studies Double-Blind Method Feedback Psychological Female Healthy Volunteers Humans Impulsive Behavior Male methylphenidate Psychiatric Status Rating Scales Psychomotor Performance Reaction Time Young Adult
A Systematic Review of the Association Between Vegan Diets and Risk of Cardiovascular Disease.
Jeenan Kaiser, Kim R van Daalen, Arjun Thayyil, Mafalda Tasso de Almeida Ribeiro Reis Cocco, Daniela Caputo, Clare Oliver-Williams
Feb 04, 2021
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