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Assessment of Aspartate and Bicarbonate Produced From Hyperpolarized [1-13C]Pyruvate as Markers of Renal Gluconeogenesis.
As both a consumer and producer of glucose, the kidney plays a significant role in glucose homeostasis. Measuring renal gluconeogenesis requires invasive techniques, and less invasive methods would allow renal gluconeogenesis to...
A method to disentangle and quantify host anabolic turnover in photosymbiotic holobionts with subcellular resolution
Abstract: A wide range of organisms host photosynthesizing symbionts. In these animals the metabolic exchange between host and symbionts has prevented in situ host anabolic turnover to be studied without the confounding effect...
Assessment of Aspartate and Bicarbonate Produced From Hyperpolarized [1-13C]Pyruvate as Markers of Renal Gluconeogenesis.
As both a consumer and producer of glucose, the kidney plays a significant role in glucose homeostasis. Measuring renal gluconeogenesis requires invasive techniques, and less invasive methods would allow renal gluconeogenesis to...
Photochemistry of pyruvic acid is governed by photo-induced intermolecular electron transfer through hydrogen bonds.
Despite more than 85 years of research, the mechanism behind the photodecarboxylation of pyruvic acid remains elusive. Most studies focused on the gas and liquid phase of diluted solutions of pyruvic acid to understand the...
A method to disentangle and quantify host anabolic turnover in photosymbiotic holobionts with subcellular resolution.
A wide range of organisms host photosynthesizing symbionts. In these animals the metabolic exchange between host and symbionts has prevented in situ host anabolic turnover to be studied without the confounding effect of...
A method to disentangle and quantify host anabolic turnover in photosymbiotic holobionts with subcellular resolution.
A wide range of organisms host photosynthesizing symbionts. In these animals the metabolic exchange between host and symbionts has prevented in situ host anabolic turnover to be studied without the confounding effect of...
Published by: Communications biology
A method to disentangle and quantify host anabolic turnover in photosymbiotic holobionts with subcellular resolution
Abstract: A wide range of organisms host photosynthesizing symbionts. In these animals the metabolic exchange between host and symbionts has prevented in situ host anabolic turnover to be studied without the confounding effect...
Labile Photo‐Induced Free Radical in α‐Ketoglutaric Acid
Adam P Gaunt, Jennifer S Lewis, Friederike Hesse, Tian Cheng, Irene Marco‐Rius, Kevin M Brindle, Arnaud Comment
Dec 15, 2021
Abstract: Hyperpolarized (HP) 13C magnetic resonance enables non‐invasive probing of metabolism in vivo. To date, only 13C‐molecules hyperpolarized with persistent trityl radicals have been injected in humans. We show here that...
Probing hepatic metabolism of [2- 13 C]dihydroxyacetone in vivo with 1 H-decoupled hyperpolarized 13 C-MR
Irene Marco-Rius, Alan J. Wright, De-En Hu, Dragana Savic, Jack J. Miller, Kerstin N. Timm, Damian Tyler, Kevin M. Brindle, Arnaud Comment
Feb 26, 2021
RESEARCH ARTICLE Basic Science - Preclinical spectroscopy Carbon-13 Magnetic Resonance Spectroscopy Gluconeogenesis Glycolysis Liver metabolism Dynamic Nuclear Polarisation Hyperpolarisation
Published by: Springer International Publishing
Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized 13 C magnetic resonance
Emine Can, Mor Mishkovsky, Hikari A. I. Yoshihara, Nicolas Kunz, Dominique-Laurent Couturier, Ulf Petrausch, Marie-Agnès Doucey, Arnaud Comment
Jan 12, 2021
Abstract: The metabolic shift induced in human CD4+ T lymphocytes by stimulation is characterized by an upregulation of glycolysis, leading to an augmentation in lactate production. This adaptation has already been highlighted...
Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR.
Irene Marco-Rius, Alan J Wright, De-En Hu, Dragana Savic, Jack J Miller, Kerstin N Timm, Damian Tyler, Kevin M Brindle, Arnaud Comment
Sep 02, 2020
OBJECTIVES: To enhance detection of the products of hyperpolarized [2-13C]dihydroxyacetone metabolism for assessment of three metabolic pathways in the liver in vivo. Hyperpolarized [2-13C]DHAc emerged as a promising substrate...
Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized 13C magnetic resonance.
Emine Can, Mor Mishkovsky, Hikari A I Yoshihara, Nicolas Kunz, Dominique-Laurent Couturier, Ulf Petrausch, Marie-Agnès Doucey, Arnaud Comment
Feb 14, 2020
The metabolic shift induced in human CD4+ T lymphocytes by stimulation is characterized by an upregulation of glycolysis, leading to an augmentation in lactate production. This adaptation has already been highlighted with...
Published by: Scientific reports
A Comment Aspect-Level User Preference Transfer Model for Cross-Domain Recommendations
Traditional cross-domain recommendation models make it difficult to deeply mine users' aspect-level preferences from comment information due to existing problems such as polysemy of comment text, sparse comment data, and user...
Published by: IGI Global Scientific Publishing
Probing hepatic metabolism of [2- 13 C]dihydroxyacetone in vivo with 1 H-decoupled hyperpolarized 13 C-MR
Irene Marco-Rius, Alan J. Wright, De-En Hu, Dragana Savic, Jack J. Miller, Kerstin N. Timm, Damian Tyler, Kevin M. Brindle, Arnaud Comment
Sep 10, 2021
RESEARCH ARTICLE Basic Science - Preclinical spectroscopy Carbon-13 Magnetic Resonance Spectroscopy Gluconeogenesis Glycolysis Liver metabolism Dynamic Nuclear Polarisation Hyperpolarisation
Published by: Springer International Publishing
Labile Photo-Induced Free Radical in α-Ketoglutaric Acid
Adam P Gaunt, Jennifer S Lewis, Friederike Hesse, Tian Cheng, Irene Marco-Rius, Kevin M Brindle, Arnaud Comment
Dec 15, 2021
Hyperpolarized (HP) 13 C magnetic resonance enables non-invasive probing of metabolism in vivo. To date, only 13 C-molecules hyperpolarized with persistent trityl radicals have been injected in humans. We show here that the free...
Hyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma.
Mor Mishkovsky, Olga Gusyatiner, Bernard Lanz, Cristina Cudalbu, Irene Vassallo, Marie-France Hamou, Jocelyne Bloch, Arnaud Comment, Rolf Gruetter, Monika E Hegi
May 21, 2021
Glioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front is highly relevant for tumor recurrence but is generally...
Design of a User Comment Management System Based on Text Mining
Abuduaini Abudureheman
Jan 01, 2023
Presently, text mining in e-commerce reviews predominantly focus on singular sentiment analysis, yet constraints persist in sentiment score computation, semantic inclination discernment, and lexicon construction. To address...
Published by: IGI Global Scientific Publishing
Comment
Christopher Jennison
May 31, 2023
Group sequential Phase III trial designs enable early stopping for positive or negative study outcomes. Response-adaptive randomisation can be included in such designs with the sampling ratio in each group of subjects...
A Fine-Grained Sentiment Analysis Method Using Transformer for Weibo Comment Text
Many existing fine-grained sentiment analysis (FGSA) methods have problems such as easy loss of fine-grained information, difficulty in solving polysemy and imbalanced sample categories. Therefore, a Transformer based FGSA...
Published by: IGI Global Scientific Publishing
Estimating the total prevalence of PTSD among the UK police force
Two recent surveys have reported widely differing prevalence rates for posttraumatic stress disorder (PTSD) within the U.K. police force. Stevelink et al. (2020) reported a rate of 3.9% whereas a survey conducted for the charity...
Humans prevalence Stress Disorders Post-Traumatic Police Diagnostic and Statistical Manual of Mental Disorders United Kingdom
Published by: PLOS ONE
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