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Common Functions of Disordered Proteins across Evolutionary Distant Organisms.
Intrinsically disordered proteins and regions typically lack a well-defined structure and thus fall outside the scope of the classic sequence-structure-function relationship. Hence, classic sequence- or structure-based...
Common Functions of Disordered Proteins across Evolutionary Distant Organisms
Intrinsically disordered proteins and regions typically lack a well-defined structure and thus fall outside the scope of the classic sequence−structure−function relationship. Hence, classic sequence- or structure-based...
TAF6delta orchestrates an apoptotic transcriptome profile and interacts functionally with p53.
Emmanuelle Wilhelm, Mara Kornete, Brice Targat, Jimmy Vigneault-Edwards, Mattia Frontini, Laszlo Tora, Arndt Benecke, Brendan Bell
Sep 26, 2018
BACKGROUND: TFIID is a multiprotein complex that plays a pivotal role in the regulation of RNA polymerase II (Pol II) transcription owing to its core promoter recognition and co-activator functions. TAF6 is a core TFIID subunit...
Species- and tissue-specific differences in ROS metabolism during exposure to hypoxia and hyperoxia plus recovery in marine sculpins.
Animals that inhabit environments that fluctuate in oxygen must not only contend with disruptions to aerobic metabolism, but also the potential effects of reactive oxygen species (ROS). The goal of this study was to compare...
An excitable Rho GTPase signaling network generates dynamic subcellular contraction patterns.
Melanie Graessl, Johannes Koch, Abram Calderon, Dominic Kamps, Soumya Banerjee, Tomáš Mazel, Nina Schulze, Jana Kathrin Jungkurth, Rutuja Patwardhan, Djamschid Solouk, Nico Hampe, Bernd Hoffmann, Leif Dehmelt, Perihan Nalbant
Nov 19, 2019
Rho GTPase-based signaling networks control cellular dynamics by coordinating protrusions and retractions in space and time. Here, we reveal a signaling network that generates pulses and propagating waves of cell contractions....
The Grizzly, September 10, 2009
Caitlin Dalik, Katie Callahan, Zach Shamberg, Gianna Paone, Roger Lee, Lisa Jobe, Kristin Cichowski, Liz Kilmer, Emily Arndt, Maryanne Berthel, Eva Bramesco, Carly Siegler, Kate Lechleitner, Jarod Groome
Jan 01, 0001
Barack Obama Dating Game: "Czar" Power Do Deals at the Bars Mean Bad News for Your Health? Escape Velocity is Rising to New Heights: 2009 Preview Discover the Unknown Through the International Film Festival Over 300 Students...
Ursinus College Collegeville Pennsylvania newspaper Alcohol Residence Life dance International Film Festival peer mentors field hockey Football cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Convergent evolution of conserved mitochondrial pathways underlies repeated adaptation to extreme environments.
Ryan Greenway, Nick Barts, Chathurika Henpita, Anthony P Brown, Lenin Arias Rodriguez, Carlos M Rodríguez Peña, Sabine Arndt, Gigi Y Lau, Michael P Murphy, Lei Wu, Dingbo Lin, Michael Tobler, Joanna L Kelley, Jennifer H Shaw
Jul 06, 2020
Extreme environments test the limits of life; yet, some organisms thrive in harsh conditions. Extremophile lineages inspire questions about how organisms can tolerate physiochemical stressors and whether the repeated...
Epithelial calcineurin controls microbiota-dependent intestinal tumor development.
Kenneth Peuker, Stefanie Muff, Jun Wang, Sven Künzel, Esther Bosse, Yvonne Zeissig, Giuseppina Luzzi, Marijana Basic, Anne Strigli, Andrea Ulbricht, Arthur Kaser, Alexander Arlt, Triantafyllos Chavakis, Gijs R van den Brink, Clemens Schafmayer, Jan-Hendrik Egberts, Thomas Becker, Marco E Bianchi, André Bleich, Christoph Röcken, Jochen Hampe, Stefan Schreiber, John F Baines, Richard S Blumberg, Sebastian Zeissig
Aug 09, 2016
Animals Blotting Western Calcineurin Cell Proliferation Cell Survival Colorectal Neoplasms Disease Models Animal Electrophoretic Mobility Shift Assay Epithelial Cells Fecal Microbiota Transplantation Flow Cytometry Gastrointestinal Microbiome Genes APC HCT116 Cells HT29 Cells Humans Immunohistochemistry In Situ Hybridization Fluorescence Intestinal Mucosa Intestinal Neoplasms Intestines Mice NFATC Transcription Factors Neoplastic Stem Cells Organoids Prognosis RNA Ribosomal 16S Reverse Transcriptase Polymerase Chain Reaction Tissue Array Analysis
MitoNeoD
Maria M Shchepinova, Andrew G Cairns, Tracy A Prime, Angela Logan, Andrew M James, Andrew R Hall, Sara Vidoni, Sabine Arndt, Stuart T Caldwell, Hiran A Prag, Victoria R Pell, Thomas Krieg, John F Mulvey, Pooja Yadav, James N Cobley, Thomas P Bright, Hans M Senn, Robert F Anderson, Michael P Murphy, Richard C Hartley
Dec 10, 2018
Mitochondrial superoxide (O2⋅-) underlies much oxidative damage and redox signaling. Fluorescent probes can detect O2⋅-, but are of limited applicability in vivo, while in cells their usefulness is constrained by side reactions...
The Grizzly, January 28, 2010
Caitlin Dalik, Katie Callahan, Nikhil Popat, Gianna Paone, Maryanne Berthel, Lisa Jobe, Emily Arndt, Emily Haldeman, Ellen Bernhard, Carly Siegler, Zach Shamberg, Helen Ann Coin, Christopher Michael, Kate Lechleitner
Jan 01, 0001
Ursinus Students Celebrate MLK Jr. Day Recyclemania: Ursinus to Get in the Game Bisphenol-A: Focus of Ursinus Professor's Research Ursinus is Top 100 Making the Landscape at the Berman Spring Dancing Brings Fundraising and...
Ursinus College Collegeville Pennsylvania newspaper Martin Luther King recycling Rebecca Roberts college rankings Berman Art Museum Edward Burtynsky dance Swimming cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer.
Sonja Neumeyer, Barbara L Banbury, Volker Arndt, Sonja I Berndt, Stephane Bezieau, Stephanie A Bien, Dan D Buchanan, Katja Butterbach, Bette J Caan, Peter T Campbell, Graham Casey, Andrew T Chan, Stephen J Chanock, James Y Dai, Steven Gallinger, Edward L Giovannucci, Graham G Giles, William M Grady, Jochen Hampe, Michael Hoffmeister, John L Hopper, Li Hsu, Mark A Jenkins, Amit Joshi, Susanna C Larsson, Loic Le Marchand, Annika Lindblom, Victor Moreno, Mathieu Lemire, Li Li, Yi Lin, Kenneth Offit, Polly A Newcomb, Paul D Pharaoh, John D Potter, Lihong Qi, Gad Rennert, Clemens Schafmayer, Robert E Schoen, Martha L Slattery, Mingyang Song, Cornelia M Ulrich, Aung K Win, Emily White, Alicja Wolk, Michael O Woods, Anna H Wu, Stephen B Gruber, Hermann Brenner, Ulrike Peters, Jenny Chang-Claude
Jul 13, 2018
BACKGROUND: Substantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer (CRC) risk, indicating a role of exogenous sex hormones in CRC development. However, findings on...
Interaction Between GAD65 Antibodies and Dietary Fish Intake or Plasma Phospholipid n-3 Polyunsaturated Fatty Acids on Incident Adult-Onset Diabetes
Josefin E Löfvenborg, Sofia Carlsson, Tomas Andersson, Christiane S Hampe, Albert Koulman, María Dolores Chirlaque Lopez, Paula Jakszyn, Verena A Katzke, Tilman Kühn, Cecilie Kyrø, Giovanna Masala, Peter M Nilsson, Kim Overvad, Salvatore Panico, Maria-Jose Sánchez, Yvonne van der Schouw, Matthias B Schulze, Anne Tjønneland, Elisabete Weiderpass, Elio Riboli, Nita G Forouhi, Stephen J Sharp, Olov Rolandsson, Nicholas J Wareham
Jan 15, 2021
Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo.
Lee M Booty, Justyna M Gawel, Filip Cvetko, Stuart T Caldwell, Andrew R Hall, John F Mulvey, Andrew M James, Elizabeth C Hinchy, Tracy A Prime, Sabine Arndt, Cristiane Beninca, Thomas P Bright, Menna R Clatworthy, John R Ferdinand, Hiran A Prag, Angela Logan, Julien Prudent, Thomas Krieg, Richard C Hartley, Michael P Murphy
May 15, 2019
Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart
Min Park, Takanori Nishimura, Carlos D. Baeza-Garza, Stuart T. Caldwell, Pamela Boon Li Pun, Hiran A. Prag, Tim Young, Olga Sauchanka, Angela Logan, Marleen Forkink, Anja V. Gruszczyk, Tracy A. Prime, Sabine Arndt, Alba Naudi, Reinald Pamplona, Melinda T. Coughlan, Mitchel Tate, Rebecca H. Ritchie, Federico Caicci, Nina Kaludercic, Fabio Di Lisa, Robin A. J. Smith, Richard C. Hartley, Michael P. Murphy, Thomas Krieg
Nov 18, 2020
Abstract: Purpose: HFpEF (heart failure with preserved ejection fraction) is a major consequence of diabetic cardiomyopathy with no effective treatments. Here, we have characterized Akita mice as a preclinical model of HFpEF and...
Autoimmunity plays a role in the onset of diabetes after 40 years of age.
Olov Rolandsson, Christiane S Hampe, Stephen J Sharp, Eva Ardanaz, Heiner Boeing, Guy Fagherazzi, Francesca Romana Mancini, Peter M Nilsson, Kim Overvad, Maria-Dolores Chirlaque, Miren Dorronsoro, Marc J Gunter, Rudolf Kaaks, Timothy J Key, Kay-Tee Khaw, Vittorio Krogh, Tilman Kühn, Domenico Palli, Salvatore Panico, Carlotta Sacerdote, Maria-José Sánchez, Gianluca Severi, Annemieke MW Spijkerman, Rosario Tumino, Yvonne T van der Schouw, Elio Riboli, Nita G Forouhi, Claudia Langenberg, Nicholas J Wareham
Dec 03, 2019
AIMS/HYPOTHESIS: Type 1 and type 2 diabetes differ with respect to pathophysiological factors such as beta cell function, insulin resistance and phenotypic appearance, but there may be overlap between the two forms of diabetes....
Autoimmunity plays a role in the onset of diabetes after 40 years of age
Olov Rolandsson, Christiane S. Hampe, Stephen J. Sharp, Eva Ardanaz, Heiner Boeing, Guy Fagherazzi, Francesca Romana Mancini, Peter M. Nilsson, Kim Overvad, Maria-Dolores Chirlaque, Miren Dorronsoro, Marc J. Gunter, Rudolf Kaaks, Timothy J. Key, Kay-Tee Khaw, Vittorio Krogh, Tilman Kühn, Domenico Palli, Salvatore Panico, Carlotta Sacerdote, Maria-José Sánchez, Gianluca Severi, Annemieke M. W. Spijkerman, Rosario Tumino, Yvonne T. van der Schouw, Elio Riboli, Nita G. Forouhi, Claudia Langenberg, Nicholas J. Wareham
Nov 10, 2020
Autoimmunity plays a role in the onset of diabetes after 40 years of age
Olov Rolandsson, Christiane S. Hampe, Stephen J. Sharp, Eva Ardanaz, Heiner Boeing, Guy Fagherazzi, Francesca Romana Mancini, Peter M. Nilsson, Kim Overvad, Maria-Dolores Chirlaque, Miren Dorronsoro, Marc J. Gunter, Rudolf Kaaks, Timothy J. Key, Kay-Tee Khaw, Vittorio Krogh, Tilman Kühn, Domenico Palli, Salvatore Panico, Carlotta Sacerdote, Maria-José Sánchez, Gianluca Severi, Annemieke M. W. Spijkerman, Rosario Tumino, Yvonne T. van der Schouw, Elio Riboli, Nita G. Forouhi, Claudia Langenberg, Nicholas J. Wareham
Jun 06, 2020
Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart.
Min Park, Takanori Nishimura, Carlos D Baeza-Garza, Stuart T Caldwell, Pamela Boon Li Pun, Hiran A Prag, Tim Young, Olga Sauchanka, Angela Logan, Marleen Forkink, Anja V Gruszczyk, Tracy A Prime, Sabine Arndt, Alba Naudi, Reinald Pamplona, Melinda T Coughlan, Mitchel Tate, Rebecca H Ritchie, Federico Caicci, Nina Kaludercic, Fabio Di Lisa, Robin AJ Smith, Richard C Hartley, Michael P Murphy, Thomas Krieg
Sep 29, 2020
Advanced glycation endproducts (AGE) Akita mice Diabetes Heart failure with preserved ejection fraction (HFpEF) Mitochondria Animals Benzamides Cardiovascular Agents Diabetic Cardiomyopathies Disease Models Animal Glycation End Products Advanced Heart Failure Male Mice Inbred C57BL Mice Mutant Strains Mitochondria Heart Stroke Volume Ventricular Dysfunction Left Ventricular Function Left
Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart
Min Park, Takanori Nishimura, Carlos D. Baeza-Garza, Stuart T. Caldwell, Pamela Boon Li Pun, Hiran A. Prag, Tim Young, Olga Sauchanka, Angela Logan, Marleen Forkink, Anja V. Gruszczyk, Tracy A. Prime, Sabine Arndt, Alba Naudi, Reinald Pamplona, Melinda T. Coughlan, Mitchel Tate, Rebecca H. Ritchie, Federico Caicci, Nina Kaludercic, Fabio Di Lisa, Robin A. J. Smith, Richard C. Hartley, Michael P. Murphy, Thomas Krieg
Sep 26, 2021
Abstract: Purpose: HFpEF (heart failure with preserved ejection fraction) is a major consequence of diabetic cardiomyopathy with no effective treatments. Here, we have characterized Akita mice as a preclinical model of HFpEF and...
Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic
Charlotte Thibeault, Barbara Mühlemann, Elisa T Helbig, Mirja Mittermaier, Tilman Lingscheid, Pinkus Tober-Lau, Lil A Meyer-Arndt, Leonie Meiners, Paula Stubbemann, Sascha S Haenel, Laure Bosquillon de Jarcy, Lena Lippert, Moritz Pfeiffer, Miriam S Stegemann, Robert Roehle, Janine Wiebach, Stefan Hippenstiel, Thomas Zoller, Holger Müller-Redetzky, Alexander Uhrig, Felix Balzer, Christof von Kalle, Norbert Suttorp, Terry C Jones, Christian Drosten, Martin Witzenrath, Leif E Sander, Pa-COVID study Group, Victor M Corman, Florian Kurth
Jul 28, 2021
Artificial respiration COVID-19 Nucleic Acid Testing Coronavirus disease 2019 (COVID-19) Mechanical ventilation prospective study Respiratory Distress Syndrome Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Symptom Assessment Viral concentration covid-19 Cohort Studies Germany Hospitalization Humans Hypertension Kinetics Prospective Studies Respiration Artificial Risk Factors SARS-CoV-2 Tertiary Care Centers Time Factors Viral Load Virus Shedding
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