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Face Masks Protect From Infection but May Impair Social Cognition in Older Adults and People With Dementia.
The coronavirus disease 2019 (COVID-19) pandemic will have a high impact on older adults and people with Alzheimer's disease and other dementias. Social cognition enables the understanding of another individual's feelings...
Mindreading From the Eyes Declines With Aging - Evidence From 1,603 Subjects.
Jana Kynast, Eva Maria Quinque, Maryna Polyakova, Tobias Luck, Steffi G Riedel-Heller, Simon Baron-Cohen, Andreas Hinz, A Veronica Witte, Julia Sacher, Arno Villringer, Matthias L Schroeter
Dec 23, 2020
Social cognition, in particular mindreading, enables the understanding of another individual's feelings, intentions, desires, and mental states. The Reading the Mind in the Eyes Test (RMET) captures the ability to identify...
Mindreading From the Eyes Declines With Aging – Evidence From 1,603 Subjects
Jana Kynast, Eva Maria Quinque, Maryna Polyakova, Tobias Luck, Steffi G. Riedel-Heller, Simon Baron-Cohen, Andreas Hinz, A. Veronica Witte, Julia Sacher, Arno Villringer, Matthias L. Schroeter
Nov 11, 2020
Social cognition, in particular mindreading, enables the understanding of another individual’s feelings, intentions, desires, and mental states. The Reading the Mind in the Eyes Test (RMET) captures the ability to identify...
Arf6 Can Trigger Wave Regulatory Complex-Dependent Actin Assembly Independent of Arno.
The small GTPase ADP-ribosylation factor 6 (Arf6) anchors at the plasma membrane to orchestrate key functions, such as membrane trafficking and regulating cortical actin cytoskeleton rearrangement. A number of studies have...
MACROPHAGES Phagocytosis Actin Cytoskeleton Arf GTPases Wave regulatory complex host–pathogen interplay
Published by: International journal of molecular sciences
Arf6 Can Trigger Wave Regulatory Complex-Dependent Actin Assembly Independent of Arno
The small GTPase ADP-ribosylation factor 6 (Arf6) anchors at the plasma membrane to orchestrate key functions, such as membrane trafficking and regulating cortical actin cytoskeleton rearrangement. A number of studies have...
Arf6 Can Trigger Wave Regulatory Complex-Dependent Actin Assembly Independent of Arno.
The small GTPase ADP-ribosylation factor 6 (Arf6) anchors at the plasma membrane to orchestrate key functions, such as membrane trafficking and regulating cortical actin cytoskeleton rearrangement. A number of studies have...
The Nested Kingman Coalescent
The nested Kingman coalescent describes the ancestral tree of a population undergoing neutral evolution at the level of individuals and at the level of species, simultaneously. We study the speed at which the number of...
The Nested Kingman Coalescent
The nested Kingman coalescent describes the ancestral tree of a population undergoing neutral evolution at the level of individuals and at the level of species, simultaneously. We study the speed at which the number of...
Tumour necrosis factor inhibitor monotherapy vs combination with MTX in the treatment of PsA
Frank Behrens, Juan D Cañete, Ignazio Olivieri, Arno W van Kuijk, Neil McHugh, Bernard Combe
May 01, 2015
The aim of this study was to review the available evidence on TNF inhibitor monotherapy vs combination therapy with MTX in PsA.
Tumour necrosis factor inhibitor monotherapy vs combination with MTX in the treatment of PsA
Frank Behrens, Juan D Cañete, Ignazio Olivieri, Arno W van Kuijk, Neil McHugh, Bernard Combe
May 01, 2015
The aim of this study was to review the available evidence on TNF inhibitor monotherapy vs combination therapy with MTX in PsA.
The current and potential health benefits of the National Health Service Health Check cardiovascular disease prevention programme in England
Oliver T Mytton, Christopher Jackson, Arno Steinacher, Anna Goodman, Claudia Langenberg, Simon Griffin, Nick Wareham, James Woodcock
Mar 14, 2018
BACKGROUND: The National Health Service (NHS) Health Check programme was introduced in 2009 in England to systematically assess all adults in midlife for cardiovascular disease risk factors. However, its current benefit and...
Clinical utility gene card for
Neringa Jurkute, Anna Majander, Richard Bowman, Marcela Votruba, Stephen Abbs, James Acheson, Guy Lenaers, Patrizia Amati-Bonneau, Mariya Moosajee, Gavin Arno, Patrick Yu-Wai-Man
May 13, 2019
Impact of Adalimumab Treatment on Interleukin-17 and Interleukin-17 Receptor Expression in Skin and Synovium of Psoriatic Arthritis Patients with Mild Psoriasis.
Janne W Bolt, Arno W van Kuijk, Marcel BM Teunissen, Dennis van der Coelen, Saïda Aarrass, Daniëlle M Gerlag, Paul P Tak, Marleen G van de Sande, Maria C Lebre, Lisa GM van Baarsen
Jan 30, 2022
Interleukin (IL)-17 and tumor necrosis factor-alpha (TNF)-α are key players in psoriatic arthritis (PsA) pathogenesis. While both cytokines can be therapeutically targeted with beneficial clinical outcome, it is unclear whether...
Assessment of the incorporation of CNV surveillance into gene panel next-generation sequencing testing for inherited retinal diseases.
Jamie M Ellingford, Bradley Horn, Christopher Campbell, Gavin Arno, Stephanie Barton, Catriona Tate, Sanjeev Bhaskar, Panagiotis I Sergouniotis, Rachel L Taylor, Keren J Carss, Lucy FL Raymond, Michel Michaelides, Simon C Ramsden, Andrew R Webster, Graeme CM Black
Mar 23, 2018
BACKGROUND: Diagnostic use of gene panel next-generation sequencing (NGS) techniques is commonplace for individuals with inherited retinal dystrophies (IRDs), a highly genetically heterogeneous group of disorders. However, these...
copy-number variation inherited retinal disease Molecular genetics next-generation sequencing Adaptor Proteins Signal Transducing Algorithms Cytoskeletal Proteins DNA Copy Number Variations Gene Duplication Gene Frequency Genetic Predisposition to Disease High-Throughput Nucleotide Sequencing Humans Membrane Proteins Retinal Dystrophies Ribonucleoproteins Small Nuclear Workflow
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment.
Henk-Jan van den Ham, Jason D Cooper, Jakub Tomasik, Sabine Bahn, Joeri L Aerts, Albert DME Osterhaus, Rob A Gruters, Arno C Andeweg, DC-TRN trial investigators
May 23, 2018
OBJECTIVES: To characterize the host response to dendritic cell-based immunotherapy and subsequent combined antiretroviral therapy (cART) interruption in HIV-1-infected individuals at the plasma protein level. DESIGN: An...
A robust human norovirus replication model in zebrafish larvae.
Jana Van Dycke, Annelii Ny, Nádia Conceição-Neto, Jan Maes, Myra Hosmillo, Arno Cuvry, Ian Goodfellow, Tatiane C Nogueira, Erik Verbeken, Jelle Matthijnssens, Peter de Witte, Johan Neyts, Joana Rocha-Pereira
Oct 28, 2019
Human noroviruses (HuNoVs) are the most common cause of foodborne illness, with a societal cost of $60 billion and 219,000 deaths/year. The lack of robust small animal models has significantly hindered the understanding of...
The role of Pb oxidation state of the precursor in the formation of 2D perovskite microplates.
SSBP1-Disease Update
Neringa Jurkute, Fabiana D'Esposito, Anthony G Robson, Robert DS Pitceathly, Francesca Cordeiro, F Lucy Raymond, Anthony T Moore, Michel Michaelides, Patrick Yu-Wai-Man, Andrew R Webster, Gavin Arno, Genomics England Research Consortium
Jan 28, 2022
Adolescent Amino Acid Sequence Child Preschool DNA Mitochondrial DNA-Binding Proteins Electroretinography Female Genes Recessive Genotyping Techniques Humans Male Middle Aged Mitochondrial Diseases Mitochondrial Proteins Molecular Conformation Molecular Sequence Data Mutation Missense Optic Atrophy Pedigree Penetrance Protein Stability Protein Structure Quaternary Retinal Dystrophies whole genome sequencing
Impact of Adalimumab Treatment on Interleukin-17 and Interleukin-17 Receptor Expression in Skin and Synovium of Psoriatic Arthritis Patients with Mild Psoriasis.
The Ursinus Weekly, February 9, 1942
Dancers at Lorelei to slide and glide with Wally Spotts Vespers speaker calls attention to spiritual conflict College work-study plan to enable students to work in defense plants "Toyland Fantasy" by Betty Urich will be...
Ursinus College Collegeville Pennsylvania newspaper May Day pageant debate team David Adney International Relations Club William C. Thoroughgood YMCA YWCA sororities fraternities Basketball wrestling cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Biallelic variants in coenzyme Q10 biosynthesis pathway genes cause a retinitis pigmentosa phenotype.
Neringa Jurkute, Francesca Cancellieri, Lisa Pohl, Catherina HZ Li, Robert A Heaton, Janine Reurink, James Bellingham, Mathieu Quinodoz, Georgia Yioti, Maria Stefaniotou, Marianna Weener, Theresia Zuleger, Tobias B Haack, Katarina Stingl, Genomics England Research Consortium, Carel B Hoyng, Omar A Mahroo, Iain Hargreaves, F Lucy Raymond, Michel Michaelides, Carlo Rivolta, Susanne Kohl, Susanne Roosing, Andrew R Webster, Gavin Arno
Nov 20, 2022
The aim of this study was to investigate coenzyme Q10 (CoQ10) biosynthesis pathway defects in inherited retinal dystrophy. Individuals affected by inherited retinal dystrophy (IRD) underwent exome or genome sequencing for...
Genetic Basis of Inherited Retinal Disease in a Molecularly Characterized Cohort of More Than 3000 Families from the United Kingdom.
Nikolas Pontikos, Gavin Arno, Neringa Jurkute, Elena Schiff, Rola Ba-Abbad, Samantha Malka, Ainoa Gimenez, Michalis Georgiou, Genevieve Wright, Monica Armengol, Hannah Knight, Menachem Katz, Mariya Moosajee, Patrick Yu-Wai-Man, Anthony T Moore, Michel Michaelides, Andrew R Webster, Omar A Mahroo
Jan 04, 2021
PURPOSE: In a large cohort of molecularly characterized inherited retinal disease (IRD) families, we investigated proportions with disease attributable to causative variants in each gene. DESIGN: Retrospective study of...
A clinical and molecular characterisation of CRB1-associated maculopathy.
Kamron N Khan, Anthony Robson, Omar AR Mahroo, Gavin Arno, Chris F Inglehearn, Monica Armengol, Naushin Waseem, Graham E Holder, Keren J Carss, Lucy F Raymond, Andrew R Webster, Anthony T Moore, Martin McKibbin, Maria M van Genderen, James A Poulter, Michel Michaelides, UK Inherited Retinal Disease Consortium
Nov 22, 2018
To date, over 150 disease-associated variants in CRB1 have been described, resulting in a range of retinal disease phenotypes including Leber congenital amaurosis and retinitis pigmentosa. Despite this, no genotype-phenotype...
Adolescent Adult Alleles Child Child Preschool Electronic Health Records Eye Proteins Female Genetic Association Studies Genetic Predisposition to Disease Genetic Testing Humans Infant Infant Newborn Macular degeneration Male Membrane Proteins Nerve Tissue Proteins Retinal Photoreceptor Cell Outer Segment Young Adult
SSBP1 mutations in dominant optic atrophy with variable retinal degeneration.
Neringa Jurkute, Costin Leu, Hans-Martin Pogoda, Gavin Arno, Anthony G Robson, Gudrun Nürnberg, Janine Altmüller, Holger Thiele, Susanne Motameny, Mohammad Reza Toliat, Kate Powell, Wolfgang Höhne, Michel Michaelides, Andrew R Webster, Anthony T Moore, Matthias Hammerschmidt, Peter Nürnberg, Patrick Yu-Wai-Man, Marcela Votruba
Jul 26, 2019
OBJECTIVE: Autosomal dominant optic atrophy (ADOA) starts in early childhood with loss of visual acuity and color vision deficits. OPA1 mutations are responsible for the majority of cases, but in a portion of patients with a...
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