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Results: 53
Multi-trait genome-wide association study identifies new loci associated with optic disc parameters.
Pieter WM Bonnemaijer, Elisabeth M van Leeuwen, Adriana I Iglesias, Puya Gharahkhani, Veronique Vitart, Anthony P Khawaja, Mark Simcoe, René Höhn, Angela J Cree, Rob P Igo, International Glaucoma Genetics Consortium, NEIGHBORHOOD Consortium, UK Biobank Eye and Vision Consortium, Aslihan Gerhold-Ay, Stefan Nickels, James F Wilson, Caroline Hayward, Thibaud S Boutin, Ozren Polašek, Tin Aung, Chiea Chuen Khor, Najaf Amin, Andrew J Lotery, Janey L Wiggs, Ching-Yu Cheng, Pirro G Hysi, Christopher J Hammond, Alberta AHJ Thiadens, Stuart MacGregor, Caroline CW Klaver, Cornelia M van Duijn
Nov 26, 2020
genome-wide association studies Optic Nerve Diseases Case-Control Studies Computational Biology Gene Expression Profiling Genetic Association Studies Genetic Predisposition to Disease Genome-Wide Association Study Glaucoma Humans Molecular Sequence Annotation Optic Disk Optic Nerve Diseases Polymorphism Single Nucleotide Quantitative Trait Loci Quantitative Trait Heritable Signal Transduction
Where Does ’Ayyē Come From? Proclisis and Affix Pleonasm in the Biblical Hebrew Interrogatives ’Ē and ’Ayyē
Abstract
Interrogatives from the base *’ayy- are common throughout Semitic. Two of the reflexes of this base in Biblical Hebrew, ’ē ‘where?’ and ’ayyē ‘where?’, exhibit atypical...
Benjamin Kantor
May 14, 2019
Evidence for downregulation of the negative regulator SPRED2 in clinical prostate cancer.
BACKGROUND: SPRED1 and 2 are key negative regulators of MAPK signalling in mammalian cells. Here, we investigate the expression and functional role of SPREDs in prostate cancer. METHODS: A transcriptome bank of microdissected...
Adaptor Proteins Signal Transducing Blotting Western Cell Movement Cell Proliferation Cohort Studies Down-Regulation Dual Specificity Phosphatase 1 Humans Intracellular Signaling Peptides and Proteins Male Membrane Proteins Neoplasm Grading Prognosis Prostatic Hyperplasia Prostatic Neoplasms RNA Messenger RNA Small Interfering Real-Time Polymerase Chain Reaction Receptors Interleukin Repressor Proteins Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Tumor Cells Cultured
A comparison of operative and margin outcomes from surgeon learning curves in robot assisted radical prostatectomy in a changing referral practice.
Introduction The aim of this study was to explore the impact of increasing proportions of high risk referrals on surgical margin outcomes of a surgeon's learning curve in robotic prostatectomy. Methods All patients in this study...
Early oncological outcomes Learning Curve Robot assisted radical prostatectomy Adult Aged Humans Learning Curve Male Margins of Excision Middle Aged Neoplasm Staging Prospective Studies Prostatectomy Prostatic Neoplasms Referral and Consultation risk Robotic Surgical Procedures Treatment Outcome United Kingdom
Identification of pathologically insignificant prostate cancer is not accurate in unscreened men.
GL Shaw, BC Thomas, SN Dawson, G Srivastava, SL Vowler, VJ Gnanapragasam, NC Shah, AY Warren, DE Neal
Jun 11, 2018
BACKGROUND: Identification of men harbouring insignificant prostate cancer (PC) is important in selecting patients for active surveillance. Tools have been developed in PSA-screened populations to identify such men based on...
Adenocarcinoma Aged Area Under Curve Biopsy Needle Early Detection of Cancer False Negative Reactions Humans Lymphatic Metastasis Magnetic Resonance Imaging Male Middle Aged Neoplasm Grading Neoplasm Staging Organ Size Patient Selection Predictive Value of Tests Prostate Prostate-specific antigen Prostatic Neoplasms ROC Curve Retrospective Studies Risk Assessment Seminal vesicles Sensitivity and Specificity Tumor Burden Watchful Waiting
The hydrogen economy
N MacDowell, N Sunny, N Brandon, H Herzog, AY Ku, W Maas, A Ramirez, DM Reiner, GN Sant, N Shah
Oct 07, 2021
For hydrogen to play a meaningful role in a sustainable energy system, all elements of the value chain must scale coherently. Advocates support electrolytic (green) hydrogen or (blue) hydrogen that relies on methane reformation...
Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis.
Acrylamides Apoptosis Carcinoma Renal Cell Epithelial Cells Gene Expression Regulation Neoplastic Humans In Situ Nick-End Labeling Kidney Neoplasms Kidney Tubules Necrosis Organ Culture Techniques Quinazolinones RNA Messenger Receptor-Interacting Protein Serine-Threonine Kinases Receptors Tumor Necrosis Factor Type I Signal Transduction Sulfonamides Tumor Necrosis Factor-alpha Up-Regulation
SMT-Solving Induction Proofs of Inequalities
This paper accompanies a new dataset of non-linear real arithmetic problems for the SMT-LIB benchmark collection. The problems come from an automated proof procedure of Gerhold-Kauers, which is well suited for solution by...
SMT-Solving Induction Proofs of Inequalities
This paper accompanies a new dataset of non-linear real arithmetic problems for the SMT-LIB benchmark collection. The problems come from an automated proof procedure of Gerhold-Kauers, which is well suited for solution by...
Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity
AW Nelson, AJ Groen, JL Miller, AY Warren, KA Holmes, GA Tarulli, WD Tilley, BS Katzenellenbogen, JR Hawse, VJ Gnanapragasam, JS Carroll
Mar 31, 2017
Thrombomodulin in patients with mild to moderate bleeding tendency.
Dino Mehic, Alexander Tolios, Stefanie Hofer, Cihan Ay, Helmuth Haslacher, Kate Downes, Matthias Haimel, Ingrid Pabinger, Johanna Gebhart
Oct 10, 2021
INTRODUCTION: A massive increase of soluble thrombomodulin (sTM) due to variants in the thrombomodulin gene (THBD) has recently been identified as a novel bleeding disorder. AIM: To investigate sTM levels and underlying genetic...
Monoamine oxidase-A promotes protective autophagy in human SH-SY5Y neuroblastoma cells through Bcl-2 phosphorylation.
Aslihan Ugun-Klusek, Theodosis S Theodosi, Julia C Fitzgerald, Florence Burté, Christoph Ufer, David J Boocock, Patrick Yu-Wai-Man, Lynn Bedford, E Ellen Billett
Dec 07, 2018
Monoamine oxidases (MAOs) are located on the outer mitochondrial membrane and are drug targets for the treatment of neurological disorders. MAOs control the levels of neurotransmitters in the brain via oxidative deamination and...
Autophagy Monoamine Oxidase neurodegeneration Reactive Oxygen Species Autophagy Caspases Cell Line Tumor Cell Survival Fluorescent Antibody Technique Gene Expression Humans Immunohistochemistry Mitochondria Models Biological Monoamine Oxidase Neuroblastoma Oxidation-Reduction Oxidative Stress Phosphorylation Proteome Proteomics Proto-Oncogene Proteins c-bcl-2 Reactive Oxygen Species
Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype.
JLL Robinson, TE Hickey, AY Warren, SL Vowler, T Carroll, AD Lamb, N Papoutsoglou, DE Neal, WD Tilley, JS Carroll
May 02, 2019
Castration-resistant prostate cancer (CRPC) continues to pose a significant clinical challenge with new generation second-line hormonal therapies affording limited improvement in disease outcome. As the androgen receptor (AR)...
Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure.
Joachim M Gerhold, Şirin Cansiz-Arda, Madis Lõhmus, Oskar Engberg, Aurelio Reyes, Helga van Rennes, Alberto Sanz, Ian J Holt, Helen M Cooper, Johannes N Spelbrink
Nov 23, 2017
The helicase Twinkle is indispensable for mtDNA replication in nucleoids. Previously, we showed that Twinkle is tightly membrane-associated even in the absence of mtDNA, which suggests that Twinkle is part of a membrane-attached...
Three-year experience of a dedicated prostate mpMRI pre-biopsy programme and effect on timed cancer diagnostic pathways.
T Barrett, R Slough, N Sushentsev, N Shaida, BC Koo, I Caglic, V Kozlov, AY Warren, V Thankappannair, C Pinnock, N Shah, K Saeb-Parsy, VJ Gnanapragasam, E Sala, C Kastner
Sep 09, 2019
AIM: To evaluate the effect of pre-biopsy magnetic resonance imaging (MRI) on cancer diagnostic times, and to report MRI-directed pathology outcomes. MATERIALS AND METHODS: In total, 1483 patients were referred with prostate...
A Segue From Search to Dialogue
Jon Mason, Marcella Dillig, Anselm Böhmer, Stephen Bolaji, Illie Isso, Mirona Stănescu, Hilal Sahin, Aslihan Kuraner
Feb 07, 2024
For over two decades, educational technologies have been embedded within an approach to inquiry dominated by the “search paradigm.” However, conversational AI presents an opportunity to shift this paradigm towards enhancing...
Artificial Intelligence Education Educational Technologies Computer Science and Information Technology Security and Forensics
Published by: IGI Global Scientific Publishing
Hospitalization and Mortality Risk for COVID-19 Cases With SARS-CoV-2 AY.4.2 (VUI-21OCT-01) Compared to Non-AY.4.2 Delta Variant Sublineages.
The Financial Impact on Reimbursement of Moderately Hypofractionated Postoperative Radiation Therapy for Breast Cancer
GN Marta, D Ramiah, O Kaidar-Person, A Kirby, C Coles, R Jagsi, T Hijal, G Sancho, Y Zissiadis, J-P Pignol, AY Ho, SH-C Cheng, BV Offersen, I Meattini, P Poortmans
Jan 06, 2021
AIMS: Moderately hypofractionated breast irradiation has been evaluated in several prospective studies, resulting in wide acceptance of shorter treatment protocols for postoperative breast irradiation. Reimbursement for...
Corrigendum
The helicase Twinkle is indispensable for mtDNA replication in nucleoids. Previously, we showed that Twinkle is tightly membrane-associated even in the absence of mtDNA, which suggests that Twinkle is part of a...
Joachim M Gerhold, Şirin Cansiz-Arda, Madis Lõhmus, Oskar Engberg, Aurelio Reyes, Helga van Rennes, Alberto Sanz, Ian J Holt, Helen M Cooper, Johannes N Spelbrink
Nov 23, 2017
Life Without GPR7, the Neuropeptide W1 Receptor: Regulation of Energy Homeostasis by GPR7 and its Endogenous Neuropeptide Ligands
Makoto Ishii
Jan 01, 0001
Classic lesion experiments from the 1940s have established the hypothalamus as playing an essential role in controlling energy homeostasis. Gold-thioglucose (GTG) induces lesions in the ventromedial nucleus of the hypothalamus...
Published by: Rockefeller University
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