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Results: 30
Activating transcription factor-2 (ATF2) is a key determinant of resistance to endocrine treatment in an in vitro model of breast cancer.
Athina Giannoudis, Mohammed Imad Malki, Bharath Rudraraju, Hisham Mohhamed, Suraj Menon, Triantafillos Liloglou, Simak Ali, Jason S Carroll, Carlo Palmieri
Nov 30, 2020
BACKGROUND: Activating transcription factor-2 (ATF2), a member of the leucine zipper family of DNA binding proteins, has been implicated as a tumour suppressor in breast cancer. However, its exact role in breast cancer endocrine...
ATF2 Breast Cancer endocrine resistance Tamoxifen Activating Transcription Factor 2 Antineoplastic Agents Hormonal Breast Neoplasms Cell Movement Drug Resistance Neoplasm Female Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Knockdown Techniques Humans MCF-7 Cells Oligonucleotide Array Sequence Analysis Receptors Estrogen Tamoxifen
Activating transcription factor-2 (ATF2) is a key determinant of resistance to endocrine treatment in an in vitro model of breast cancer
Athina Giannoudis, Mohammed Imad Malki, Bharath Rudraraju, Hisham Mohhamed, Suraj Menon, Triantafillos Liloglou, Simak Ali, Jason S. Carroll, Carlo Palmieri
Nov 16, 2020
Abstract: Background: Activating transcription factor-2 (ATF2), a member of the leucine zipper family of DNA binding proteins, has been implicated as a tumour suppressor in breast cancer. However, its exact role in breast cancer...
Drug Cues, Conditioned Reinforcement, and Drug Seeking
Barry J Everitt
Aug 29, 2018
Athina Markou spent a research period in my laboratory, then in the Department of Anatomy in Cambridge University, in 1991 to help us establish a cocaine-seeking procedure. Thus we embarked on developing a second-order schedule...
Mental health outcomes after SARS-CoV-2 vaccination in the United States
BACKGROUND: Worsening of anxiety and depressive symptoms have been widely described during the COVID-19 pandemic. It can be hypothesized that vaccination could link to reduced symptoms of anxiety and/or depression. However, to...
Feasibility of Using 3D Printed Polyvinyl Alcohol (PVA) for Creating Self-Healing Vascular Tunnels in Cement System.
Pursuing long-term self-healing infrastructures has gained popularity in the construction field. Vascular networks have the potential to achieve long-term self-healing in cementitious infrastructures. To avoid further monitoring...
A vascularized tumoroid model for human glioblastoma angiogenesis.
Functionalisation of a heat-derived and bio-inert albumin hydrogel with extracellular matrix by air plasma treatment.
John Ong, Junzhe Zhao, Galit Katarivas Levy, James Macdonald, Alexander W Justin, Athina E Markaki
Jun 26, 2020
Advances in the generation of bioengineered bile ducts.
Alexander W Justin, Kourosh Saeb-Parsy, Athina E Markaki, Ludovic Vallier, Fotios Sampaziotis
Jan 30, 2018
Biomimetic and electroactive 3D scaffolds for human neural crest-derived stem cell expansion and osteogenic differentiation
Donata Iandolo, Jonathan Sheard, Galit Karavitas Levy, Charalampos Pitsalidis, Ellasia Tan, Anthony Dennis, Ji-Seon Kim, Athina E. Markaki, Darius Widera, Róisín M. Owens
Dec 03, 2020
Abstract: Osteoporosis is a skeletal disease characterized by bone loss and bone microarchitectural deterioration. The combination of smart materials and stem cells represents a new therapeutic approach. In the present study...
Physical and biological characterization of ferromagnetic fiber networks
Rose L Spear, Brajith Srigengan, Suresh Neelakantan, Wolfram Bosbach, Roger A Brooks, Athina E Markaki
Aug 22, 2014
Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue.
Olivia C Tysoe, Alexander W Justin, Teresa Brevini, Si Emma Chen, Krishnaa T Mahbubani, Anna K Frank, Hajer Zedira, Espen Melum, Kourosh Saeb-Parsy, Athina E Markaki, Ludovic Vallier, Fotios Sampaziotis
Jun 17, 2019
Pediatric liver transplantation is often required as a consequence of biliary disorders because of the lack of alternative treatments for repairing or replacing damaged bile ducts. To address the lack of availability of...
Dysconnectivity of a brain functional network was associated with blood inflammatory markers in depression.
Athina R Aruldass, Manfred G Kitzbichler, Sarah E Morgan, Sol Lim, Mary-Ellen Lynall, Lorinda Turner, Petra Vertes, Wellcome Trust Consortium for Neuroimmunology of Mood Disorders and Alzheimer’s Disease (NIMA), Jonathan Cavanagh, Phil Cowen, Carmine M Pariante, Neil A Harrison, Edward T Bullmore
Aug 23, 2021
OBJECTIVE: There is increasing evidence for a subgroup of major depressive disorder (MDD) associated with heightened peripheral blood inflammatory markers. In this study, we aimed to understand the mechanistic brain-immune axis...
Biomimetic and electroactive 3D scaffolds for human neural crest-derived stem cell expansion and osteogenic differentiation
Donata Iandolo, Jonathan Sheard, Galit Karavitas Levy, Charalampos Pitsalidis, Ellasia Tan, Anthony Dennis, Ji-Seon Kim, Athina E. Markaki, Darius Widera, Róisín M. Owens
Sep 28, 2020
Abstract: Osteoporosis is a skeletal disease characterized by bone loss and bone microarchitectural deterioration. The combination of smart materials and stem cells represents a new therapeutic approach. In the present study...
Spatial heterogeneity of cell-matrix adhesive forces predicts human glioblastoma migration.
Rasha Rezk, Bill Zong Jia, Astrid Wendler, Ivan Dimov, Colin Watts, Athina E Markaki, Kristian Franze, Alexandre J Kabla
Jul 14, 2020
BACKGROUND: Glioblastoma (GBM) is a highly aggressive incurable brain tumor. The main cause of mortality in GBM patients is the invasive rim of cells migrating away from the main tumor mass and invading healthy parts of the...
Effective Use of Animal Models for Therapeutic Development in Psychiatric and Substance Use Disorders.
Athina Markou and others argue forcefully for the adoption of a "translational-back translational strategy" for central nervous system drug discovery involving novel application of drugs with established safety profiles in...
Animal models atomoxetine Drug Discovery Ketamine Review Varenicline Adrenergic Uptake Inhibitors Animals Antidepressive Agents Atomoxetine Hydrochloride Attention Deficit Disorder with Hyperactivity Depressive Disorder Drug Discovery Humans Ketamine Mental Disorders Models Animal Nicotinic Agonists Tobacco Use Disorder Varenicline
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