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Results: 147
Nuclear localisation of Aurora-A
Francesco Davide Naso, Dalila Boi, Camilla Ascanelli, Georgiana Pamfil, Catherine Lindon, Alessandro Paiardini, Giulia Guarguaglini
Jun 11, 2021
The Aurora-A kinase regulates cell division, by controlling centrosome biology and spindle assembly. Cancer cells often display elevated levels of the kinase, due to amplification of the gene locus, increased transcription or...
Aurora
Abstract: Atmospheric retrievals of exoplanetary transmission spectra provide important constraints on various properties, such as chemical abundances, cloud/haze properties, and characteristic temperatures, at the day–night...
Aurora
Abstract: Atmospheric retrievals of exoplanetary transmission spectra provide important constraints on various properties, such as chemical abundances, cloud/haze properties, and characteristic temperatures, at the day–night...
Aurora
Atmospheric retrievals of exoplanetary transmission spectra provide important
constraints on various properties such as chemical abundances, cloud/haze
properties, and characteristic temperatures, at the day-night...
Control of Chromosome Segregation by the Aurora B Complex
Srinath Cidambi Sampath
Jan 01, 0001
Chromosome segregation during cell division requires spindle assembly around M-phase chromatin. In cells lacking centrosomes, such as those found in female meiosis, chromosomes themselves nucleate and stabilize microtubules in...
Chromosome Segregation chromosomal passenger complex CPC activation Aurora B spindle assembly Life Sciences
Published by: Rockefeller University
Aurora B-dependent polarization of the cortical actomyosin network during mitotic exit.
The isotropic metaphase actin cortex progressively polarizes as the anaphase spindle elongates during mitotic exit. This involves the loss of actomyosin cortex from opposing cell poles and the accumulation of an actomyosin belt...
The disputed sound of the aurora borealis
Fiona Amery
Aug 18, 2021
This paper discusses heightened interest in the potential audibility of the aurora borealis during the First and Second International Polar Years (IPYs) of 1882–3 and 1932–3. Galvanized by a growing volume of local accounts...
Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix.
Selena G Burgess, Manjeet Mukherjee, Sarah Sabir, Nimesh Joseph, Cristina Gutiérrez-Caballero, Mark W Richards, Nicolas Huguenin-Dezot, Jason W Chin, Eileen J Kennedy, Mark Pfuhl, Stephen J Royle, Fanni Gergely, Richard Bayliss
Jul 05, 2018
Aurora-A regulates the recruitment of TACC3 to the mitotic spindle through a phospho-dependent interaction with clathrin heavy chain (CHC). Here, we describe the structural basis of these interactions, mediated by three motifs...
The disputed sound of the aurora borealis
This paper discusses heightened interest in the potential audibility of the aurora borealis during the First and Second International Polar Years (IPYs) of 1882–3 and 1932–3. Galvanized by a growing volume...
Fiona Amery
Feb 02, 2022
The disputed sound of the aurora borealis
This paper discusses heightened interest in the potential audibility of the aurora borealis during the First and Second International Polar Years (IPYs) of 1882–3 and 1932–3. Galvanized by a growing volume...
Fiona Amery
Aug 26, 2021
Allosteric Targeting of Aurora A Kinase Using Small Molecules
BACKGROUND: Aurora A (AurA) kinase is a key mitotic protein implicated in cancer. Several small molecule inhibitors targeting the ATP binding site of this enzyme are in various stages of clinical development. However, these...
AURKA AurA-TPX2 inhibition Aurora A TPX2 allosteric inhibition Kinase inhibitors proteinprotein
interaction type IV inhibitors. Allosteric Regulation Allosteric Site Anacardic Acids Aurora Kinase A Cell Cycle Proteins Cell Line Tumor Felodipine Humans Microtubule-Associated Proteins Nuclear Proteins Protein Binding Protein Kinase Inhibitors
Enhanced Efficacy of Aurora Kinase Inhibitors in G2/M Checkpoint Deficient TP53 Mutant Uterine Carcinomas Is Linked to the Summation of LKB1-AKT-p53 Interactions.
Katherine N Lynch, Joyce F Liu, Nikolas Kesten, Kin-Hoe Chow, Aniket Shetty, Ruiyang He, Mosammat Faria Afreen, Liping Yuan, Ursula A Matulonis, Whitfield B Growdon, Michael G Muto, Neil S Horowitz, Colleen M Feltmate, Michael J Worley, Ross S Berkowitz, Christopher P Crum, Bo R Rueda, Sarah J Hill
Jul 07, 2021
Uterine carcinoma (UC) is the most common gynecologic malignancy in the United States. TP53 mutant UCs cause a disproportionate number of deaths due to limited therapies for these tumors and the lack of mechanistic understanding...
Enhanced Efficacy of Aurora Kinase Inhibitors in G2/M Checkpoint Deficient TP53 Mutant Uterine Carcinomas Is Linked to the Summation of LKB1–AKT–p53 Interactions
Katherine N. Lynch, Joyce F. Liu, Nikolas Kesten, Kin-Hoe Chow, Aniket Shetty, Ruiyang He, Mosammat Faria Afreen, Liping Yuan, Ursula A. Matulonis, Whitfield B. Growdon, Michael G. Muto, Neil S. Horowitz, Colleen M. Feltmate, Michael J. Worley, Ross S. Berkowitz, Christopher P. Crum, Bo R. Rueda, Sarah J. Hill
May 04, 2021
Uterine carcinoma (UC) is the most common gynecologic malignancy in the United States. TP53 mutant UCs cause a disproportionate number of deaths due to limited therapies for these tumors and the lack of mechanistic understanding...
Regulation of mitochondrial dynamics by Aurora A kinase
Aurora A kinase (AURKA) is a major regulator of mitosis and an important driver of cancer progression. The roles of AURKA outside of mitosis, and how these might contribute to cancer progression, are not well understood. Here we...
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.
Daniel J Cole, Matej Janecek, Jamie E Stokes, Maxim Rossmann, John C Faver, Grahame J McKenzie, Ashok R Venkitaraman, Marko Hyvönen, David R Spring, David J Huggins, William L Jorgensen
Jun 15, 2018
Free energy perturbation theory, in combination with enhanced sampling of protein-ligand binding modes, is evaluated in the context of fragment-based drug design, and used to design two new small-molecule inhibitors of the...
Phosphorylation by Aurora B kinase regulates caspase-2 activity and function
Yoon Lim, Dylan De Bellis, Jarrod J. Sandow, Luisa Capalbo, Pier Paolo D’Avino, James M. Murphy, Andrew I. Webb, Loretta Dorstyn, Sharad Kumar
Feb 09, 2021
Abstract: Mitotic catastrophe (MC) is an important oncosuppressive mechanism that serves to eliminate cells that become polyploid or aneuploid due to aberrant mitosis. Previous studies have demonstrated that the activation and...
Phosphorylation by Aurora B kinase regulates caspase-2 activity and function
Yoon Lim, Dylan De Bellis, Jarrod J. Sandow, Luisa Capalbo, Pier Paolo D’Avino, James M. Murphy, Andrew I. Webb, Loretta Dorstyn, Sharad Kumar
Aug 18, 2021
Abstract: Mitotic catastrophe (MC) is an important oncosuppressive mechanism that serves to eliminate cells that become polyploid or aneuploid due to aberrant mitosis. Previous studies have demonstrated that the activation and...
Modernity, gender and the spectre of coloniality in the "Moroccan Texts" of Carmen de Burgos and Aurora Bertrana
B Epps
Jan 10, 2017
This article examines two works by Carmen de Burgos and Aurora Bertrana situated in Morocco—En la guerra, from 1909, and El Marroc sensual i fanatic from 1936—in the light of three interrelated questions: gender, nationality and...
Phosphorylation by Aurora B kinase regulates caspase-2 activity and function
Yoon Lim, Dylan De Bellis, Jarrod J. Sandow, Luisa Capalbo, Pier Paolo D’Avino, James M. Murphy, Andrew I. Webb, Loretta Dorstyn, Sharad Kumar
Jan 07, 2021
Abstract: Mitotic catastrophe (MC) is an important oncosuppressive mechanism that serves to eliminate cells that become polyploid or aneuploid due to aberrant mitosis. Previous studies have demonstrated that the activation and...
Phosphorylation by Aurora B kinase regulates caspase-2 activity and function.
Yoon Lim, Dylan De Bellis, Jarrod J Sandow, Luisa Capalbo, Pier Paolo D'Avino, James M Murphy, Andrew I Webb, Loretta Dorstyn, Sharad Kumar
Nov 01, 2021
Mitotic catastrophe (MC) is an important oncosuppressive mechanism that serves to eliminate cells that become polyploid or aneuploid due to aberrant mitosis. Previous studies have demonstrated that the activation and catalytic...
A kinase-independent function for AURORA-A in replisome assembly during DNA replication initiation.
The catalytic activity of human AURORA-A kinase (AURKA) regulates mitotic progression, and its frequent overexpression in major forms of epithelial cancer is associated with aneuploidy and carcinogenesis. Here, we report an...
Excess TPX2 Interferes with Microtubule Disassembly and Nuclei Reformation at Mitotic Exit.
Francesco D Naso, Valentina Sterbini, Elena Crecca, Italia A Asteriti, Alessandra D Russo, Maria Giubettini, Enrico Cundari, Catherine Lindon, Alessandro Rosa, Giulia Guarguaglini
Feb 24, 2020
The microtubule-associated protein TPX2 is a key mitotic regulator that contributes through distinct pathways to spindle assembly. A well-characterised function of TPX2 is the activation, stabilisation and spindle localisation...
Milky Way's Eccentric Constituents with Gaia, APOGEE, and GALAH
Abstract
We report the results of an unsupervised decomposition of the local stellar halo in the chemodynamical space spanned by the abundance measurements from APOGEE DR17 and...
Excess TPX2 Interferes with Microtubule Disassembly and Nuclei Reformation at Mitotic Exit
Francesco D. Naso, Valentina Sterbini, Elena Crecca, Italia A. Asteriti, Alessandra D. Russo, Maria Giubettini, Enrico Cundari, Catherine Lindon, Alessandro Rosa, Giulia Guarguaglini
Feb 07, 2020
The microtubule-associated protein TPX2 is a key mitotic regulator that contributes through distinct pathways to spindle assembly. A well-characterised function of TPX2 is the activation, stabilisation and spindle localisation...
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