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Aviva Stadium
The Aviva Stadium, Dublin, is the first stadium to be designed from start to finish using commercially available parametric modelling software. A single model in Bentley’s Generative Components was shared between architects and...
Aviva Stadium
The Aviva Stadium, Dublin, is the first stadium to be designed from start to finish using commercially available parametric modelling software. A single model in Bentley’s Generative Components was shared between architects and...
Aviva Stadium
The nature of large complex buildings requires specialized skills across a multi-disciplinary team and high levels of collaboration and communication. By taking a parametric approach to design and construction, high quality...
Aviva Stadium
The nature of large complex buildings requires specialized skills across a multi-disciplinary team and high levels of collaboration and communication. By taking a parametric approach to design and construction, high quality...
Aviva Stadium - the use of parametric modelling in structural design
Paul Shepherd
Feb 01, 2011
The new 51 700 seat Aviva Stadium build at Lansdowne Road and completed in early 2010 provides a world class sporting facility for the city of Dublin, Ireland. Due to the nature of the site and its surroundings a responsive...
Aviva Stadium - the use of parametric modelling in structural design
Paul Shepherd
Feb 01, 2011
The new 51 700 seat Aviva Stadium build at Lansdowne Road and completed in early 2010 provides a world class sporting facility for the city of Dublin, Ireland. Due to the nature of the site and its surroundings a responsive...
Tau aggregation and its relation to selected forms of neuronal cell death.
How neurons die in neurodegenerative diseases is still unknown. The distinction between apoptosis as a genetically controlled mechanism, and necrosis, which was viewed as an unregulated process, has blurred with the...
Cultured subventricular zone progenitor cells transduced with neurogenin-2 become mature glutamatergic neurons and integrate into the dentate gyrus.
Cell origin and culture history determine successful integration of neural precursor transplants into the dentate gyrus of the adult rat.
A Method for the Acute and Rapid Degradation of Endogenous Proteins.
Dean Clift, William A McEwan, Larisa I Labzin, Vera Konieczny, Binyam Mogessie, Leo C James, Melina Schuh
Dec 12, 2018
Methods for the targeted disruption of protein function have revolutionized science and greatly expedited the systematic characterization of genes. Two main approaches are currently used to disrupt protein function: DNA knockout...
Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia.
Jack Brelstaff, Aviva M Tolkovsky, Bernardino Ghetti, Michel Goedert, Maria Grazia Spillantini
Oct 03, 2018
Tau protein forms insoluble filamentous inclusions that are closely associated with nerve cell death in many neurodegenerative diseases. How neurons die in these tauopathies is unclear. We report that living neurons with tau...
Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates.
Jack H Brelstaff, Matthew Mason, Taxiarchis Katsinelos, William A McEwan, Bernardino Ghetti, Aviva M Tolkovsky, Maria Grazia Spillantini
Nov 24, 2021
[Figure: see text].
Published by: Science advances
The Lantern, 2019-2020
Colleen Murphy, Jeremy Moyer, Adam Mlodzinski, Samuel Ernst, Lauren Toscano, Gabriel Tenaglia, Griffin Banks, Madison McColgan, Ria Malones, Rachel Thornton, Gabby DeMelfi, Liam Worcheck, Ryan Savage, Vanessa Worley, Aviva Schuh, Emily Bradigan, Kiley Addis, Shayna Kushner, Kevin Leon, Tommy Armstrong, Matthew Schmitz, Millie Drury, Jenna Lozzi, Sarah Buck, Cyn Ercole, Morgan Mason, Janice Partee, Madison Rodak, Daniel Walker, Jordan Gagan, Brooke Yanaga, Kate I. Foley, Matthew Li, Zach Brink, Jessica White, Anastasia Dziekan, Jadidsa Perez, Ian Abrahams, Lindsey Reilly, Kalina Witkowska, Kristen Cooney, Julia Paiano, Kylie Halko, Tiffini Eckenrod, Kelsey Gavin
Jan 01, 0001
Cochlea, Greek for Snail That Light in the Sky Overview Effect The Running Man Sunset Rabbits What Happened While You Were Drunk Last Saturday Night 21st Century Frankenstein Passing I Saw the Veil Star Crossed Subtle...
Ursinus College Collegeville Pennsylvania Lantern Literary Magazine poetry fiction Creative Nonfiction Visual arts Arts and Humanities Creative Writing fiction illustration Nonfiction poetry
Published by: Ursinus College
Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates.
Jack H Brelstaff, Matthew Mason, Taxiarchis Katsinelos, William A McEwan, Bernardino Ghetti, Aviva M Tolkovsky, Maria Grazia Spillantini
Nov 03, 2021
HLA-DR/DQ molecular mismatch
Chris Wiebe, Vasilis Kosmoliaptsis, Denise Pochinco, Ian W Gibson, Julie Ho, Patricia E Birk, Aviva Goldberg, Martin Karpinski, Jamie Shaw, David N Rush, Peter W Nickerson
Sep 18, 2019
Alloimmune risk stratification in renal transplantation has lacked the necessary prognostic biomarkers to personalize recipient care or optimize clinical trials. HLA molecular mismatch improves precision compared to traditional...
clinical research/practice clinical trial design Histocompatibility kidney transplantation/nephrology major histocompatibility complex (MHC) rejection: T cell mediated (TCMR) rejection: antibody-mediated (ABMR) risk assessment/risk stratification Adult Biomarkers Child Epitopes Female HLA-DQ Antigens HLA-DR Antigens Histocompatibility Testing Humans Isoantigens Kidney Transplantation Male Middle Aged Models Molecular Prognosis Risk Factors Tissue Donors Transplantation Immunology
The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice.
Jack Brelstaff, Bernardino Ossola, Jonas J Neher, Therése Klingstedt, K Peter R Nilsson, Michel Goedert, Maria Grazia Spillantini, Aviva M Tolkovsky
Jun 12, 2015
The complete costs of genome sequencing
Katharina Schwarze, James Buchanan, Jilles M Fermont, Helene Dreau, Mark W Tilley, John M Taylor, Pavlos Antoniou, Samantha JL Knight, Carme Camps, Melissa M Pentony, Erika M Kvikstad, Steve Harris, Niko Popitsch, Alistair T Pagnamenta, Anna Schuh, Jenny C Taylor, Sarah Wordsworth
Nov 26, 2019
PURPOSE: The translation of genome sequencing into routine health care has been slow, partly because of concerns about affordability. The aspirational cost of sequencing a genome is $1000, but there is little evidence to support...
Cortical morphology at birth reflects spatiotemporal patterns of gene expression in the fetal human brain.
Gareth Ball, Jakob Seidlitz, Jonathan O'Muircheartaigh, Ralica Dimitrova, Daphna Fenchel, Antonios Makropoulos, Daan Christiaens, Andreas Schuh, Jonathan Passerat-Palmbach, Jana Hutter, Lucilio Cordero-Grande, Emer Hughes, Anthony Price, Jo V Hajnal, Daniel Rueckert, Emma C Robinson, A David Edwards
Dec 07, 2020
Brain Cerebral Cortex Female Fetal Organ Maturity Fetus Functional Neuroimaging Gene Expression Profiling Gene Expression Regulation Developmental Gestational Age Humans Infant Newborn Infant Premature Male Multiparametric Magnetic Resonance Imaging Neurogenesis Pregnancy premature birth Spatio-Temporal Analysis
The complete costs of genome sequencing
Katharina Schwarze, James Buchanan, Jilles M. Fermont, Helene Dreau, Mark W. Tilley, John M. Taylor, Pavlos Antoniou, Samantha J. L. Knight, Carme Camps, Melissa M. Pentony, Erika M. Kvikstad, Steve Harris, Niko Popitsch, Alistair T. Pagnamenta, Anna Schuh, Jenny C. Taylor, Sarah Wordsworth
Jul 29, 2020
Abstract: Purpose: The translation of genome sequencing into routine health care has been slow, partly because of concerns about affordability. The aspirational cost of sequencing a genome is $1000, but there is little evidence...
Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models.
Lindsay McMurray, Jennifer A Macdonald, Nisha Kuzhuppilly Ramakrishnan, Yanyan Zhao, David W Williamson, Ole Tietz, Xiaoyun Zhou, Steven Kealey, Steven G Fagan, Tomáš Smolek, Veronika Cubinkova, Norbert Žilka, Maria Grazia Spillantini, Aviva M Tolkovsky, Michel Goedert, Franklin I Aigbirhio
Feb 16, 2021
Aggregated tau protein is a core pathology present in several neurodegenerative diseases. Therefore, the development and application of positron emission tomography (PET) imaging radiotracers that selectively bind to aggregated...
Distinct genetic changes reveal evolutionary history and heterogeneous molecular grade of DLBCL with MYC / BCL2 double-hit
Francesco Cucco, Sharon Barrans, Chulin Sha, Alexandra Clipson, Simon Crouch, Rachel Dobson, Zi Chen, Joe Sneath Thompson, Matthew A. Care, Thomas Cummin, Josh Caddy, Hongxiang Liu, Anne Robinson, Anna Schuh, Jude Fitzgibbon, Daniel Painter, Alexandra Smith, Eve Roman, Reuben Tooze, Catherine Burton, Andrew J. Davies, David R. Westhead, Peter W. M. Johnson, Ming-Qing Du
Dec 22, 2020
Abstract: Using a Burkitt lymphoma-like gene expression signature, we recently defined a high-risk molecular high-grade (MHG) group mainly within germinal centre B-cell like diffuse large B-cell lymphomas (GCB-DLBCL), which was...
Molecular High-Grade B-Cell Lymphoma
Chulin Sha, Sharon Barrans, Francesco Cucco, Michael A Bentley, Matthew A Care, Thomas Cummin, Hannah Kennedy, Joe S Thompson, Rahman Uddin, Lisa Worrillow, Rebecca Chalkley, Moniek van Hoppe, Sophia Ahmed, Tom Maishman, Josh Caddy, Anna Schuh, Christoph Mamot, Catherine Burton, Reuben Tooze, Andrew Davies, Ming-Qing Du, Peter WM Johnson, David R Westhead
Feb 01, 2019
Antibodies Monoclonal Murine-Derived Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Bortezomib cyclophosphamide Databases Genetic Doxorubicin Female Humans Lymphoma Large B-Cell Diffuse Male Middle Aged Neoplasm Grading prednisone Proportional Hazards Models Randomized Controlled Trials as Topic Retrospective Studies Rituximab Transcriptome Vincristine
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