Search
Results: 30
Hepatomegaly Associated with Non-Obstructive Sinusoidal Dilation in Experimental Visceral Leishmaniasis.
Kota Maeda, Sonya Sadoughi, Ayako Morimoto, Kazuyuki Uchida, James K Chambers, Chizu Sanjoba, Junya Yamagishi, Yasuyuki Goto
Oct 21, 2021
Visceral leishmaniasis (VL) is the most severe form of leishmaniasis caused by protozoan parasites of the genus Leishmania. Hepatomegaly is one of the most frequent clinical manifestations of VL, whereas immunopathology of the...
Impact of loss-to-follow-up on cancer survival estimates for small populations
Objectives: The accuracy of the ascertainment of vital status impacts the validity of cancer survival. This study assesses the potential impact of loss-to-follow-up on survival in Japan, both nationally and in the samples seen...
Power, participation and their problems
Ayako Ebata, Catherine Hodge, Dorien Braam, Linda Waldman, Joanne Sharp, Hayley MacGregor, Henrietta Moore
Apr 17, 2020
The use of Participatory Epidemiology in veterinary research intends to include livestock keepers and other local stakeholders in research processes and the development of solutions to animal health problems, including...
Crystal structure of tripartite-type ABC transporter MacB from Acinetobacter baumannii.
Ui Okada, Eiki Yamashita, Arthur Neuberger, Mayu Morimoto, Hendrik W van Veen, Satoshi Murakami
Jan 24, 2018
The MacA-MacB-TolC tripartite complex is a transmembrane machine that spans both plasma membrane and outer membrane and actively extrudes substrates, including macrolide antibiotics, virulence factors, peptides and cell envelope...
ATP-Binding Cassette Transporters Acinetobacter baumannii Amino Acid Sequence Bacterial Proteins Conserved Sequence Crystallography X-Ray Drug Resistance Multiple Bacterial Escherichia coli Models Molecular Protein Domains Protein Structure Quaternary Recombinant Proteins Sequence Homology Amino Acid
Role of BRCA1-associated protein (BRAP) variant in childhood pulmonary arterial hypertension
Ayako Chida-Nagai, Masaki Shintani, Hiroki Sato, Tomotaka Nakayama, Masaki Nii, Hiroyuki Akagawa, Toru Furukawa, Amer Rana, Yoshiyuki Furutani, Kei Inai, Shigeaki Nonoyama, Toshio Nakanishi
Mar 13, 2019
Ancient DNA reveals multiple origins and migration waves of extinct Japanese brown bear lineages.
Takahiro Segawa, Takahiro Yonezawa, Hiroshi Mori, Ayumi Akiyoshi, Morten E Allentoft, Ayako Kohno, Fuyuki Tokanai, Eske Willerslev, Naoki Kohno, Hidenori Nishihara
Sep 02, 2021
Little is known about how mammalian biogeography on islands was affected by sea-level fluctuations. In the Japanese Archipelago, brown bears (Ursus arctos) currently inhabit only Hokkaido, the northern island, but Pleistocene...
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.
Prajwal Ciryam, Isabella A Lambert-Smith, Daniel M Bean, Rosie Freer, Fernando Cid, Gian Gaetano Tartaglia, Darren N Saunders, Mark R Wilson, Stephen G Oliver, Richard I Morimoto, Christopher M Dobson, Michele Vendruscolo, Giorgio Favrin, Justin J Yerbury
Dec 14, 2020
motor neuron disease protein aggregation Protein homeostasis protein misfolding supersaturation Amyotrophic Lateral Sclerosis Brain DNA-Binding Proteins Humans Inclusion Bodies Motor Neurons Mutation Protein Aggregates protein aggregation Pathological Protein Folding RNA-Binding Protein FUS Spinal Cord Spinal Nerves Superoxide Dismutase Superoxide Dismutase-1
A metastable subproteome underlies inclusion formation in muscle proteinopathies
Prajwal Ciryam, Matthew Antalek, Fernando Cid, Gian Gaetano Tartaglia, Christopher M. Dobson, Anne-Katrin Guettsches, Britta Eggers, Matthias Vorgerd, Katrin Marcus, Rudolf A. Kley, Richard I. Morimoto, Michele Vendruscolo, Conrad C. Weihl
Dec 02, 2020
Abstract: Protein aggregation is a pathological feature of neurodegenerative disorders. We previously demonstrated that protein inclusions in the brain are composed of supersaturated proteins, which are abundant and...
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Oct 14, 2020
Abstract: The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically...
Ancient DNA reveals multiple origins and migration waves of extinct Japanese brown bear lineages
Takahiro Segawa, Takahiro Yonezawa, Hiroshi Mori, Ayumi Akiyoshi, Morten E. Allentoft, Ayako Kohno, Fuyuki Tokanai, Eske Willerslev, Naoki Kohno, Hidenori Nishihara
Aug 11, 2021
Little is known about how mammalian biogeography on islands was affected by sea-level fluctuations. In the Japanese Archipelago, brown bears (Ursus arctos) currently inhabit only Hokkaido, the northern island, but Pleistocene...
A metastable subproteome underlies inclusion formation in muscle proteinopathies.
Prajwal Ciryam, Matthew Antalek, Fernando Cid, Gian Gaetano Tartaglia, Christopher M Dobson, Anne-Katrin Guettsches, Britta Eggers, Matthias Vorgerd, Katrin Marcus, Rudolf A Kley, Richard I Morimoto, Michele Vendruscolo, Conrad C Weihl
Feb 13, 2020
Protein aggregation is a pathological feature of neurodegenerative disorders. We previously demonstrated that protein inclusions in the brain are composed of supersaturated proteins, which are abundant and aggregation-prone, and...
A metastable subproteome underlies inclusion formation in muscle proteinopathies.
Prajwal Ciryam, Matthew Antalek, Fernando Cid, Gian Gaetano Tartaglia, Christopher M Dobson, Anne-Katrin Guettsches, Britta Eggers, Matthias Vorgerd, Katrin Marcus, Rudolf A Kley, Richard I Morimoto, Michele Vendruscolo, Conrad C Weihl
Jan 06, 2020
Protein aggregation is a pathological feature of neurodegenerative disorders. We previously demonstrated that protein inclusions in the brain are composed of supersaturated proteins, which are abundant and aggregation-prone, and...
Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory
Eric J. Brunner, Koutatsu Maruyama, Martin Shipley, Noriko Cable, Hiroyasu Iso, Ayako Hiyoshi, Daryth Stallone, Meena Kumari, Adam Tabak, Archana Singh-Manoux, John Wilson, Claudia Langenberg, Nick Wareham, David Boniface, Aroon Hingorani, Mika Kivimäki, Clare Llewellyn
Mar 29, 2021
Abstract: Background/objectives: The mediating role of eating behaviors in genetic susceptibility to weight gain during mid-adult life is not fully understood. This longitudinal study aims to help us understand contributions of...
Reassessment of the phylogenetic relationships of the late Miocene apes Hispanopithecus and Rudapithecus based on vestibular morphology.
Alessandro Urciuoli, Clément Zanolli, Sergio Almécija, Amélie Beaudet, Jean Dumoncel, Naoki Morimoto, Masato Nakatsukasa, Salvador Moyà-Solà, David R Begun, David M Alba
May 24, 2021
Late Miocene great apes are key to reconstructing the ancestral morphotype from which earliest hominins evolved. Despite consensus that the late Miocene dryopith great apes Hispanopithecus laietanus (Spain) and Rudapithecus...
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
Alisa F Zyryanova, Kazuhiro Kashiwagi, Claudia Rato, Heather P Harding, Ana Crespillo-Casado, Luke A Perera, Ayako Sakamoto, Madoka Nishimoto, Mayumi Yonemochi, Mikako Shirouzu, Takuhiro Ito, David Ron
Oct 26, 2020
The small molecule ISRIB antagonizes the activation of the integrated stress response (ISR) by phosphorylated translation initiation factor 2, eIF2(αP). ISRIB and eIF2(αP) bind distinct sites in their common target, eIF2B, a...
CRISPR/Cas9-homologous recombination cell stress drug action Eukaryotic Initiation Factor-2B mRNA translation Phosphorylation Protein Binding protein biosynthesis/drug effects Protein Conformation Acetamides Allosteric Regulation Animals Binding Sites CHO Cells Cricetulus Cryoelectron Microscopy Cyclohexylamines Eukaryotic Initiation Factor-2 Eukaryotic Initiation Factor-2B HeLa Cells Humans Phosphorylation
Ancient DNA reveals multiple origins and migration waves of extinct Japanese brown bear lineages.
Takahiro Segawa, Takahiro Yonezawa, Hiroshi Mori, Ayumi Akiyoshi, Morten E Allentoft, Ayako Kohno, Fuyuki Tokanai, Eske Willerslev, Naoki Kohno, Hidenori Nishihara
Sep 13, 2021
Little is known about how mammalian biogeography on islands was affected by sea-level fluctuations. In the Japanese Archipelago, brown bears (Ursus arctos) currently inhabit only Hokkaido, the northern island, but...
Published by: Royal Society open science
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants.
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Mar 27, 2020
The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically important...
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Aug 26, 2021
Abstract: The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically...
Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory.
Eric J Brunner, Koutatsu Maruyama, Martin Shipley, Noriko Cable, Hiroyasu Iso, Ayako Hiyoshi, Daryth Stallone, Meena Kumari, Adam Tabak, Archana Singh-Manoux, John Wilson, Claudia Langenberg, Nick Wareham, David Boniface, Aroon Hingorani, Mika Kivimäki, Clare Llewellyn
Feb 01, 2021
BACKGROUND/OBJECTIVES: The mediating role of eating behaviors in genetic susceptibility to weight gain during mid-adult life is not fully understood. This longitudinal study aims to help us understand contributions of genetic...
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Feb 25, 2021
Abstract: The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically...
The penultimate deglaciation
Laurie Menviel, Emilie Capron, Aline Govin, Andrea Dutton, Lev Tarasov, Ayako Abe-Ouchi, Russell N Drysdale, Philip L Gibbard, Lauren Gregoire, Feng He, Ruza F Ivanovic, Masa Kageyama, Kenji Kawamura, Amaelle Landais, Bette L Otto-Bliesner, Ikumi Oyabu, Polychronis C Tzedakis, Eric Wolff, Xu Zhang
Aug 23, 2019
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Oct 26, 2020
Abstract: The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically...
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Oct 12, 2020
Abstract: The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically...
Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory
Eric J. Brunner, Koutatsu Maruyama, Martin Shipley, Noriko Cable, Hiroyasu Iso, Ayako Hiyoshi, Daryth Stallone, Meena Kumari, Adam Tabak, Archana Singh-Manoux, John Wilson, Claudia Langenberg, Nick Wareham, David Boniface, Aroon Hingorani, Mika Kivimäki, Clare Llewellyn
Aug 02, 2021
Abstract: Background/objectives: The mediating role of eating behaviors in genetic susceptibility to weight gain during mid-adult life is not fully understood. This longitudinal study aims to help us understand contributions of...
|
|< |
< |
1 |