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ONEST (Observers Needed to Evaluate Subjective Tests) Analysis of Stromal Tumour-Infiltrating Lymphocytes (sTILs) in Breast Cancer and Its Limitations.
Bálint Cserni, Darren Kilmartin, Mark O'Loughlin, Xavier Andreu, Zsuzsanna Bagó-Horváth, Simonetta Bianchi, Ewa Chmielik, Paulo Figueiredo, Giuseppe Floris, Maria Pia Foschini, Anikó Kovács, Päivi Heikkilä, Janina Kulka, Anne-Vibeke Laenkholm, Inta Liepniece-Karele, Caterina Marchiò, Elena Provenzano, Peter Regitnig, Angelika Reiner, Aleš Ryška, Anna Sapino, Elisabeth Specht Stovgaard, Cecily Quinn, Vasiliki Zolota, Mark Webber, Sharon A Glynn, Rita Bori, Erika Csörgő, Orsolya Oláh-Németh, Tamás Pancsa, Anita Sejben, István Sejben, András Vörös, Tamás Zombori, Tibor Nyári, Grace Callagy, Gábor Cserni
Mar 06, 2023
ONEST (Observers Needed to Evaluate Subjective Tests) Analysis of Stromal Tumour-Infiltrating Lymphocytes (sTILs) in Breast Cancer and Its Limitations.
Bálint Cserni, Darren Kilmartin, Mark O'Loughlin, Xavier Andreu, Zsuzsanna Bagó-Horváth, Simonetta Bianchi, Ewa Chmielik, Paulo Figueiredo, Giuseppe Floris, Maria Pia Foschini, Anikó Kovács, Päivi Heikkilä, Janina Kulka, Anne-Vibeke Laenkholm, Inta Liepniece-Karele, Caterina Marchiò, Elena Provenzano, Peter Regitnig, Angelika Reiner, Aleš Ryška, Anna Sapino, Elisabeth Specht Stovgaard, Cecily Quinn, Vasiliki Zolota, Mark Webber, Sharon A Glynn, Rita Bori, Erika Csörgő, Orsolya Oláh-Németh, Tamás Pancsa, Anita Sejben, István Sejben, András Vörös, Tamás Zombori, Tibor Nyári, Grace Callagy, Gábor Cserni
Mar 28, 2023
Tumour-infiltrating lymphocytes (TILs) reflect antitumour immunity. Their evaluation of histopathology specimens is influenced by several factors and is subject to issues of reproducibility. ONEST (Observers Needed to Evaluate...
reproducibility Breast Cancer TILs triple-negative Tumour-infiltrating lymphocytes sTILs ONEST international immuno-oncology biomarker working group European Working Group for Breast Screening Pathology observers needed to evaluate subjective tests
Published by: Cancers
AI-Based Solution for Sustainability Tracing for Companies
Many companies look for novel ways to trace their operational sustainability. The application of AI to analyze and make sense of the big data the company holds represents one promising approach for this aim. The authors study...
Published by: IGI Global Scientific Publishing
Leading exponential finite size corrections for non-diagonal form factors
Abstract
We derive the leading exponential finite volume corrections in two dimensional integrable models for non-diagonal form factors in diagonally...
The ortho effect in directed C-H activation.
Balázs L Tóth, Anna Monory, Orsolya Egyed, Attila Domján, Attila Bényei, Bálint Szathury, Zoltán Novák, András Stirling
Jul 28, 2021
The success of transition metal-catalysed ortho-directed C-H activation is often plagued by the effects of undesirable interactions between the directing group (DG) and other groups introduced into the aromatic core of the...
Establishment and Characterization of a Brca1-/-, p53-/- Mouse Mammary Tumor Cell Line.
Lilla Hámori, Gyöngyi Kudlik, Kornélia Szebényi, Nóra Kucsma, Bálint Szeder, Ádám Póti, Ferenc Uher, György Várady, Dávid Szüts, József Tóvári, András Füredi, Gergely Szakács
Apr 27, 2020
Breast cancer is the most commonly occurring cancer in women and the second most common cancer overall. By the age of 80, the estimated risk for breast cancer for women with germline BRCA1 or BRCA2 mutations is around 80%....
Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth.
Adi L Tarca, Bálint Ármin Pataki, Roberto Romero, Marina Sirota, Yuanfang Guan, Rintu Kutum, Nardhy Gomez-Lopez, Bogdan Done, Gaurav Bhatti, Thomas Yu, Gaia Andreoletti, Tinnakorn Chaiworapongsa, DREAM Preterm Birth Prediction Challenge Consortium, Sonia S Hassan, Chaur-Dong Hsu, Nima Aghaeepour, Gustavo Stolovitzky, Istvan Csabai, James C Costello
Jun 25, 2021
Identification of pregnancies at risk of preterm birth (PTB), the leading cause of newborn deaths, remains challenging given the syndromic nature of the disease. We report a longitudinal multi-omics study coupled with a DREAM...
Aptamers collaborative competition human transcriptome arrays Machine Learning plasma proteomics predictive modeling preterm labor and delivery spontaneous preterm birth whole blood transcriptomics Adult Asymptomatic Diseases Biomarkers Blood Proteins Cell-Free Nucleic Acids Crowdsourcing Female Gestational Age Humans Infant Newborn Longitudinal Studies pre-eclampsia Pregnancy premature birth Proteomics ROC Curve Transcriptome
Intra-Tumour Heterogeneity Is One of the Main Sources of Inter-Observer Variation in Scoring Stromal Tumour Infiltrating Lymphocytes in Triple Negative Breast Cancer.
Darren Kilmartin, Mark O'Loughlin, Xavier Andreu, Zsuzsanna Bagó-Horváth, Simonetta Bianchi, Ewa Chmielik, Gábor Cserni, Paulo Figueiredo, Giuseppe Floris, Maria Pia Foschini, Anikó Kovács, Päivi Heikkilä, Janina Kulka, Anne-Vibeke Laenkholm, Inta Liepniece-Karele, Caterina Marchiò, Elena Provenzano, Peter Regitnig, Angelika Reiner, Aleš Ryška, Anna Sapino, Elisabeth Specht Stovgaard, Cecily Quinn, Vasiliki Zolota, Mark Webber, Davood Roshan, Sharon A Glynn, Grace Callagy
Oct 13, 2021
Stromal tumour infiltrating lymphocytes (sTILs) are a strong prognostic marker in triple negative breast cancer (TNBC). Consistency scoring sTILs is good and was excellent when an internet-based scoring aid developed by the...
Intra-Tumour Heterogeneity Is One of the Main Sources of Inter-Observer Variation in Scoring Stromal Tumour Infiltrating Lymphocytes in Triple Negative Breast Cancer
Darren Kilmartin, Mark O’Loughlin, Xavier Andreu, Zsuzsanna Bagó-Horváth, Simonetta Bianchi, Ewa Chmielik, Gábor Cserni, Paulo Figueiredo, Giuseppe Floris, Maria Pia Foschini, Anikó Kovács, Päivi Heikkilä, Janina Kulka, Anne-Vibeke Laenkholm, Inta Liepniece-Karele, Caterina Marchiò, Elena Provenzano, Peter Regitnig, Angelika Reiner, Aleš Ryška, Anna Sapino, Elisabeth Specht Stovgaard, Cecily Quinn, Vasiliki Zolota, Mark Webber, Davood Roshan, Sharon A. Glynn, Grace Callagy
Sep 02, 2021
Stromal tumour infiltrating lymphocytes (sTILs) are a strong prognostic marker in triple negative breast cancer (TNBC). Consistency scoring sTILs is good and was excellent when an internet-based scoring aid developed by the...
A structural biology community assessment of AlphaFold2 applications.
Mehmet Akdel, Douglas EV Pires, Eduard Porta Pardo, Jürgen Jänes, Arthur O Zalevsky, Bálint Mészáros, Patrick Bryant, Lydia L Good, Roman A Laskowski, Gabriele Pozzati, Aditi Shenoy, Wensi Zhu, Petras Kundrotas, Victoria Ruiz Serra, Carlos Hm Rodrigues, Alistair S Dunham, David Burke, Neera Borkakoti, Sameer Velankar, Adam Frost, Jérôme Basquin, Kresten Lindorff-Larsen, Alex Bateman, Andrey V Kajava, Alfonso Valencia, Sergey Ovchinnikov, Janani Durairaj, David B Ascher, Janet M Thornton, Norman E Davey, Amelie Stein, Arne Elofsson, Tristan I Croll, Pedro Beltrao
Dec 09, 2022
Most proteins fold into 3D structures that determine how they function and orchestrate the biological processes of the cell. Recent developments in computational methods for protein structure predictions have reached the...
A structural biology community assessment of AlphaFold2 applications.
Mehmet Akdel, Douglas EV Pires, Eduard Porta Pardo, Jürgen Jänes, Arthur O Zalevsky, Bálint Mészáros, Patrick Bryant, Lydia L Good, Roman A Laskowski, Gabriele Pozzati, Aditi Shenoy, Wensi Zhu, Petras Kundrotas, Victoria Ruiz Serra, Carlos Hm Rodrigues, Alistair S Dunham, David Burke, Neera Borkakoti, Sameer Velankar, Adam Frost, Jérôme Basquin, Kresten Lindorff-Larsen, Alex Bateman, Andrey V Kajava, Alfonso Valencia, Sergey Ovchinnikov, Janani Durairaj, David B Ascher, Janet M Thornton, Norman E Davey, Amelie Stein, Arne Elofsson, Tristan I Croll, Pedro Beltrao
Feb 16, 2023
Most proteins fold into 3D structures that determine how they function and orchestrate the biological processes of the cell. Recent developments in computational methods for protein structure predictions have reached the...
The Earth BioGenome Project 2020
Harris A Lewin, Stephen Richards, Erez Lieberman Aiden, Miguel L Allende, John M Archibald, Miklós Bálint, Katharine B Barker, Bridget Baumgartner, Katherine Belov, Giorgio Bertorelle, Mark L Blaxter, Jing Cai, Nicolette D Caperello, Keith Carlson, Juan Carlos Castilla-Rubio, Shu-Miaw Chaw, Lei Chen, Anna K Childers, Jonathan A Coddington, Dalia A Conde, Montserrat Corominas, Keith A Crandall, Andrew J Crawford, Federica DiPalma, Richard Durbin, ThankGod E Ebenezer, Scott V Edwards, Olivier Fedrigo, Paul Flicek, Giulio Formenti, Richard A Gibbs, M Thomas P Gilbert, Melissa M Goldstein, Jennifer Marshall Graves, Henry T Greely, Igor V Grigoriev, Kevin J Hackett, Neil Hall, David Haussler, Kristofer M Helgen, Carolyn J Hogg, Sachiko Isobe, Kjetill Sigurd Jakobsen, Axel Janke, Erich D Jarvis, Warren E Johnson, Steven JM Jones, Elinor K Karlsson, Paul J Kersey, Jin-Hyoung Kim, W John Kress, Shigehiro Kuraku, Mara Kn Lawniczak, James H Leebens-Mack, Xueyan Li, Kerstin Lindblad-Toh, Xin Liu, Jose V Lopez, Tomas Marques-Bonet, Sophie Mazard, Jonna AK Mazet, Camila J Mazzoni, Eugene W Myers, Rachel J O'Neill, Sadye Paez, Hyun Park, Gene E Robinson, Cristina Roquet, Oliver A Ryder, Jamal SM Sabir, H Bradley Shaffer, Timothy M Shank, Jacob S Sherkow, Pamela S Soltis, Boping Tang, Leho Tedersoo, Marcela Uliano-Silva, Kun Wang, Xiaofeng Wei, Regina Wetzer, Julia L Wilson, Xun Xu, Huanming Yang, Anne D Yoder, Guojie Zhang
Feb 19, 2022
Critical assessment of protein intrinsic disorder prediction
Marco Necci, Damiano Piovesan, Silvio C. E. Tosatto, Md Tamjidul Hoque, Ian Walsh, Sumaiya Iqbal, Michele Vendruscolo, Pietro Sormanni, Chen Wang, Daniele Raimondi, Ronesh Sharma, Yaoqi Zhou, Thomas Litfin, Oxana Valerianovna Galzitskaya, Michail Yu. Lobanov, Wim Vranken, Björn Wallner, Claudio Mirabello, Nawar Malhis, Zsuzsanna Dosztányi, Gábor Erdős, Bálint Mészáros, Jianzhao Gao, Kui Wang, Gang Hu, Zhonghua Wu, Alok Sharma, Jack Hanson, Kuldip Paliwal, Isabelle Callebaut, Tristan Bitard-Feildel, Gabriele Orlando, Zhenling Peng, Jinbo Xu, Sheng Wang, David T. Jones, Domenico Cozzetto, Fanchi Meng, Jing Yan, Jörg Gsponer, Jianlin Cheng, Tianqi Wu, Lukasz Kurgan, Vasilis J. Promponas, Stella Tamana, Cristina Marino-Buslje, Elizabeth Martínez-Pérez, Anastasia Chasapi, Christos Ouzounis, A. Keith Dunker, Andrey V. Kajava, Jeremy Y. Leclercq, Burcu Aykac-Fas, Matteo Lambrughi, Emiliano Maiani, Elena Papaleo, Lucia Beatriz Chemes, Lucía Álvarez, Nicolás S. González-Foutel, Valentin Iglesias, Jordi Pujols, Salvador Ventura, Nicolás Palopoli, Guillermo Ignacio Benítez, Gustavo Parisi, Claudio Bassot, Arne Elofsson, Sudha Govindarajan, John Lamb, Marco Salvatore, András Hatos, Alexander Miguel Monzon, Martina Bevilacqua, Ivan Mičetić, Giovanni Minervini, Lisanna Paladin, Federica Quaglia, Emanuela Leonardi, Norman Davey, Tamas Horvath, Orsolya Panna Kovacs, Nikoletta Murvai, Rita Pancsa, Eva Schad, Beata Szabo, Agnes Tantos, Sandra Macedo-Ribeiro, Jose Antonio Manso, Pedro José Barbosa Pereira, Radoslav Davidović, Nevena Veljkovic, Borbála Hajdu-Soltész, Mátyás Pajkos, Tamás Szaniszló, Mainak Guharoy, Tamas Lazar, Mauricio Macossay-Castillo, Peter Tompa
May 08, 2021
Abstract: Intrinsically disordered proteins, defying the traditional protein structure–function paradigm, are a challenge to study experimentally. Because a large part of our knowledge rests on computational predictions, it is...