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DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair
Blended Learning
As we approach a new normal in post-COVID-19 pedagogy, we need to consider blended learning (BL) as a significant contribution to precautionary and preventive actions for containing the spread of COVID-19. This paper provides a...
Published by: IGI Global Scientific Publishing
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.
Broken chromosomes arising from DNA double-strand breaks result from endogenous events such as the production of reactive oxygen species during cellular metabolism, as well as from exogenous sources such as ionizing radiation....
Determining the burden of fungal infections in Zimbabwe.
Zimbabwe currently faces several healthcare challenges, most notably HIV and associated infections including tuberculosis (TB), malaria and recently outbreaks of cholera, typhoid fever and COVID-19. Fungal infections, which are...
The Role of Knowledge in Enhancing SME Innovation
This study examines the knowledge of entrepreneurs on the complex concept of innovation before assessing how they apply this knowledge to increase the propensity to develop new products and services. Within this context...
Published by: IGI Global Scientific Publishing
Beyond definition
BL Fraser
Dec 13, 2009
This paper considers the process of organising semantic information in bilingual dictionaries with diachronic coverage, from selecting the textual source-material to designing the entries. The discussion centres on practical...
Protection against oxaliplatin-induced mechanical and thermal hypersensitivity in Sarm1-/- mice.
Stacey Anne Gould, Matthew White, Anna L Wilbrey, Erzsébet Pór, Michael Philip Coleman, Robert Adalbert
Jan 28, 2021
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect of cancer treatment, often associated with degeneration of sensory axons or their terminal regions. Presence of the slow Wallerian...
Structural biology of DNA repair
Takashi Ochi, Lynn Sibanda, Qian Wu, Dima Chirgadze, Victor M Bolanos-Garcia, Tom Blundell
Mar 12, 2021
Published by: Journal of nucleic acids
Critical evaluation of climate syntheses to benchmark CMIP6/PMIP4 127 ka Last Interglacial simulations in the high-latitude regions
Prioritising Risk Factors for Type 2 Diabetes
PURPOSE OF THE REVIEW: Causality has been demonstrated for few of the many putative risk factors for type 2 diabetes (T2D) emerging from observational epidemiology. Genetic approaches are increasingly being used to infer...
Multifunctionality of Nanoengineered Self-Sensing Lattices Enabled by Additive Manufacturing
Lightweight cellular materials are engineered to enhance performance attributes such as energy absorption, specific stiffness, negative Poisson's ratio, negative thermal expansion coefficient, etc. However, self‐sensing...
Is vigorous-intensity physical activity required for improving bone mass in adolescence? Findings from a Brazilian birth cohort.
RM Bielemann, VV Ramires, FC Wehrmeister, H Gonçalves, MCF Assunção, U Ekelund, BL Horta
Mar 11, 2019
Double dissociation of the requirement for GluN2B- and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memory
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