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Results: 180
Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in Bmpr2-deficient mice.
Alexi Crosby, Mark R Toshner, Mark R Southwood, Elaine Soon, Benjamin J Dunmore, Emily Groves, Stephen Moore, Penny Wright, Katrin Ottersbach, Cavan Bennett, Jose Guerrero, Cedric Ghevaert, Nicholas W Morrell
Nov 15, 2018
Increasing evidence suggests that patients with pulmonary arterial hypertension (PAH) demonstrate abnormalities in the bone marrow (BM) and hematopoietic progenitor cells. In addition, PAH is associated with myeloproliferative...
Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling.
Eman Khatib-Massalha, Suditi Bhattacharya, Hassan Massalha, Adi Biram, Karin Golan, Orit Kollet, Anju Kumari, Francesca Avemaria, Ekaterina Petrovich-Kopitman, Shiri Gur-Cohen, Tomer Itkin, Isabell Brandenburger, Asaf Spiegel, Ziv Shulman, Zachary Gerhart-Hines, Shalev Itzkovitz, Matthias Gunzer, Stefan Offermanns, Ronen Alon, Amiram Ariel, Tsvee Lapidot
Nov 30, 2020
Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis for their effector functions. How glycolysis and its major byproduct lactate are triggered in bone marrow (BM) neutrophils and...
Neuronal regulation of bone marrow stem cell niches.
The bone marrow (BM) is the primary site of postnatal hematopoiesis and hematopoietic stem cell (HSC) maintenance. The BM HSC niche is an essential microenvironment which evolves and responds to the physiological demands of...
Human Bone Marrow Mesenchymal Stromal Cell-Derived CXCL12, IL-6 and GDF-15 and Their Capacity to Support IgG-Secreting Cells in Culture Are Divergently Affected by Doxorubicin
Various subsets of bone marrow mesenchymal stromal cells (BM MSCs), including fibroblasts, endothelial, fat and reticular cells, are implicated in the regulation of the hematopoietic microenvironment and the survival of...
Gintare Lasaviciute, Anna Höbinger, Dorina Ujvari, Daniel Salamon, Aisha Yusuf, Mikael Sundin, Eva Sverremark-Ekström, Rayan Chikhi, Anna Nilsson, Shanie Saghafian-Hedengren
Mar 15, 2021
Hematology Cancer Stem Cell Research - Nonembryonic - Non-Human Stem Cell Research - Nonembryonic - Human Stem Cell Research Pediatric Regenerative Medicine Transplantation 2 Aetiology 5.2 Cellular and gene therapies 5 Development of treatments and therapeutic interventions 2.1 Biological and endogenous factors Cancer Inflammatory and immune system
Correlation Analysis of Water Demand and Predictive Variables for Short-Term Forecasting Models
Operational and economic aspects of water distribution make water demand forecasting paramount for water distribution systems (WDSs) management. However, water demand introduces high levels of uncertainty in WDS hydraulic...
Hematopoietic stem and progenitor cells outside the bone marrow
Bone marrow (BM) is the primary site of adult blood production, hosting the majority of all hematopoietic stem and progenitor cells (HSPCs). Rare HSPCs are also found outside of the BM at steady state. In times of large...
Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance.
Karin Golan, Anju Kumari, Orit Kollet, Eman Khatib-Massalha, Mohana Devi Subramaniam, Zulma S Ferreira, Francesca Avemaria, Sylwia Rzeszotek, Andrés García-García, Stephanie Xie, Eugenia Flores-Figueroa, Shiri Gur-Cohen, Tomer Itkin, Aya Ludin-Tal, Hassan Massalha, Biana Bernshtein, Andrzej K Ciechanowicz, Alexander Brandis, Tevie Mehlman, Suditi Bhattacharya, Mayla Bertagna, Hui Cheng, Ekaterina Petrovich-Kopitman, Tomasz Janus, Nathali Kaushansky, Tao Cheng, Irit Sagi, Mariusz Z Ratajczak, Simón Méndez-Ferrer, John E Dick, Regina P Markus, Tsvee Lapidot
Nov 20, 2018
Hematopoietic stem and progenitor cells (HSPCs) tightly couple maintenance of the bone marrow (BM) reservoir, including undifferentiated long-term repopulating hematopoietic stem cells (LT-HSCs), with intensive daily production...
TNF Bone Marrow differentiation and egress hematopoietic stem and progenitor cells light and darkness maintenance and retention melatonin Norepinephrine stem cell repopulation potential vascular permeability Animals Cell Differentiation Cells Cultured Darkness Epigenesis Genetic Hematopoietic Stem Cells LIGHT Mice Mice Inbred C57BL Transcription Factors
Efficient homing of antibody-secreting cells to the bone marrow requires RNA-binding protein ZFP36L1.
Cell migration relies on coordinated activity of chemotactic and guidance receptors. Here, we report a specific role for the RNA-binding protein ZFP36L1 in limiting the abundance of molecules involved in the homing of...
Animals Antibody-Producing Cells Antigens B-Lymphocytes Base Sequence Bone Marrow Butyrate Response Factor 1 Cell Count Cell Death Cell Membrane Cell Movement G-Protein-Coupled Receptor Kinase 2 Gene Expression Regulation Germinal Center Immunization Integrins Lysophospholipids Mice Inbred C57BL Receptors CXCR4 Receptors G-Protein-Coupled Signal Transduction Sphingosine Sphingosine-1-Phosphate Receptors Spleen
Laminin Levels Regulate Tissue Migration and Anterior-Posterior Polarity during Egg Morphogenesis in Drosophila.
María C Díaz de la Loza, Alfonsa Díaz-Torres, Federico Zurita, Alicia E Rosales-Nieves, Emad Moeendarbary, Kristian Franze, María D Martín-Bermudo, Acaimo González-Reyes
Mar 28, 2018
Basement membranes (BMs) are specialized extracellular matrices required for tissue organization and organ formation. We study the role of laminin and its integrin receptor in the regulation of tissue migration during Drosophila...
Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes.
Andrés García-García, Claudia Korn, María García-Fernández, Olivia Domingues, Javier Villadiego, Daniel Martín-Pérez, Joan Isern, José A Bejarano-García, Jacques Zimmer, José A Pérez-Simón, Juan J Toledo-Aral, Tatiana Michel, Matti S Airaksinen, Simón Méndez-Ferrer
Dec 07, 2018
Hematopoietic stem and progenitor cells (HSPCs) and leukocytes circulate between the bone marrow (BM) and peripheral blood following circadian oscillations. Autonomic sympathetic noradrenergic signals have been shown to regulate...
Animals Bone Marrow Cells Cell Adhesion Cell Movement Cells Cultured Chemotaxis Cholinergic Agents Circadian Rhythm Endothelium Vascular Female Glial Cell Line-Derived Neurotrophic Factor Receptors Hematopoietic Stem Cells Leukocytes Male Mice Mice Inbred C57BL Mice Knockout Parasympathetic Nervous System Receptors Adrenergic beta-2 Receptors Adrenergic beta-3 Receptors G-Protein-Coupled sympathetic nervous system
Molecular interactome between HSCs and their niches.
Simón Méndez-Ferrer
Nov 18, 2019
Because hematopoietic stem cells (HSCs) were found to require a bone marrow (BM) habitat for long-term function, many studies have attempted to dissect key cellular and molecular interactions between HSCs and their BM...
Correlation Analysis of Water Demand and Predictive Variables for Short-Term Forecasting Models
Operational and economic aspects of water distribution make water demand forecasting paramount for water distribution systems (WDSs) management. However, water demand introduces high levels of uncertainty in WDS hydraulic...
Spermatogonia Loss Correlates with LAMA 1 Expression in Human Prepubertal Testes Stored for Fertility Preservation
Magdalena Kurek, Elisabet Åkesson, Masahito Yoshihara, Elizabeth Oliver, Yanhua Cui, Martin Becker, João Pedro Alves-Lopes, Ragnar Bjarnason, Patrik Romerius, Mikael Sundin, Ulrika Norén Nyström, Cecilia Langenskiöld, Hartmut Vogt, Lars Henningsohn, Cecilia Petersen, Olle Söder, Jingtao Guo, Rod T. Mitchell, Kirsi Jahnukainen, Jan-Bernd Stukenborg
Jan 29, 2021
Fertility preservation for male childhood cancer survivors not yet capable of producing mature spermatozoa, relies on experimental approaches such as testicular explant culture. Although the first steps in somatic maturation can...
Schechter’s eye for the extraordinary
BM Outhwaite
Apr 21, 2017
Schechter’s eye for the extraordinary
Effects of immediate postexercise carbohydrate ingestion with and without protein on neutrophil degranulation
The purpose of the study was to determine the effects of carbohydrate (CHO) intake, with and without protein (PRO), immediately after prolonged strenuous exercise on circulating bacterially stimulated neutrophil degranulation....
Effects of immediate postexercise carbohydrate ingestion with and without protein on neutrophil degranulation
The purpose of the study was to determine the effects of carbohydrate (CHO) intake, with and without protein (PRO), immediately after prolonged strenuous exercise on circulating bacterially stimulated neutrophil degranulation....
Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.
Larissa S Carnevalli, Roberta Scognamiglio, Nina Cabezas-Wallscheid, Susann Rahmig, Elisa Laurenti, Kohei Masuda, Lars Jöckel, Andrea Kuck, Stefanie Sujer, Apostolos Polykratis, Miriam Erlacher, Manolis Pasparakis, Marieke AG Essers, Andreas Trumpp
Aug 28, 2020
The serine protease granzyme B (GzmB) is stored in the granules of cytotoxic T and NK cells and facilitates immune-mediated destruction of virus-infected cells. In this study, we use genetic tools to report novel roles for GzmB...
Animals Apoptosis Bone Marrow Cell Proliferation Colony-Forming Units Assay DNA Primers Drug Therapy Enzyme-Linked Immunosorbent Assay Flow Cytometry Fluorouracil Gene Expression Regulation Granzymes Hematopoietic Stem Cells Immunohistochemistry Lipopolysaccharides Mice Mice Inbred C57BL Mice Knockout Microarray Analysis Mitochondria Real-Time Polymerase Chain Reaction Signal Transduction Stress Physiological
Does Teacher Encouragement Influence Students’ Educational Progress? A Propensity-Score Matching Analysis
BM Alcott
Mar 22, 2017
Theory suggests that teacher encouragement can aid students’ educational progress, but there are not yet quantitative inferential studies that assess its longer-term impact. With data from the Longitudinal Study of Young People...
Deciphering Master Gene Regulators and Associated Networks of Human Mesenchymal Stromal Cells.
Elena Sánchez-Luis, Andrea Joaquín-García, Francisco J Campos-Laborie, Fermín Sánchez-Guijo, Javier De Las Rivas
Jun 22, 2020
Mesenchymal Stromal Cells (MSC) are multipotent cells characterized by self-renewal, multilineage differentiation, and immunomodulatory properties. To obtain a gene regulatory profile of human MSCs, we generated a compendium of...
Spermatogonia Loss Correlates with LAMA 1 Expression in Human Prepubertal Testes Stored for Fertility Preservation.
Magdalena Kurek, Elisabet Åkesson, Masahito Yoshihara, Elizabeth Oliver, Yanhua Cui, Martin Becker, João Pedro Alves-Lopes, Ragnar Bjarnason, Patrik Romerius, Mikael Sundin, Ulrika Norén Nyström, Cecilia Langenskiöld, Hartmut Vogt, Lars Henningsohn, Cecilia Petersen, Olle Söder, Jingtao Guo, Rod T Mitchell, Kirsi Jahnukainen, Jan-Bernd Stukenborg
Apr 09, 2021
Fertility preservation for male childhood cancer survivors not yet capable of producing mature spermatozoa, relies on experimental approaches such as testicular explant culture. Although the first steps in somatic maturation can...
Might Progress Assessments Hinder Equitable Progress? Evidence from England
BM Alcott
Aug 01, 2017
Prior research has highlighted the importance of educational achievement throughout school in predicting subsequent progression to higher education in England. However, progress assessments may not only demonstrate students’...
Laminin levels regulate tissue migration and anterior-posterior polarity during egg morphogenesis in Drosophila
K Franze
Jun 27, 2017
Basement membranes (BMs) are specialized extracellular matrices required for tissue organisation and organ formation. Here we study the role of laminin and its integrin receptor in the regulation of tissue migration during...
Social network community detection and hybrid optimization for dividing water supply into district metered areas
Bruno M. Brentan, Enrique Campbell, Thaisa Goulart, Daniel Manzi, Gustavo Meirelles, Manuel Herrera, Joaquin Izquierdo, Edevar Luvizotto Jr.
May 01, 2018
Water supply utilities need to properly manage their systems to guarantee a quality supply. One way to manage large systems is through division into district metered areas (DMAs). Graph clustering with an unknown number of...
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