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Results: 65
Valproic acid disables the Nrf2 anti-oxidant response in acute myeloid leukaemia cells enhancing reactive oxygen species-mediated killing.
Yao Jiang, Andrew D Southam, Sandro Trova, Flavio Beke, Bader Alhazmi, Thomas Francis, Anshul Radotra, Alessandro di Maio, Mark T Drayson, Chris M Bunce, Farhat L Khanim
Jan 28, 2022
BACKGROUND: We previously demonstrated the in vitro killing of AML cells by the combination of the lipid-lowering agent bezafibrate (BEZ) and the contraceptive hormone medroxyprogesterone acetate (MPA). A phase II trial...
Functions of the 5' and 3' ends of calicivirus genomes.
Caliciviruses Norovirus RNA secondary structures RNA–protein interactions 3' Untranslated Regions 5' Untranslated Regions Animals Caliciviridae Conserved Sequence Genome Viral Host-Pathogen Interactions Humans Models Biological Nucleic Acid Conformation Promoter Regions Genetic RNA Viral Transcription Genetic Virus Replication
Mechanisms of Controlled Proteolysis during Drosophila Spermatogenesis: Coordinate Action of Apoptotic Caspases and the Ubiquitin-Proteasome System
Maya Bader
Jan 01, 0001
The regulation of apoptosis, or programmed cell death has been the subject of a vast body of research because of its implication in normal development, tissue homeostasis and a wide range of diseases. The major point of focus...
Drosophila spermatogenesis Apoptosis caspase activation ubiquitin-proteasome systems sperm differentiation dmPI31 F-Box regulatory complex Life Sciences
Published by: Rockefeller University
Hydraulic Pressure Ripple Energy Harvesting
Huifang Xiao, Min Pan, Harry Chu, Chris Bowen, Sebastian Bader, Javier Aranda, Meiling Zhu
Mar 03, 2022
The need for wireless condition monitoring and control of hydraulic systems in an autonomous and battery-free manner is attracting increasing attention in an effort to provide improved sensing functionality, monitoring of system...
Effective Approximation for the Semiclassical Schrödinger Equation
The computation of the semiclassical Schrödinger equation presents major challenges because of the presence of a small parameter. Assuming periodic boundary conditions, the standard approach consists of semi-discretisation...
Effective Approximation for the Semiclassical Schrödinger Equation
The computation of the semiclassical Schrödinger equation presents major challenges because of the presence of a small parameter. Assuming periodic boundary conditions, the standard approach consists of semi-discretisation...
Microfluidics-based super-resolution microscopy enables nanoscopic characterization of blood stem cell rolling.
Karmen AbuZineh, Luay I Joudeh, Bader Al Alwan, Samir M Hamdan, Jasmeen S Merzaban, Satoshi Habuchi
Sep 20, 2018
Hematopoietic stem/progenitor cell (HSPC) homing occurs via cell adhesion mediated by spatiotemporally organized ligand-receptor interactions. Although molecules and biological processes involved in this multistep cellular...
Mapping the Hsp90 genetic interaction network in <em>Candida albicans</em> reveals environmental contingency and rewired circuitry
The molecular chaperone Hsp90 regulates the folding of diverse signal transducers in all eukaryotes, profoundly affecting cellular circuitry. In fungi, Hsp90 influences development, drug resistance, and evolution. Hsp90...
Mapping the Hsp90 genetic interaction network in <em>Candida albicans</em> reveals environmental contingency and rewired circuitry
The molecular chaperone Hsp90 regulates the folding of diverse signal transducers in all eukaryotes, profoundly affecting cellular circuitry. In fungi, Hsp90 influences development, drug resistance, and evolution. Hsp90...
Extending the Role of Diffusion of Innovation Theory (DOI) in Achieving the Strategic Goal of the Firm With the Moderating Effect of Cost Leadership
The information system literature has long emphasized the importance of employee acceptance of information technology for achieving strategic goal of the firm and organizational performance. Consequently, this study investigates...
Published by: IGI Global Scientific Publishing
Hydraulic Pressure Ripple Energy Harvesting
Huifang Xiao, Min Pan, Harry Chu, Chris Bowen, Sebastian Bader, Javier Aranda, Meiling Zhu
Mar 03, 2022
The need for wireless condition monitoring and control of hydraulic systems in an autonomous and battery-free manner is attracting increasing attention in an effort to provide improved sensing functionality, monitoring of system...
Neutronic investigation of alternative & composite burnable poisons for the soluble-boron-free and long life civil marine small modular reactor cores.
Syed Bahauddin Alam, Bader Almutairi, Tuhfatur Ridwan, Dinesh Kumar, Cameron S Goodwin, Kirk D Atkinson, Geoffrey T Parks
Nov 27, 2019
Concerns about the effects of global warming provide a strong case to consider how best nuclear power could be applied to marine propulsion. Currently, there are persistent efforts worldwide to combat global warming, and that...
Optical Fiber Sensors
Mohamed Elsherif, Ahmed E Salih, Monserrat Gutiérrez Muñoz, Fahad Alam, Bader AlQattan, Dennyson Savariraj Antonysamy, Mohamed Fawzi Zaki, Ali K Yetisen, Seongjun Park, Timothy D Wilkinson, Haider Butt
Jul 14, 2022
Fiber‐optic technology emerged originally for applications in data transmission and telecommunications. However, sensors based on fiber‐optics have been developed rapidly because of their excellent sensing performances and...
Study on E-Commerce Adoption in SMEs Under the Institutional Perspective
This article investigates and discusses the institutional factors influencing decisions of e-commerce adoption in Saudi small and medium enterprises (SMEs) from the temporal view. This article has been conducted in two phases: a...
Published by: IGI Global Scientific Publishing
Enhanced variable reluctance energy harvesting for self-powered monitoring
Ying Zhang, Wei Wang, Junxiao Xie, Yaguo Lei, Junyi Cao, Ye Xu, Sebastian Bader, Chris Bowen, Bengt Oelmann
Sep 01, 2022
With the rapid development of microelectronic technology, wireless sensor nodes have been widely used in rotational equipment for health condition monitoring. However, for many low-frequency applications, there still remains...
Neutronic investigation of alternative & composite burnable poisons for the soluble-boron-free and long life civil marine small modular reactor cores.
Syed Bahauddin Alam, Bader Almutairi, Tuhfatur Ridwan, Dinesh Kumar, Cameron S Goodwin, Kirk D Atkinson, Geoffrey T Parks
Jan 27, 2020
Concerns about the effects of global warming provide a strong case to consider how best nuclear power could be applied to marine propulsion. Currently, there are persistent efforts worldwide to combat global warming, and that...
Intercellular network structure and regulatory motifs in the human hematopoietic system.
Wenlian Qiao, Weijia Wang, Elisa Laurenti, Andrei L Turinsky, Shoshana J Wodak, Gary D Bader, John E Dick, Peter W Zandstra
Aug 28, 2020
The hematopoietic system is a distributed tissue that consists of functionally distinct cell types continuously produced through hematopoietic stem cell (HSC) differentiation. Combining genomic and phenotypic data with...
Enhanced variable reluctance energy harvesting for self-powered monitoring
Ying Zhang, Wei Wang, Junxiao Xie, Yaguo Lei, Junyi Cao, Ye Xu, Sebastian Bader, Chris Bowen, Bengt Oelmann
Sep 01, 2022
With the rapid development of microelectronic technology, wireless sensor nodes have been widely used in rotational equipment for health condition monitoring. However, for many low-frequency applications, there still remains...
Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal.
Stephanie Z Xie, Laura Garcia-Prat, Veronique Voisin, Robin Ferrari, Olga I Gan, Elvin Wagenblast, Kerstin B Kaufmann, Andy GX Zeng, Shin-Ichiro Takayanagi, Ishita Patel, Esther K Lee, Joseph Jargstorf, Gareth Holmes, Guy Romm, Kristele Pan, Michelle Shoong, Aditi Vedi, Chiara Luberto, Mark D Minden, Gary D Bader, Elisa Laurenti, John E Dick
Sep 26, 2019
DEGS1 StemRegenin-1 UM171 Autophagy Fenretinide Hematopoietic stem cell lipidomics sphingolipid metabolism umbilical cord blood Unfolded Protein Response Animals Autophagy Cell Differentiation Cell Self Renewal Cell Survival Endoplasmic reticulum stress Fatty Acid Desaturases Female Fenretinide Gene Expression Regulation Gene Knockdown Techniques Hematopoietic Stem Cells Humans Male Mass Spectrometry Mice Mice Inbred NOD Proteostasis RNA Small Interfering RNA-seq Single-Cell Analysis sphingolipids Transplantation Heterologous
Insights into the Origin of High Activity of Ni<sub>5</sub>P<sub>4</sub>(0001) for Hydrogen Evolution Reaction.
Hydrogen evolution reaction (HER) is directly relevant to green hydrogen production from water splitting. Recently, a low-cost Ni5P4 material has been demonstrated experimentally and theoretically to...
Insights into the Origin of High Activity of Ni5P4(0001) for Hydrogen Evolution Reaction.
Hydrogen evolution reaction (HER) is directly relevant to green hydrogen production from water splitting. Recently, a low-cost Ni5P4 material has been demonstrated experimentally and theoretically to exhibit excellent...
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