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Results: 10507
SORL1 mutations in early- and late-onset Alzheimer disease.
Michael L Cuccaro, Regina M Carney, Yalun Zhang, Christopher Bohm, Brian W Kunkle, Badri N Vardarajan, Patrice L Whitehead, Holly N Cukier, Richard Mayeux, Peter St George-Hyslop, Margaret A Pericak-Vance
Feb 07, 2019
OBJECTIVE: To characterize the clinical and molecular effect of mutations in the sortilin-related receptor (SORL1) gene. METHODS: We performed whole-exome sequencing in early-onset Alzheimer disease (EOAD) and late-onset...
1109 Neurosciences Biomedical Basic Science Human Genome Alzheimer's Disease Clinical Research Dementia Brain Disorders Neurodegenerative aging Genetics Acquired Cognitive Impairment Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Neurological 2.1 Biological and endogenous factors
Ultra-rare mutations in SRCAP segregate in Caribbean Hispanic families with Alzheimer disease.
Badri N Vardarajan, Giuseppe Tosto, Roger Lefort, Lei Yu, David A Bennett, Philip L De Jager, Sandra Barral, Dolly Reyes-Dumeyer, Peter L Nagy, Joseph H Lee, Rong Cheng, Martin Medrano, Rafael Lantigua, Ekaterina Rogaeva, Peter St George-Hyslop, Richard Mayeux
Mar 22, 2018
OBJECTIVE: To identify rare coding variants segregating with late-onset Alzheimer disease (LOAD) in Caribbean Hispanic families. METHODS: Whole-exome sequencing (WES) was completed in 110 individuals from 31 Caribbean Hispanic...
A Comparative Analysis of Deep Learning Approaches for Network Intrusion Detection Systems (N-IDSs)
Recently, due to the advance and impressive results of deep learning techniques in the fields of image recognition, natural language processing and speech recognition for various long-standing artificial intelligence (AI) tasks...
Published by: IGI Global Scientific Publishing
The neural basis of hot and cold cognition in depressed patients, unaffected relatives, and low-risk healthy controls
BACKGROUND: Modern cognitive neuropsychological models of depression posit that negatively biased emotional ("hot") processing confers risk for depression, while preserved executive function ("cold") cognition promotes...
Non-Lorentzian SU(1, n) Spacetime Symmetry In Various Dimensions
We discuss non-Lorentzian Lagrangian field theories in $2n-1$ dimensions that
admit an $SU(1,n)$ spacetime symmetry which includes a scaling transformation.
These can be obtained by a conformal compactification of a...
Exact properties of an integrated correlator in N = 4 SU( N ) SYM
Abstract: We present a novel expression for an integrated correlation function of four superconformal primaries in SU(N) N = 4 supersymmetric Yang-Mills (N = 4 SYM) theory. This integrated correlator, which is based on...
Factorisation of 3d N = 4 twisted indices and the geometry of vortex moduli space
We study the twisted indices of $\mathcal{N}=4$ supersymmetric gauge theories
in three dimensions on spatial $S^{2}$ with an angular momentum refinement. We
demonstrate factorisation of the index into holomorphic blocks for...
Uncertainty Class Activation Map (U-CAM) using Gradient Certainty method
Understanding and explaining deep learning models is an imperative task. Towards this, we propose a method that obtains gradient-based certainty estimates that also provide visual attention maps. Particularly, we solve for...
Uncertainty Class Activation Map (U-CAM) using Gradient Certainty method
Understanding and explaining deep learning models is an imperative task. Towards this, we propose a method that obtains gradient-based certainty estimates that also provide visual attention maps. Particularly, we solve for...
Polyglycerol-based hydrogels and nanogels
Hydrogels and nanogels have emerged as promising materials for biomedical applications owing to their large surface area and tunable mechanical and chemical properties. Their large surface area is well suited for bioconjugation...
HONORING TORSEN N. WIESEL
The Rockefeller University
Jan 01, 0001
A Celebration in Honor of Torsten N. Wiesel: Entering his Tenth Decade
Published by: The Rockefeller University
Voltammetric Monitoring of a Solid-Liquid Phase Transition in N,N,N’,N’-Tetraoctyl-2,6-diamino-9,10-anthraquinone (TODAQ)
Sun Yhik Ahn, Thomas Forder, Matthew Jones, Richard Blackburn, Paul Fordred, Steven Bull, Frank Marken
Jan 31, 2020
Exploratory experiments on effects from a phase transition are reported for a low-melting microcrystalline anthraquinone (N,N,N′,N′-tetraoctyl-2,6-diamino-9,10-anthraquinone or TODAQ). Data for the solid-liquid phase...
Battery materials Calorimetry Melting point Phase Transition Plastic crystalline solids Triple phase boundary Voltammetry /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/1600/1603 name=Electrochemistry /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
Probabilistic framework for solving Visual Dialog
In this paper, we propose a probabilistic framework for solving the task of ‘Visual Dialog’. Solving this task requires reasoning and understanding of visual modality, language modality, and common sense knowledge to answer....
Role of p73 in Alzheimer disease
Badri Vardarajan, David Vergote, Fadel Tissir, Mark Logue, Jing Yang, Nathalie Daude, Kunie Ando, Ekaterina Rogaeva, Joseph Lee, Rong Cheng, Jean-Pierre Brion, Mahdi Ghani, Beipei Shi, Clinton T Baldwin, Satyabrata Kar, Richard Mayeux, Paul Fraser, André M Goffinet, Peter St George-Hyslop, Lindsay A Farrer, David Westaway
Apr 02, 2013
Aged Aged 80 and over Alzheimer Disease Animals Benzofurans Blotting Western DNA-Binding Proteins Disease Models Animal Female Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Immunohistochemistry Male Mice Mice Transgenic Nuclear Proteins Polymorphism Single Nucleotide Quinolines Tumor Protein p73 Tumor Suppressor Proteins tau Proteins
k-Root-n
Blockchains such as the bitcoin blockchain depend on reaching a global consensus on the distributed ledger; therefore, they suffer from well-known scalability problems. This paper proposes an algorithm that avoids...
Zvi Schreiber
Feb 08, 2020
Exact properties of an integrated correlator in N = 4 SU(N) SYM
Abstract
We present a novel expression for an integrated correlation function of four superconformal primaries in SU(N )...
The N-terminal RASSF family
The RASSF (Ras-association domain family) has recently gained several new members and now contains ten proteins (RASSF1–10), several of which are potential tumour suppressors. The family can be split into two groups, the...
Voltammetric Monitoring of a Solid-Liquid Phase Transition in N,N,N’,N’-Tetraoctyl-2,6-diamino-9,10-anthraquinone (TODAQ)
Sun Yhik Ahn, Thomas Forder, Matthew Jones, Richard Blackburn, Paul Fordred, Steven Bull, Frank Marken
Jan 31, 2020
Exploratory experiments on effects from a phase transition are reported for a low-melting microcrystalline anthraquinone (N,N,N′,N′-tetraoctyl-2,6-diamino-9,10-anthraquinone or TODAQ). Data for the solid-liquid phase...
Battery materials Calorimetry Melting point Phase Transition Plastic crystalline solids Triple phase boundary Voltammetry /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/1600/1603 name=Electrochemistry /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering
On (n+1/2)-Engel groups
Let n be a positive integer. We say that a group G is an (n+1/2)-Engel group if it satisfies the law [ x, y n, x ] = 1. The variety of (n+1/2)-Engel groups lies between the varieties of n-Engel groups and (n+1) -Engel groups. In...
The N-terminal RASSF family
The RASSF (Ras-association domain family) has recently gained several new members and now contains ten proteins (RASSF1–10), several of which are potential tumour suppressors. The family can be split into two groups, the...
Dollfustrema durum n. sp. and Heterobucephalopsis perardua n. sp. (Digenea: Bucephalidae) from the giant moray eel, Gymnothorax javanicus (Bleeker) (Anguilliformes
Matthew J Nolan, Stephen S Curran, Terrence L Miller, Scott C Cutmore, Cinzia Cantacessi, Thomas H Cribb
Jul 16, 2015
[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy.
[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (antagonist G) inhibits small cell lung cancer (SCLC) growth and is entering Phase II clinical investigation for the treatment of SCLC. As well as acting as a neuropeptide...
Acetylcysteine Animals Antineoplastic Agents Antineoplastic Agents Phytogenic Apoptosis CHO Cells Carcinoma Small Cell Cell Division Cricetinae Drug Synergism Etoposide Free Radical Scavengers Glutathione Growth Inhibitors JNK Mitogen-Activated Protein Kinases Lipid Peroxidation Lung Neoplasms MAP Kinase Kinase 4 Mitogen-Activated Protein Kinase Kinases Oligopeptides Oxidation-Reduction Reactive Oxygen Species Stimulation Chemical Transcription Factor AP-1 Transcription Genetic Tumor Cells Cultured
HRIS Symbolic Adoption, Its Relationship With Technological Adoption Factors, WLB, and Creativity
The study examines the relationship between technology adoption factors (performance expectancy, effort expectancy, and social influence) on employee creativity and work-life balance. The study examines the mediating role of the...
Published by: IGI Global Scientific Publishing
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