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Drug Cues, Conditioned Reinforcement, and Drug Seeking
Barry J Everitt
Aug 29, 2018
Athina Markou spent a research period in my laboratory, then in the Department of Anatomy in Cambridge University, in 1991 to help us establish a cocaine-seeking procedure. Thus we embarked on developing a second-order schedule...
A Novel Retrieval-Dependent Memory Process Revealed by the Arrest of ERK1/2 Activation in the Basolateral Amygdala.
Fully consolidated fear memories can be maintained or inhibited by retrieval-dependent mechanisms depending on the degree of re-exposure to fear cues. Short exposures promote memory maintenance through reconsolidation, and long...
Bidirectional Modulation of Alcohol-Associated Memory Reconsolidation through Manipulation of Adrenergic Signaling.
Compulsive Alcohol Seeking Results from a Failure to Disengage Dorsolateral Striatal Control over Behavior.
Addictive behaviour in experimental animals
Since the introduction of intravenous drug self-administration methodology over 50 years ago, experimental investigation of addictive behaviour has delivered an enormous body of data on the neural, psychological and molecular...
The Basolateral Amygdala to Nucleus Accumbens Core Circuit Mediates the Conditioned Reinforcing Effects of Cocaine-Paired Cues on Cocaine Seeking.
Individual differences in the engagement of habitual control over alcohol seeking predict the development of compulsive alcohol seeking and drinking.
Excessive drinking is an important behavioural characteristic of alcohol addiction, but not the only one. Individuals addicted to alcohol crave alcoholic beverages, spend time seeking alcohol despite negative consequences and...
Individual differences in the engagement of habitual control over alcohol seeking predict the development of compulsive alcohol seeking and drinking
Abstract: Excessive drinking is an important behavioural characteristic of alcohol addiction, but not the only one. Individuals addicted to alcohol crave alcoholic beverages, spend time seeking alcohol despite negative...
Original Article Original Articles Alcohol Compulsivity Contingency degradation devaluation Quinine seeking
Published by: Addiction Biology
Negative Urgency Exacerbates Relapse to Cocaine Seeking After Abstinence.
Maxime Fouyssac, Yolanda Peña-Oliver, Mickaёl Puaud, Nicole TY Lim, Chiara Giuliano, Barry J Everitt, David Belin
Oct 15, 2021
The anterior insular cortex in the rat exerts an inhibitory influence over the loss of control of heroin intake and subsequent propensity to relapse.
Dhaval D Joshi, Mickaël Puaud, Maxime Fouyssac, Aude Belin-Rauscent, Barry Everitt, David Belin
Jun 24, 2020
Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits.
Jennifer E Murray, Aude Belin-Rauscent, Marine Simon, Chiara Giuliano, Marianne Benoit-Marand, Barry J Everitt, David Belin
Oct 07, 2015
Alcohol-Preferring Rats Show Goal Oriented Behaviour to Food Incentives but Are Neither Sign-Trackers Nor Impulsive.
Yolanda Peña-Oliver, Chiara Giuliano, Daina Economidou, Charles R Goodlett, Trevor W Robbins, Jeffrey W Dalley, Barry J Everitt
Jun 23, 2015
Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions
Alexander C. W. Smith, Sietse Jonkman, Alexandra G. Difeliceantonio, Richard M. O’Connor, Soham Ghoshal, Michael F. Romano, Barry J. Everitt, Paul J. Kenny
Aug 26, 2021
Abstract: Comparatively little is known about how new instrumental actions are encoded in the brain. Using whole-brain c-Fos mapping, we show that neural activity is increased in the anterior dorsolateral striatum (aDLS) of mice...
Heroin seeking becomes dependent on dorsal striatal dopaminergic mechanisms and can be decreased by N-acetylcysteine.
Ritchy Hodebourg, Jennifer E Murray, Maxime Fouyssac, Mickaël Puaud, Barry J Everitt, David Belin
May 15, 2018
The alarming increase in heroin overdoses in the USA is a reminder of the need for efficacious and novel treatments for opiate addiction. This may reflect the relatively poor understanding of the neural basis of heroin, as...
Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions.
Alexander CW Smith, Sietse Jonkman, Alexandra G Difeliceantonio, Richard M O'Connor, Soham Ghoshal, Michael F Romano, Barry J Everitt, Paul J Kenny
Nov 01, 2021
Comparatively little is known about how new instrumental actions are encoded in the brain. Using whole-brain c-Fos mapping, we show that neural activity is increased in the anterior dorsolateral striatum (aDLS) of mice that...
Baclofen decreases compulsive alcohol drinking in rats characterized by reduced levels of GAT-3 in the central amygdala.
Lucia Marti-Prats, Aude Belin-Rauscent, Maxime Fouyssac, Mickaël Puaud, Paul J Cocker, Barry J Everitt, David Belin
Jan 15, 2021
Baclofen decreases compulsive alcohol drinking in rats characterized by reduced levels of GAT‐3 in the central amygdala
Lucia Marti‐Prats, Aude Belin‐Rauscent, Maxime Fouyssac, Mickaël Puaud, Paul J Cocker, Barry J Everitt, David Belin
Jun 24, 2021
Abstract: While most individuals with access to alcohol drink it recreationally, some vulnerable individuals eventually lose control over their intake and progressively develop compulsive alcohol drinking and decreased interest...
Original Article preclinical studies Alcohol Baclofen central amygdala compulsive alcohol drinking GABA transporter GAT‐3
Published by: Addiction Biology
The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking
Chiara Giuliano, Charles R Goodlett, Daina Economidou, Maria P García-Pardo, David Belin, Trevor W Robbins, Edward T Bullmore, Barry J Everitt
Jun 19, 2015
Alcohol Deterrents Alcohol Drinking Alcohol-Related Disorders Animals Blood Alcohol Content Choice Behavior Conditioning Operant Cues Disease Models Animal Dose-Response Relationship Drug Drug Evaluation Preclinical Drug-Seeking Behavior Indans Male Naltrexone Narcotic Antagonists Rats Receptors Opioid mu Reinforcement psychology Species Specificity Triazoles
Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions.
Alexander C W Smith, Sietse Jonkman, Alexandra G Difeliceantonio, Richard M O'Connor, Soham Ghoshal, Michael F Romano, Barry J Everitt, Paul J Kenny
Sep 26, 2021
Comparatively little is known about how new instrumental actions are encoded in the brain. Using whole-brain c-Fos mapping, we show that neural activity is increased in the anterior dorsolateral striatum (aDLS) of mice that...
Corpus Striatum Neurons Animals Mice Inbred C57BL Mice Rats Rats Long-Evans Receptors Dopamine D1 Receptors Dopamine D2 Behavior Animal Conditioning Operant Male
Published by: Nature Communications
Environment-dependent behavioral traits and experiential factors shape addiction vulnerability.
Maxime Fouyssac, Mickaël Puaud, Eric Ducret, Lucia Marti-Prats, Nathalie Vanhille, Solène Ansquer, Xinxuan Zhang, Aude Belin-Rauscent, Chiara Giuliano, Jean-Luc Houeto, Barry J Everitt, David Belin
Dec 16, 2020
Ketamine effects on memory reconsolidation favor a learning model of delusions.
Philip R Corlett, Victoria Cambridge, Jennifer M Gardner, Jennifer S Piggot, Danielle C Turner, Jessica C Everitt, Fernando Sergio Arana, Hannah L Morgan, Amy L Milton, Jonathan L Lee, Michael RF Aitken, Anthony Dickinson, Barry J Everitt, Anthony R Absalom, Ram Adapa, Naresh Subramanian, Jane R Taylor, John H Krystal, Paul C Fletcher
Apr 23, 2020
Delusions are the persistent and often bizarre beliefs that characterise psychosis. Previous studies have suggested that their emergence may be explained by disturbances in prediction error-dependent learning. Here we set up...
Withdrawal from escalated cocaine self-administration impairs reversal learning by disrupting the effects of negative feedback on reward exploitation
Peter Zhukovsky, Mickael Puaud, Bianca Jupp, Júlia Sala-Bayo, Johan Alsiö, Jing Xia, Lydia Searle, Zoe Morris, Aryan Sabir, Chiara Giuliano, Barry J Everitt, David Belin, Trevor W Robbins, Jeffrey W Dalley
Apr 05, 2019
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