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Detailed analysis of the genetic and epigenetic signatures of iPSC-derived mesodiencephalic dopaminergic neurons.
Reinhard Roessler, Sebastien A Smallwood, Jesse V Veenvliet, Petros Pechlivanoglou, Su-Ping Peng, Koushik Chakrabarty, Marian JA Groot-Koerkamp, R Jeroen Pasterkamp, Evelyn Wesseling, Gavin Kelsey, Erik Boddeke, Marten P Smidt, Sjef Copray
Jun 24, 2019
Induced pluripotent stem cells (iPSCs) hold great promise for in vitro generation of disease-relevant cell types, such as mesodiencephalic dopaminergic (mdDA) neurons involved in Parkinson's disease. Although iPSC-derived...
Walking blindfolded unveils unique contributions of behavioural approach and inhibition to lateral spatial bias.
Healthy individuals display a tendency to allocate attention unequally across space, and this bias has implications for how individuals interact with their environments. However, the origins of this phenomenon remain relatively...
Modeling Inner Proton Belt Variability at Energies 1 to 10 MeV Using BAS-PRO
Abstract: Geomagnetically trapped protons forming Earth's proton radiation belt pose a hazard to orbiting spacecraft. In particular, solar cell degradation is caused by non‐ionising collisions with protons at energies of several...
Effective and Efficient Classification of Topically-Enriched Domain-Specific Text Snippets
Due to the explosive growth in the amount of text snippets over the past few years and their sparsity of text, organizations are unable to effectively and efficiently classify them, missing out on business opportunities. This...
Published by: IGI Global Scientific Publishing
Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.
Rune E Kuhre, Nicolai J Wewer Albrechtsen, Olav Larsen, Sara L Jepsen, Emilie Balk-Møller, Daniel B Andersen, Carolyn F Deacon, Kristina Schoonjans, Frank Reimann, Fiona M Gribble, Reidar Albrechtsen, Bolette Hartmann, Mette M Rosenkilde, Jens J Holst
Jun 05, 2018
OBJECTIVE: Bile acids (BAs) facilitate fat absorption and may play a role in glucose and metabolism regulation, stimulating the secretion of gut hormones. The relative importance and mechanisms involved in BA-stimulated...
Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells.
Mohamed-Sami Trabelsi, Mehdi Daoudi, Janne Prawitt, Sarah Ducastel, Véronique Touche, Sama I Sayin, Alessia Perino, Cheryl A Brighton, Yasmine Sebti, Jérôme Kluza, Olivier Briand, Hélène Dehondt, Emmanuelle Vallez, Emilie Dorchies, Grégory Baud, Valeria Spinelli, Nathalie Hennuyer, Sandrine Caron, Kadiombo Bantubungi, Robert Caiazzo, Frank Reimann, Philippe Marchetti, Philippe Lefebvre, Fredrik Bäckhed, Fiona M Gribble, Kristina Schoonjans, François Pattou, Anne Tailleux, Bart Staels, Sophie Lestavel
Jan 31, 2020
Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and the nuclear receptor FXR. BA sequestrants (BAS) complex bile acids in the intestinal lumen and decrease intestinal FXR activity. The BAS-BA...
Animals Anticholesteremic Agents Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Bile Acids and Salts Blood Glucose Colesevelam Hydrochloride Colon Diet High-Fat Enteroendocrine Cells Glucagon-Like Peptide 1 Glycolysis Humans Ileum Insulin Insulin Secretion Insulin-Secreting Cells Intestinal Mucosa Intestines Jejunum Mice Mice Knockout Mice Obese Nuclear Proteins obesity Proglucagon RNA Messenger Receptors Cytoplasmic and Nuclear Receptors G-Protein-Coupled Sequestering Agents Signal Transduction Transcription Factors
Habit and climate change
Many climate-relevant behaviours are habitual. Habits are memory-based propensities to respond automatically to specific cues, acquired by repetition of behaviours in stable contexts. Socio-cognitive models are widely used to...
Explosion in weighted hyperbolic random graphs and geometric inhomogeneous random graphs
In this paper we study weighted distances in scale-free spatial network models: hyperbolic random graphs, geometric inhomogeneous random graphs and scale-free percolation. In hyperbolic random graphs...
Robot-Assisted Versus Laparoscopic Distal Pancreatectomy in Patients with Resectable Pancreatic Cancer
Jeffrey W Chen, Tess ME van Ramshorst, Sanne Lof, Bilal Al-Sarireh, Bergthor Bjornsson, Ugo Boggi, Fernando Burdio, Giovanni Butturini, Riccardo Casadei, Andrea Coratti, Mathieu D'Hondt, Safi Dokmak, Bjørn Edwin, Alessandro Esposito, Jean M Fabre, Giovanni Ferrari, Fadhel S Ftériche, Giuseppe K Fusai, Bas Groot Koerkamp, Thilo Hackert, Asif Jah, Jin-Young Jang, Emanuele F Kauffmann, Tobias Keck, Alberto Manzoni, Marco V Marino, Quintus Molenaar, Elizabeth Pando, Patrick Pessaux, Andrea Pietrabissa, Zahir Soonawalla, Robert P Sutcliffe, Lea Timmermann, Steven White, Vincent S Yip, Alessandro Zerbi, Mohammad Abu Hilal, Marc G Besselink, European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS)
Apr 10, 2023
BACKGROUND: Robot-assisted distal pancreatectomy (RDP) is increasingly used as an alternative to laparoscopic distal pancreatectomy (LDP) in patients with resectable pancreatic cancer but comparative multicenter studies...
Promoting sustainability
Bas Verplanken
May 01, 2018
Behaviours of individuals and households have major and cumulative impacts on the ecology and sustainable development. A generic segmentation model of sustainable behaviour is presented based on three fundamental drivers of...
Making Sense of Sustainability
This article investigated what the term “sustainability” meant to a group of proenvironmental people living in Peterborough, in the east of England. The data was collected and analyzed using Interpretative Phenomenological...
On the nature of eco-anxiety
Three studies investigated habitual worry about global warming as an example of 'eco-anxiety'. The key question was whether such worrying is constructive (a motivated pro-environmental response) or unconstructive (a symptom of...
Digenic DUOX1 and DUOX2 mutations in cases with congenital hypothyroidism
Z Aycan, H Cangul, M Muzza, VN Bas, L Fugazzola, VK Chatterjee, L Persani, N Schoenmakers
Aug 01, 2017
Context: The DUOX2 enzyme generates hydrogen peroxide (H2O2), a crucial electron acceptor for the TPO-catalyzed iodination and coupling reactions mediating thyroid hormone biosynthesis. DUOX2 mutations result in...
Habitual behaviors or patterns of practice? Explaining and changing repetitive climate-relevant actions
Understanding human behavior lies at the heart of responses to climate change. Many environmentally relevant behavior patterns are frequent, stable, and persistent. There is an increasing focus on understanding these patterns...
Making Sense of Sustainability
This article investigated what the term “sustainability” meant to a group of proenvironmental people living in Peterborough, in the east of England. The data was collected and analyzed using Interpretative Phenomenological...
Promoting sustainability
Bas Verplanken
May 01, 2018
Behaviours of individuals and households have major and cumulative impacts on the ecology and sustainable development. A generic segmentation model of sustainable behaviour is presented based on three fundamental drivers of...
The maximal degree in random recursive graphs with random weights
We study a generalisation of the random recursive tree (RRT) model and its multigraph counterpart, the uniform directed acyclic graph (DAG). Here, vertices are equipped with a random vertex-weight representing initial...
A phase transition for preferential attachment models with additive fitness
Preferential attachment models form a popular class of growing networks, where Preferential attachment models form a popular class of growing networks, where incoming vertices are preferably connected to vertices with high...
A phase transition for preferential attachment models with additive fitness
Preferential attachment models form a popular class of growing networks, where Preferential attachment models form a popular class of growing networks, where incoming vertices are preferably connected to vertices with high...
Explosion in weighted hyperbolic random graphs and geometric inhomogeneous random graphs
In this paper we study weighted distances in scale-free spatial network models: hyperbolic random graphs, geometric inhomogeneous random graphs and scale-free percolation. In hyperbolic random graphs...
The maximal degree in random recursive graphs with random weights
We study a generalisation of the random recursive tree (RRT) model and its multigraph counterpart, the uniform directed acyclic graph (DAG). Here, vertices are equipped with a random vertex-weight representing initial...
Habit and climate change
Many climate-relevant behaviours are habitual. Habits are memory-based propensities to respond automatically to specific cues, acquired by repetition of behaviours in stable contexts. Socio-cognitive models are widely used to...
Self-criticism as a mediator in the relationship between unhealthy perfectionism and distress
Unhealthy or negative perfectionism has been identified as both a risk and maintaining factor for a range of psychological difficulties. A cross-sectional online study with a predominantly student population (n = 381)...
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