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Is children's weight a public health or a private family issue?
BACKGROUND: The National Child Measurement Programme (NCMP) is a child weight monitoring system in England, taking place in the first and final years of primary school. Many local authorities consider it important to inform...
Chapter One - The genus <i>Geobacillus </i>and their biotechnological potential
The genus Geobacillus comprises a group of Gram-positive thermophilic bacteria, including obligate aerobes, denitrifiers, and facultative anaerobes that can grow over a range of 45-75°C. Originally classified as group...
PathwayBooster
BACKGROUND: Despite several recent advances in the automated generation of draft metabolic reconstructions, the manual curation of these networks to produce high quality genome-scale metabolic models remains a...
PathwayBooster
BACKGROUND: Despite several recent advances in the automated generation of draft metabolic reconstructions, the manual curation of these networks to produce high quality genome-scale metabolic models remains a...
Chapter One - The genus <i>Geobacillus </i>and their biotechnological potential
The genus Geobacillus comprises a group of Gram-positive thermophilic bacteria, including obligate aerobes, denitrifiers, and facultative anaerobes that can grow over a range of 45-75°C. Originally classified as group...
Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma.
Joseph J Caumanns, Katrien Berns, G Bea A Wisman, Rudolf SN Fehrmann, Tushar Tomar, Harry Klip, Gert J Meersma, E Marielle Hijmans, Annemiek MC Gennissen, Evelien W Duiker, Desiree Weening, Hiroaki Itamochi, Roelof JC Kluin, Anna KL Reyners, Michael J Birrer, Helga B Salvesen, Ignace Vergote, Els Van Nieuwenhuysen, James Brenton, E Ioana Braicu, Jolanta Kupryjanczyk, Beata Spiewankiewicz, Lorenza Mittempergher, René Bernards, Ate GJ van der Zee, Steven de Jong
Sep 10, 2018
Purpose: Advanced-stage ovarian clear cell carcinoma (OCCC) is unresponsive to conventional platinum-based chemotherapy. Frequent alterations in OCCC include deleterious mutations in the tumor suppressor ARID1A and activating...
Adenocarcinoma Clear Cell Animals Cell Line Tumor Cell Proliferation Class I Phosphatidylinositol 3-Kinases DNA-Binding Proteins Female Gene Expression Regulation Neoplastic Heterografts Humans Mechanistic Target of Rapamycin Complex 1 Mechanistic Target of Rapamycin Complex 2 Mice Morpholines Mutation Nuclear Proteins Ovarian Neoplasms Signal Transduction Transcription Factors
Is children's weight a public health or a private family issue?
BACKGROUND: The National Child Measurement Programme (NCMP) is a child weight monitoring system in England, taking place in the first and final years of primary school. Many local authorities consider it important to inform...
Understanding the Photoluminescence Quenching of Liquid Exfoliated WS<sub>2</sub> Monolayers
Zhaojun Li, Farnia Rashvand, Hope Bretscher, Beata M Szydłowska, James Xiao, Claudia Backes, Akshay Rao
Jan 04, 2023
Monolayer transition metal dichalcogenides (TMDs) are being investigated as active materials in optoelectronic devices due to their strong excitonic effects. While mechanical exfoliation (ME) of monolayer TMDs is limited to...
Understanding the Photoluminescence Quenching of Liquid Exfoliated WS 2 Monolayers
Zhaojun Li, paragon-plus: 6272024, Farnia Rashvand, paragon-plus: 6272071, Hope Bretscher, paragon-plus: 4152013, Beata M. Szydłowska, paragon-plus: 3467686, James Xiao, paragon-plus: 4302392, Claudia Backes, paragon-plus: 2579493, Akshay Rao, paragon-plus: 1071888
Mar 15, 2023
Monolayer transition metal dichalcogenides (TMDs) are being investigated as active materials in optoelectronic devices due to their strong excitonic effects. While mechanical exfoliation (ME) of monolayer TMDs is limited to...
Understanding the Photoluminescence Quenching of Liquid Exfoliated WS<sub>2</sub> Monolayers.
Zhaojun Li, Farnia Rashvand, Hope Bretscher, Beata M Szydłowska, James Xiao, Claudia Backes, Akshay Rao
Feb 09, 2023
Monolayer transition metal dichalcogenides (TMDs) are being investigated as active materials in optoelectronic devices due to their strong excitonic effects. While mechanical exfoliation (ME) of monolayer TMDs is limited to...
Cellular Chaperone Function of Intrinsically Disordered Dehydrin ERD14
Nikoletta Murvai, Lajos Kalmar, Beata Szabo, Eva Schad, András Micsonai, József Kardos, László Buday, Kyou-Hoon Han, Peter Tompa, Agnes Tantos
Jun 09, 2021
Disordered plant chaperones play key roles in helping plants survive in harsh conditions, and they are indispensable for seeds to remain viable. Aside from well-known and thoroughly characterized globular chaperone proteins...
Cellular Chaperone Function of Intrinsically Disordered Dehydrin ERD14.
Nikoletta Murvai, Lajos Kalmar, Beata Szabo, Eva Schad, András Micsonai, József Kardos, László Buday, Kyou-Hoon Han, Peter Tompa, Agnes Tantos
Aug 02, 2021
Disordered plant chaperones play key roles in helping plants survive in harsh conditions, and they are indispensable for seeds to remain viable. Aside from well-known and thoroughly characterized globular chaperone proteins...
Mechanochemical Polarization of Contiguous Cell Walls Shapes Plant Pavement Cells.
Mateusz Majda, Peter Grones, Ida-Maria Sintorn, Thomas Vain, Pascale Milani, Pawel Krupinski, Beata Zagórska-Marek, Corrado Viotti, Henrik Jönsson, Ewa J Mellerowicz, Olivier Hamant, Stéphanie Robert
Jan 31, 2018
The epidermis of aerial plant organs is thought to be limiting for growth, because it acts as a continuous load-bearing layer, resisting tension. Leaf epidermis contains jigsaw puzzle piece-shaped pavement cells whose shape has...
Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells.
Justyna Ulanska-Poutanen, Jakub Mieczkowski, Chao Zhao, Katarzyna Konarzewska, Beata Kaza, Hartmut Bf Pohl, Lukasz Bugajski, Bozena Kaminska, Robin Jm Franklin, Malgorzata Zawadzka
Nov 19, 2018
Schwann Cells adult CNS progenitors neuroscience perivascular niche rat remyelination Animals Astrocytes Bone Morphogenetic Proteins Cell Differentiation Cellular Microenvironment Central Nervous System Demyelinating Diseases Endothelial Cells Gene Expression Regulation Ligands Oligodendroglia Peripheral Nervous System RNA Messenger Rats Stem Cell Niche Stem Cells Wnt Signaling Pathway Wounds and Injuries
Pathogenic ACVR1R206H activation by Activin A-induced receptor clustering and autophosphorylation.
An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis.
Alexander J Ainscough, Timothy J Smith, Maike Haensel, Christopher J Rhodes, Adam Fellows, Harry J Whitwell, Eleni Vasilaki, Kelly Gray, Adrian Freeman, Luke S Howard, John Wharton, Benjamin Dunmore, Paul D Upton, Martin R Wilkins, Joshua B Edel, Beata Wojciak-Stothard
Nov 08, 2022
Pulmonary arterial hypertension (PAH) is an unmet clinical need. The lack of models of human disease is a key obstacle to drug development. We present a biomimetic model of pulmonary arterial endothelial-smooth muscle cell...
Interplay of Structural Disorder and Short Binding Elements in the Cellular Chaperone Function of Plant Dehydrin ERD14.
Nikoletta Murvai, Lajos Kalmar, Bianka Szalaine Agoston, Beata Szabo, Agnes Tantos, Gyorgy Csikos, András Micsonai, József Kardos, Didier Vertommen, Phuong N Nguyen, Nevena Hristozova, Andras Lang, Denes Kovacs, Laszlo Buday, Kyou-Hoon Han, Andras Perczel, Peter Tompa
Sep 01, 2020
Details of the functional mechanisms of intrinsically disordered proteins (IDPs) in living cells is an area not frequently investigated. Here, we dissect the molecular mechanism of action of an IDP in cells by detailed...
cell protection chaperone client protein in-cell NMR intrinsic structural disorder pre-structured motif Arabidopsis Arabidopsis Proteins Escherichia coli Heat-Shock Response Intrinsically Disordered Proteins Microbial Viability Microorganisms Genetically-Modified Molecular Chaperones Protein Binding Protein Domains Proteome
Interplay of Structural Disorder and Short Binding Elements in the Cellular Chaperone Function of Plant Dehydrin ERD14
Nikoletta Murvai, Lajos Kalmar, Bianka Szalaine Agoston, Beata Szabo, Agnes Tantos, Gyorgy Csikos, András Micsonai, József Kardos, Didier Vertommen, Phuong N. Nguyen, Nevena Hristozova, Andras Lang, Denes Kovacs, Laszlo Buday, Kyou-Hoon Han, Andras Perczel, Peter Tompa
Aug 08, 2020
Details of the functional mechanisms of intrinsically disordered proteins (IDPs) in living cells is an area not frequently investigated. Here, we dissect the molecular mechanism of action of an IDP in cells by detailed...
Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities
Takuhiro Sonoyama, Lukas K. J. Stadler, Mingyan Zhu, Julia M. Keogh, Elana Henning, Fuki Hisama, Peter Kirwan, Magdalena Jura, Beata K. Blaszczyk, David C. DeWitt, Bas Brouwers, Marko Hyvönen, Inês Barroso, Florian T. Merkle, Suzanne M. Appleyard, Gary A. Wayman, I. Sadaf Farooqi
Jun 04, 2021
Abstract: Brain-derived neurotrophic factor (BDNF) signals through its high affinity receptor Tropomyosin receptor kinase-B (TrkB) to regulate neuronal development, synapse formation and plasticity. In rodents, genetic...
Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities.
Takuhiro Sonoyama, Lukas KJ Stadler, Mingyan Zhu, Julia M Keogh, Elana Henning, Fuki Hisama, Peter Kirwan, Magdalena Jura, Beata K Blaszczyk, David C DeWitt, Bas Brouwers, Marko Hyvönen, Inês Barroso, Florian T Merkle, Suzanne M Appleyard, Gary A Wayman, I Sadaf Farooqi
Jul 16, 2020
Brain-derived neurotrophic factor (BDNF) signals through its high affinity receptor Tropomyosin receptor kinase-B (TrkB) to regulate neuronal development, synapse formation and plasticity. In rodents, genetic disruption of Bdnf...
p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells.
Manikandan Periyasamy, Anup K Singh, Carolina Gemma, Christian Kranjec, Raed Farzan, Damien A Leach, Naveenan Navaratnam, Hajnalka L Pálinkás, Beata G Vértessy, Tim R Fenton, John Doorbar, Frances Fuller-Pace, David W Meek, R Charles Coombes, Laki Buluwela, Simak Ali
Sep 05, 2018
Cancer genome sequencing has implicated the cytosine deaminase activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) genes as an important source of mutations in diverse cancers, with APOBEC3B...
An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis.
Alexander J Ainscough, Timothy J Smith, Maike Haensel, Christopher J Rhodes, Adam Fellows, Harry J Whitwell, Eleni Vasilaki, Kelly Gray, Adrian Freeman, Luke S Howard, John Wharton, Benjamin Dunmore, Paul D Upton, Martin R Wilkins, Joshua B Edel, Beata Wojciak-Stothard
Dec 09, 2022
Pulmonary arterial hypertension (PAH) is an unmet clinical need. The lack of models of human disease is a key obstacle to drug development. We present a biomimetic model of pulmonary arterial endothelial-smooth muscle cell...
IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction.
Sjoerd D Joustra, Ferdinand Roelfsema, AS Paul van Trotsenburg, Harald J Schneider, Robert P Kosilek, Herman M Kroon, John G Logan, Natalie C Butterfield, Xiang Zhou, Chirine Toufaily, Beata Bak, Marc-Olivier Turgeon, Emilie Brûlé, Frederik J Steyn, Mark Gurnell, Olympia Koulouri, Paul Le Tissier, Pierre Fontanaud, JH Duncan Bassett, Graham R Williams, Wilma Oostdijk, Jan M Wit, Alberto M Pereira, Nienke R Biermasz, Daniel J Bernard, Nadia Schoenmakers
Sep 23, 2019
Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.
Madalene Earp, Jonathan P Tyrer, Stacey J Winham, Hui-Yi Lin, Ganna Chornokur, Joe Dennis, Katja KH Aben, Hoda Anton-Culver, Natalia Antonenkova, Elisa V Bandera, Yukie T Bean, Matthias W Beckmann, Line Bjorge, Natalia Bogdanova, Louise A Brinton, Angela Brooks-Wilson, Fiona Bruinsma, Clareann H Bunker, Ralf Butzow, Ian G Campbell, Karen Carty, Jenny Chang-Claude, Linda S Cook, Daniel W Cramer, Julie M Cunningham, Cezary Cybulski, Agnieszka Dansonka-Mieszkowska, Evelyn Despierre, Jennifer A Doherty, Thilo Dörk, Andreas du Bois, Matthias Dürst, Douglas F Easton, Diana M Eccles, Robert P Edwards, Arif B Ekici, Peter A Fasching, Brooke L Fridley, Aleksandra Gentry-Maharaj, Graham G Giles, Rosalind Glasspool, Marc T Goodman, Jacek Gronwald, Philipp Harter, Alexander Hein, Florian Heitz, Michelle AT Hildebrandt, Peter Hillemanns, Claus K Hogdall, Estrid Høgdall, Satoyo Hosono, Edwin S Iversen, Anna Jakubowska, Allan Jensen, Bu-Tian Ji, Audrey Y Jung, Beth Y Karlan, Melissa Kellar, Lambertus A Kiemeney, Boon Kiong Lim, Susanne K Kjaer, Camilla Krakstad, Jolanta Kupryjanczyk, Diether Lambrechts, Sandrina Lambrechts, Nhu D Le, Shashi Lele, Jenny Lester, Douglas A Levine, Zheng Li, Dong Liang, Jolanta Lissowska, Karen Lu, Jan Lubinski, Lene Lundvall, Leon FAG Massuger, Keitaro Matsuo, Valerie McGuire, John R McLaughlin, Iain McNeish, Usha Menon, Roger L Milne, Francesmary Modugno, Kirsten B Moysich, Roberta B Ness, Heli Nevanlinna, Kunle Odunsi, Sara H Olson, Irene Orlow, Sandra Orsulic, James Paul, Tanja Pejovic, Liisa M Pelttari, Jenny B Permuth, Malcolm C Pike, Elizabeth M Poole, Barry Rosen, Mary Anne Rossing, Joseph H Rothstein, Ingo B Runnebaum, Iwona K Rzepecka, Eva Schernhammer, Ira Schwaab, Xiao-Ou Shu, Yurii B Shvetsov, Nadeem Siddiqui, Weiva Sieh, Honglin Song, Melissa C Southey, Beata Spiewankiewicz, Lara Sucheston-Campbell, Ingvild L Tangen, Soo-Hwang Teo, Kathryn L Terry, Pamela J Thompson, Lotte Thomsen, Shelley S Tworoger, Anne M van Altena, Ignace Vergote, Liv Cecilie Vestrheim Thomsen, Robert A Vierkant, Christine S Walsh, Shan Wang-Gohrke, Nicolas Wentzensen, Alice S Whittemore, Kristine G Wicklund, Lynne R Wilkens, Yin-Ling Woo, Anna H Wu, Xifeng Wu, Yong-Bing Xiang, Hannah Yang, Wei Zheng, Argyrios Ziogas, Alice W Lee, Celeste L Pearce, Andrew Berchuck, Joellen M Schildkraut, Susan J Ramus, Alvaro NA Monteiro, Steven A Narod, Thomas A Sellers, Simon A Gayther, Linda E Kelemen, Georgia Chenevix-Trench, Harvey A Risch, Paul DP Pharoah, Ellen L Goode, Catherine M Phelan
Sep 05, 2018
Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer mortality in American women. Normal ovarian physiology is intricately connected to small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and...
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