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Results: 40
Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population.
Marcella Montagnese, Franziska Knolle, Joost Haarsma, Juliet D Griffin, Alex Richards, Petra E Vertes, Beatrix Kiddle, Paul C Fletcher, Peter B Jones, Michael J Owen, Peter Fonagy, Edward T Bullmore, Raymond J Dolan, NSPN Consortium, Michael Moutoussis, Ian M Goodyer, Graham K Murray
Apr 30, 2020
Prediction of five-year mortality after COPD diagnosis using primary care records
Accurate prognosis information after a diagnosis of chronic obstructive pulmonary disease (COPD) would facilitate earlier and better informed decisions about the use of prevention strategies and advanced care plans. We therefore...
Alzheimer's disease
OBJECTIVE: Peripheral protein biomarkers of Alzheimer's disease (AD) may help identify novel treatment avenues by allowing early diagnosis, recruitment to clinical trials, and treatment initiation. The purpose of this review was...
1109 Neurosciences Biomedical Clinical Medicine and Science aging Neurosciences Dementia Neurodegenerative Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Alzheimer's Disease Brain Disorders Acquired Cognitive Impairment Neurological 4.1 Discovery and preclinical testing of markers and technologies
Challenges and Pitfalls of Using Repeat Spirometry Recordings in Routine Primary Care Data to Measure FEV1 Decline in a COPD Population.
BACKGROUND: Electronic healthcare records (EHR) are increasingly used in epidemiological studies but are often viewed as lacking quality compared to randomised control trials and prospective cohorts. Studies of patients with...
Characteristics, service use and mortality of clusters of multimorbid patients in England
Abstract: Background: Multimorbidity is associated with mortality and service use, with specific types of multimorbidity having differential effects. Additionally, multimorbidity is often negatively associated with participation...
Prediction of five-year mortality after COPD diagnosis using primary care records.
Accurate prognosis information after a diagnosis of chronic obstructive pulmonary disease (COPD) would facilitate earlier and better informed decisions about the use of prevention strategies and advanced care plans. We therefore...
Inhaled corticosteroids and FEV1 decline in chronic obstructive pulmonary disease
Rate of FEV1 decline in COPD is heterogeneous and the extent to which inhaled corticosteroids (ICS) influence the rate of decline is unclear. The majority of previous reviews have investigated specific ICS and non-ICS inhalers...
Characteristics, service use and mortality of clusters of multimorbid patients in England
Abstract: Background: Multimorbidity is associated with mortality and service use, with specific types of multimorbidity having differential effects. Additionally, multimorbidity is often negatively associated with participation...
Characteristics, service use and mortality of clusters of multimorbid patients in England
BACKGROUND:Multimorbidity is associated with mortality and service use, with specific types of multimorbidity having differential effects. Additionally, multimorbidity is often negatively associated with participation in...
pattern recognition validation Chronic conditions latent class analysis Age stratification Multimorbidity phenotype
Published by: BMC medicine
Inhaled corticosteroids and FEV1 decline in chronic obstructive pulmonary disease
COPD Inhaled Corticosteroids lung function Review Administration Inhalation Adrenal Cortex Hormones Disease Progression Drug Therapy Combination Evidence-Based Medicine Female Forced Expiratory Volume Humans Male Prognosis Pulmonary Disease Chronic Obstructive Quality of life Randomized Controlled Trials as Topic Respiratory Function Tests Risk Assessment Severity of Illness Index Treatment Outcome United States
Inhaled corticosteroids and FEV 1 decline in chronic obstructive pulmonary disease
Hannah R. Whittaker, Debbie Jarvis, Mohamed R. Sheikh, Steven J. Kiddle, Jennifer K. Quint
Dec 03, 2020
Abstract: Rate of FEV1 decline in COPD is heterogeneous and the extent to which inhaled corticosteroids (ICS) influence the rate of decline is unclear. The majority of previous reviews have investigated specific ICS and non-ICS...
Characteristics, service use and mortality of clusters of multimorbid patients in England
Accelerated FEV1 decline and risk of cardiovascular disease and mortality in a primary care population of COPD patients.
Hannah R Whittaker, Chloe Bloom, Ann Morgan, Deborah Jarvis, Steven J Kiddle, Jennifer K Quint
Oct 21, 2020
Accelerated lung function decline has been associated with increased risk of cardiovascular disease (CVD) in a general population, but little is known about this association in chronic obstructive pulmonary disease (COPD). We...
Metabolomic Profiling in Patients with Different Hemodynamic Subtypes of Severe Aortic Valve Stenosis.
Philipp Bengel, Manar Elkenani, Bo E Beuthner, Maik Pietzner, Belal A Mohamed, Beatrix Pollok-Kopp, Ralph Krätzner, Karl Toischer, Miriam Puls, Andreas Fischer, Lutz Binder, Gerd Hasenfuß, Moritz Schnelle
Feb 21, 2023
Severe aortic stenosis (AS) is a common pathological condition in an ageing population imposing significant morbidity and mortality. Based on distinct hemodynamic features, i.e., ejection fraction (EF), transvalvular gradient...
Metabolomic Profiling in Patients with Different Hemodynamic Subtypes of Severe Aortic Valve Stenosis.
Philipp Bengel, Manar Elkenani, Bo E Beuthner, Maik Pietzner, Belal A Mohamed, Beatrix Pollok-Kopp, Ralph Krätzner, Karl Toischer, Miriam Puls, Andreas Fischer, Lutz Binder, Gerd Hasenfuß, Moritz Schnelle
Feb 03, 2023
Cohort profile: The NSPN 2400 Cohort
B Kiddle, B Inkster, G Prabhu, M Moutoussis, KJ Whitaker, NSPN Consortium, ET Bullmore, RJ Dolan, P Fonagy, IM Goodyer, PB Jones
Jul 03, 2017
Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome.
Cornelis A Albers, Ana Cvejic, Rémi Favier, Evelien E Bouwmans, Marie-Christine Alessi, Paul Bertone, Gregory Jordan, Ross NW Kettleborough, Graham Kiddle, Myrto Kostadima, Randy J Read, Botond Sipos, Suthesh Sivapalaratnam, Peter A Smethurst, Jonathan Stephens, Katrin Voss, Alan Nurden, Augusto Rendon, Paquita Nurden, Willem H Ouwehand
Aug 20, 2020
Gray platelet syndrome (GPS) is a predominantly recessive platelet disorder that is characterized by mild thrombocytopenia with large platelets and a paucity of α-granules; these abnormalities cause mostly moderate but in rare...
Adult Aged Animals Animals Genetically Modified Base Sequence Blood Platelets Cytoplasmic Granules Embryo Nonmammalian Female Gene Expression Regulation Developmental Gray Platelet Syndrome Humans Male Middle Aged Molecular Sequence Data Nerve Tissue Proteins Pedigree Secretory Vesicles Sequence Analysis DNA Sequence Homology Nucleic Acid Young Adult Zebrafish
A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis.
Nicola Voyle, Aoife Keohane, Stephen Newhouse, Katie Lunnon, Caroline Johnston, Hilkka Soininen, Iwona Kloszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Simon Lovestone, Angela Hodges, Steven Kiddle, Richard JB Dobson
Jun 11, 2018
BACKGROUND: Recent studies indicate that gene expression levels in blood may be able to differentiate subjects with Alzheimer's disease (AD) from normal elderly controls and mild cognitively impaired (MCI) subjects. However...
Immunosenescence and Cytomegalovirus
Graham Pawelec, Arne Akbar, Peter Beverley, Calogero Caruso, Evelyna Derhovanessian, Tamas Fülöp, Paul Griffiths, Beatrix Grubeck-Loebenstein, Klaus Hamprecht, Gerhard Jahn, Florian Kern, Sven D Koch, Anis Larbi, Andrea B Maier, Derek Macallan, Paul Moss, Sandrine Samson, Jan Strindhall, Emanuelle Trannoy, Mark Wills
Jun 14, 2011
Genetic Risk as a Marker of Amyloid-β and Tau Burden in Cerebrospinal Fluid.
Nicola Voyle, Hamel Patel, Amos Folarin, Stephen Newhouse, Caroline Johnston, Pieter Jelle Visser, Richard JB Dobson, Steven J Kiddle, EDAR and DESCRIPA study groups and the Alzheimer’s Disease Neuroimaging Initiative
May 21, 2018
Alzheimer’s disease biomarker Blood multi-modal polygenic risk score Tau Aged Aged 80 and over Alzheimer Disease Amyloid beta-Peptides Apolipoproteins E Biomarkers Cohort Studies Databases Factual Early Diagnosis Female Humans Logistic Models Male Oligonucleotide Array Sequence Analysis Polymorphism Single Nucleotide Positron-Emission Tomography tau Proteins
Dysregulated Antibody, Natural Killer Cell and Immune Mediator Profiles in Autoimmune Thyroid Diseases.
Tiphaine C Martin, Kristina M Ilieva, Alessia Visconti, Michelle Beaumont, Steven J Kiddle, Richard JB Dobson, Massimo Mangino, Ee Mun Lim, Marija Pezer, Claire J Steves, Jordana T Bell, Scott G Wilson, Gordan Lauc, Mario Roederer, John P Walsh, Tim D Spector, Sophia N Karagiannis
Mar 10, 2020
Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly.
Sarah Westwood, Emanuela Leoni, Abdul Hye, Steven Lynham, Mizanur R Khondoker, Nicholas J Ashton, Steven J Kiddle, Alison L Baird, Ricardo Sainz-Fuertes, Rufina Leung, John Graf, Cristina Tan Hehir, David Baker, Cristina Cereda, Chantal Bazenet, Malcolm Ward, Madhav Thambisetty, Simon Lovestone
Jun 11, 2018
Increasingly, clinical trials for Alzheimer's disease (AD) are being conducted earlier in the disease phase and with biomarker confirmation using in vivo amyloid PET imaging or CSF tau and Aβ measures to quantify pathology....
KeywordsAlzheimer’s disease Amyloid biological markers Blood Plasma Preclinical Proteomics Aged Alzheimer Disease Amyloidogenic Proteins Aniline Compounds Benzothiazoles Biomarkers Brain Brain Chemistry Female Humans Male Positron-Emission Tomography Tandem Mass Spectrometry Thiazoles alpha-Macroglobulins
Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic
Rajiv V Dave, Beatrix Elsberger, Vicky P Taxiarchi, Ashu Gandhi, Cliona C Kirwan, Baek Kim, Elizabeth M Camacho, Charlotte E Coles, Ellen Copson, Alona Courtney, Kieran Horgan, Patricia Fairbrother, Chris Holcombe, Jamie J Kirkham, Daniel R Leff, Stuart A McIntosh, Rachel O'Connell, Ricardo Pardo, Shelley Potter, Tim Rattay, Nisha Sharma, Raghavan Vidya, Ramsey I Cutress, B-MaP-C study collaborative
Apr 17, 2023
PURPOSE: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst...
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