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Results: 36
Metabolomic Profiling in Patients with Different Hemodynamic Subtypes of Severe Aortic Valve Stenosis.
Philipp Bengel, Manar Elkenani, Bo E Beuthner, Maik Pietzner, Belal A Mohamed, Beatrix Pollok-Kopp, Ralph Krätzner, Karl Toischer, Miriam Puls, Andreas Fischer, Lutz Binder, Gerd Hasenfuß, Moritz Schnelle
Feb 03, 2023
Metabolomic Profiling in Patients with Different Hemodynamic Subtypes of Severe Aortic Valve Stenosis.
Philipp Bengel, Manar Elkenani, Bo E Beuthner, Maik Pietzner, Belal A Mohamed, Beatrix Pollok-Kopp, Ralph Krätzner, Karl Toischer, Miriam Puls, Andreas Fischer, Lutz Binder, Gerd Hasenfuß, Moritz Schnelle
Feb 21, 2023
Severe aortic stenosis (AS) is a common pathological condition in an ageing population imposing significant morbidity and mortality. Based on distinct hemodynamic features, i.e., ejection fraction (EF), transvalvular gradient...
Turning Clients into Superheroes through Accessibility Consulting
Robbie Kopp
Jan 01, 0001
Breaking Down the Physical and Digital Walls to Access from the Inside Out. Including people with disabilities in physical and online spaces is often overlooked in the scheme of social justice. The presenter will talk about...
Published by: Winthrop University
UK Consumers’ Preferences for Ethical Attributes of Floating Rice
Vietnam plays an important role in bearing global food security. However, Vietnamese rice farmers face several challenges, including pressures to develop sustainable livelihoods while reducing the environmental impacts of their...
Immunosenescence and Cytomegalovirus
Graham Pawelec, Arne Akbar, Peter Beverley, Calogero Caruso, Evelyna Derhovanessian, Tamas Fülöp, Paul Griffiths, Beatrix Grubeck-Loebenstein, Klaus Hamprecht, Gerhard Jahn, Florian Kern, Sven D Koch, Anis Larbi, Andrea B Maier, Derek Macallan, Paul Moss, Sandrine Samson, Jan Strindhall, Emanuelle Trannoy, Mark Wills
Jun 14, 2011
Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance.
Eliana MC Tacconi, Sophie Badie, Giuliana De Gregoriis, Timo Reisländer, Xianning Lai, Manuela Porru, Cecilia Folio, John Moore, Arnaud Kopp, Júlia Baguña Torres, Deborah Sneddon, Marcus Green, Simon Dedic, Jonathan W Lee, Ankita Sati Batra, Oscar M Rueda, Alejandra Bruna, Carlo Leonetti, Carlos Caldas, Bart Cornelissen, Laurent Brino, Anderson Ryan, Annamaria Biroccio, Madalena Tarsounas
Jul 31, 2019
BRCA1 BRCA2 DNA damage responses alkylating agents cisplatin Animals BRCA1 Protein BRCA2 Protein Cell Line Tumor Chlorambucil Cricetinae Drug Delivery Systems Drug Resistance Neoplasm Humans Leukemia Lymphocytic Chronic B-Cell Male Mice Mice SCID Peroxisome Proliferator-Activated Receptors Phthalazines Piperazines Xenograft Model Antitumor Assays
Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population.
Marcella Montagnese, Franziska Knolle, Joost Haarsma, Juliet D Griffin, Alex Richards, Petra E Vertes, Beatrix Kiddle, Paul C Fletcher, Peter B Jones, Michael J Owen, Peter Fonagy, Edward T Bullmore, Raymond J Dolan, NSPN Consortium, Michael Moutoussis, Ian M Goodyer, Graham K Murray
Apr 30, 2020
Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic
Rajiv V Dave, Beatrix Elsberger, Vicky P Taxiarchi, Ashu Gandhi, Cliona C Kirwan, Baek Kim, Elizabeth M Camacho, Charlotte E Coles, Ellen Copson, Alona Courtney, Kieran Horgan, Patricia Fairbrother, Chris Holcombe, Jamie J Kirkham, Daniel R Leff, Stuart A McIntosh, Rachel O'Connell, Ricardo Pardo, Shelley Potter, Tim Rattay, Nisha Sharma, Raghavan Vidya, Ramsey I Cutress, B-MaP-C study collaborative
Apr 17, 2023
PURPOSE: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst...
British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic.
Nicholas A Kennedy, Gareth-Rhys Jones, Christopher A Lamb, Richard Appleby, Ian Arnott, R Mark Beattie, Stuart Bloom, Alenka J Brooks, Rachel Cooney, Robin J Dart, Cathryn Edwards, Aileen Fraser, Daniel R Gaya, Subrata Ghosh, Kay Greveson, Richard Hansen, Ailsa Hart, A Barney Hawthorne, Bu'Hussain Hayee, Jimmy K Limdi, Charles D Murray, Gareth C Parkes, Miles Parkes, Kamal Patel, Richard C Pollok, Nick Powell, Chris S Probert, Tim Raine, Shaji Sebastian, Christian Selinger, Philip J Smith, Catherine Stansfield, Lisa Younge, James O Lindsay, Peter M Irving, Charlie W Lees
Jun 26, 2020
The COVID-19 pandemic is putting unprecedented pressures on healthcare systems globally. Early insights have been made possible by rapid sharing of data from China and Italy. In the UK, we have rapidly mobilised inflammatory...
Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD.
Nicholas A Kennedy, Simeng Lin, James R Goodhand, Neil Chanchlani, Benjamin Hamilton, Claire Bewshea, Rachel Nice, Desmond Chee, JR Fraser Cummings, Aileen Fraser, Peter M Irving, Nikolaos Kamperidis, Klaartje B Kok, Christopher Andrew Lamb, Jonathan Macdonald, Shameer Mehta, Richard Cg Pollok, Tim Raine, Philip J Smith, Ajay Mark Verma, Simon Jochum, Timothy J McDonald, Shaji Sebastian, Charlie W Lees, Nick Powell, Tariq Ahmad, Contributors to the CLARITY IBD study
Apr 28, 2021
OBJECTIVE: Delayed second dose SARS-CoV-2 vaccination trades maximal effectiveness for a lower level of immunity across more of the population. We investigated whether patients with inflammatory bowel disease treated with...
BNT162b2 CLARITY covid-19 ChAdOx1 nCoV-19 TNF Autoimmune Disease inflammatory bowel disease inflammatory diseases Infliximab vaccine vedolizumab Adult Antibodies Monoclonal Humanized Antibodies Viral Antibody Formation BNT162 Vaccine covid-19 COVID-19 Vaccines ChAdOx1 nCoV-19 Female Gastrointestinal Agents Humans Inflammatory Bowel Diseases Infliximab Male Middle Aged SARS-CoV-2 Serologic Tests
Adaptations to the British Society of Gastroenterology guidelines on the management of acute severe UC in the context of the COVID-19 pandemic
Shahida Din, Alexandra Kent, Richard C Pollok, Susanna Meade, Nicholas A Kennedy, Ian Arnott, R Mark Beattie, Felix Chua, Rachel Cooney, Robin J Dart, James Galloway, Daniel R Gaya, Subrata Ghosh, Mark Griffiths, Laura Hancock, Richard Hansen, Ailsa Hart, Christopher Andrew Lamb, Charlie W Lees, Jimmy K Limdi, James O Lindsay, Kamal Patel, Nick Powell, Charles D Murray, Chris Probert, Tim Raine, Christian Selinger, Shaji Sebastian, Philip J Smith, Phil Tozer, Andrew Ustianowski, Lisa Younge, Mark A Samaan, Peter M Irving
Jun 22, 2020
Objective: Management of acute severe UC (ASUC) during the novel COVID-19 pandemic presents significant dilemmas. We aimed to provide COVID-19-specific guidance using current British Society of Gastroenterology (BSG) guidelines...
British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic
Nicholas A Kennedy, Gareth-Rhys Jones, Christopher A Lamb, Richard Appleby, Ian Arnott, R Mark Beattie, Stuart Bloom, Alenka J Brooks, Rachel Cooney, Robin J Dart, Cathryn Edwards, Aileen Fraser, Daniel R Gaya, Subrata Ghosh, Kay Greveson, Richard Hansen, Ailsa Hart, A Barney Hawthorne, Bu'Hussain Hayee, Jimmy K Limdi, Charles D Murray, Gareth C Parkes, Miles Parkes, Kamal Patel, Richard C Pollok, Nick Powell, Chris S Probert, Tim Raine, Shaji Sebastian, Christian Selinger, Philip J Smith, Catherine Stansfield, Lisa Younge, James O Lindsay, Peter M Irving, Charlie W Lees
Apr 30, 2020
The COVID-19 pandemic is putting unprecedented pressures on healthcare systems globally. Early insights have been made possible by rapid sharing of data from China and Italy. In the UK, we have rapidly mobilised inflammatory...
Adaptations to the British Society of Gastroenterology guidelines on the management of acute severe UC in the context of the COVID-19 pandemic
Shahida Din, Alexandra Kent, Richard C Pollok, Susanna Meade, Nicholas A Kennedy, Ian Arnott, R Mark Beattie, Felix Chua, Rachel Cooney, Robin J Dart, James Galloway, Daniel R Gaya, Subrata Ghosh, Mark Griffiths, Laura Hancock, Richard Hansen, Ailsa Hart, Christopher Andrew Lamb, Charlie W Lees, Jimmy K Limdi, James O Lindsay, Kamal Patel, Nick Powell, Charles D Murray, Chris Probert, Tim Raine, Christian Selinger, Shaji Sebastian, Philip J Smith, Phil Tozer, Andrew Ustianowski, Lisa Younge, Mark A Samaan, Peter M Irving
Jun 08, 2020
Objective: Management of acute severe UC (ASUC) during the novel COVID-19 pandemic presents significant dilemmas. We aimed to provide COVID-19-specific guidance using current British Society of Gastroenterology (BSG) guidelines...
British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic.
Nicholas A Kennedy, Gareth-Rhys Jones, Christopher A Lamb, Richard Appleby, Ian Arnott, R Mark Beattie, Stuart Bloom, Alenka J Brooks, Rachel Cooney, Robin J Dart, Cathryn Edwards, Aileen Fraser, Daniel R Gaya, Subrata Ghosh, Kay Greveson, Richard Hansen, Ailsa Hart, A Barney Hawthorne, Bu'Hussain Hayee, Jimmy K Limdi, Charles D Murray, Gareth C Parkes, Miles Parkes, Kamal Patel, Richard C Pollok, Nick Powell, Chris S Probert, Tim Raine, Shaji Sebastian, Christian Selinger, Philip J Smith, Catherine Stansfield, Lisa Younge, James O Lindsay, Peter M Irving, Charlie W Lees
May 19, 2020
The COVID-19 pandemic is putting unprecedented pressures on healthcare systems globally. Early insights have been made possible by rapid sharing of data from China and Italy. In the UK, we have rapidly mobilised inflammatory...
Ulcerative colitis Crohn's Disease Crohn's Colitis Humans Pneumonia Viral Coronavirus Infections Inflammatory Bowel Diseases Immunosuppressive Agents Antiviral Agents Risk Assessment Pandemics United Kingdom Betacoronavirus
Published by: Gut
Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab.
Nicholas A Kennedy, James R Goodhand, Claire Bewshea, Rachel Nice, Desmond Chee, Simeng Lin, Neil Chanchlani, Jeffrey Butterworth, Rachel Cooney, Nicholas M Croft, Ailsa L Hart, Peter M Irving, Klaartje B Kok, Christopher A Lamb, Jimmy K Limdi, Jonathan Macdonald, Dermot PB McGovern, Shameer J Mehta, Charles D Murray, Kamal V Patel, Richard Cg Pollok, Timothy Raine, Richard K Russell, Christian P Selinger, Philip J Smith, Jack Bowden, Timothy J McDonald, Charlie W Lees, Shaji Sebastian, Nicholas Powell, Tariq Ahmad, Contributors to the CLARITY IBD study
Mar 23, 2021
OBJECTIVE: Antitumour necrosis factor (anti-TNF) drugs impair protective immunity following pneumococcal, influenza and viral hepatitis vaccination and increase the risk of serious respiratory infections. We sought to determine...
covid-19 Autoimmune Disease CLARITY inflammatory bowel disease inflammatory diseases Infliximab vedoluzimab Adult Antibodies Monoclonal Humanized Antibodies Viral Antibody Formation covid-19 Female Gastrointestinal Agents Humans Inflammatory Bowel Diseases Infliximab Male Middle Aged Prospective Studies SARS-CoV-2 Serologic Tests United Kingdom
First international workshop of the ATM and cancer risk group (4-5 December 2019).
Fabienne Lesueur, Douglas F Easton, Anne-Laure Renault, Sean V Tavtigian, Jonine L Bernstein, Zsofia Kote-Jarai, Rosalind A Eeles, Dijana Plaseska-Karanfia, Lidia Feliubadaló, Spanish ATM working group, Banu Arun, Natalie Herold, Beatrix Versmold, Rita Katharina Schmutzler, GC-HBOC, Tú Nguyen-Dumont, Melissa C Southey, Leila Dorling, Alison M Dunning, Paola Ghiorzo, Bruna Samia Dalmasso, Eve Cavaciuti, Dorothée Le Gal, Nicholas J Roberts, Mev Dominguez-Valentin, Matti Rookus, Alexander MR Taylor, Alisa M Goldstein, David E Goldgar, CARRIERS and Ambry Groups, Dominique Stoppa-Lyonnet, Nadine Andrieu
Apr 14, 2021
The first International Workshop of the ATM and Cancer Risk group focusing on the role of Ataxia-Telangiectasia Mutated (ATM) gene in cancer was held on December 4 and 5, 2019 at Institut Curie in Paris, France. It was motivated...
Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection
Oliver Stirrup, James Blackstone, Fiona Mapp, Alyson MacNeil, Monica Panca, Alison Holmes, Nicholas Machin, Gee Yen Shin, Tabitha Mahungu, Kordo Saeed, Tranprit Saluja, Yusri Taha, Nikunj Mahida, Cassie Pope, Anu Chawla, Maria-Teresa Cutino-Moguel, Asif Tamuri, Rachel Williams, Alistair Darby, David L Robertson, Flavia Flaviani, Eleni Nastouli, Samuel Robson, Darren Smith, Matthew Loose, Kenneth Laing, Irene Monahan, Beatrix Kele, Sam Haldenby, Ryan George, Matthew Bashton, Adam A Witney, Matthew Byott, Francesc Coll, Michael Chapman, Sharon J Peacock, COG-UK HOCI Investigators, COVID-19 Genomics UK (COG-UK) Consortium, Joseph Hughes, Gaia Nebbia, David G Partridge, Matthew Parker, James Richard Price, Christine Peters, Sunando Roy, Luke B Snell, Thushan I de Silva, Emma Thomson, Paul Flowers, Andrew Copas, Judith Breuer
Oct 25, 2022
covid-19 EPIDEMIOLOGY Global Health Healthcare-associated infection Hospital-acquired infection human infection control infection prevention infectious disease microbiology molecular epidemiology viral genomics Humans SARS-CoV-2 covid-19 Prospective Studies infection control Cross Infection Hospitals
Adaptations to the British Society of Gastroenterology guidelines on the management of acute severe UC in the context of the COVID-19 pandemic
Shahida Din, Alexandra Kent, Richard C Pollok, Susanna Meade, Nicholas A Kennedy, Ian Arnott, R Mark Beattie, Felix Chua, Rachel Cooney, Robin J Dart, James Galloway, Daniel R Gaya, Subrata Ghosh, Mark Griffiths, Laura Hancock, Richard Hansen, Ailsa Hart, Christopher Andrew Lamb, Charlie W Lees, Jimmy K Limdi, James O Lindsay, Kamal Patel, Nick Powell, Charles D Murray, Chris Probert, Tim Raine, Christian Selinger, Shaji Sebastian, Philip J Smith, Phil Tozer, Andrew Ustianowski, Lisa Younge, Mark A Samaan, Peter M Irving
Jun 29, 2020
OBJECTIVE: Management of acute severe UC (ASUC) during the novel COVID-19 pandemic presents significant dilemmas. We aimed to provide COVID-19-specific guidance using current British Society of Gastroenterology (BSG) guidelines...
Adaptations to the British Society of Gastroenterology guidelines on the management of acute severe UC in the context of the COVID-19 pandemic
Shahida Din, Alexandra Kent, Richard C Pollok, Susanna Meade, Nicholas A Kennedy, Ian Arnott, R Mark Beattie, Felix Chua, Rachel Cooney, Robin J Dart, James Galloway, Daniel R Gaya, Subrata Ghosh, Mark Griffiths, Laura Hancock, Richard Hansen, Ailsa Hart, Christopher Andrew Lamb, Charlie W Lees, Jimmy K Limdi, James O Lindsay, Kamal Patel, Nick Powell, Charles D Murray, Chris Probert, Tim Raine, Christian Selinger, Shaji Sebastian, Philip J Smith, Phil Tozer, Andrew Ustianowski, Lisa Younge, Mark A Samaan, Peter M Irving
Jun 10, 2020
Objective: Management of acute severe UC (ASUC) during the novel COVID-19 pandemic presents significant dilemmas. We aimed to provide COVID-19-specific guidance using current British Society of Gastroenterology (BSG) guidelines...
DrosoPhyla
Cédric Finet, Victoria A Kassner, Antonio B Carvalho, Henry Chung, Jonathan P Day, Stephanie Day, Emily K Delaney, Francine C De Ré, Héloïse D Dufour, Eduardo Dupim, Hiroyuki F Izumitani, Thaísa B Gautério, Jessa Justen, Toru Katoh, Artyom Kopp, Shigeyuki Koshikawa, Ben Longdon, Elgion L Loreto, Maria DS Nunes, Komal KB Raja, Mark Rebeiz, Michael G Ritchie, Gayane Saakyan, Tanya Sneddon, Machiko Teramoto, Venera Tyukmaeva, Thyago Vanderlinde, Emily E Wey, Thomas Werner, Thomas M Williams, Lizandra J Robe, Masanori J Toda, Ferdinand Marlétaz
Sep 08, 2021
The vinegar fly Drosophila melanogaster is a pivotal model for invertebrate development, genetics, physiology, neuroscience, and disease. The whole family Drosophilidae, which contains over 4,400 species, offers a plethora of...
CMV and Immunosenescence
Rafael Solana, Raquel Tarazona, Allison E Aiello, Arne N Akbar, Victor Appay, Mark Beswick, Jos A Bosch, Carmen Campos, Sara Cantisán, Luka Cicin-Sain, Evelyna Derhovanessian, Sara Ferrando-Martínez, Daniela Frasca, Tamas Fulöp, Sheila Govind, Beatrix Grubeck-Loebenstein, Ann Hill, Mikko Hurme, Florian Kern, Anis Larbi, Miguel López-Botet, Andrea B Maier, Janet E McElhaney, Paul Moss, Elissaveta Naumova, Janko Nikolich-Zugich, Alejandra Pera, Jerrald L Rector, Natalie Riddell, Beatriz Sanchez-Correa, Paolo Sansoni, Delphine Sauce, Rene van Lier, George C Wang, Mark R Wills, Maciej Zieliński, Graham Pawelec
Mar 01, 2013
SARS-CoV-2 lineage B.1.1.7 is associated with greater disease severity among hospitalised women but not men
Oliver Stirrup, Florencia Boshier, Cristina Venturini, José Afonso Guerra-Assunção, Adela Alcolea-Medina, Angela Beckett, Themoula Charalampous, Ana da Silva Filipe, Sharon Glaysher, Tabassum Khan, Raghavendran Kulasegaran Shylini, Beatrix Kele, Irene Monahan, Guy Mollett, Matthew Parker, Emanuela Pelosi, Paul Randell, Sunando Roy, Joshua Taylor, Sophie Weller, Eleri Wilson-Davies, Phillip Wade, Rachel Williams, COG-UK-HOCI Variant substudy consortium, COVID-19 Genomics UK (COG-UK) Consortium, Andrew Copas, Maria-Teresa Cutino-Moguel, Nick Freemantle, Andrew C Hayward, Alison Holmes, Joseph Hughes, Tabitha Mahungu, Gaia Nebbia, David Partridge, Cassie Pope, James Price, Samuel Robson, Kordo Saeed, Thushan de Silva, Luke Snell, Emma Thomson, Adam A Witney, Judith Breuer
Oct 21, 2021
The NeST (Neoadjuvant systemic therapy in breast cancer) study
I. Whitehead, G. W. Irwin, F. Bannon, C. E. Coles, E. Copson, R. I. Cutress, R. V. Dave, M. D. Gardiner, M. Grayson, C. Holcombe, S. Irshad, C. O’Brien, R. L. O’Connell, C. Palmieri, A. M. Shaaban, N. Sharma, J. K. Singh, S. Potter, S. A. McIntosh, Liz Clayton, Ellen Copson, Karina Cox, Tim Crook, Beatrix Elsberger, Ahmed Ghoneima, Sirwan Hadad, Anita Hargreaves, Paul Healy, Adam Heetun, Dan Henderson, Julia Henderson, Natalie Hirst, Fiona Hoar, Mike Hughes, Emma Iddles, Sheeba Irshad, Tracey Irvine, Stacey Jones, Sarantos Kaptanis, Emma MacInnes, Andrew McCanny, Linda McLaughlin, Anthony Neal, Rachel O’Connell, Neill Patani, Belinda Pearce, Mandana Pennick, Simon Pilgrim, Rene Roux, Matthew Rowland, Sunita Saha, Kavita Sharma, Jagdeep Singh, Chiara Sirianni, Brendan Skelly, Rachel Soulsby, Mark Tatterton, Rob Thomas, Medy Tsalic, Raghavan Vidya, Olivia Waker, Lisa Whisker, Ian Whitehead, Janet Woods
Jan 22, 2021
Abstract: Background: Neoadjuvant systemic therapy (NST) is increasingly used in the treatment of breast cancer, yet it is clear that there is significant geographical variation in its use in the UK. This study aimed to examine...
The Alpha variant was not associated with excess nosocomial SARS-CoV-2 infection in a multi-centre UK hospital study.
Florencia AT Boshier, Cristina Venturini, Oliver Stirrup, José Afonso Guerra-Assunção, Adela Alcolea-Medina, Angela H Becket, Matthew Byott, Themoula Charalampous, Ana Da Silva Filipe, Dan Frampton, Sharon Glaysher, Tabassum Khan, Raghavendran Kulasegara-Shylini, Beatrix Kele, Irene M Monahan, Guy Mollett, Matthew Parker, Emanuela Pelosi, Paul Randell, Sunando Roy, Joshua F Taylor, Sophie J Weller, Eleri Wilson-Davies, Phillip Wade, Rachel Williams, Andrew J Copas, Teresa Cutino-Moguel, Nick Freemantle, Andrew C Hayward, Alison Holmes, Joseph Hughes, Tabitha W Mahungu, Gaia Nebbia, Eleni Nastouli, David G Partridge, Cassie F Pope, James R Price, Samuel C Robson, Kordo Saeed, Gee Yen Shin, Thushan I de Silva, Luke B Snell, Emma C Thomson, Adam A Witney, Judith Breuer, The COVID-19 Genomics UK (COG-UK) consortium COG-UK HOCI Variant Substudy consortium*
Nov 01, 2021
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