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Results: 60
Drosophila astrocytes cover specific territories of the CNS neuropil and are instructed to differentiate by Prospero, a key effector of Notch.
Emilie Peco, Sejal Davla, Darius Camp, Stephanie M Stacey, Matthias Landgraf, Don J van Meyel
Apr 05, 2016
Astrocyte development Astroglial map Notch Pointed Prospero Animals Astrocytes Cell Lineage Central Nervous System DNA-Binding Proteins Drosophila Proteins Drosophila melanogaster Excitatory Amino Acid Transporter 1 Excitatory Amino Acid Transporter 2 Gene Expression Regulation Developmental Nerve Tissue Proteins Neurogenesis Neuroglia Neuropil Nuclear Proteins Proto-Oncogene Proteins RNA Interference RNA Small Interfering Receptors Notch Transcription Factors
Passive and iontophoretic transdermal delivery of phenobarbital
The objective of this investigation was to evaluate phenobarbital transdermal delivery for possible use in paediatric care. In vitro experiments were performed using intact pig skin and barriers from which the stratum corneum...
Passive and iontophoretic transdermal delivery of phenobarbital
The objective of this investigation was to evaluate phenobarbital transdermal delivery for possible use in paediatric care. In vitro experiments were performed using intact pig skin and barriers from which the stratum corneum...
Effects of iontophoresis, hydration, and permeation enhancers on human nail plate
Purpose:
To investigate whether permeation enhancement techniques affect the nail plate.
Methods:
Infrared and impedance spectroscopies examined the effects of hydration, iontophoresis and N-acetyl-L-cysteine...
To investigate whether permeation enhancement techniques affect the nail plate.
Methods:
Infrared and impedance spectroscopies examined the effects of hydration, iontophoresis and N-acetyl-L-cysteine...
Effects of iontophoresis, hydration, and permeation enhancers on human nail plate
Purpose:
To investigate whether permeation enhancement techniques affect the nail plate.
Methods:
Infrared and impedance spectroscopies examined the effects of hydration, iontophoresis and N-acetyl-L-cysteine...
To investigate whether permeation enhancement techniques affect the nail plate.
Methods:
Infrared and impedance spectroscopies examined the effects of hydration, iontophoresis and N-acetyl-L-cysteine...
Transdermal flux predictions for selected selective oestrogen receptor modulators (SERMs)
Sevgi Güngör, M. Begoña Delgado-Charro, Valérie Masini-Etévé, Russell O. Potts, Richard H. Guy
Dec 28, 2013
The aim of this work was to evaluate the feasibility of delivering transdermally a series of highly lipophilic compounds (log P ~ 4-7), comprising several selective oestrogen receptor modulators and a modified testosterone...
Oxidative Stress and Inflammatory Markers in Abdominal Aortic Aneurysm.
David Sánchez-Infantes, Meritxell Nus, Miquel Navas-Madroñal, Joan Fité, Belén Pérez, Antonio J Barros-Membrilla, Begoña Soto, José Martínez-González, Mercedes Camacho, Cristina Rodriguez, Ziad Mallat, María Galán
Apr 19, 2021
Abdominal aortic aneurysm (AAA) is increasing due to aging of the population and is a major cause of death among the elderly. Ultrasound screening programs are useful in early diagnosis, but aneurysm size is not always a good...
Transdermal flux predictions for selected selective oestrogen receptor modulators (SERMs)
Sevgi Güngör, M. Begoña Delgado-Charro, Valérie Masini-Etévé, Russell O. Potts, Richard H. Guy
Dec 28, 2013
The aim of this work was to evaluate the feasibility of delivering transdermally a series of highly lipophilic compounds (log P ~ 4-7), comprising several selective oestrogen receptor modulators and a modified testosterone...
L-Arginine Ameliorates Defective Autophagy in GM2 Gangliosidoses by mTOR Modulation
Beatriz Castejón-Vega, Alejandro Rubio, Antonio J. Pérez-Pulido, José L. Quiles, Jon D. Lane, Beatriz Fernández-Domínguez, María Begoña Cachón-González, Carmen Martín-Ruiz, Alberto Sanz, Timothy M. Cox, Elísabet Alcocer-Gómez, Mario D. Cordero
Nov 22, 2021
Aims: Tay–Sachs and Sandhoff diseases (GM2 gangliosidosis) are autosomal recessive disorders of lysosomal function that cause progressive neurodegeneration in infants and young children. Impaired hydrolysis catalysed by...
Skin Pharmacokinetics of Transdermal Scopolamine
Andrea Pensado, Laura Hattam, K. A.Jane White, Anita McGrogan, Annette L. Bunge, Richard H. Guy, M. Begoña Delgado-Charro
Jul 05, 2021
Prediction of skin absorption and local bioavailability from topical formulations remains a difficult task. An important challenge in forecasting topical bioavailability is the limited information available about local and...
DPK modeling scopolamine in vitro release test in vitro skin permeation skin pharmacokinetics topical drug bioavailability /dk/atira/pure/subjectarea/asjc/1300/1313 name=Molecular Medicine /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery
Iontophoresis of minoxidil sulphate loaded microparticles, a strategy for follicular drug targeting?
Guilherme M. Gelfuso, M. Angélica de Oliveira Barros, M. Begoña Delgado-Charro, Richard H. Guy, Renata F. V. Lopez
Oct 01, 2015
The feasibility of targeting drugs to hair follicles by a combination of microencapsulation and iontophoresis has been evaluated. Minoxidil sulphate (MXS), which is used in the treatment of alopecia, was selected as a...
Iontophoresis of minoxidil sulphate loaded microparticles, a strategy for follicular drug targeting?
Guilherme M. Gelfuso, M. Angélica de Oliveira Barros, M. Begoña Delgado-Charro, Richard H. Guy, Renata F. V. Lopez
Oct 01, 2015
The feasibility of targeting drugs to hair follicles by a combination of microencapsulation and iontophoresis has been evaluated. Minoxidil sulphate (MXS), which is used in the treatment of alopecia, was selected as a...
Oxidative Stress and Inflammatory Markers in Abdominal Aortic Aneurysm
David Sánchez-Infantes, Meritxell Nus, Miquel Navas-Madroñal, Joan Fité, Belén Pérez, Antonio J. Barros-Membrilla, Begoña Soto, José Martínez-González, Mercedes Camacho, Cristina Rodriguez, Ziad Mallat, María Galán
Apr 15, 2021
Abdominal aortic aneurysm (AAA) is increasing due to aging of the population and is a major cause of death among the elderly. Ultrasound screening programs are useful in early diagnosis, but aneurysm size is not always a good...
Decrease in Myelin-Associated Lipids Precedes Neuronal Loss and Glial Activation in the CNS of the Sandhoff Mouse as Determined by Metabolomics
Emmanuelle Lecommandeur, Maria Begoña Cachón-González, Susannah Boddie, Ben D. McNally, Andrew W. Nicholls, Timothy M. Cox, Julian L. Griffin
Dec 31, 2020
Sandhoff disease (SD) is a lysosomal disease caused by mutations in the gene coding for the β subunit of β-hexosaminidase, leading to deficiency in the enzymes β-hexosaminidase (HEX) A and B. SD is characterised by an...
Skin Pharmacokinetics of Transdermal Scopolamine
Andrea Pensado, Laura Hattam, K. A.Jane White, Anita McGrogan, Annette L. Bunge, Richard H. Guy, M. Begoña Delgado-Charro
Jul 05, 2021
Prediction of skin absorption and local bioavailability from topical formulations remains a difficult task. An important challenge in forecasting topical bioavailability is the limited information available about local and...
DPK modeling scopolamine in vitro release test in vitro skin permeation skin pharmacokinetics topical drug bioavailability /dk/atira/pure/subjectarea/asjc/1300/1313 name=Molecular Medicine /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery
Drug delivery into microneedle-porated nails from nanoparticle reservoirs
Wing Sin Chiu, Natalie A. Belsey, Natalie L. Garrett, Julian Moger, Gareth J. Price, M. Begoña Delgado-Charro, Richard H. Guy
Dec 28, 2015
This study demonstrates the potential of polymeric nanoparticles as drug reservoirs for sustained topical drug delivery into microneedle-treated human nail. Laser scanning confocal microscopy was used to image the delivery of...
Drug delivery into microneedle-porated nails from nanoparticle reservoirs
Wing Sin Chiu, Natalie A. Belsey, Natalie L. Garrett, Julian Moger, Gareth J. Price, M. Begoña Delgado-Charro, Richard H. Guy
Dec 28, 2015
This study demonstrates the potential of polymeric nanoparticles as drug reservoirs for sustained topical drug delivery into microneedle-treated human nail. Laser scanning confocal microscopy was used to image the delivery of...
Gene transfer corrects acute GM2 gangliosidosis--potential therapeutic contribution of perivascular enzyme flow.
M Begoña Cachón-González, Susan Z Wang, Rosamund McNair, Josephine Bradley, David Lunn, Robin Ziegler, Seng H Cheng, Timothy M Cox
Jun 03, 2019
A genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitis.
Raquel López-Mejías, F David Carmona, Santos Castañeda, Fernanda Genre, Sara Remuzgo-Martínez, Belén Sevilla-Perez, Norberto Ortego-Centeno, Javier Llorca, Begoña Ubilla, Verónica Mijares, Trinitario Pina, José A Miranda-Filloy, Antonio Navas Parejo, Diego de Argila, Maximiliano Aragües, Esteban Rubio, Manuel León Luque, Juan María Blanco-Madrigal, Eva Galíndez-Aguirregoikoa, David Jayne, Ricardo Blanco, Javier Martín, Miguel A González-Gay
Feb 24, 2020
The genetic component of Immunoglobulin-A (IgA) vasculitis is still far to be elucidated. To increase the current knowledge on the genetic component of this vasculitis we performed the first genome-wide association study (GWAS)...
L-Arginine Ameliorates Defective Autophagy in GM2 Gangliosidoses by mTOR Modulation.
Beatriz Castejón-Vega, Alejandro Rubio, Antonio J Pérez-Pulido, José L Quiles, Jon D Lane, Beatriz Fernández-Domínguez, María Begoña Cachón-González, Carmen Martín-Ruiz, Alberto Sanz, Timothy M Cox, Elísabet Alcocer-Gómez, Mario D Cordero
Jan 07, 2022
AIMS: Tay-Sachs and Sandhoff diseases (GM2 gangliosidosis) are autosomal recessive disorders of lysosomal function that cause progressive neurodegeneration in infants and young children. Impaired hydrolysis catalysed by...
GM2 gangliosidosis L-arginine Autophagy mTOR Arginine Autophagosomes Autophagy Cathepsins FIBROBLASTS Gangliosidoses GM2 Hexosaminidase A Hexosaminidase B Humans Lysosomes Mutation Permeability Proto-Oncogene Proteins c-akt Sandhoff Disease Signal Transduction TOR Serine-Threonine Kinases Tay-Sachs Disease Transcriptome
The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver
Natascha Hruschka, Mark Kalisz, Maria Subijana, Osvaldo Graña-Castro, Francisco Del Cano-Ochoa, Laia Paré Brunet, Igor Chernukhin, Ana Sagrera, Aurelien De Reynies, Bernhard Kloesch, Suet-Feung Chin, Octavio Burgués, David Andreu, Begoña Bermejo, Juan Miguel Cejalvo, Joe Sutton, Carlos Caldas, Santiago Ramón-Maiques, Jason S. Carroll, Aleix Prat, Francisco X. Real, Paola Martinelli
Feb 09, 2021
The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver.
Natascha Hruschka, Mark Kalisz, Maria Subijana, Osvaldo Graña-Castro, Francisco Del Cano-Ochoa, Laia Paré Brunet, Igor Chernukhin, Ana Sagrera, Aurelien De Reynies, Bernhard Kloesch, Suet-Feung Chin, Octavio Burgués, David Andreu, Begoña Bermejo, Juan Miguel Cejalvo, Joe Sutton, Carlos Caldas, Santiago Ramón-Maiques, Jason S Carroll, Aleix Prat, Francisco X Real, Paola Martinelli
Sep 15, 2020
As the catalog of oncogenic driver mutations is expanding, it becomes clear that alterations in a given gene might have different functions and should not be lumped into one class. The transcription factor GATA3 is a paradigm of...
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