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Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells.
Nick Powell, Eirini Pantazi, Polychronis Pavlidis, Anastasia Tsakmaki, Katherine Li, Feifei Yang, Aimee Parker, Carmen Pin, Domenico Cozzetto, Danielle Minns, Emilie Stolarczyk, Svetlana Saveljeva, Rami Mohamed, Paul Lavender, Behdad Afzali, Jonathan Digby-Bell, Tsui Tjir-Li, Arthur Kaser, Joshua Friedman, Thomas T MacDonald, Gavin A Bewick, Graham M Lord
Dec 17, 2019
OBJECTIVE: The functional role of interleukin-22 (IL22) in chronic inflammation is controversial, and mechanistic insights into how it regulates target tissue are lacking. In this study, we evaluated the functional role of IL22...
ER stress Interleukin 22 inflammatory bowel disease Animals Anti-Bacterial Agents Apoptosis Cell Survival Chronic Disease Colitis Colon Crohn Disease Disease Models Animal Endoplasmic reticulum stress Epithelial Cells Gastrointestinal Agents Humans Interleukin-17 Interleukin-23 Interleukins Intestinal Mucosa Mice Organoids Patient acuity Phenylbutyrates Recombinant Proteins Transcription Genetic Tunicamycin Unfolded Protein Response Ustekinumab
BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.
Behdad Afzali, Juha Grönholm, Jana Vandrovcova, Charlotte O'Brien, Hong-Wei Sun, Ine Vanderleyden, Fred P Davis, Ahmad Khoder, Yu Zhang, Ahmed N Hegazy, Alejandro V Villarino, Ira W Palmer, Joshua Kaufman, Norman R Watts, Majid Kazemian, Olena Kamenyeva, Julia Keith, Anwar Sayed, Dalia Kasperaviciute, Michael Mueller, Jason D Hughes, Ivan J Fuss, Mohammed F Sadiyah, Kim Montgomery-Recht, Joshua McElwee, Nicholas P Restifo, Warren Strober, Michelle A Linterman, Paul T Wingfield, Holm H Uhlig, Rahul Roychoudhuri, Timothy J Aitman, Peter Kelleher, Michael J Lenardo, John J O'Shea, Nichola Cooper, Arian DJ Laurence
Jun 24, 2019
The transcriptional programs that guide lymphocyte differentiation depend on the precise expression and timing of transcription factors (TFs). The TF BACH2 is essential for T and B lymphocytes and is associated with an...
Adrenal Cortex Hormones Adult Autoimmune Diseases Basic-Leucine Zipper Transcription Factors Colitis Female Fever Haploinsufficiency Heterozygote Humans Immunologic Deficiency Syndromes Lymphopenia Male Middle Aged Mutation Pancytopenia Pedigree Polymorphism Single Nucleotide Recurrence Respiratory Tract Infections Splenomegaly Syndrome Tomography X-Ray Computed Young Adult
A Hierarchical Taxonomy of Psychopathology Can Transform Mental Health Research.
Christopher C Conway, Miriam K Forbes, Kelsie T Forbush, Eiko I Fried, Michael N Hallquist, Roman Kotov, Stephanie N Mullins-Sweatt, Alexander J Shackman, Andrew E Skodol, Susan C South, Matthew Sunderland, Monika A Waszczuk, David H Zald, Mohammad H Afzali, Marina A Bornovalova, Natacha Carragher, Anna R Docherty, Katherine G Jonas, Robert F Krueger, Praveetha Patalay, Aaron L Pincus, Jennifer L Tackett, Ulrich Reininghaus, Irwin D Waldman, Aidan GC Wright, Johannes Zimmermann, Bo Bach, R Michael Bagby, Michael Chmielewski, David C Cicero, Lee Anna Clark, Tim Dalgleish, Colin G DeYoung, Christopher J Hopwood, Masha Y Ivanova, Robert D Latzman, Christopher J Patrick, Camilo J Ruggero, Douglas B Samuel, David Watson, Nicholas R Eaton
Mar 25, 2019
For more than a century, research on psychopathology has focused on categorical diagnoses. Although this work has produced major discoveries, growing evidence points to the superiority of a dimensional approach to the science of...