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Results: 36
Height, body mass index and prostate cancer risk and mortality by way of detection and cancer risk category.
Sylvia HJ Jochems, Pär Stattin, Christel Häggström, Bengt Järvholm, Marju Orho-Melander, Angela M Wood, Tanja Stocks
Oct 07, 2020
Obesity is a risk factor for advanced, but not localised, prostate cancer (PCa), and for poor prognosis. However, the detection of localised PCa through asymptomatic screening might influence these associations. We investigated...
Association between blood pressure and BMI with bladder cancer risk and mortality in 340,000 men in three Swedish cohorts.
Stanley Teleka, Sylvia HJ Jochems, Christel Häggström, Angela M Wood, Bengt Järvholm, Marju Orho-Melander, Fredrik Liedberg, Tanja Stocks
Mar 09, 2021
BACKGROUND: The relation between obesity, blood pressure (BP) and bladder cancer (BC) risk and mortality remains unclear, partially due to potential confounding by smoking, the strongest risk factor for BC, and not accounting...
Enhanced variable reluctance energy harvesting for self-powered monitoring
Ying Zhang, Wei Wang, Junxiao Xie, Yaguo Lei, Junyi Cao, Ye Xu, Sebastian Bader, Chris Bowen, Bengt Oelmann
Sep 01, 2022
With the rapid development of microelectronic technology, wireless sensor nodes have been widely used in rotational equipment for health condition monitoring. However, for many low-frequency applications, there still remains...
Condition monitoring Energy harvesting Low-frequency rotation Variable reluctance /dk/atira/pure/subjectarea/asjc/2200/2215 name=Building and Construction /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering /dk/atira/pure/subjectarea/asjc/2100/2100 name=General Energy /dk/atira/pure/subjectarea/asjc/2300/2308 name=Management, Monitoring, Policy and Law
Enhanced variable reluctance energy harvesting for self-powered monitoring
Ying Zhang, Wei Wang, Junxiao Xie, Yaguo Lei, Junyi Cao, Ye Xu, Sebastian Bader, Chris Bowen, Bengt Oelmann
Sep 01, 2022
With the rapid development of microelectronic technology, wireless sensor nodes have been widely used in rotational equipment for health condition monitoring. However, for many low-frequency applications, there still remains...
Condition monitoring Energy harvesting Low-frequency rotation Variable reluctance /dk/atira/pure/subjectarea/asjc/2200/2215 name=Building and Construction /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering /dk/atira/pure/subjectarea/asjc/2100/2100 name=General Energy /dk/atira/pure/subjectarea/asjc/2300/2308 name=Management, Monitoring, Policy and Law
Neoadjuvant Chemoradiotherapy and Surgery for Esophageal Squamous Cell Carcinoma Versus Definitive Chemoradiotherapy With Salvage Surgery as Needed
Magnus Nilsson, Halla Olafsdottir, Gabriella Alexandersson von Döbeln, Fernanda Villegas, Giovanna Gagliardi, Mats Hellström, Qiao-Li Wang, Hemming Johansson, Val Gebski, Jakob Hedberg, Fredrik Klevebro, Sheraz Markar, Elizabeth Smyth, Pernilla Lagergren, Ghazwan Al-Haidari, Lars Cato Rekstad, Eirik Kjus Aahlin, Bengt Wallner, David Edholm, Jan Johansson, Eva Szabo, John V Reynolds, CS Pramesh, Naveen Mummudi, Amit Joshi, Lorenzo Ferri, Rebecca Ks Wong, Chris O'Callaghan, Jelena Lukovic, Kelvin Kw Chan, Trevor Leong, Andrew Barbour, Mark Smithers, Yin Li, Xiaozheng Kang, Feng-Ming Kong, Yin-Kai Chao, Tom Crosby, Christiane Bruns, Hanneke van Laarhoven, Mark van Berge Henegouwen, Richard van Hillegersberg, Riccardo Rosati, Guillaume Piessen, Giovanni de Manzoni, Florian Lordick
Jul 27, 2022
BACKGROUND: The globally dominant treatment with curative intent for locally advanced esophageal squamous cell carcinoma (ESCC) is neoadjuvant chemoradiotherapy (nCRT) with subsequent esophagectomy. This multimodal treatment...
Microbial regulation of the L cell transcriptome.
Tulika Arora, Rozita Akrami, Ramona Pais, Linda Bergqvist, Bengt R Johansson, Thue W Schwartz, Frank Reimann, Fiona M Gribble, Fredrik Bäckhed
Apr 26, 2018
L cells are an important class of enteroendocrine cells secreting hormones such as glucagon like peptide-1 and peptide YY that have several metabolic and physiological effects. The gut is home to trillions of bacteria affecting...
Transient misfolding dominates multidomain protein folding.
Alessandro Borgia, Katherine R Kemplen, Madeleine B Borgia, Andrea Soranno, Sarah Shammas, Bengt Wunderlich, Daniel Nettels, Robert B Best, Jane Clarke, Benjamin Schuler
Oct 13, 2015
The association of electronic health literacy with behavioural and psychological coronary artery disease risk factors in patients after percutaneous coronary intervention
Gunhild Brørs, Håvard Dalen, Heather Allore, Christi Deaton, Bengt Fridlund, Cameron D Norman, Pernille Palm, Tore Wentzel-Larsen, Tone M Norekvål
Apr 17, 2023
AIMS: Fundamental roadblocks, such as non-use and low electronic health (eHealth) literacy, prevent the implementation of eHealth resources. The aims were to study internet usage for health information and eHealth literacy in...
Mobile PEAR transcription factors integrate positional cues to prime cambial growth.
Shunsuke Miyashima, Pawel Roszak, Iris Sevilem, Koichi Toyokura, Bernhard Blob, Jung-Ok Heo, Nathan Mellor, Hanna Help-Rinta-Rahko, Sofia Otero, Wouter Smet, Mark Boekschoten, Guido Hooiveld, Kayo Hashimoto, Ondřej Smetana, Riccardo Siligato, Eva-Sophie Wallner, Ari Pekka Mähönen, Yuki Kondo, Charles W Melnyk, Thomas Greb, Keiji Nakajima, Rosangela Sozzani, Anthony Bishopp, Bert De Rybel, Ykä Helariutta
Feb 06, 2019
Single-cell transcriptional and functional analysis of dopaminergic neurons in organoid-like cultures derived from human fetal midbrain.
Marcella Birtele, Petter Storm, Yogita Sharma, Janko Kajtez, Jenny Nelander Wahlestedt, Edoardo Sozzi, Fredrik Nilsson, Simon Stott, Xiaoling L He, Bengt Mattsson, Daniella Rylander Ottosson, Roger A Barker, Alessandro Fiorenzano, Malin Parmar
Dec 12, 2022
Conservation of vaccine antigen sequences encoded by sequenced strains of Streptococcus equi subsp. equi.
Sara Frosth, Ellen Ruth A Morris, Hayley Wilson, Lars Frykberg, Karin Jacobsson, Julian Parkhill, Jan-Ingmar Flock, Tim Wood, Bengt Guss, David M Aanensen, Ashley G Boyle, Miia Riihimäki, Noah D Cohen, Andrew S Waller
Jan 28, 2022
Towards a cancer mission in Horizon Europe
Anton Berns, Ulrik Ringborg, Julio E Celis, Manuel Heitor, Neil K Aaronson, Nancy Abou-Zeid, Hans-Olov Adami, Kathi Apostolidis, Michael Baumann, Alberto Bardelli, René Bernards, Yvonne Brandberg, Carlos Caldas, Fabien Calvo, Caroline Dive, Angelika Eggert, Alexander Eggermont, Carolina Espina, Frederik Falkenburg, Jérôme Foucaud, Douglas Hanahan, Ulrike Helbig, Bengt Jönsson, Mette Kalager, Sakari Karjalainen, Miklós Kásler, Pamela Kearns, Klas Kärre, Denis Lacombe, Francesco de Lorenzo, Françoise Meunier, Gerd Nettekoven, Simon Oberst, Péter Nagy, Thierry Philip, Richard Price, Joachim Schüz, Eric Solary, Peter Strang, Josep Tabernero, Emile Voest
Sep 04, 2020
A comprehensive translational cancer research approach focused on personalized and precision medicine, and covering the entire cancer research-care-prevention continuum has the potential to achieve in 2030 a 10-year...
European healthcare systems cancer mission cancer research/care/prevention continuum comprehensive cancer centres patient empowerment Science policy Cancer Survivors Clinical Trials as Topic Europe Humans Neoplasms Organizational Innovation Palliative Care Patient Participation specialization Translational Research Biomedical
The ARCA Registry
Andreas Traschütz, Selina Reich, Astrid D. Adarmes, Mathieu Anheim, Mahmoud Reza Ashrafi, Jonathan Baets, A. Nazli Basak, Enrico Bertini, Bernard Brais, Cynthia Gagnon, Janina Gburek-Augustat, Hasmet A. Hanagasi, Anna Heinzmann, Rita Horvath, Peter De Jonghe, Christoph Kamm, Peter Klivenyi, Thomas Klopstock, Martina Minnerop, Alexander Münchau, Mathilde Renaud, Richard H. Roxburgh, Filippo M. Santorelli, Tommaso Schirinzi, Deborah A. Sival, Dagmar Timmann, Stefan Vielhaber, Michael Wallner, Bart P. van de Warrenburg, Ginevra Zanni, Stephan Zuchner, Thomas Klockgether, Rebecca Schüle, Ludger Schöls, PREPARE Consortium, Matthis Synofzik
Jul 28, 2021
Autosomal recessive cerebellar ataxias (ARCAs) form an ultrarare yet expanding group of neurodegenerative multisystemic diseases affecting the cerebellum and other neurological or non-neurological systems. With the advent of...
Adaptive responses of animals to climate change are most likely insufficient.
Viktoriia Radchuk, Thomas Reed, Céline Teplitsky, Martijn van de Pol, Anne Charmantier, Christopher Hassall, Peter Adamík, Frank Adriaensen, Markus P Ahola, Peter Arcese, Jesús Miguel Avilés, Javier Balbontin, Karl S Berg, Antoni Borras, Sarah Burthe, Jean Clobert, Nina Dehnhard, Florentino de Lope, André A Dhondt, Niels J Dingemanse, Hideyuki Doi, Tapio Eeva, Joerns Fickel, Iolanda Filella, Frode Fossøy, Anne E Goodenough, Stephen JG Hall, Bengt Hansson, Michael Harris, Dennis Hasselquist, Thomas Hickler, Jasmin Joshi, Heather Kharouba, Juan Gabriel Martínez, Jean-Baptiste Mihoub, James A Mills, Mercedes Molina-Morales, Arne Moksnes, Arpat Ozgul, Deseada Parejo, Philippe Pilard, Maud Poisbleau, Francois Rousset, Mark-Oliver Rödel, David Scott, Juan Carlos Senar, Constanti Stefanescu, Bård G Stokke, Tamotsu Kusano, Maja Tarka, Corey E Tarwater, Kirsten Thonicke, Jack Thorley, Andreas Wilting, Piotr Tryjanowski, Juha Merilä, Ben C Sheldon, Anders Pape Møller, Erik Matthysen, Fredric Janzen, F Stephen Dobson, Marcel E Visser, Steven R Beissinger, Alexandre Courtiol, Stephanie Kramer-Schadt
Feb 12, 2020
Biological responses to climate change have been widely documented across taxa and regions, but it remains unclear whether species are maintaining a good match between phenotype and environment, i.e. whether observed trait...
Globetrotting strangles
Catriona Mitchell, Karen F Steward, Amelia RL Charbonneau, Saoirse Walsh, Hayley Wilson, John F Timoney, Ulli Wernery, Marina Joseph, David Craig, Kees van Maanen, Annelies Hoogkamer-van Gennep, Albertine Leon, Lucjan Witkowski, Magdalena Rzewuska, Ilona Stefańska, Monika Żychska, Gunther van Loon, Ray Cursons, Olivia Patty, Els Acke, James R Gilkerson, Charles El-Hage, Joanne Allen, Hiroshi Bannai, Yuta Kinoshita, Hidekazu Niwa, Teótimo Becú, John Pringle, Bengt Guss, Reinhard Böse, Yvonne Abbott, Lisa Katz, Bernadette Leggett, Tom C Buckley, Shlomo E Blum, Fátima Cruz López, Ana Fernández Ros, Maria Cristina Marotti Campi, Silvia Preziuso, Carl Robinson, J Richard Newton, Ellen Schofield, Ben Brooke, Mike Boursnell, Nicolas de Brauwere, Roxane Kirton, Charlotte K Barton, Khalil Abudahab, Ben Taylor, Corin A Yeats, Richard Goater, David M Aanensen, Simon R Harris, Julian Parkhill, Matthew TG Holden, Andrew S Waller
May 07, 2021
The equine disease strangles, which is characterized by the formation of abscesses in the lymph nodes of the head and neck, is one of the most frequently diagnosed infectious diseases of horses around the world. The causal...
Adaptive responses of animals to climate change are most likely insufficient
Viktoriia Radchuk, Thomas Reed, Céline Teplitsky, Martijn van de Pol, Anne Charmantier, Christopher Hassall, Peter Adamík, Frank Adriaensen, Markus P. Ahola, Peter Arcese, Jesús Miguel Avilés, Javier Balbontin, Karl S. Berg, Antoni Borras, Sarah Burthe, Jean Clobert, Nina Dehnhard, Florentino de Lope, André A. Dhondt, Niels J. Dingemanse, Hideyuki Doi, Tapio Eeva, Joerns Fickel, Iolanda Filella, Frode Fossøy, Anne E. Goodenough, Stephen J. G. Hall, Bengt Hansson, Michael Harris, Dennis Hasselquist, Thomas Hickler, Jasmin Joshi, Heather Kharouba, Juan Gabriel Martínez, Jean-Baptiste Mihoub, James A. Mills, Mercedes Molina-Morales, Arne Moksnes, Arpat Ozgul, Deseada Parejo, Philippe Pilard, Maud Poisbleau, Francois Rousset, Mark-Oliver Rödel, David Scott, Juan Carlos Senar, Constanti Stefanescu, Bård G. Stokke, Tamotsu Kusano, Maja Tarka, Corey E. Tarwater, Kirsten Thonicke, Jack Thorley, Andreas Wilting, Piotr Tryjanowski, Juha Merilä, Ben C. Sheldon, Anders Pape Møller, Erik Matthysen, Fredric Janzen, F. Stephen Dobson, Marcel E. Visser, Steven R. Beissinger, Alexandre Courtiol, Stephanie Kramer-Schadt
Jul 22, 2020
Abstract: Biological responses to climate change have been widely documented across taxa and regions, but it remains unclear whether species are maintaining a good match between phenotype and environment, i.e. whether observed...
Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis.
Hao Yu Chen, Benjamin J Cairns, Aeron M Small, Hannah A Burr, Athithan Ambikkumar, Andreas Martinsson, Sébastien Thériault, Hans Markus Munter, Brian Steffen, Richard Zhang, Rebecca T Levinson, Christian M Shaffer, Jian Rong, Emily Sonestedt, Line Dufresne, Johan Ljungberg, Ulf Näslund, Bengt Johansson, Dilrini K Ranatunga, Rachel A Whitmer, Matthew J Budoff, Albert Nguyen, Ramachandran S Vasan, Martin G Larson, William S Harris, Scott M Damrauer, Ken D Stark, S Matthijs Boekholdt, Nicholas J Wareham, Philippe Pibarot, Benoit J Arsenault, Patrick Mathieu, Vilmundur Gudnason, Christopher J O'Donnell, Jerome I Rotter, Michael Y Tsai, Wendy S Post, Robert Clarke, Stefan Söderberg, Yohan Bossé, Quinn S Wells, J Gustav Smith, Daniel J Rader, Mark Lathrop, James C Engert, George Thanassoulis
Mar 31, 2020
IMPORTANCE: Aortic stenosis (AS) has no approved medical treatment. Identifying etiological pathways for AS could identify pharmacological targets. OBJECTIVE: To identify novel genetic loci and pathways associated with AS....
The ARCA Registry
Andreas Traschütz, Selina Reich, Astrid D Adarmes, Mathieu Anheim, Mahmoud Reza Ashrafi, Jonathan Baets, A Nazli Basak, Enrico Bertini, Bernard Brais, Cynthia Gagnon, Janina Gburek-Augustat, Hasmet A Hanagasi, Anna Heinzmann, Rita Horvath, Peter De Jonghe, Christoph Kamm, Peter Klivenyi, Thomas Klopstock, Martina Minnerop, Alexander Münchau, Mathilde Renaud, Richard H Roxburgh, Filippo M Santorelli, Tommaso Schirinzi, Deborah A Sival, Dagmar Timmann, Stefan Vielhaber, Michael Wallner, Bart P van de Warrenburg, Ginevra Zanni, Stephan Zuchner, Thomas Klockgether, Rebecca Schüle, Ludger Schöls, PREPARE Consortium, Matthis Synofzik
Aug 17, 2021
Autosomal recessive cerebellar ataxias (ARCAs) form an ultrarare yet expanding group of neurodegenerative multisystemic diseases affecting the cerebellum and other neurological or non-neurological systems. With the advent of...
Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation.
Rona J Strawbridge, Angela Silveira, Marcel den Hoed, Stefan Gustafsson, Jian'an Luan, Denis Rybin, Josée Dupuis, Ruifang Li-Gao, Maryam Kavousi, Abbas Dehghan, Kadri Haljas, Jari Lahti, Jesper R Gådin, Alexandra Bäcklund, Ulf de Faire, Karl Gertow, Phillipe Giral, Anuj Goel, Steve E Humphries, Sudhir Kurl, Claudia Langenberg, Lars L Lannfelt, Lars Lind, Cecilia CM Lindgren, Elmo Mannarino, Dennis O Mook-Kanamori, Andrew P Morris, Renée de Mutsert, Rainer Rauramaa, Peter Saliba-Gustafsson, Bengt Sennblad, Andries J Smit, Ann-Christine Syvänen, Elena Tremoli, Fabrizio Veglia, Björn Zethelius, Hanna M Björck, Johan G Eriksson, Albert Hofman, Oscar H Franco, Hugh Watkins, J Wouter Jukema, Jose C Florez, Nicholas J Wareham, James B Meigs, Erik Ingelsson, Damiano Baldassarre, Anders Hamsten, IMPROVE study group
Feb 02, 2018
BACKGROUND AND AIMS: Increased proinsulin relative to insulin levels have been associated with subclinical atherosclerosis (measured by carotid intima-media thickness (cIMT)) and are predictive of future cardiovascular disease...
Atherosclerosis Genetic variants Intima-media-thickness Mendelian randomisation Proinsulin SINGLE NUCLEOTIDE POLYMORPHISMS Asymptomatic Diseases Carotid Artery Diseases Carotid Intima-Media Thickness Chromosomes Human Pair 15 Europe Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Humans Linear Models Male Mendelian Randomization Analysis Phenotype Polymorphism Single Nucleotide Proinsulin Quantitative Trait Loci Risk Factors Vascular Remodeling
Critical assessment of protein intrinsic disorder prediction
Marco Necci, Damiano Piovesan, Silvio C. E. Tosatto, Md Tamjidul Hoque, Ian Walsh, Sumaiya Iqbal, Michele Vendruscolo, Pietro Sormanni, Chen Wang, Daniele Raimondi, Ronesh Sharma, Yaoqi Zhou, Thomas Litfin, Oxana Valerianovna Galzitskaya, Michail Yu. Lobanov, Wim Vranken, Björn Wallner, Claudio Mirabello, Nawar Malhis, Zsuzsanna Dosztányi, Gábor Erdős, Bálint Mészáros, Jianzhao Gao, Kui Wang, Gang Hu, Zhonghua Wu, Alok Sharma, Jack Hanson, Kuldip Paliwal, Isabelle Callebaut, Tristan Bitard-Feildel, Gabriele Orlando, Zhenling Peng, Jinbo Xu, Sheng Wang, David T. Jones, Domenico Cozzetto, Fanchi Meng, Jing Yan, Jörg Gsponer, Jianlin Cheng, Tianqi Wu, Lukasz Kurgan, Vasilis J. Promponas, Stella Tamana, Cristina Marino-Buslje, Elizabeth Martínez-Pérez, Anastasia Chasapi, Christos Ouzounis, A. Keith Dunker, Andrey V. Kajava, Jeremy Y. Leclercq, Burcu Aykac-Fas, Matteo Lambrughi, Emiliano Maiani, Elena Papaleo, Lucia Beatriz Chemes, Lucía Álvarez, Nicolás S. González-Foutel, Valentin Iglesias, Jordi Pujols, Salvador Ventura, Nicolás Palopoli, Guillermo Ignacio Benítez, Gustavo Parisi, Claudio Bassot, Arne Elofsson, Sudha Govindarajan, John Lamb, Marco Salvatore, András Hatos, Alexander Miguel Monzon, Martina Bevilacqua, Ivan Mičetić, Giovanni Minervini, Lisanna Paladin, Federica Quaglia, Emanuela Leonardi, Norman Davey, Tamas Horvath, Orsolya Panna Kovacs, Nikoletta Murvai, Rita Pancsa, Eva Schad, Beata Szabo, Agnes Tantos, Sandra Macedo-Ribeiro, Jose Antonio Manso, Pedro José Barbosa Pereira, Radoslav Davidović, Nevena Veljkovic, Borbála Hajdu-Soltész, Mátyás Pajkos, Tamás Szaniszló, Mainak Guharoy, Tamas Lazar, Mauricio Macossay-Castillo, Peter Tompa
May 08, 2021
Abstract: Intrinsically disordered proteins, defying the traditional protein structure–function paradigm, are a challenge to study experimentally. Because a large part of our knowledge rests on computational predictions, it is...
Cardiovascular Risk Factors Associated With Venous Thromboembolism.
John Gregson, Stephen Kaptoge, Thomas Bolton, Lisa Pennells, Peter Willeit, Stephen Burgess, Steven Bell, Michael Sweeting, Eric B Rimm, Christopher Kabrhel, Bengt Zöller, Gerd Assmann, Vilmundur Gudnason, Aaron R Folsom, Volker Arndt, Astrid Fletcher, Paul E Norman, Børge G Nordestgaard, Akihiko Kitamura, Bakhtawar K Mahmoodi, Peter H Whincup, Matthew Knuiman, Veikko Salomaa, Christa Meisinger, Wolfgang Koenig, Maryam Kavousi, Henry Völzke, Jackie A Cooper, Toshiharu Ninomiya, Edoardo Casiglia, Beatriz Rodriguez, Yoav Ben-Shlomo, Jean-Pierre Després, Leon Simons, Elizabeth Barrett-Connor, Cecilia Björkelund, Marlene Notdurfter, Daan Kromhout, Jackie Price, Susan E Sutherland, Johan Sundström, Jussi Kauhanen, John Gallacher, Joline WJ Beulens, Rachel Dankner, Cyrus Cooper, Simona Giampaoli, Jason F Deen, Agustín Gómez de la Cámara, Lewis H Kuller, Annika Rosengren, Peter J Svensson, Dorothea Nagel, Carlos J Crespo, Hermann Brenner, Juan R Albertorio-Diaz, Robert Atkins, Eric J Brunner, Martin Shipley, Inger Njølstad, Deborah A Lawlor, Yvonne T van der Schouw, Randi Marie Selmer, Maurizio Trevisan, WM Monique Verschuren, Philip Greenland, Sylvia Wassertheil-Smoller, Gordon DO Lowe, Angela M Wood, Adam S Butterworth, Simon G Thompson, John Danesh, Emanuele Di Angelantonio, Tom Meade, Emerging Risk Factors Collaboration
Feb 11, 2019
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
Rona J Strawbridge, Josée Dupuis, Inga Prokopenko, Adam Barker, Emma Ahlqvist, Denis Rybin, John R Petrie, Mary E Travers, Nabila Bouatia-Naji, Antigone S Dimas, Alexandra Nica, Eleanor Wheeler, Han Chen, Benjamin F Voight, Jalal Taneera, Stavroula Kanoni, John F Peden, Fabiola Turrini, Stefan Gustafsson, Carina Zabena, Peter Almgren, David JP Barker, Daniel Barnes, Elaine M Dennison, Johan G Eriksson, Per Eriksson, Elodie Eury, Lasse Folkersen, Caroline S Fox, Timothy M Frayling, Anuj Goel, Harvest F Gu, Momoko Horikoshi, Bo Isomaa, Anne U Jackson, Karen A Jameson, Eero Kajantie, Julie Kerr-Conte, Teemu Kuulasmaa, Johanna Kuusisto, Ruth JF Loos, Jian'an Luan, Konstantinos Makrilakis, Alisa K Manning, María Teresa Martínez-Larrad, Narisu Narisu, Maria Nastase Mannila, John Ohrvik, Clive Osmond, Laura Pascoe, Felicity Payne, Avan A Sayer, Bengt Sennblad, Angela Silveira, Alena Stancáková, Kathy Stirrups, Amy J Swift, Ann-Christine Syvänen, Tiinamaija Tuomi, Ferdinand M van 't Hooft, Mark Walker, Michael N Weedon, Weijia Xie, Björn Zethelius, DIAGRAM Consortium, GIANT Consortium, MuTHER Consortium, CARDIoGRAM consortium, C4D Consortium, Halit Ongen, Anders Mälarstig, Jemma C Hopewell, Danish Saleheen, John Chambers, Sarah Parish, John Danesh, Jaspal Kooner, Claes-Göran Ostenson, Lars Lind, Cyrus C Cooper, Manuel Serrano-Ríos, Ele Ferrannini, Tom J Forsen, Robert Clarke, Maria Grazia Franzosi, Udo Seedorf, Hugh Watkins, Philippe Froguel, Paul Johnson, Panos Deloukas, Francis S Collins, Markku Laakso, Emmanouil T Dermitzakis, Michael Boehnke, Mark I McCarthy, Nicholas J Wareham, Leif Groop, François Pattou, Anna L Gloyn, George V Dedoussis, Valeriya Lyssenko, James B Meigs, Inês Barroso, Richard M Watanabe, Erik Ingelsson, Claudia Langenberg, Anders Hamsten, Jose C Florez
May 09, 2018
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D)....
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight
Daniel I Swerdlow, David Preiss, Karoline B Kuchenbaecker, Michael V Holmes, Jorgen EL Engmann, Tina Shah, Reecha Sofat, Stefan Stender, Paul CD Johnson, Robert A Scott, Maarten Leusink, Niek Verweij, Stephen J Sharp, Yiran Guo, Claudia Giambartolomei, Christina Chung, Anne Peasey, Antoinette Amuzu, KaWah Li, Jutta Palmen, Philip Howard, Jackie A Cooper, Fotios Drenos, Yun R Li, Gordon Lowe, John Gallacher, Marlene CW Stewart, Ioanna Tzoulaki, Sarah G Buxbaum, Daphne L van der A, Nita G Forouhi, N Charlotte Onland-Moret, Yvonne T van der Schouw, Renate B Schnabel, Jaroslav A Hubacek, Ruzena Kubinova, Migle Baceviciene, Abdonas Tamosiunas, Andrzej Pajak, Roman Topor-Madry, Urszula Stepaniak, Sofia Malyutina, Damiano Baldassarre, Bengt Sennblad, Elena Tremoli, Ulf de Faire, Fabrizio Veglia, Ian Ford, J Wouter Jukema, Rudi GJ Westendorp, Gert Jan de Borst, Pim A de Jong, Ale Algra, Wilko Spiering, Anke H Maitland-van der Zee, Olaf H Klungel, Anthonius de Boer, Pieter A Doevendans, Charles B Eaton, Jennifer G Robinson, David Duggan, DIAGRAM Consortium, MAGIC Consortium, InterAct Consortium, John Kjekshus, John R Downs, Antonio M Gotto, Anthony C Keech, Roberto Marchioli, Gianni Tognoni, Peter S Sever, Neil R Poulter, David D Waters, Terje R Pedersen, Pierre Amarenco, Haruo Nakamura, John JV McMurray, James D Lewsey, Daniel I Chasman, Paul M Ridker, Aldo P Maggioni, Luigi Tavazzi, Kausik K Ray, Sreenivasa Rao Kondapally Seshasai, JoAnn E Manson, Jackie F Price, Peter H Whincup, Richard W Morris, Debbie A Lawlor, George Davey Smith, Yoav Ben-Shlomo, Pamela J Schreiner, Myriam Fornage, David S Siscovick, Mary Cushman, Meena Kumari, Nick J Wareham, WM Monique Verschuren, Susan Redline, Sanjay R Patel, John C Whittaker, Anders Hamsten, Joseph A Delaney, Caroline Dale, Tom R Gaunt, Andrew Wong, Diana Kuh, Rebecca Hardy, Sekar Kathiresan, Berta A Castillo, Pim van der Harst, Eric J Brunner, Anne Tybjaerg-Hansen, Michael G Marmot, Ronald M Krauss, Michael Tsai, Josef Coresh, Ronald C Hoogeveen, Bruce M Psaty, Leslie A Lange, Hakon Hakonarson, Frank Dudbridge, Steve E Humphries, Philippa J Talmud, Mika Kivimäki, Nicholas J Timpson, Claudia Langenberg, Folkert W Asselbergs, Mikhail Voevoda, Martin Bobak, Hynek Pikhart, James G Wilson, Alex P Reiner, Brendan J Keating, Aroon D Hingorani, Naveed Sattar
Nov 07, 2018
BACKGROUND: Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug...
Aged Body Mass Index Body Weight Cholesterol HDL Cholesterol LDL Diabetes mellitus Type 2 Female Genetic Testing Humans Hydroxymethylglutaryl CoA Reductases Hydroxymethylglutaryl-CoA Reductase Inhibitors Male Middle Aged Polymorphism Single Nucleotide Randomized Controlled Trials as Topic Risk Factors
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.
Nora Franceschini, Claudia Giambartolomei, Paul S de Vries, Chris Finan, Joshua C Bis, Rachael P Huntley, Ruth C Lovering, Salman M Tajuddin, Thomas W Winkler, Misa Graff, Maryam Kavousi, Caroline Dale, Albert V Smith, Edith Hofer, Elisabeth M van Leeuwen, Ilja M Nolte, Lingyi Lu, Markus Scholz, Muralidharan Sargurupremraj, Niina Pitkänen, Oscar Franzén, Peter K Joshi, Raymond Noordam, Riccardo E Marioni, Shih-Jen Hwang, Solomon K Musani, Ulf Schminke, Walter Palmas, Aaron Isaacs, Adolfo Correa, Alan B Zonderman, Albert Hofman, Alexander Teumer, Amanda J Cox, André G Uitterlinden, Andrew Wong, Andries J Smit, Anne B Newman, Annie Britton, Arno Ruusalepp, Bengt Sennblad, Bo Hedblad, Bogdan Pasaniuc, Brenda W Penninx, Carl D Langefeld, Christina L Wassel, Christophe Tzourio, Cristiano Fava, Damiano Baldassarre, Daniel H O'Leary, Daniel Teupser, Diana Kuh, Elena Tremoli, Elmo Mannarino, Enzo Grossi, Eric Boerwinkle, Eric E Schadt, Erik Ingelsson, Fabrizio Veglia, Fernando Rivadeneira, Frank Beutner, Ganesh Chauhan, Gerardo Heiss, Harold Snieder, Harry Campbell, Henry Völzke, Hugh S Markus, Ian J Deary, J Wouter Jukema, Jacqueline de Graaf, Jacqueline Price, Janne Pott, Jemma C Hopewell, Jingjing Liang, Joachim Thiery, Jorgen Engmann, Karl Gertow, Kenneth Rice, Kent D Taylor, Klodian Dhana, Lambertus ALM Kiemeney, Lars Lind, Laura M Raffield, Lenore J Launer, Lesca M Holdt, Marcus Dörr, Martin Dichgans, Matthew Traylor, Matthias Sitzer, Meena Kumari, Mika Kivimaki, Mike A Nalls, Olle Melander, Olli Raitakari, Oscar H Franco, Oscar L Rueda-Ochoa, Panos Roussos, Peter H Whincup, Philippe Amouyel, Philippe Giral, Pramod Anugu, Quenna Wong, Rainer Malik, Rainer Rauramaa, Ralph Burkhardt, Rebecca Hardy, Reinhold Schmidt, Renée de Mutsert, Richard W Morris, Rona J Strawbridge, S Goya Wannamethee, Sara Hägg, Sonia Shah, Stela McLachlan, Stella Trompet, Sudha Seshadri, Sudhir Kurl, Susan R Heckbert, Susan Ring, Tamara B Harris, Terho Lehtimäki, Tessel E Galesloot, Tina Shah, Ulf de Faire, Vincent Plagnol, Wayne D Rosamond, Wendy Post, Xiaofeng Zhu, Xiaoling Zhang, Xiuqing Guo, Yasaman Saba, MEGASTROKE Consortium, Abbas Dehghan, Adrie Seldenrijk, Alanna C Morrison, Anders Hamsten, Bruce M Psaty, Cornelia M van Duijn, Deborah A Lawlor, Dennis O Mook-Kanamori, Donald W Bowden, Helena Schmidt, James F Wilson, James G Wilson, Jerome I Rotter, Joanna M Wardlaw, John Deanfield, Julian Halcox, Leo-Pekka Lyytikäinen, Markus Loeffler, Michele K Evans, Stéphanie Debette, Steve E Humphries, Uwe Völker, Vilmundur Gudnason, Aroon D Hingorani, Johan LM Björkegren, Juan P Casas, Christopher J O'Donnell
Dec 20, 2018
Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide...
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