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Results: 1188
Characterisation of protein-truncating and missense variants in PALB2 in 15 768 women from Malaysia and Singapore.
Pei Sze Ng, Rick ACM Boonen, Eldarina Wijaya, Chan Eng Chong, Milan Sharma, Sabine Knaup, Shivaani Mariapun, Weang Kee Ho, Joanna Lim, Sook-Yee Yoon, Nur Aishah Mohd Taib, Mee Hoong See, Jingmei Li, Swee Ho Lim, Ern Yu Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Veronique Kiat-Mien Tan, Rob Martinus van Dam, Kartini Rahmat, Cheng Har Yip, Sara Carvalho, Craig Luccarini, Caroline Baynes, Alison M Dunning, Antonis Antoniou, Haico Van Attikum, Douglas F Easton, Mikael Hartman, Soo Hwang Teo
May 13, 2021
BACKGROUND: Rare protein-truncating variants (PTVs) in partner and localiser of BRCA2 (PALB2) confer increased risk to breast cancer, but relatively few studies have reported the prevalence in South-East Asian populations. Here...
Characterisation of protein-truncating and missense variants in PALB2 in 15 768 women from Malaysia and Singapore
Pei Sze Ng, Rick ACM Boonen, Eldarina Wijaya, Chan Eng Chong, Milan Sharma, Sabine Knaup, Shivaani Mariapun, Weang Kee Ho, Joanna Lim, Sook-Yee Yoon, Nur Aishah Mohd Taib, Mee Hoong See, Jingmei Li, Swee Ho Lim, Ern Yu Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Veronique Kiat-Mien Tan, Rob Martinus van Dam, Kartini Rahmat, Cheng Har Yip, Sara Carvalho, Craig Luccarini, Caroline Baynes, Alison M Dunning, Antonis Antoniou, Haico Van Attikum, Douglas F Easton, Mikael Hartman, Soo Hwang Teo
Apr 07, 2021
Germline breast cancer susceptibility genes, tumor characteristics, and survival
Peh Joo Ho, Alexis J. Khng, Hui Wen Loh, Weang-Kee Ho, Cheng Har Yip, Nur Aishah Mohd-Taib, Veronique Kiak Mien Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Ern Yu Tan, Swee Ho Lim, Suniza Jamaris, Yirong Sim, Fuh Yong Wong, Joanne Ngeow, Elaine Hsuen Lim, Mei Chee Tai, Eldarina Azfar Wijaya, Soo Chin Lee, Ching Wan Chan, Shaik Ahmad Buhari, Patrick M. Y. Chan, Juliana J. C. Chen, Jaime Chin Mui Seah, Wai Peng Lee, Chi Wei Mok, Geok Hoon Lim, Evan Woo, Sung-Won Kim, Jong Won Lee, Min Hyuk Lee, Sue K. Park, Alison M. Dunning, Douglas F. Easton, Marjanka K. Schmidt, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
Dec 15, 2021
Abstract: Background: Mutations in certain genes are known to increase breast cancer risk. We study the relevance of rare protein-truncating variants (PTVs) that may result in loss-of-function in breast cancer susceptibility...
Germline breast cancer susceptibility genes, tumor characteristics, and survival.
Peh Joo Ho, Alexis J Khng, Hui Wen Loh, Weang-Kee Ho, Cheng Har Yip, Nur Aishah Mohd-Taib, Veronique Kiak Mien Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Ern Yu Tan, Swee Ho Lim, Suniza Jamaris, Yirong Sim, Fuh Yong Wong, Joanne Ngeow, Elaine Hsuen Lim, Mei Chee Tai, Eldarina Azfar Wijaya, Soo Chin Lee, Ching Wan Chan, Shaik Ahmad Buhari, Patrick MY Chan, Juliana JC Chen, Jaime Chin Mui Seah, Wai Peng Lee, Chi Wei Mok, Geok Hoon Lim, Evan Woo, Sung-Won Kim, Jong Won Lee, Min Hyuk Lee, Sue K Park, Alison M Dunning, Douglas F Easton, Marjanka K Schmidt, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
Jan 10, 2022
BACKGROUND: Mutations in certain genes are known to increase breast cancer risk. We study the relevance of rare protein-truncating variants (PTVs) that may result in loss-of-function in breast cancer susceptibility genes on...
Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models
Peh Joo Ho, Weang Kee Ho, Alexis J Khng, Yen Shing Yeoh, Benita Kiat-Tee Tan, Ern Yu Tan, Geok Hoon Lim, Su-Ming Tan, Veronique Kiak Mien Tan, Cheng-Har Yip, Nur-Aishah Mohd-Taib, Fuh Yong Wong, Elaine Hsuen Lim, Joanne Ngeow, Wen Yee Chay, Lester Chee Hao Leong, Wei Sean Yong, Chin Mui Seah, Siau Wei Tang, Celene Wei Qi Ng, Zhiyan Yan, Jung Ah Lee, Kartini Rahmat, Tania Islam, Tiara Hassan, Mei-Chee Tai, Chiea Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Xueling Sim, Alison M Dunning, Manjeet K Bolla, Antonis Antoniou, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
Apr 26, 2022
BACKGROUND: Family history, and genetic and non-genetic risk factors can stratify women according to their individual risk of developing breast cancer. The extent of overlap between these risk predictors is not clear. METHODS...
Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models
Peh Joo Ho, Weang Kee Ho, Alexis J Khng, Yen Shing Yeoh, Benita Kiat-Tee Tan, Ern Yu Tan, Geok Hoon Lim, Su-Ming Tan, Veronique Kiak Mien Tan, Cheng-Har Yip, Nur-Aishah Mohd-Taib, Fuh Yong Wong, Elaine Hsuen Lim, Joanne Ngeow, Wen Yee Chay, Lester Chee Hao Leong, Wei Sean Yong, Chin Mui Seah, Siau Wei Tang, Celene Wei Qi Ng, Zhiyan Yan, Jung Ah Lee, Kartini Rahmat, Tania Islam, Tiara Hassan, Mei-Chee Tai, Chiea Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Xueling Sim, Alison M Dunning, Manjeet K Bolla, Antonis C Antoniou, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
May 27, 2022
BACKGROUND: Family history, and genetic and non-genetic risk factors can stratify women according to their individual risk of developing breast cancer. The extent of overlap between these risk predictors is not clear. METHODS...
European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
Weang-Kee Ho, Min-Min Tan, Nasim Mavaddat, Mei-Chee Tai, Shivaani Mariapun, Jingmei Li, Peh-Joo Ho, Joe Dennis, Jonathan P. Tyrer, Manjeet K. Bolla, Kyriaki Michailidou, Qin Wang, Daehee Kang, Ji-Yeob Choi, Suniza Jamaris, Xiao-Ou Shu, Sook-Yee Yoon, Sue K. Park, Sung-Won Kim, Chen-Yang Shen, Jyh-Cherng Yu, Ern Yu Tan, Patrick Mun Yew Chan, Kenneth Muir, Artitaya Lophatananon, Anna H. Wu, Daniel O. Stram, Keitaro Matsuo, Hidemi Ito, Ching Wan Chan, Joanne Ngeow, Wei Sean Yong, Swee Ho Lim, Geok Hoon Lim, Ava Kwong, Tsun L. Chan, Su Ming Tan, Jaime Seah, Esther M. John, Allison W. Kurian, Woon-Puay Koh, Chiea Chuen Khor, Motoki Iwasaki, Taiki Yamaji, Kiak Mien Veronique Tan, Kiat Tee Benita Tan, John J. Spinelli, Kristan J. Aronson, Siti Norhidayu Hasan, Kartini Rahmat, Anushya Vijayananthan, Xueling Sim, Paul D. P. Pharoah, Wei Zheng, Alison M. Dunning, Jacques Simard, Rob Martinus van Dam, Cheng-Har Yip, Nur Aishah Mohd Taib, Mikael Hartman, Douglas F. Easton, Soo-Hwang Teo, Antonis C. Antoniou
Jul 31, 2020
Abstract: Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data...
Relevance of the MHC region for breast cancer susceptibility in Asians.
Peh Joo Ho, Alexis Jiaying Khng, Benita Kiat-Tee Tan, Ern Yu Tan, Su-Ming Tan, Veronique Kiak Mien Tan, Geok Hoon Lim, Kristan J Aronson, Tsun L Chan, Ji-Yeob Choi, Joe Dennis, Weang-Kee Ho, Ming-Feng Hou, Hidemi Ito, Motoki Iwasaki, Esther M John, Daehee Kang, Sung-Won Kim, Allison W Kurian, Ava Kwong, Artitaya Lophatananon, Keitaro Matsuo, Nur Aishah Mohd-Taib, Kenneth Muir, Rachel A Murphy, Sue K Park, Chen-Yang Shen, Xiao-Ou Shu, Soo Hwang Teo, Qin Wang, Taiki Yamaji, Wei Zheng, Manjeet K Bolla, Alison M Dunning, Douglas F Easton, Paul DP Pharoah, Mikael Hartman, Jingmei Li
Aug 18, 2022
BACKGROUND: Human leukocyte antigen (HLA) genes play critical roles in immune surveillance, an important defence against tumors. Imputing HLA genotypes from existing single-nucleotide polymorphism datasets is low-cost and...
The relationship between alcohol intake and falls hospitalization
Guo Jeng Tan, Maw Pin Tan, Robert N Luben, Nicholas J Wareham, Kay-Tee Khaw, Phyo Kyaw Myint
Aug 19, 2021
AIM: To evaluate the relationship between habitual alcohol consumption and the risk of falls hospitalization. METHODS: The EPIC-Norfolk is a prospective population-based cohort study in Norfolk, UK. In total, 25 637 community...
Application of Bayesian analysis to the doubly labelled water method for total energy expenditure in humans.
RATIONALE: The doubly labelled water (DLW) method is the reference method for the estimation of free-living total energy expenditure (TEE). In this method, where both 2 H and 18 O are employed, different approaches have been...
Characterisation of nanovoiding in dental porcelain using small angle neutron scattering and transmission electron microscopy
Alexander Lunt, Ann Terry, Siqi Ying, Nikolaos Baimpas, Tan Sui, Saurabh Kabra, Joe Kelleher, Stephen King, Neo Tee Khin, Alexander M. Korsunsky
May 01, 2017
Objectives Recent studies of the yttria partially stabilised zirconia–porcelain interface have revealed the presence of near-interface porcelain nanovoiding which reduces toughness and leads to component failure. One...
Dental porcelain Nanovoiding small angle neutron scattering Transmission electron microscopy /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/3500/3500 name=General Dentistry /dk/atira/pure/subjectarea/asjc/2200/2211 name=Mechanics of Materials
Use of Medications with Anticholinergic Properties and the Long-Term Risk of Hospitalization for Falls and Fractures in the EPIC-Norfolk Longitudinal Cohort Study.
Maw Pin Tan, Guo Jeng Tan, Sumaiyah Mat, Robert N Luben, Nicholas J Wareham, Kay-Tee Khaw, Phyo Kyaw Myint
Jan 13, 2020
Characterisation of nanovoiding in dental porcelain using small angle neutron scattering and transmission electron microscopy
Alexander Lunt, Ann Terry, Siqi Ying, Nikolaos Baimpas, Tan Sui, Saurabh Kabra, Joe Kelleher, Stephen King, Neo Tee Khin, Alexander M. Korsunsky
May 01, 2017
Objectives Recent studies of the yttria partially stabilised zirconia–porcelain interface have revealed the presence of near-interface porcelain nanovoiding which reduces toughness and leads to component failure. One...
Dental porcelain Nanovoiding small angle neutron scattering Transmission electron microscopy /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/3500/3500 name=General Dentistry /dk/atira/pure/subjectarea/asjc/2200/2211 name=Mechanics of Materials
A comparative transmission electron microscopy, energy dispersive x-ray spectroscopy and spatially resolved micropillar compression study of the yttria partially stabilised zirconia - Porcelain interface in dental prosthesis
Alexander J.G. Lunt, Gaurav Mohanty, Siqi Ying, Jiří Dluhoš, Tan Sui, Tee K. Neo, Johann Michler, Alexander M. Korsunsky
Dec 01, 2015
Recent studies into the origins of failure of yttria partially stabilised zirconia-porcelain veneered prosthesis have revealed the importance of micro-to-nano scale characterisation of this interface zone. Current...
Energy dispersive X-ray spectroscopy Micropillar compression/microcompression scanning electron microscopy Transmission electron microscopy Yttria partially stabilised zirconia-porcelain interface /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/3100/3110 name=Surfaces and Interfaces /dk/atira/pure/subjectarea/asjc/2500/2508 name=Surfaces, Coatings and Films /dk/atira/pure/subjectarea/asjc/2500/2506 name=Metals and Alloys /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
Weang-Kee Ho, Min-Min Tan, Nasim Mavaddat, Mei-Chee Tai, Shivaani Mariapun, Jingmei Li, Peh-Joo Ho, Joe Dennis, Jonathan P. Tyrer, Manjeet K. Bolla, Kyriaki Michailidou, Qin Wang, Daehee Kang, Ji-Yeob Choi, Suniza Jamaris, Xiao-Ou Shu, Sook-Yee Yoon, Sue K. Park, Sung-Won Kim, Chen-Yang Shen, Jyh-Cherng Yu, Ern Yu Tan, Patrick Mun Yew Chan, Kenneth Muir, Artitaya Lophatananon, Anna H. Wu, Daniel O. Stram, Keitaro Matsuo, Hidemi Ito, Ching Wan Chan, Joanne Ngeow, Wei Sean Yong, Swee Ho Lim, Geok Hoon Lim, Ava Kwong, Tsun L. Chan, Su Ming Tan, Jaime Seah, Esther M. John, Allison W. Kurian, Woon-Puay Koh, Chiea Chuen Khor, Motoki Iwasaki, Taiki Yamaji, Kiak Mien Veronique Tan, Kiat Tee Benita Tan, John J. Spinelli, Kristan J. Aronson, Siti Norhidayu Hasan, Kartini Rahmat, Anushya Vijayananthan, Xueling Sim, Paul D. P. Pharoah, Wei Zheng, Alison M. Dunning, Jacques Simard, Rob Martinus van Dam, Cheng-Har Yip, Nur Aishah Mohd Taib, Mikael Hartman, Douglas F. Easton, Soo-Hwang Teo, Antonis C. Antoniou
Aug 02, 2021
Abstract: Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data...
Hybrid Organic-Inorganic Perovskite Superstructures for Ultrapure Green Emissions.
Wen Kiat Chan, Jiawei Chen, Donglei Zhou, Junzhi Ye, Ricardo Javier Vázquez, Cheng Zhou, Guillermo Carlos Bazan, Akshay Rao, Zhongzheng Yu, Timothy Thatt Yang Tan
Apr 11, 2023
All inorganic CsPbBr3 superstructures (SSs) have attracted much research interest due to their unique photophysical properties, such as their large emission red-shifts and super-radiant burst emissions. These...
Hybrid Organic-Inorganic Perovskite Superstructures for Ultrapure Green Emissions.
Wen Kiat Chan, Jiawei Chen, Donglei Zhou, Junzhi Ye, Ricardo Javier Vázquez, Cheng Zhou, Guillermo Carlos Bazan, Akshay Rao, Zhongzheng Yu, Timothy Thatt Yang Tan
Mar 06, 2023
A comparative transmission electron microscopy, energy dispersive x-ray spectroscopy and spatially resolved micropillar compression study of the yttria partially stabilised zirconia - Porcelain interface in dental prosthesis
Alexander J.G. Lunt, Gaurav Mohanty, Siqi Ying, Jiří Dluhoš, Tan Sui, Tee K. Neo, Johann Michler, Alexander M. Korsunsky
Dec 01, 2015
Recent studies into the origins of failure of yttria partially stabilised zirconia-porcelain veneered prosthesis have revealed the importance of micro-to-nano scale characterisation of this interface zone. Current...
Energy dispersive X-ray spectroscopy Micropillar compression/microcompression scanning electron microscopy Transmission electron microscopy Yttria partially stabilised zirconia-porcelain interface /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/3100/3110 name=Surfaces and Interfaces /dk/atira/pure/subjectarea/asjc/2500/2508 name=Surfaces, Coatings and Films /dk/atira/pure/subjectarea/asjc/2500/2506 name=Metals and Alloys /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes.
Atish Kizhakeyil, Nurmahirah Binte Mohammed Zaini, Zhi Sheng Poh, Brandon Han Siang Wong, Xinpeng Loh, Aik Seng Ng, Zun Siong Low, Praseetha Prasannan, Chun Gong, Michelle Guet Khim Tan, Chandramouli Nagarajan, Dachuan Huang, Pang Wan Lu, Jing Quan Lim, Sharon Barrans, Choon Kiat Ong, Soon Thye Lim, Wee Joo Chng, George Follows, Daniel J Hodson, Ming Qing Du, Yeow Tee Goh, Suat Hoon Tan, Nicholas Francis Grigoropoulos, Navin Kumar Verma
Oct 22, 2021
DDX3X mutation Drug Resistance Hematolymphoid malignancy Prognosis Tumour metastasis Antineoplastic Agents Biomarkers Tumor Cell Line Tumor Cyclin D1 DEAD-box RNA Helicases Disease Progression Drug Resistance Neoplasm Humans Lymphoma Large B-Cell Diffuse Lymphoma Non-Hodgkin Mitogen-Activated Protein Kinases Mutation Prognosis STAT3 Transcription Factor Exome Sequencing
European polygenic risk score for prediction of breast cancer shows similar performance in Asian women.
Weang-Kee Ho, Min-Min Tan, Nasim Mavaddat, Mei-Chee Tai, Shivaani Mariapun, Jingmei Li, Peh-Joo Ho, Joe Dennis, Jonathan P Tyrer, Manjeet K Bolla, Kyriaki Michailidou, Qin Wang, Daehee Kang, Ji-Yeob Choi, Suniza Jamaris, Xiao-Ou Shu, Sook-Yee Yoon, Sue K Park, Sung-Won Kim, Chen-Yang Shen, Jyh-Cherng Yu, Ern Yu Tan, Patrick Mun Yew Chan, Kenneth Muir, Artitaya Lophatananon, Anna H Wu, Daniel O Stram, Keitaro Matsuo, Hidemi Ito, Ching Wan Chan, Joanne Ngeow, Wei Sean Yong, Swee Ho Lim, Geok Hoon Lim, Ava Kwong, Tsun L Chan, Su Ming Tan, Jaime Seah, Esther M John, Allison W Kurian, Woon-Puay Koh, Chiea Chuen Khor, Motoki Iwasaki, Taiki Yamaji, Kiak Mien Veronique Tan, Kiat Tee Benita Tan, John J Spinelli, Kristan J Aronson, Siti Norhidayu Hasan, Kartini Rahmat, Anushya Vijayananthan, Xueling Sim, Paul DP Pharoah, Wei Zheng, Alison M Dunning, Jacques Simard, Rob Martinus van Dam, Cheng-Har Yip, Nur Aishah Mohd Taib, Mikael Hartman, Douglas F Easton, Soo-Hwang Teo, Antonis C Antoniou
Sep 09, 2020
Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from...
Molecular mechanisms behind mRNA localization in axons.
Messenger RNA (mRNA) localization allows spatiotemporal regulation of the proteome at the subcellular level. This is observed in the axons of neurons, where mRNA localization is involved in regulating neuronal development and...
Observing separate spin and charge Fermi seas in a strongly correlated one-dimensional conductor.
Pedro MT Vianez, Yiqing Jin, María Moreno, Ankita S Anirban, Anne Anthore, Wooi Kiat Tan, Jonathan P Griffiths, Ian Farrer, David A Ritchie, Andrew J Schofield, Oleksandr Tsyplyatyev, Christopher JB Ford
Jul 18, 2022
An electron is usually considered to have only one form of kinetic energy, but could it have more, for its spin and charge, by exciting other electrons? In one dimension (1D), the physics of interacting electrons is captured...
Application of Internet of Things and Blockchain in Information Security and Privacy Protection of Global Organizations
Access control data will continue to be exposed to the threat of privacy leakage even if blockchain technology currently offers a new solution for the security and privacy of the internet of things (IoT). However, its usability...
Published by: IGI Global Scientific Publishing
Genetic analysis of wheat sensitivity to the ToxB fungal effector from Pyrenophora tritici-repentis, the causal agent of tan spot
Beatrice Corsi, Lawrence Percival-Alwyn, Rowena C. Downie, Luca Venturini, Elyce M. Iagallo, Camila Campos Mantello, Charlie McCormick-Barnes, Pao Theen See, Richard P. Oliver, Caroline S. Moffat, James Cockram
Jun 06, 2020
Abstract: Key message: Genetic mapping of sensitivity to the Pyrenophora tritici-repentis effector ToxB allowed development of a diagnostic genetic marker, and investigation of wheat pedigrees allowed transmission of sensitive...
Implications of the variation in biological 18 O natural abundance in body water to inform use of Bayesian methods for modelling total energy expenditure when using doubly labelled water.
RATIONALE: Variation in 18 O natural abundance can lead to errors in the calculation of total energy expenditure (TEE) when using the doubly labelled water (DLW) method. The use of Bayesian statistics allows a distribution to be...
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