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Results: 410
Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease.
Neha Mishra, Konrad Aden, Johanna I Blase, Nathan Baran, Dora Bordoni, Florian Tran, Claudio Conrad, Diana Avalos, Charlot Jaeckel, Michael Scherer, Signe B Sørensen, Silja H Overgaard, Berenice Schulte, Susanna Nikolaus, Guillaume Rey, Gilles Gasparoni, Paul A Lyons, Joachim L Schultze, Jörn Walter, Vibeke Andersen, SYSCID Consortium, Emmanouil T Dermitzakis, Stefan Schreiber, Philip Rosenstiel
Oct 25, 2022
BACKGROUND AND AIMS: Treatment with tumor necrosis factor α (TNFα) antagonists in IBD patients suffers from primary non-response rates of up to 40%. Biomarkers for early prediction of therapy success are missing. We investigated...
Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease.
Neha Mishra, Konrad Aden, Johanna I Blase, Nathan Baran, Dora Bordoni, Florian Tran, Claudio Conrad, Diana Avalos, Charlot Jaeckel, Michael Scherer, Signe B Sørensen, Silja H Overgaard, Berenice Schulte, Susanna Nikolaus, Guillaume Rey, Gilles Gasparoni, Paul A Lyons, Joachim L Schultze, Jörn Walter, Vibeke Andersen, SYSCID Consortium, Emmanouil T Dermitzakis, Stefan Schreiber, Philip Rosenstiel
Sep 25, 2022
Protease and gag diversity and drug resistance mutations among treatment-naive Mexican people living with HIV.
Samantha Climaco-Arvizu, Víctor Flores-López, Carolina González-Torres, Francisco Javier Gaytán-Cervantes, María Concepción Hernández-García, Paola Berenice Zárate-Segura, Monserrat Chávez-Torres, Emiliano Tesoro-Cruz, Sandra María Pinto-Cardoso, Vilma Carolina Bekker-Méndez
May 10, 2022
INTRODUCTION: In Mexico, HIV genotyping is performed in people living with HIV (PLWH) failing their first-line antiretroviral (ARV) regimen; it is not routinely done for all treatment-naive PLWH before ARV initiation. The first...
Antiretroviral Therapy Gag HIV drug resistance mutations HIV genotyping human immunodeficiency virus Next generation sequencing Protease Adult Anti-HIV Agents Anti-Retroviral Agents Drug Resistance Viral Female Genotype HIV Infections HIV Protease HIV-1 Humans Male Mexico Mutation Peptide Hydrolases Reverse Transcriptase Inhibitors
The effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based T 1 relaxometry in patients with prostate cancer
Nikita Sushentsev, Joshua D. Kaggie, Guido Buonincontri, Rolf F. Schulte, Martin J. Graves, Vincent J. Gnanapragasam, Tristan Barrett
Nov 24, 2020
Abstract: Magnetic resonance fingerprinting (MRF) is a rapidly developing fast quantitative mapping technique able to produce multiple property maps with reduced sensitivity to motion. MRF has shown promise in improving the...
The Association Between Food Addiction and Weight Status in School-Age Children and Adolescents.
BACKGROUND: The association between food addiction (FA) and weight status in children and adolescents remains poorly understood. This study aimed to elucidate the association between FA and weight status using the validated...
A rapid intrinsic heart rate resetting response with thermal acclimation in rainbow trout, Oncorhynchus mykiss.
Rachel L Sutcliffe, Shaorong Li, Matthew JH Gilbert, Patricia M Schulte, Kristi M Miller, Anthony P Farrell
Apr 28, 2020
Linking Diversity and Mental Health
Niklas Schulte, Friedrich M Götz, Fabienne Partsch, Tim Goldmann, Lea Smidt, Bertolt Meyer
Jul 14, 2020
Diversity and psychological health issues at the workplace are pressing issues in today's organizations. However, research linking two fields is scant. To bridge this gap, drawing from team faultline research, social...
High-throughput surface marker screen on primary human breast tissues reveals further cellular heterogeneity.
BACKGROUND: Normal human breast tissues are a heterogeneous mix of epithelial and stromal subtypes in different cell states. Delineating the spectrum of cellular heterogeneity will provide new insights into normal cellular...
Diagnostic uncertainty in pediatric chronic pain
Alexandra Neville, Abbie Jordan, Tamar Pincus, Cara Nania, Fiona Schulte, Keith Yeates, Melanie Noel
Nov 30, 2020
Introduction: Diagnostic uncertainty (DU), which is the perception that a label or explanation for a patient’s health problem is missing or inaccurate, has been linked to distress, anxiety, and difficulty coping among adults...
Diagnostic uncertainty in pediatric chronic pain
Alexandra Neville, Abbie Jordan, Tamar Pincus, Cara Nania, Fiona Schulte, Keith Yeates, Melanie Noel
Nov 30, 2020
Introduction: Diagnostic uncertainty (DU), which is the perception that a label or explanation for a patient’s health problem is missing or inaccurate, has been linked to distress, anxiety, and difficulty coping among adults...
The effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based T1 relaxometry in patients with prostate cancer.
Nikita Sushentsev, Joshua D Kaggie, Guido Buonincontri, Rolf F Schulte, Martin J Graves, Vincent J Gnanapragasam, Tristan Barrett
Nov 04, 2020
Index sorting resolves heterogeneous murine hematopoietic stem cell populations.
Reiner Schulte, Nicola K Wilson, Janine CM Prick, Chiara Cossetti, Michal K Maj, Berthold Gottgens, David G Kent
Jun 09, 2015
The Association Between Food Addiction and Weight Status in School-Age Children and Adolescents.
Background: The association between food addiction (FA) and weight status in children and adolescents remains poorly understood. This study aimed to elucidate the association between FA and weight status using the validated...
Characterization and correction of center-frequency effects in X-nuclear eddy current compensations on a clinical MR system.
Mary A McLean, R Scott Hinks, Joshua D Kaggie, Ramona Woitek, Frank Riemer, Martin J Graves, Dominick JO McIntyre, Ferdia A Gallagher, Rolf F Schulte
Oct 30, 2020
The SYMPTOM-upper gastrointestinal study
Napin Karnchanachari, Shakira Milton, Tjuntu Muhlen-Schulte, Riati Scarborough, Jennifer F Holland, Fiona M Walter, John Zalcberg, Jon Emery
May 09, 2022
OBJECTIVE: There is limited evidence on the development of pancreatic and oesophagogastric cancer, how patients decide to seek help and the factors impacting help-seeking. Our study, the first in Australia, aimed to explore...
A longitudinal examination of the interpersonal fear avoidance model of pain
Alexandra Neville, Daniel C. Kopala-Sibley, Sabine Soltani, Gordon J.G. Asmundson, Abbie Jordan, R. Nicholas Carleton, Keith Owen Yeates, Fiona Schulte, Melanie Noel
Jan 31, 2021
Youth with chronic pain and their parents face uncertainty regarding their diagnosis, treatment, and prognosis. Given the uncertain nature of chronic pain and high comorbidity of anxiety among youth, intolerance of...
A longitudinal examination of the interpersonal fear avoidance model of pain
Alexandra Neville, Daniel C. Kopala-Sibley, Sabine Soltani, Gordon J.G. Asmundson, Abbie Jordan, R. Nicholas Carleton, Keith Owen Yeates, Fiona Schulte, Melanie Noel
Jan 31, 2021
Youth with chronic pain and their parents face uncertainty regarding their diagnosis, treatment, and prognosis. Given the uncertain nature of chronic pain and high comorbidity of anxiety among youth, intolerance of...
The use of adverse outcome pathways in the safety evaluation of food additives.
Mathieu Vinken, Nynke Kramer, Timothy EH Allen, Yvette Hoffmans, Natalie Thatcher, Sara Levorato, Heinz Traussnig, Stefan Schulte, Alan Boobis, Anette Thiel, Ivonne MCM Rietjens
Jun 04, 2020
In the last decade, adverse outcome pathways have been introduced in the fields of toxicology and risk assessment of chemicals as pragmatic tools with broad application potential. While their use in the pharmaceutical and...
Feasibility of Quantitative Magnetic Resonance Fingerprinting in Ovarian Tumors for T1 and T2 Mapping in a PET/MR Setting.
Joshua D Kaggie, Surrin Deen, Dimitri A Kessler, Mary A McLean, Guido Buonincontri, Rolf F Schulte, Helen Addley, Evis Sala, James Brenton, Martin J Graves, Ferdia A Gallagher
Mar 13, 2019
INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes.
David Dunger, Sylvaine FA Bruggraber, Adrian P Mander, Loredana Marcovecchio, Timothy Tree, Piotr Jaroslaw Chmura, Mikael Knip, Anke M Schulte, Chantal Mathieu, INNODIA consortium
May 18, 2022
BACKGROUND: The INNODIA consortium has established a pan-European infrastructure using validated centres to prospectively evaluate clinical data from individuals with newly diagnosed type 1 diabetes combined with centralised...
Structural analysis of the genome of breast cancer cell line ZR-75-30 identifies twelve expressed fusion genes.
Ina Schulte, Elizabeth M Batty, Jessica CM Pole, Katherine A Blood, Steven Mo, Susanna L Cooke, Charlotte Ng, Kevin L Howe, Suet-Feung Chin, James D Brenton, Carlos Caldas, Karen D Howarth, Paul AW Edwards
Jan 18, 2013
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