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Reconstructing aspects of human embryogenesis with pluripotent stem cells
Berna Sozen, Victoria Jorgensen, Bailey A. T. Weatherbee, Sisi Chen, Meng Zhu, Magdalena Zernicka-Goetz
Sep 21, 2021
Abstract: Understanding human development is of fundamental biological and clinical importance. Despite its significance, mechanisms behind human embryogenesis remain largely unknown. Here, we attempt to model human early embryo...
Reconstructing aspects of human embryogenesis with pluripotent stem cells.
Berna Sozen, Victoria Jorgensen, Bailey A T Weatherbee, Sisi Chen, Meng Zhu, Magdalena Zernicka-Goetz
Oct 23, 2021
Understanding human development is of fundamental biological and clinical importance. Despite its significance, mechanisms behind human embryogenesis remain largely unknown. Here, we attempt to model human early embryo...
Pluripotent Stem Cells Blastocyst Humans Adaptor Proteins Signal Transducing Cell Culture Techniques Sequence Analysis RNA Gene Expression Cell Lineage Embryonic Development Models Biological GATA3 Transcription Factor Embryo Mammalian Phospholipase C beta SOXB1 Transcription Factors SOXF Transcription Factors Single-Cell Analysis Biomarkers
Published by: Nature Communications
Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid.
Berna Sozen, Andy L Cox, Joachim De Jonghe, Min Bao, Florian Hollfelder, David M Glover, Magdalena Zernicka-Goetz
Dec 19, 2019
Mammalian blastocysts comprise three distinct cell lineages essential for development beyond implantation: the pluripotent epiblast, which generates the future embryo, and surrounding it the extra-embryonic primitive endoderm...
Blastoid development Embryo Endoderm Extended pluripotency in vitro preimplantation Stem Cells trophoblast Animals Blastocyst Cell Differentiation Cell Lineage Embryo Implantation Embryo Mammalian Embryonic Development Endoderm Gene Expression Regulation Developmental Mice Mouse embryonic stem cells
Reconstructing aspects of human embryogenesis with pluripotent stem cells.
Berna Sozen, Victoria Jorgensen, Bailey AT Weatherbee, Sisi Chen, Meng Zhu, Magdalena Zernicka-Goetz
Aug 26, 2021
Understanding human development is of fundamental biological and clinical importance. Despite its significance, mechanisms behind human embryogenesis remain largely unknown. Here, we attempt to model human early embryo...
Adaptor Proteins Signal Transducing Biomarkers Blastocyst Cell Culture Techniques Cell Lineage Embryo Mammalian Embryonic Development GATA3 Transcription Factor Gene Expression Humans Models Biological Phospholipase C beta Pluripotent Stem Cells SOXB1 Transcription Factors SOXF Transcription Factors Sequence Analysis RNA Single-Cell Analysis
Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures.
Berna Sozen, Gianluca Amadei, Andy Cox, Ran Wang, Ellen Na, Sylwia Czukiewska, Lia Chappell, Thierry Voet, Geert Michel, Naihe Jing, David M Glover, Magdalena Zernicka-Goetz
Jul 17, 2019
Animals Cell Communication Cell Differentiation Cell Line Cell Lineage Cell Movement Coculture Techniques Embryo Mammalian Endoderm Epithelial-Mesenchymal Transition Gastrulation Gene Expression Regulation Developmental Gestational Age Mice Mouse embryonic stem cells Phenotype Transcriptome Trophoblasts
Human embryo polarization requires PLC signaling to mediate trophectoderm specification.
Meng Zhu, Marta Shahbazi, Angel Martin, Chuanxin Zhang, Berna Sozen, Mate Borsos, Rachel S Mandelbaum, Richard J Paulson, Matteo A Mole, Marga Esbert, Shiny Titus, Richard T Scott, Alison Campbell, Simon Fishel, Viviana Gradinaru, Han Zhao, Keliang Wu, Zi-Jiang Chen, Emre Seli, Maria J de los Santos, Magdalena Zernicka Goetz
Oct 28, 2021
Published by: eLife
Human embryo polarization requires PLC signaling to mediate trophectoderm specification
Meng Zhu, Marta Shahbazi, Angel Martin, Chuanxin Zhang, Berna Sozen, Mate Borsos, Rachel S Mandelbaum, Richard J Paulson, Matteo A Mole, Marga Esbert, Shiny Titus, Richard T Scott, Alison Campbell, Simon Fishel, Viviana Gradinaru, Han Zhao, Keliang Wu, Zi-Jiang Chen, Emre Seli, Maria J de los Santos, Magdalena Zernicka Goetz
Oct 13, 2021
Human embryo polarization requires PLC signaling to mediate trophectoderm specification.
Meng Zhu, Marta Shahbazi, Angel Martin, Chuanxin Zhang, Berna Sozen, Mate Borsos, Rachel S Mandelbaum, Richard J Paulson, Matteo A Mole, Marga Esbert, Shiny Titus, Richard T Scott, Alison Campbell, Simon Fishel, Viviana Gradinaru, Han Zhao, Keliang Wu, Zi-Jiang Chen, Emre Seli, Maria J de los Santos, Magdalena Zernicka Goetz
Oct 27, 2021
Cell Biology Cell Polarity developmental biology Human embryo preimplantation Actins Adult Body Patterning Cell Differentiation Cell Lineage Cell Polarity Embryo Culture Techniques Embryo Mammalian Female GATA3 Transcription Factor Gene Expression Regulation Developmental Gene Expression Regulation Enzymologic Humans Phosphoinositide Phospholipase C Phospholipase C beta Pregnancy Signal Transduction Time Factors Young Adult
Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings.
Eva Velthorst, Josephine Mollon, Robin M Murray, Lieuwe de Haan, Inez Myin Germeys, David C Glahn, Celso Arango, Els van der Ven, Marta Di Forti, Miguel bernardo, Sinan Guloksuz, Philippe Delespaul, Gisela Mezquida, Silvia Amoretti, Julio Bobes, Pilar A Saiz, María Paz García-Portilla, José Luis Santos, Estela Jiménez-López, Julio Sanjuan, Eduardo J Aguilar, Manuel Arrojo, Angel Carracedo, Gonzalo López, Javier González-Peñas, Mara Parellada, Cem Atbaşoğlu, Meram Can Saka, Alp Üçok, Köksal Alptekin, Berna Akdede, Tolga Binbay, Vesile Altınyazar, Halis Ulaş, Berna Yalınçetin, Güvem Gümüş-Akay, Burçin Cihan Beyaz, Haldun Soygür, Eylem Şahin Cankurtaran, Semra Ulusoy Kaymak, Nadja P Maric, Marina M Mihaljevic, Sanja Andric Petrovic, Tijana Mirjanic, Cristina Marta Del-Ben, Laura Ferraro, Charlotte Gayer-Anderson, Peter B Jones, Hannah E Jongsma, James B Kirkbride, Caterina La Cascia, Antonio Lasalvia, Sarah Tosato, Pierre-Michel Llorca, Paulo Rossi Menezes, Craig Morgan, Diego Quattrone, Marco Menchetti, Jean-Paul Selten, Andrei Szöke, Ilaria Tarricone, Andrea Tortelli, Philip McGuire, Lucia Valmaggia, Matthew J Kempton, Mark van der Gaag, Anita Riecher-Rössler, Rodrigo A Bressan, Neus Barrantes-Vidal, Barnaby Nelson, Patrick McGorry, Chris Pantelis, Marie-Odile Krebs, Stephan Ruhrmann, Gabriele Sachs, Bart PF Rutten, Jim van Os, Behrooz Z Alizadeh, Therese van Amelsvoort, Agna A Bartels-Velthuis, Richard Bruggeman, Nico J van Beveren, Jurjen J Luykx, Wiepke Cahn, Claudia JP Simons, Rene S Kahn, Frederike Schirmbeck, Ruud van Winkel, EU-GEI High Risk Study, Abraham Reichenberg
Nov 24, 2020
An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures.
Grace Collord, Patrick Tarpey, Natalja Kurbatova, Inigo Martincorena, Sebastian Moran, Manuel Castro, Tibor Nagy, Graham Bignell, Francesco Maura, Matthew D Young, Jorge Berna, Jose MC Tubio, Chris E McMurran, Adam MH Young, Mathijs Sanders, Imran Noorani, Stephen J Price, Colin Watts, Elke Leipnitz, Matthias Kirsch, Gabriele Schackert, Danita Pearson, Abel Devadass, Zvi Ram, V Peter Collins, Kieren Allinson, Michael D Jenkinson, Rasheed Zakaria, Khaja Syed, C Oliver Hanemann, Jemma Dunn, Michael W McDermott, Ramez W Kirollos, George S Vassiliou, Manel Esteller, Sam Behjati, Alvis Brazma, Thomas Santarius, Ultan McDermott
Jan 02, 2019
Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles of...
Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer.
Andrea Strakova, Máire Ní Leathlobhair, Guo-Dong Wang, Ting-Ting Yin, Ilona Airikkala-Otter, Janice L Allen, Karen M Allum, Leontine Bansse-Issa, Jocelyn L Bisson, Artemio Castillo Domracheva, Karina F de Castro, Anne M Corrigan, Hugh R Cran, Jane T Crawford, Stephen M Cutter, Laura Delgadillo Keenan, Edward M Donelan, Ibikunle A Faramade, Erika Flores Reynoso, Eleni Fotopoulou, Skye N Fruean, Fanny Gallardo-Arrieta, Olga Glebova, Rodrigo F Häfelin Manrique, Joaquim Jgp Henriques, Natalia Ignatenko, Debbie Koenig, Marta Lanza-Perea, Remo Lobetti, Adriana M Lopez Quintana, Thibault Losfelt, Gabriele Marino, Inigo Martincorena, Simón Martínez Castañeda, Mayra F Martínez-López, Michael Meyer, Berna Nakanwagi, Andrigo B De Nardi, Winifred Neunzig, Sally J Nixon, Marsden M Onsare, Antonio Ortega-Pacheco, Maria C Peleteiro, Ruth J Pye, John F Reece, Jose Rojas Gutierrez, Haleema Sadia, Sheila K Schmeling, Olga Shamanova, Richard K Ssuna, Audrey E Steenland-Smit, Alla Svitich, Ismail Thoya Ngoka, Bogdan A Vițălaru, Anna P de Vos, Johan P de Vos, Oliver Walkinton, David C Wedge, Alvaro S Wehrle-Martinez, Mirjam G van der Wel, Sophie Ae Widdowson, Elizabeth P Murchison
Apr 26, 2016
Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer
Andrea Strakova, Thomas J. Nicholls, Adrian Baez-Ortega, Máire Ní Leathlobhair, Alexander T. Sampson, Katherine Hughes, Isobelle A. G. Bolton, Kevin Gori, Jinhong Wang, Ilona Airikkala-Otter, Janice L. Allen, Karen M. Allum, Clara L. Arnold, Leontine Bansse-Issa, Thinlay N. Bhutia, Jocelyn L. Bisson, Kelli Blank, Cristóbal Briceño, Artemio Castillo Domracheva, Anne M. Corrigan, Hugh R. Cran, Jane T. Crawford, Stephen M. Cutter, Eric Davis, Karina F. de Castro, Andrigo B. De Nardi, Anna P. de Vos, Laura Delgadillo Keenan, Edward M. Donelan, Adela R. Espinoza Huerta, Ibikunle A. Faramade, Mohammed Fazil, Eleni Fotopoulou, Skye N. Fruean, Fanny Gallardo-Arrieta, Olga Glebova, Pagona G. Gouletsou, Rodrigo F. Häfelin Manrique, Joaquim J. G. P. Henriques, Rodrigo S. Horta, Natalia Ignatenko, Yaghouba Kane, Cathy King, Debbie Koenig, Ada Krupa, Steven J. Kruzeniski, Marta Lanza-Perea, Mihran Lazyan, Adriana M. Lopez Quintana, Thibault Losfelt, Gabriele Marino, Simón Martínez Castañeda, Mayra F. Martínez-López, Bedan M. Masuruli, Michael Meyer, Edward J. Migneco, Berna Nakanwagi, Karter B. Neal, Winifred Neunzig, Sally J. Nixon, Antonio Ortega-Pacheco, Francisco Pedraza-Ordoñez, Maria C. Peleteiro, Katherine Polak, Ruth J. Pye, Juan C. Ramirez-Ante, John F. Reece, Jose Rojas Gutierrez, Haleema Sadia, Sheila K. Schmeling, Olga Shamanova, Alan G. Sherlock, Audrey E. Steenland-Smit, Alla Svitich, Lester J. Tapia Martínez, Ismail Thoya Ngoka, Cristian G. Torres, Elizabeth M. Tudor, Mirjam G. van der Wel, Bogdan A. Vițălaru, Sevil A. Vural, Oliver Walkinton, Alvaro S. Wehrle-Martinez, Sophie A. E. Widdowson, Irina Zvarich, Patrick F. Chinnery, Maria Falkenberg, Claes M. Gustafsson, Elizabeth P. Murchison
Jun 17, 2021
Abstract: Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for ‘selfish’ traits, such as replicative...
Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer.
Andrea Strakova, Thomas J Nicholls, Adrian Baez-Ortega, Máire Ní Leathlobhair, Alexander T Sampson, Katherine Hughes, Isobelle AG Bolton, Kevin Gori, Jinhong Wang, Ilona Airikkala-Otter, Janice L Allen, Karen M Allum, Clara L Arnold, Leontine Bansse-Issa, Thinlay N Bhutia, Jocelyn L Bisson, Kelli Blank, Cristóbal Briceño, Artemio Castillo Domracheva, Anne M Corrigan, Hugh R Cran, Jane T Crawford, Stephen M Cutter, Eric Davis, Karina F de Castro, Andrigo B De Nardi, Anna P de Vos, Laura Delgadillo Keenan, Edward M Donelan, Adela R Espinoza Huerta, Ibikunle A Faramade, Mohammed Fazil, Eleni Fotopoulou, Skye N Fruean, Fanny Gallardo-Arrieta, Olga Glebova, Pagona G Gouletsou, Rodrigo F Häfelin Manrique, Joaquim Jgp Henriques, Rodrigo S Horta, Natalia Ignatenko, Yaghouba Kane, Cathy King, Debbie Koenig, Ada Krupa, Steven J Kruzeniski, Marta Lanza-Perea, Mihran Lazyan, Adriana M Lopez Quintana, Thibault Losfelt, Gabriele Marino, Simón Martínez Castañeda, Mayra F Martínez-López, Bedan M Masuruli, Michael Meyer, Edward J Migneco, Berna Nakanwagi, Karter B Neal, Winifred Neunzig, Sally J Nixon, Antonio Ortega-Pacheco, Francisco Pedraza-Ordoñez, Maria C Peleteiro, Katherine Polak, Ruth J Pye, Juan C Ramirez-Ante, John F Reece, Jose Rojas Gutierrez, Haleema Sadia, Sheila K Schmeling, Olga Shamanova, Alan G Sherlock, Audrey E Steenland-Smit, Alla Svitich, Lester J Tapia Martínez, Ismail Thoya Ngoka, Cristian G Torres, Elizabeth M Tudor, Mirjam G van der Wel, Bogdan A Vițălaru, Sevil A Vural, Oliver Walkinton, Alvaro S Wehrle-Martinez, Sophie Ae Widdowson, Irina Zvarich, Patrick F Chinnery, Maria Falkenberg, Claes M Gustafsson, Elizabeth P Murchison
May 28, 2020
Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer
Andrea Strakova, Thomas J. Nicholls, Adrian Baez-Ortega, Máire Ní Leathlobhair, Alexander T. Sampson, Katherine Hughes, Isobelle A. G. Bolton, Kevin Gori, Jinhong Wang, Ilona Airikkala-Otter, Janice L. Allen, Karen M. Allum, Clara L. Arnold, Leontine Bansse-Issa, Thinlay N. Bhutia, Jocelyn L. Bisson, Kelli Blank, Cristóbal Briceño, Artemio Castillo Domracheva, Anne M. Corrigan, Hugh R. Cran, Jane T. Crawford, Stephen M. Cutter, Eric Davis, Karina F. de Castro, Andrigo B. De Nardi, Anna P. de Vos, Laura Delgadillo Keenan, Edward M. Donelan, Adela R. Espinoza Huerta, Ibikunle A. Faramade, Mohammed Fazil, Eleni Fotopoulou, Skye N. Fruean, Fanny Gallardo-Arrieta, Olga Glebova, Pagona G. Gouletsou, Rodrigo F. Häfelin Manrique, Joaquim J. G. P. Henriques, Rodrigo S. Horta, Natalia Ignatenko, Yaghouba Kane, Cathy King, Debbie Koenig, Ada Krupa, Steven J. Kruzeniski, Marta Lanza-Perea, Mihran Lazyan, Adriana M. Lopez Quintana, Thibault Losfelt, Gabriele Marino, Simón Martínez Castañeda, Mayra F. Martínez-López, Bedan M. Masuruli, Michael Meyer, Edward J. Migneco, Berna Nakanwagi, Karter B. Neal, Winifred Neunzig, Sally J. Nixon, Antonio Ortega-Pacheco, Francisco Pedraza-Ordoñez, Maria C. Peleteiro, Katherine Polak, Ruth J. Pye, Juan C. Ramirez-Ante, John F. Reece, Jose Rojas Gutierrez, Haleema Sadia, Sheila K. Schmeling, Olga Shamanova, Alan G. Sherlock, Audrey E. Steenland-Smit, Alla Svitich, Lester J. Tapia Martínez, Ismail Thoya Ngoka, Cristian G. Torres, Elizabeth M. Tudor, Mirjam G. van der Wel, Bogdan A. Vițălaru, Sevil A. Vural, Oliver Walkinton, Alvaro S. Wehrle-Martinez, Sophie A. E. Widdowson, Irina Zvarich, Patrick F. Chinnery, Maria Falkenberg, Claes M. Gustafsson, Elizabeth P. Murchison
Jun 16, 2020
Abstract: Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for ‘selfish’ traits, such as replicative...