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Ion-Pair-Directed Borylation of Aromatic Phosphonium Salts.
Control of positional selectivity in C-H activation reactions remains a challenge for synthetic chemists. Noncovalent catalysis has the potential to be a powerful strategy to address this challenge. As a part of our ongoing...
Lifting the hood of supply and demand for trademarks of start‐ups
This paper estimates simultaneously the supply and the demand determinants of the trademark adoption decision made by start‐ups. We use a partial observability econometric model, as non‐adoption is unobserved. Estimation is by...
Site-selective installation of an electrophilic handle on proteins for bioconjugation.
Site-selective protein modification strategies can be used to insert non-natural functional groups into protein structures. Herein, we report on the use of the bis-electrophile 3-bromo-2-bromomethyl-1-propene as a reagent to...
Golgi anti-apoptotic proteins are highly conserved ion channels that affect apoptosis and cell migration.
Guia Carrara, Nuno Saraiva, Maddy Parsons, Bernadette Byrne, David Prole, Colin Taylor, Geoffrey Smith
May 20, 2015
Golgi anti-apoptotic proteins are highly conserved ion channels that affect apoptosis and cell migration.
Guia Carrara, Nuno Saraiva, Maddy Parsons, Bernadette Byrne, David L Prole, Colin W Taylor, Geoffrey L Smith
Aug 10, 2017
Amyloid Β-Peptide Increases Mitochondria-Endoplasmic Reticulum Contact Altering Mitochondrial Function and Autophagosome Formation in Alzheimer's Disease-Related Models.
Nuno Santos Leal, Giacomo Dentoni, Bernadette Schreiner, Luana Naia, Antonio Piras, Caroline Graff, Antonio Cattaneo, Giovanni Meli, Maho Hamasaki, Per Nilsson, Maria Ankarcrona
Nov 29, 2020
Recent findings have shown that the connectivity and crosstalk between mitochondria and the endoplasmic reticulum (ER) at mitochondria-ER contact sites (MERCS) are altered in Alzheimer's disease (AD) and in AD-related models....
Alzheimer’s disease Mitochondria-ER contact sites amyloid β-peptide Autophagy Mitochondria Aged Aged 80 and over Alzheimer Disease Amyloid beta-Peptides Animals Autophagosomes Brain Disease Models Animal Endoplasmic Reticulum Female Homeostasis Humans Male Mice Mice Transgenic Middle Aged Mitochondria Mitochondrial Membrane Transport Proteins Mitochondrial Membranes Neurons Up-Regulation
Pedagogical Innovation in Higher Education
Bernadette Knewstubb, Jae Major, Sandi Tait-McCutcheon, Robin Averill, Amanda Gilbert, Anita Mortlock, Liz Jones
Jul 01, 2020
Quality teaching in higher education (HE) is gaining increasing international attention and pedagogical innovation is seen as an important construct of quality teaching. The drivers for pedagogical innovation include the need...
Published by: IGI Global Scientific Publishing
Adjuvant endocrine therapy after breast cancer
Jo Brett, Mary Boulton, Debbie Fenlon, Nick J Hulbert-Williams, Fiona M Walter, Peter Donnelly, Bernadette A Lavery, Adrienne Morgan, Carolyn Morris, Eila K Watson
Mar 29, 2018
INTRODUCTION: Despite evidence of the efficacy of adjuvant endocrine therapy (AET) in reducing the risk of recurrence and mortality after treatment for primary breast cancer, adherence to AET is suboptimal. This study aimed to...
Psychometric properties of the Beliefs about Medicine Questionnaire-adjuvant endocrine therapy (BMQ-AET) for women taking AETs following early-stage breast cancer.
Jo Brett, Nick J Hulbert-Williams, Deborah Fenlon, Mary Boulton, Fiona M Walter, Peter Donnelly, Bernadette Lavery, Adrienne Morgan, Carolyn Morris, Rob Horne, Eila Watson
May 03, 2018
This study evaluated the Beliefs about Medicine Questionnaire to explore adherence to adjuvant endocrine therapy after treatment for breast cancer (BMQ-AET). Factor structure of the BMQ-AET was explored alongside internal...
Simian Immunodeficiency Virus Infection of Chimpanzees (Pan troglodytes) Shares Features of Both Pathogenic and Non-pathogenic Lentiviral Infections.
Edward JD Greenwood, Fabian Schmidt, Ivanela Kondova, Henk Niphuis, Vida L Hodara, Leah Clissold, Kirsten McLay, Bernadette Guerra, Sharon Redrobe, Luis D Giavedoni, Robert E Lanford, Krishna K Murthy, François Rouet, Jonathan L Heeney
Aug 28, 2015
Animals Ape Diseases Autoimmune Diseases Biomarkers CD4 Lymphocyte Count Female HIV-1 Hyperplasia Lentivirus Infections Lentiviruses Primate Lymph Nodes Male Myxovirus Resistance Proteins Neopterin Pan troglodytes Peptide Fragments Receptors TNF-Related Apoptosis-Inducing Ligand Simian Acquired Immunodeficiency Syndrome Simian Immunodeficiency Virus Thrombocytopenia Viral Load beta 2-Microglobulin
Investigation of a Cluster of Sequence Type 22 Methicillin-Resistant Staphylococcus aureus Transmission in a Community Setting.
Michelle S Toleman, Emmeline R Watkins, Tom Williams, Beth Blane, Belinda Sadler, Ewan M Harrison, Francesc Coll, Julian Parkhill, Bernadette Nazareth, Nicholas M Brown, Sharon J Peacock
Sep 02, 2019
BACKGROUND: Whole-genome sequencing (WGS) has typically been used to confirm or refute hospital/ward outbreaks of methicillin-resistant Staphylococcus aureus (MRSA) identified through routine practice. However, appropriately...
MRSA community EPIDEMIOLOGY General Practice genome sequencing Adolescent Adult Aged Aged 80 and over Bacteremia Child Cross Infection DNA Bacterial Disease Outbreaks Female General Practice Genome Bacterial Humans Male Methicillin-Resistant Staphylococcus aureus Middle Aged Phylogeny Prospective Studies Public Health Sequence Analysis DNA Staphylococcal Infections United Kingdom whole genome sequencing Young Adult
Survival prediction using temporal muscle thickness measurements on cranial magnetic resonance images in patients with newly diagnosed brain metastases.
Julia Furtner, Anna S Berghoff, Omar M Albtoush, Ramona Woitek, Ulrika Asenbaum, Daniela Prayer, Georg Widhalm, Brigitte Gatterbauer, Karin Dieckmann, Peter Birner, Bernadette Aretin, Rupert Bartsch, Christoph C Zielinski, Veronika Schöpf, Matthias Preusser
Dec 20, 2018
OBJECTIVES: To evaluate the prognostic relevance of temporal muscle thickness (TMT) in brain metastasis patients. METHODS: We retrospectively analysed TMT on magnetic resonance (MR) images at diagnosis of brain metastasis in two...
Brain metastases Cancer cachexia Diagnosis-specific graded prognostic assessment Prognosis Sarcopenia Adult Aged Brain Brain Neoplasms Breast Neoplasms Carcinoma Non-Small-Cell Lung Female Humans Lung Neoplasms Magnetic Resonance Imaging Male Middle Aged Multivariate Analysis Predictive Value of Tests Prognosis Retrospective Studies Survival Analysis Temporal Muscle
Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart.
Tom Ashmore, Bernadette O Fernandez, Cristina Branco-Price, James A West, Andrew S Cowburn, Lisa C Heather, Julian L Griffin, Randall S Johnson, Martin Feelisch, Andrew J Murray
Aug 19, 2014
Evidence for Better Lives Study
Sara Valdebenito, AJA Murray, Claire Hughes, Adriana Băban, Asvini D Fernando, Bernadette J Madrid, Catherine Ward, Joseph Osafo, Michael Dunne, Siham Sikander, Susan P Walker, Vo Van Thang, Mark Tomlinson, Pasco Fearon, Yulia Shenderovich, Marguerite Marlow, Deshanie Chathurika, Diana Taut, Manuel Eisner
Sep 28, 2020
child protection community child health EPIDEMIOLOGY Mental Health Prenatal Diagnosis Child Cohort Studies Developing Countries Exposure to Violence Female Ghana Humans intimate partner violence Jamaica Longitudinal Studies Pakistan Philippines Pregnancy Romania South Africa sri lanka Vietnam violence
What Research Questions Should the Next Generation of Birth Cohort Studies Address? An International Delphi Study of Experts.
Ruth Harriet Brown, Manuel Eisner, Sara Valdebenito, Susan Walker, Mark Tomlinson, Claire Hughes, Catherine L Ward, Joseph Osafo, Siham Sikander, Pasco Fearon, Michael P Dunne, Bernadette Madrid, Adriana Baban, Vo Van Thang, Asvini D Fernando, Aja L Murray
Jun 26, 2020
OBJECTIVE: Birth cohort studies (BCS) have generated a wealth of invaluable basic scientific and policy-relevant information on a wide range of issues in child health and development. This study sought to explore what research...
Perceived stress during the prenatal period
Laura Katus, Sarah Foley, Aja L Murray, Bao-Yen Luong-Thanh, Diana Taut, Adriana Baban, Bernadette Madrid, Asvini D Fernando, Siham Sikander, Catherine L Ward, Joseph Osafo, Marguerite Marlow, Stefani du Toit, Susan Walker, Thang Van Vo, Pasco Fearon, Sara Valdebenito, Manuel P Eisner, Claire Hughes
May 09, 2022
Prenatal attachment
Sarah Foley, Claire Hughes, Aja Louise Murray, Adriana Baban, Asvini D. Fernando, Bernadette Madrid, Joseph Osafo, Siham Sikander, Fahad Abbasi, Susan Walker, Bao-Yen Luong-Thanh, Thang Van Vo, Mark Tomlinson, Pasco Fearon, Catherine L. Ward, Sara Valdebenito, Manuel Eisner
Jul 28, 2021
The Dementias Platform UK (DPUK) Data Portal.
Sarah Bauermeister, Christopher Orton, Simon Thompson, Roger A Barker, Joshua R Bauermeister, Yoav Ben-Shlomo, Carol Brayne, David Burn, Archie Campbell, Catherine Calvin, Siddharthan Chandran, Nishi Chaturvedi, Geneviève Chêne, Iain P Chessell, Anne Corbett, Daniel HJ Davis, Mike Denis, Carole Dufouil, Paul Elliott, Nick Fox, Derek Hill, Scott M Hofer, Michele T Hu, Christoph Jindra, Frank Kee, Chi-Hun Kim, Changsoo Kim, Mika Kivimaki, Ivan Koychev, Rachael A Lawson, Gerry J Linden, Ronan A Lyons, Clare Mackay, Paul M Matthews, Bernadette McGuiness, Lefkos Middleton, Catherine Moody, Katrina Moore, Duk L Na, John T O'Brien, Sebastien Ourselin, Shantini Paranjothy, Ki-Soo Park, David J Porteous, Marcus Richards, Craig W Ritchie, Jonathan D Rohrer, Martin N Rossor, James B Rowe, Rachael Scahill, Christian Schnier, Jonathan M Schott, Sang W Seo, Matthew South, Matthew Steptoe, Sarah J Tabrizi, Andrea Tales, Therese Tillin, Nicholas J Timpson, Arthur W Toga, Pieter-Jelle Visser, Richard Wade-Martins, Tim Wilkinson, Julie Williams, Andrew Wong, John EJ Gallacher
Apr 28, 2020
The Dementias Platform UK Data Portal is a data repository facilitating access to data for 3 370 929 individuals in 42 cohorts. The Data Portal is an end-to-end data management solution providing a secure, fully auditable...
Key contribution of eIF4H-mediated translational control in tumor promotion.
Charlotte Vaysse, Céline Philippe, Yvan Martineau, Cathy Quelen, Corinne Hieblot, Claire Renaud, Yvan Nicaise, Aurore Desquesnes, Maria Pannese, Thomas Filleron, Ghislaine Escourrou, Malcolm Lawson, Robert C Rintoul, Marie Bernadette Delisle, Stéphane Pyronnet, Pierre Brousset, Hervé Prats, Christian Touriol
Sep 05, 2018
Dysregulated expression of translation initiation factors has been associated with carcinogenesis, but underlying mechanisms remains to be fully understood. Here we show that eIF4H (eukaryotic translation initiation factor 4H)...
IRES chemoresistance eIF4H helicase lung carcinoma Translation Initiation Factor Animals Antineoplastic Agents Apoptosis Blotting Western Cell Cycle Cell Line Tumor Cell Proliferation cisplatin Etoposide Eukaryotic Initiation Factors Female Gene Expression Regulation Neoplastic HeLa Cells Humans Lung Neoplasms Male Mice Mice Nude NIH 3T3 Cells Protein Biosynthesis RNA Interference RNAi Therapeutics Reverse Transcriptase Polymerase Chain Reaction Tumor Burden Xenograft Model Antitumor Assays
Equity-Efficiency Trade-offs Associated With Alternative Approaches to Deceased Donor Kidney Allocation
Bernadette Li, John A Cairns, Rachel J Johnson, Christopher JE Watson, Paul Roderick, Gabriel C Oniscu, Wendy Metcalfe, J Andrew Bradley, Charles R Tomson, Heather Draper, John L Forsythe, Christopher Dudley, Rommel Ravanan
Sep 27, 2019
BACKGROUND: The number of patients waiting to receive a kidney transplant outstrips the supply of donor organs. We sought to quantify trade-offs associated with different approaches to deceased donor kidney allocation in terms...
Adolescent Adult Age Factors Computer Simulation Cost-Benefit Analysis Donor Selection Female Health Care Costs Health Care Rationing Health Services Accessibility health status Healthcare Disparities Humans Kidney Transplantation Male Middle Aged Policy Making Quality of life Quality-Adjusted Life Years Risk Assessment Risk Factors Time Factors Tissue Donors Treatment Outcome United States Waiting Lists Young Adult
Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers
Chad Lance Hemady, Lydia Gabriela Speyer, Aja Louise Murray, Ruth Harriet Brown, Franziska Meinck, Deborah Fry, Huyen Do, Siham Sikander, Bernadette Madrid, Asvini Fernando, Susan Walker, Michael Dunne, Sarah Foley, Claire Hughes, Joseph Osafo, Adriana Baban, Diana Taut, Catherine L Ward, Vo Van Thang, Pasco Fearon, Mark Tomlinson, Sara Valdebenito, Manuel Eisner
Jun 29, 2022
Associations Between ADHD Symptoms and Maternal and Birth Outcomes
Aja Louise Murray, Diana Taut, Adriana Baban, Chad Lance Hemady, Susan Walker, Joseph Osafo, Siham Sikander, Mark Tomlinson, Stefani Du Toit, Marguerite Marlow, Catherine L Ward, Asvini Fernando, Bernadette Madrid, Vo Van Thang, Hoang Dinh Tuyen, Michael Dunne, Claire Hughes, Pasco Fearon, Sara Valdebenito, Manuel Eisner
Oct 24, 2022
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