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Results: 142
The single-cell pathology landscape of breast cancer.
Hartland W Jackson, Jana R Fischer, Vito RT Zanotelli, H Raza Ali, Robert Mechera, Savas D Soysal, Holger Moch, Simone Muenst, Zsuzsanna Varga, Walter P Weber, Bernd Bodenmiller
Mar 11, 2020
Single-cell analyses have revealed extensive heterogeneity between and within human tumours1-4, but complex single-cell phenotypes and their spatial context are not at present reflected in the histological stratification that is...
Imaging mass cytometry and multiplatform genomics define the phenogenomic landscape of breast cancer
H Raza Ali, Hartland W Jackson, Vito RT Zanotelli, Esther Danenberg, Jana R Fischer, Helen Bardwell, Elena Provenzano, Oscar M Rueda, Suet-Feung Chin, Samuel Aparicio, Carlos Caldas, Bernd Bodenmiller
Mar 11, 2020
Genomic alterations shape cell phenotypes and the structure of tumor ecosystems in poorly defined ways. To investigate these
relationships, we used imaging mass cytometry to quantify the expression of 37 proteins with...
Cell-to-cell and type-to-type heterogeneity of signaling networks
Attila Gabor, Marco Tognetti, Alice Driessen, Jovan Tanevski, Baosen Guo, Wencai Cao, He Shen, Thomas Yu, Verena Chung, Single Cell Signaling in Breast Cancer DREAM Consortium members, Bernd Bodenmiller, Julio Saez-Rodriguez
Nov 19, 2021
Recent technological developments allow us to measure the status of dozens of proteins in individual cells. This opens the way to understand the heterogeneity of complex multi-signaling networks across cells and cell types, with...
Oriented Type I Collagen - A Review on Artificial Alignment Strategies
Collagen is the most abundant protein in the human body and serves many functions, from mechanical stability and elasticity in tendons and bone, to optical properties, such as transparency and a fine tuned refractive index in...
Published by: IGI Global Scientific Publishing
The canonical wall structure and intrinsic mirror symmetry
Abstract As announced in Gross and Siebert (in Algebraic geometry: Salt Lake City 2015, Proceedings of Symposia in Pure Mathematics, vol 97, no 2. AMS, Providence, pp 199–230, 2018) in 2016, we...
CubeFactory2 – an Off-Grid and Circular 3D-Printing Mini-Factory
The CubeFactory2 is a self-sufficient and luggage-sized production unit illustrating the concept of sustainable manufacturing through circularity and resource conservation. It is circular in the sense that it can create new...
mini-factory circular economy filament recycling 3D-printer making sustainable manufacturing /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth /dk/atira/pure/sustainabledevelopmentgoals/industry_innovation_and_infrastructure name=SDG 9 - Industry, Innovation, and Infrastructure /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production
Testicular organoid generation by a novel in vitro three-layer gradient system.
A system that models the testicular microenvironment and spermatogonial stem-cell (SSC) niche in vitro has not been produced yet. Here, we developed and characterized a novel three-dimensional multilayer model, the Three-Layer...
3D culture De novo morphogenesis Germ Cells Seminiferous tubules-like structures Sertoli Cells Testicular organoid Animals Blood-Testis Barrier Cell Differentiation Interleukin-1alpha Male Organoids Rats Sprague-Dawley Seminiferous Tubules Sertoli Cells Spermatozoa Testis Tissue Engineering Tretinoin Tumor Necrosis Factor-alpha
Innovating responsibly in ICT for ageing
Responsible research and innovation (RRI) is a nascent concept, promoted actively by the European Union and other policy makers around the world. Hitherto, this concept has been associated primarily with publicly funded...
Innovating responsibly in ICT for ageing
Responsible research and innovation (RRI) is a nascent concept, promoted actively by the European Union and other policy makers around the world. Hitherto, this concept has been associated primarily with publicly funded...
Large scale genomic rearrangements in selected Arabidopsis thaliana T-DNA lines are caused by T-DNA insertion mutagenesis.
BACKGROUND: Experimental proof of gene function assignments in plants is based on mutant analyses. T-DNA insertion lines provided an invaluable resource of mutants and enabled systematic reverse genetics-based investigation of...
CubeFactory2 – an Off-Grid and Circular 3D-Printing Mini-Factory
The CubeFactory2 is a self-sufficient and luggage-sized production unit illustrating the concept of sustainable manufacturing through circularity and resource conservation. It is circular in the sense that it can create new...
mini-factory circular economy filament recycling 3D-printer making sustainable manufacturing /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth /dk/atira/pure/sustainabledevelopmentgoals/industry_innovation_and_infrastructure name=SDG 9 - Industry, Innovation, and Infrastructure /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production
Big data in radiation biology and epidemiology; an overview of the historical and contemporary landscape of data and biomaterial archives.
Testicular organoids
BACKGROUND: In recent decades, a broad range of strategies have been applied to model the testicular microenvironment in vitro. These models have been utilized to study testicular physiology and development. However, a system...
Complete pan-plastome sequences enable high resolution phylogenetic classification of sugar beet and closely related crop wild relatives.
Katharina Sielemann, Boas Pucker, Nicola Schmidt, Prisca Viehöver, Bernd Weisshaar, Tony Heitkam, Daniela Holtgräwe
Feb 10, 2022
Putting High-Index Cu on the Map for High-Yield, Dry-Transferred CVD Graphene.
Oliver J Burton, Zachary Winter, Kenji Watanabe, Takashi Taniguchi, Bernd Beschoten, Christoph Stampfer, Stephan Hofmann
Jan 25, 2023
Reliable, clean transfer and interfacing of 2D material layers are technologically as important as their growth. Bringing both together remains a challenge due to the vast, interconnected parameter space. We introduce a...
Complete pan-plastome sequences enable high resolution phylogenetic classification of sugar beet and closely related crop wild relatives.
Katharina Sielemann, Boas Pucker, Nicola Schmidt, Prisca Viehöver, Bernd Weisshaar, Tony Heitkam, Daniela Holtgräwe
Mar 13, 2022
BACKGROUND: As the major source of sugar in moderate climates, sugar-producing beets (Beta vulgaris subsp. vulgaris) have a high economic value. However, the low genetic diversity within cultivated beets requires introduction of...
Self-organising human gonads generated by a Matrigel-based gradient system.
Elizabeth Oliver, João Pedro Alves-Lopes, Femke Harteveld, Rod T Mitchell, Elisabet Åkesson, Olle Söder, Jan-Bernd Stukenborg
Nov 25, 2021
BACKGROUND: Advances in three-dimensional culture technologies have led to progression in systems used to model the gonadal microenvironment in vitro. Despite demonstrating basic functionality, tissue organisation is often...
Strong correlation between the morphology of the proximal femur and the geometry of the distal femoral trochlea
Samantha J. Wright, Tim A. E. J. Boymans, Bernd Grimm, Anthony W. Miles, Oliver Kessler
Dec 01, 2014
Purpose
Previous investigations suggested that the geometry of the proximal femur may be related to osteoarthritis of the tibiofemoral joint and various patellofemoral joint conditions. This study aims to investigate...
Previous investigations suggested that the geometry of the proximal femur may be related to osteoarthritis of the tibiofemoral joint and various patellofemoral joint conditions. This study aims to investigate...
Sustainable Afterglow Room-Temperature Phosphorescence Emission Materials Generated Using Natural Phenolics
Keliang Wan, Yingxiang Zhai, Shouxin Liu, Jian Li, Shujun Li, Bernd Strehmel, Zhijun Chen, Tony D. James
Aug 01, 2022
Long-lived afterglow room-temperature phosphorescence (RTP) from natural phenolics has seldom been reported yet this is essential for the development of sustainable afterglow RTP materials. With this research, we have...
Radiocarbon offsets and old world chronology as relevant to Mesopotamia, Egypt, Anatolia and Thera (Santorini)
Sturt W. Manning, Lukas Wacker, Ulf Büntgen, Christopher Bronk Ramsey, Michael W. Dee, Bernd Kromer, Brita Lorentzen, Willy Tegel
Aug 17, 2020
Abstract: The new IntCal20 radiocarbon record continues decades of successful practice by employing one calibration curve as an approximation for different regions across the hemisphere. Here we investigate three radiocarbon...
Radiocarbon offsets and old world chronology as relevant to Mesopotamia, Egypt, Anatolia and Thera (Santorini).
Sturt W Manning, Lukas Wacker, Ulf Büntgen, Christopher Bronk Ramsey, Michael W Dee, Bernd Kromer, Brita Lorentzen, Willy Tegel
Oct 05, 2020
The new IntCal20 radiocarbon record continues decades of successful practice by employing one calibration curve as an approximation for different regions across the hemisphere. Here we investigate three radiocarbon time-series...
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