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Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation.
Bas Brouwers, Edson Mendes de Oliveira, Maria Marti-Solano, Fabiola BF Monteiro, Suli-Anne Laurin, Julia M Keogh, Elana Henning, Rebecca Bounds, Carole A Daly, Shane Houston, Vikram Ayinampudi, Natalia Wasiluk, David Clarke, Bianca Plouffe, Michel Bouvier, M Madan Babu, I Sadaf Farooqi, Jacek Mokrosiński
Apr 14, 2021
The Melanocortin-4 Receptor (MC4R) plays a pivotal role in energy homeostasis. We used human MC4R mutations associated with an increased or decreased risk of obesity to dissect mechanisms that regulate MC4R function. Most...
GPCRs Gα(s) MC4R MSH melanocortin obesity Therapy Weight Loss β-Arrestin Animals Body Weight COS Cells Cell Membrane Chlorocebus aethiops Cyclic AMP Endocytosis Extracellular Signal-Regulated MAP Kinases GTP-Binding Protein alpha Subunits Gs genetic variation HEK293 Cells Humans Models Biological Mutant Proteins Mutation Phosphorylation Protein Multimerization Receptor Melanocortin Type 4 Signal Transduction beta-Arrestins
Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction.
Sophie J Bradley, Coen H Wiegman, Max Maza Iglesias, Kok Choi Kong, Adrian J Butcher, Bianca Plouffe, Eugénie Goupil, Julie-Myrtille Bourgognon, Timothy Macedo-Hatch, Christian LeGouill, Kirsty Russell, Stéphane A Laporte, Gabriele M König, Evi Kostenis, Michel Bouvier, Kian Fan Chung, Yassine Amrani, Andrew B Tobin
Feb 21, 2020
From Naturally Occurring Tumor Immunity to Supernatural T Cells: Isolation and Characterization of a Murine T Cell Receptor Specific for Human Breast and Ovarian Tumor Antigen Cdr2
Bianca D. Santomasso
Jan 01, 0001
Patients with paraneoplastic cerebellar degeneration (PCD), a form of neuronal autoimmunity, have a co-occurring natural immune response against a protein called cdr2 in their breast and ovarian carcinomas, and thus provide an...
breast cancer immunotherapy ovarian cancer immunotherapy cdr2 adaptive T cell transfer therapy Life Sciences
Published by: Rockefeller University
Pathogenic correlation between mosaic variegated aneuploidy 1 (MVA1) and a novel BUB1B variant
Piero Pavone, Xena Giada Pappalardo, Naira Mustafa, Raffaele Falsaperla, Simona Domenica Marino, Giovanni Corsello, Sebastiano Bianca, Enrico Parano, Martino Ruggieri
Oct 28, 2022
Adaptive Intelligence Revolutionizing Learning and Sustainability in Higher Education
This chapter examines the incorporation of adaptive intelligence in higher education, focusing on its influence on conventional learning approaches and long-lasting educational strategies. Adaptive intelligence merges artificial...
Instructional Design Education Higher Education Social Sciences and Humanities Library and Information Science
Published by: IGI Global Scientific Publishing
Disentangling the effects of attentional weighting and associative mediation in perceptual learning reveals no evidence for associative mediation.
Learning to categorize perceptually similar stimuli can result in people becoming more sensitive to differences along perceptual dimensions that are relevant to category membership and/or less sensitive to equivalent differences...
Beneficial and detrimental effects of schema incongruence on memory for contextual events.
Mental schemas provide a framework into which new information can easily be integrated. In a series of experiments, we examined how incongruence that stems from a prediction error modulates memory for multicomponent events that...
Linear mixed models for replication data to efficiently allow for covariate measurement error
It is well known that measurement error in the covariates of regression models generally causes bias in parameter estimates. Correction for such biases requires information concerning the measurement error, which is often in...
Physiologically based modelling of the antiplatelet effect of aspirin
A computational approach involving mathematical modeling and in silico experiments was used to characterize the determinants of extent and duration of platelet cyclooxygenase (COX)-1 inhibition by aspirin and design precision...
Identification of the C. elegans anaphase promoting complex subunit Cdc26 by phenotypic profiling and functional rescue in yeast.
Anaphase-Promoting Complex-Cyclosome Animals Caenorhabditis elegans Cell Polarity Embryo Nonmammalian Gene Expression Profiling Genes cdc Genetic Complementation Test Genetic Vectors Meiosis Phenotype RNA Interference RNA Helminth Saccharomyces cerevisiae Ubiquitin-Protein Ligase Complexes Video Recording
Entropy Production in Exactly Solvable Systems.
The rate of entropy production by a stochastic process quantifies how far it is from thermodynamic equilibrium. Equivalently, entropy production captures the degree to which global detailed balance and time-reversal symmetry are...
D2 receptors and cognitive flexibility in marmosets
Behavioral flexibility, which allows organisms to adapt their actions in response to environmental changes, is impaired in a number of neuropsychiatric conditions, including obsessive-compulsive disorder and addiction. Studies...
Evidence accumulation in the integrated and primed Stroop tasks.
We report distributional analyses of response times (RT) in two variants of the color-word Stroop task using manual keypress responses. In the classic Stroop task, in which the color and word dimensions are integrated into a...
Incorporation of bacteria in concrete
Strength improvement of cement-based materials by the addition of bacteria has been reported over the past decade and has been mainly attributed to microbially induced calcite precipitation (MICP 1). However, the...
DnaA and the timing of chromosome replication in Escherichia coli as a function of growth rate.
Matthew AA Grant, Chiara Saggioro, Ulisse Ferrari, Bruno Bassetti, Bianca Sclavi, Marco Cosentino Lagomarsino
Mar 21, 2012
Air-entraining admixtures as a protection method for bacterial spores in self-healing cementitious composites
Ismael Justo Reinoso, Bianca Reeksting, Charlie Hamley-Bennett, Andrew Heath, Susanne Gebhard, Kevin Paine
Apr 11, 2022
Costs associated with the encapsulation process of bacterial spores continue to be a limiting factor for the commercialisation of self-healing cementitious materials. The feasibility of using air-entraining admixtures (AEAs)...
Air-entraining admixtures Bacteria Encapsulation Later-formed cracks MICP Self-healing /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2200/2215 name=Building and Construction /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science
Engineering Electron Superpositions Using a Magnetic Field
A Rydberg atom has a highly excited valence electron which is weakly bound and far from the nucleus. These atoms have exaggerated properties that make them attractive candidates for quantum computation and studies of fundamental...
Rydberg Atoms Stark Map electric fields magnetic fields matrix perpendicular Physical Sciences and Mathematics Physics
Published by: Ursinus College
Soluble Receptor for Advanced Glycation End Products (sRAGE) Is a Sensitive Biomarker in Human Pulmonary Arterial Hypertension.
Franziska Diekmann, Philippe Chouvarine, Hannes Sallmon, Louisa Meyer-Kobbe, Moritz Kieslich, Brian D Plouffe, Shashi K Murthy, Ralf Lichtinghagen, Ekaterina Legchenko, Georg Hansmann
Oct 26, 2021
Pulmonary arterial hypertension (PAH) is a progressive condition with an unmet need for early diagnosis, better monitoring, and risk stratification. The receptor for advanced glycation end products (RAGE) is activated in...
RV hypertrophy biomarker Inflammation Proliferation pulmonary arterial hypertension soluble receptor for advanced glycation end products (sRAGE) vascular injury Adult Aged Aged 80 and over Biomarkers Case-Control Studies Female Germany Humans Male Middle Aged Prognosis pulmonary arterial hypertension Receptor for Advanced Glycation End Products Sensitivity and Specificity Solubility Young Adult
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