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mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity
Abstract: Background: The RNA helicase eIF4A1 is a key component of the translation initiation machinery and is required for the translation of many pro-oncogenic mRNAs. There is increasing interest in targeting eIF4A1...
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Hyperinsulinaemic–hypoglycaemic glucose clamps in human research
Abstract: Aims/hypothesis: The hyperinsulinaemic–hypoglycaemic glucose clamp technique has been developed and applied to assess effects of and responses to hypoglycaemia under standardised conditions. However, the degree to...
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