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Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome.
Claudia Russo, Christian Osterburg, Anna Sirico, Dario Antonini, Raffaele Ambrosio, Julia Maren Würz, Jörg Rinnenthal, Marco Ferniani, Sebastian Kehrloesser, Birgit Schäfer, Peter Güntert, Satrajit Sinha, Volker Dötsch, Caterina Missero
Aug 31, 2018
AEC syndrome mouse model p63 protein aggregation Skin Animals Cleft Lip Cleft Palate Ectoderm Eye Abnormalities Frameshift Mutation HEK293 Cells Heterozygote Humans Mice Mutation Mutation Missense Phosphoproteins Protein Binding Protein Denaturation Skin Trans-Activators Transcription Factors Transcription Genetic Tumor Suppressor Proteins
Reciprocal Empowerment Through Remote Service Learning
Birgit Phillips
Jan 01, 0001
This chapter presents a novel pedagogical approach of “remote service learning” (RSL), which was applied in an undergraduate health degree program at an Austrian university. Remote service learning is a form of active blended...
Published by: IGI Global Scientific Publishing
Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level.
Daniel Coutandin, Christian Osterburg, Ratnesh Kumar Srivastav, Manuela Sumyk, Sebastian Kehrloesser, Jakob Gebel, Marcel Tuppi, Jens Hannewald, Birgit Schäfer, Eidarus Salah, Sebastian Mathea, Uta Müller-Kuller, James Doutch, Manuel Grez, Stefan Knapp, Volker Dötsch
Nov 13, 2018
Mammalian oocytes are arrested in the dictyate stage of meiotic prophase I for long periods of time, during which the high concentration of the p53 family member TAp63α sensitizes them to DNA damage-induced apoptosis. TAp63α is...
DNA Damage E. coli biophysics Cell Biology kinetically trapped state MOUSE Oocytes p63 Quality Control spring-loaded activation structural biology Animals Apoptosis DNA Damage Female Mice Oocytes Phosphoproteins Phosphorylation Protein Multimerization Protein Processing Post-Translational Quality Control Trans-Activators
Molecular insights into the powerful mucus-based adhesion of limpets (Patella vulgata L.).
Limpets (Patella vulgata L.) are renowned for their powerful attachments to rocks on wave-swept seashores. Unlike adult barnacles and mussels, limpets do not adhere permanently; instead, they repeatedly transition between...
Automated Markov state models for molecular dynamics simulations of aggregation and self-assembly.
Markov state models have become popular in the computational biochemistry and biophysics communities as a technique for identifying stationary and kinetic information of protein dynamics from molecular dynamics simulation data....
Psychophysiological reactivity, coping behaviour and intrusive memories upon multisensory Virtual Reality and Script-Driven Imagery analogue trauma
Tina Schweizer, Fritz Renner, Dali Sun, Birgit Kleim, Emily A Holmes, Brunna Tuschen-Caffier
Jan 11, 2019
BACKGROUND: Peri- and post-traumatic factors predict the differential development of stress-associated mental disorders. Prospective designs assessing these risk factors in real-time under controlled experimental conditions can...
Guided mental imagery Post-traumatic stress Psychopathology Risk Factors Stress and coping measures virtual reality Adaptation Psychological Arousal Cross-Over Studies Female Humans Imagery Psychotherapy Male Memory Prospective Studies Psychological Trauma Psychophysiology virtual reality Young Adult
To kill or to be killed
Erwin Tantoso, Birgit Eisenhaber, Miles Kirsch, Vladimir Shitov, Zhiya Zhao, Frank Eisenhaber
Jul 17, 2022
BACKGROUND: Escherichia coli (E. coli) has been one of the most studied model organisms in the history of life sciences. Initially thought just to be commensal bacteria, E. coli has shown wide phenotypic diversity including...
Evaluating the provision of paediatric liaison psychiatry services in England.
Declan Hines, Tamsin Ford, Sophie Westwood, Jessica R Barrett, Birgit Westphal, Virginia Davies, William Lee
Mar 03, 2023
BACKGROUND: Liaison psychiatry provision for children and young people in England is poorly evaluated. AIMS: We sought to evaluate paediatric liaison psychiatry provision and develop recommendations to improve practice. METHOD...
C-mannosylation supports folding and enhances stability of thrombospondin repeats.
Aleksandra Shcherbakova, Matthias Preller, Manuel H Taft, Jordi Pujols, Salvador Ventura, Birgit Tiemann, Falk Fr Buettner, Hans Bakker
Jan 11, 2020
Previous studies demonstrated importance of C-mannosylation for efficient protein secretion. To study its impact on protein folding and stability, we analyzed both C-mannosylated and non-C-mannosylated thrombospondin type 1...
C-mannosylation C. elegans D. melanogaster Biochemistry Cell Biology chemical biology Glycosylation Protein Folding Protein Stability thrombospondin type 1 repeats tryptophan-arginine ladder Animals Arginine Caenorhabditis elegans Caenorhabditis elegans Proteins Cysteine Disulfides Drosophila melanogaster Endoplasmic Reticulum Glycosylation Hydrogen Bonding Mannose Membrane Proteins Molecular Dynamics Simulation Protein Conformation Protein Folding Receptors Cell Surface Thrombospondins Tryptophan
Renewable energy powered membrane technology
Integration of renewable energy and membrane filtration technologies such as nanofiltration (NF) and reverse osmosis (RO) can provide drinking water in places where freshwater is scarce and grid electrical connections are...
Remobilization of dormant carbon from Siberian-Arctic permafrost during three past warming events.
Jannik Martens, Birgit Wild, Francesco Muschitiello, Matt O'Regan, Martin Jakobsson, Igor Semiletov, Oleg V Dudarev, Örjan Gustafsson
Oct 20, 2020
Carbon cycle models suggest that past warming events in the Arctic may have caused large-scale permafrost thaw and carbon remobilization, thus affecting atmospheric CO2 levels. However, observational records are sparse...
Renewable energy powered membrane technology
Integration of renewable energy and membrane filtration technologies such as nanofiltration (NF) and reverse osmosis (RO) can provide drinking water in places where freshwater is scarce and grid electrical connections are...
Automated methods for cell type annotation on scRNA-seq data.
The advent of single-cell sequencing started a new era of transcriptomic and genomic research, advancing our knowledge of the cellular heterogeneity and dynamics. Cell type annotation is a crucial step in analyzing single-cell...
Dengue serosurvey after a 2-month long outbreak in Nîmes, France, 2015
Tiphanie Succo, Harold Noël, Birgit Nikolay, Marianne Maquart, Amandine Cochet, Isabelle Leparc-Goffart, Olivier Catelinois, Henrik Salje, Camille Pelat, Perrine de Crouy-Chanel, Henriette de Valk, Simon Cauchemez, Cyril Rousseau
Feb 15, 2021
BackgroundClusters of dengue cases have recently become more frequent in areas of southern France colonised by the vector mosquito Aedes albopictus. In July 2015, a 2-month outbreak of dengue virus serotype 1 (DENV-1) was...
Coupling of a specific photoreactive triple-helical peptide to crosslinked collagen films restores binding and activation of DDR2 and VWF.
Jean-Daniel Malcor, Victoria Juskaite, Despoina Gavriilidou, Emma J Hunter, Natalia Davidenko, Samir Hamaia, Sanjay Sinha, Ruth E Cameron, Serena M Best, Birgit Leitinger, Richard W Farndale
Sep 21, 2018
Collagen-based scaffolds may require chemical crosslinking to achieve mechanical properties suitable for tissue engineering. Carbodiimide treatment, often used for this purpose, consumes amino acid side chains required for...
Biomaterial functionalization Biomimetic material Collagen Discoidin domain receptor 2 Triple-helical peptide von Willebrand factor Animals Biocompatible Materials COS Cells Chlorocebus aethiops Collagen Cross-Linking Reagents Discoidin Domain Receptor 2 Endothelial Cells HEK293 Cells Humans Peptides Protein Binding Tissue Scaffolds von Willebrand factor
Formation of Cu3BiS3 thin films via sulfurization of Bi-Cu metal precursors
Diego Colombara, Laurence M Peter, K Hutchings, K D Rogers, S Schäfer, Jesse T R Dufton, M Saiful Islam
Jun 01, 2012
Thin films of Cu 3BiS 3 have been produced by conversion of stacked and co-electroplated Bi-Cu metal precursors in the presence of elemental sulfur vapor. The roles of sulfurization temperature and heating rate in achieving...
Gadobutrol in Renally Impaired Patients
Henrik J Michaely, Manuela Aschauer, Hannes Deutschmann, Georg Bongartz, Matthias Gutberlet, Ramona Woitek, Birgit Ertl-Wagner, Walter Kucharczyk, Renate Hammerstingl, Francesco De Cobelli, Martin Rosenberg, Thomas Balzer, Jan Endrikat
Dec 20, 2018
OBJECTIVE: The aim of this study was to assess the potential risk of gadobutrol-enhanced magnetic resonance imaging (MRI) in patients with moderate to severe renal impairment for the development of nephrogenic systemic fibrosis...
Imaging live bee brains using minimally-invasive diagnostic radioentomology
Sensitivity of the honey bee brain volume and density to behavior (plasticity) makes it a great model for exploring the interactions between experience, behavior and brain structure. Plasticity in the adult bee brain has been...
Imaging live bee brains using minimally-invasive diagnostic radioentomology
Sensitivity of the honey bee brain volume and density to behavior (plasticity) makes it a great model for exploring the interactions between experience, behavior and brain structure. Plasticity in the adult bee brain has been...
A multi-scale cortical wiring space links cellular architecture and functional dynamics in the human brain.
Casey Paquola, Jakob Seidlitz, Oualid Benkarim, Jessica Royer, Petr Klimes, Richard AI Bethlehem, Sara Larivière, Reinder Vos de Wael, Raul Rodríguez-Cruces, Jeffery A Hall, Birgit Frauscher, Jonathan Smallwood, Boris C Bernhardt
Jan 25, 2021
The vast net of fibres within and underneath the cortex is optimised to support the convergence of different levels of brain organisation. Here, we propose a novel coordinate system of the human cortex based on an advanced model...
ComplexViewer
Colin W Combe, Marine Dumousseau Sivade, Henning Hermjakob, Joshua Heimbach, Birgit HM Meldal, Gos Micklem, Sandra Orchard, Juri Rappsilber
Sep 20, 2018
SUMMARY: Proteins frequently function as parts of complexes, assemblages of multiple proteins and other biomolecules, yet network visualizations usually only show proteins as parts of binary interactions. ComplexViewer...
Powerful sequence similarity search methods and in-depth manual analyses can identify remote homologs in many apparently "orphan" viral proteins.
Durga B Kuchibhatla, Westley A Sherman, Betty YW Chung, Shelley Cook, Georg Schneider, Birgit Eisenhaber, David G Karlin
Jan 31, 2020
The genome sequences of new viruses often contain many "orphan" or "taxon-specific" proteins apparently lacking homologs. However, because viral proteins evolve very fast, commonly used sequence similarity detection methods such...
Parents' views about healthcare professionals having real-time remote access to their young child's diabetes data
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