Search
Results: 87
Achieving Conformance to Document Standards
In the context of long-term archival of digital assets, file formats that are standardized and designed for longevity such as PDF/A are preferred. However, due to the complexity of and ambiguities in PDF standards, it is far...
IT Policy & Standardization Computer Science and Information Technology IT Policy and Standardization
Published by: IGI Global Scientific Publishing
On Engagement With ICT Standards and Their Implementations in Open Source Software Projects
This paper presents novel results concerning engagement with ICT standards and their implementations in open source software (OSS). Specifically, findings draw from observations and analysis related to standards and...
IT Policy & Standardization Computer Science and Information Technology IT Policy and Standardization
Published by: IGI Global Scientific Publishing
On PDF/A Conformance and Font Usage in PDF Documents Provided by Public Sector Organizations
The use of appropriate fonts and file formats for long-term maintenance of digital assets is a challenge for organizations in the public sector. The article reports from a study which investigated the PDF/A conformance and font...
IT Policy & Standardization Computer Science and Information Technology IT Policy and Standardization
Published by: IGI Global Scientific Publishing
OER4Schools
Sustaining educational initiatives beyond short-term pilot projects is highly challenging in low-income countries. We describe the outcomes and implications of our iterative Design-Based Implementation Research conducted in...
Deep impact
Most researchers acknowledge an intrinsic hierarchy in the scholarly journals ('journal rank') that they submit their work to, and adjust not only their submission but also their reading strategies accordingly. On the other...
Schwann cell remyelination of the central nervous system
Myelin sheaths, by supporting axonal integrity and allowing rapid saltatory impulse conduction, are of fundamental importance for neuronal function. In response to demyelinating injuries in the central nervous system (CNS)...
Deep impact
Most researchers acknowledge an intrinsic hierarchy in the scholarly journals ('journal rank') that they submit their work to, and adjust not only their submission but also their reading strategies accordingly. On the other...
Asymmetric division of contractile domains couples cell positioning and fate specification.
Jean-Léon Maître, Hervé Turlier, Rukshala Illukkumbura, Björn Eismann, Ritsuya Niwayama, François Nédélec, Takashi Hiiragi
Aug 06, 2020
During pre-implantation development, the mammalian embryo self-organizes into the blastocyst, which consists of an epithelial layer encapsulating the inner-cell mass (ICM) giving rise to all embryonic tissues. In mice, oriented...
Adaptor Proteins Signal Transducing Animals Blastocyst Blastocyst Inner Cell Mass Blastomeres Cell Cycle Proteins Cell Differentiation Cell Division Cell Lineage Cell Movement Cell Polarity Embryo Mammalian Embryonic Development Female Male Mice Phosphoproteins Protein Transport Reproducibility of Results YAP-Signaling Proteins
A Simulation-Game for Resilience Assessments in a Payment System Disruption Scenario
This paper presents a quantitative agent-based simulation model of the everyday payment system used to simulate the business and consumer consequences of loss of functionality, or disruptions of the payment system for the food...
Published by: IGI Global Scientific Publishing
A C. elegans model for neurodegeneration in Cockayne syndrome.
Amanda FC Lopes, Katarzyna Bozek, Marija Herholz, Aleksandra Trifunovic, Matthias Rieckher, Björn Schumacher
Nov 24, 2020
Cockayne syndrome (CS) is a congenital syndrome characterized by growth and mental retardation, and premature ageing. The complexity of CS and mammalian models warrants simpler metazoan models that display CS-like phenotypes...
Association of faecal elastase 1 with non-fasting triglycerides in type 2 diabetes.
Wolfgang Rathmann, Burkhard Haastert, Jan Oscarsson, Niklas Berglind, Björn Lindkvist, Nicholas J Wareham
Apr 15, 2016
cardiovascular disease Chronic pancreatitis Faecal elastase 1 Pancreatic exocrine dysfunction Triglycerides Type 2 diabetes Aged Alcohol Drinking Case-Control Studies Diabetes mellitus Type 2 England Feces Female Glycated Hemoglobin Humans Hypertriglyceridemia LIPASE Male Middle Aged Pancreatic Elastase Pancreatic Function Tests Smoking Triglycerides
Does fluoxetine reduce apathetic and depressive symptoms after stroke? An analysis of the Efficacy oF Fluoxetine-a randomized Controlled Trial in Stroke trial data set.
Jonathan Tay, EFFECTS Trial Collaboration, Björn Mårtensson, Hugh S Markus, Erik Lundström
Feb 18, 2023
An investigation of the 'female camouflage effect' in autism using a computerized ADOS-2 and a test of sex/gender differences.
Agnieszka Rynkiewicz, Björn Schuller, Erik Marchi, Stefano Piana, Antonio Camurri, Amandine Lassalle, Simon Baron-Cohen
Jan 14, 2016
ADOS-2 Computer application Diagnosis Females with autism Asperger Syndrome Autistic Disorder Child Child Preschool Communication Disorders culture Diagnosis Computer-Assisted Diagnostic Errors Emotions Facial Expression Female Fixation Ocular gestures Humans Male Parents Poland Psychomotor Performance Severity of Illness Index Sex Characteristics Sex Factors Social Behavior Software Stereotyped Behavior Surveys and Questionnaires
Modeling Prion-Like Processing of Tau Protein in Alzheimer's Disease for Pharmaceutical Development.
Claude M Wischik, Björn O Schelter, Damon J Wischik, John MD Storey, Charles R Harrington
Sep 27, 2019
Following our discovery of a fragment from the repeat domain of tau protein as a structural constituent of the PHF-core in Alzheimer's disease (AD), we developed an assay that captured several key features of the aggregation...
Epistatic interactions can moderate the antigenic effect of substitutions in haemagglutinin of influenza H3N2 virus.
Björn F Koel, David F Burke, Stefan van der Vliet, Theo M Bestebroer, Guus F Rimmelzwaan, Albert DME Osterhaus, Derek J Smith, Ron AM Fouchier
May 13, 2019
We previously showed that single amino acid substitutions at seven positions in haemagglutinin determined major antigenic change of influenza H3N2 virus. Here, the impact of two such substitutions was tested in 11 representative...
Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.
Sebastian Mueller, Thomas Engleitner, Roman Maresch, Magdalena Zukowska, Sebastian Lange, Thorsten Kaltenbacher, Björn Konukiewitz, Rupert Öllinger, Maximilian Zwiebel, Alex Strong, Hsi-Yu Yen, Ruby Banerjee, Sandra Louzada, Beiyuan Fu, Barbara Seidler, Juliana Götzfried, Kathleen Schuck, Zonera Hassan, Andreas Arbeiter, Nina Schönhuber, Sabine Klein, Christian Veltkamp, Mathias Friedrich, Lena Rad, Maxim Barenboim, Christoph Ziegenhain, Julia Hess, Oliver M Dovey, Stefan Eser, Swati Parekh, Fernando Constantino-Casas, Jorge de la Rosa, Marta I Sierra, Mario Fraga, Julia Mayerle, Günter Klöppel, Juan Cadiñanos, Pentao Liu, George Vassiliou, Wilko Weichert, Katja Steiger, Wolfgang Enard, Roland M Schmid, Fengtang Yang, Kristian Unger, Günter Schneider, Ignacio Varela, Allan Bradley, Dieter Saur, Roland Rad
Jun 25, 2018
Adaptor Proteins Signal Transducing Alleles Animals Carcinogenesis Carcinoma Pancreatic Ductal Cell Cycle Proteins Cyclin-Dependent Kinase Inhibitor p16 Disease Progression evolution Molecular Female Gene Dosage Genes myc Genes p53 Humans Male Mice Mutation NF-kappa B p52 Subunit Neoplasm Metastasis Nuclear Proteins Pancreatic Neoplasms Phenotype Phosphoproteins Proto-Oncogene Proteins p21(ras) Transcription Factors Transcriptome Transforming Growth Factor beta1 YAP-Signaling Proteins
Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells.
Björn Neumann, Roey Baror, Chao Zhao, Michael Segel, Sabine Dietmann, Khalil S Rawji, Sarah Foerster, Crystal R McClain, Kevin Chalut, Peter van Wijngaarden, Robin Jm Franklin
Sep 03, 2019
CNS regeneration Adult stem cell aging dietary restriction Metformin oligodendrocyte progenitor cell rejuvenation remyelination aging Animals Cell Differentiation Cells Cultured Central Nervous System DNA Damage Female Humans Hypoglycemic Agents Male Metformin Multiple Sclerosis oligodendrocyte precursor cells Oligodendroglia Rats rejuvenation remyelination Stem Cell Transplantation
Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21.
Lisa Michelle Restelli, Björn Oettinghaus, Mark Halliday, Cavit Agca, Maria Licci, Lara Sironi, Claudia Savoia, Jürgen Hench, Markus Tolnay, Albert Neutzner, Alexander Schmidt, Anne Eckert, Giovanna Mallucci, Luca Scorrano, Stephan Frank
Nov 13, 2018
Stress adaptation is essential for neuronal health. While the fundamental role of mitochondria in neuronal development has been demonstrated, it is still not clear how adult neurons respond to alterations in mitochondrial...
Structural insights into the formation and voltage degradation of lithium- and manganese-rich layered oxides.
Weibo Hua, Suning Wang, Michael Knapp, Steven J Leake, Anatoliy Senyshyn, Carsten Richter, Murat Yavuz, Joachim R Binder, Clare P Grey, Helmut Ehrenberg, Sylvio Indris, Björn Schwarz
Nov 25, 2020
One major challenge in the field of lithium-ion batteries is to understand the degradation mechanism of high-energy lithium- and manganese-rich layered cathode materials. Although they can deliver 30 % excess capacity compared...
Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors.
Roey Baror, Björn Neumann, Michael Segel, Kevin J Chalut, Stephen PJ Fancy, Dorothy P Schafer, Robin Jm Franklin
Feb 27, 2019
Ageing Extracellular Matrix Microglia oligodendrocyte Progenitor cells Age Factors Animals Animals Newborn Cell Differentiation Cells Cultured Cellular Senescence Central Nervous System Dose-Response Relationship Drug Microglia oligodendrocyte precursor cells Oligodendroglia Rats Rats Sprague-Dawley Transforming Growth Factor beta
The Implication of Early Chromatin Changes in X Chromosome Inactivation.
Jan Jakub Żylicz, Aurélie Bousard, Kristina Žumer, Francois Dossin, Eusra Mohammad, Simão Teixeira da Rocha, Björn Schwalb, Laurène Syx, Florent Dingli, Damarys Loew, Patrick Cramer, Edith Heard
Jan 08, 2019
During development, the precise relationships between transcription and chromatin modifications often remain unclear. We use the X chromosome inactivation (XCI) paradigm to explore the implication of chromatin changes in gene...
PRC1 PRC2 polycomb X Chromosome Inactivation XIST Embryonic Stem Cells epigenetics histone acetylation Histone deacetylase Acetylation Animals Chromatin Embryonic Stem Cells Epigenomics Female Gene Silencing Histone Deacetylases Histones Mice Polycomb-Group Proteins Protein Processing Post-Translational RNA Long Noncoding Transcription Genetic Ubiquitination X Chromosome X Chromosome Inactivation
|
|< |
< |
1 |