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How can population-based studies best be utilized to reduce the global impact of dementia? Recommendations for researchers, funders, and policymakers.
In the last two decades, there has been in-depth investigation into understanding the pathogenesis, epidemiological profiling, and clinical characterization of dementia. However, these investigations have not led to successful...
Health-related quality of life in the Cambridge City over-75s Cohort (CC75C)
Jaime Perales, Theodore D Cosco, Blossom CM Stephan, Jane Fleming, Steven Martin, Josep Maria Haro, Carol Brayne, CC75C Study
Jan 09, 2018
BACKGROUND: The assessment of Health Related Quality of Life (HRQL) is important in people with dementia as it could influence their care and support plan. Many studies on dementia do not specifically set out to measure...
A Novel Examination of Successful Aging Trajectories at the End of Life.
Theodore D Cosco, Blossom CM Stephan, Graciela Muniz, Carol Brayne, CC75C Study Collaboration
Sep 27, 2018
A successful aging (SA) index was captured in a longitudinal population-based cohort study of individuals aged 75 and older and examined longitudinally using growth mixture modelling (GMM) to identify groups with similar...
What would a population‐level approach to dementia risk reduction look like, and how would it work?
Sebastian Walsh, Ishtar Govia, Ruth Peters, Edo Richard, Blossom CM Stephan, Nikki‐Anne Wilson, Lindsay Wallace, Kaarin J Anstey, Carol Brayne
Feb 17, 2023
Dementia is a leading global public health challenge. Prevention approaches have traditionally focused on individual-level strategies. However, such approaches have limited potential, particularly for resource-constrained...
Protocol for the Delirium and Cognitive Impact in Dementia (DECIDE) study
Sarah J Richardson, Daniel HJ Davis, Blossom Stephan, Louise Robinson, Carol Brayne, Linda Barnes, Stuart Parker, Louise M Allan
May 05, 2017
BACKGROUND: Delirium is common, affecting at least 20% of older hospital inpatients. It is widely accepted that delirium is associated with dementia but the degree of causation within this relationship is unclear. Previous...
A comparison of health expectancies over two decades in England
Carol Jagger, Fiona E Matthews, Pia Wohland, Tony Fouweather, Blossom CM Stephan, Louise Robinson, Antony Arthur, Carol Brayne, Medical Research Council Cognitive Function and Ageing Collaboration
Nov 09, 2018
BACKGROUND: Whether rises in life expectancy are increases in good-quality years is of profound importance worldwide, with population ageing. We investigate how various health expectancies have changed in England between 1991...
Two-decade change in prevalence of cognitive impairment in the UK.
Connor Richardson, Blossom CM Stephan, Louise Robinson, Carol Brayne, Fiona E Matthews, Cognitive Function and Ageing Study Collaboration
Sep 04, 2020
Identification of individuals at high risk of dementia has usually focused attention on the clinical concept of mild cognitive impairment (MCI), which captures an intermediate state between normal cognitive ageing and dementia....
Recurrent delirium over 12 months predicts dementia
Sarah J Richardson, Daniel HJ Davis, Blossom CM Stephan, Louise Robinson, Carol Brayne, Linda E Barnes, John-Paul Taylor, Stuart G Parker, Louise M Allan
Jan 04, 2021
BACKGROUND: Delirium is common, distressing and associated with poor outcomes. Previous studies investigating the impact of delirium on cognitive outcomes have been limited by incomplete ascertainment of baseline cognition or...
Delirium and Delirium Severity Predict the Trajectory of the Hierarchical Assessment of Balance and Mobility in Hospitalized Older People
Sarah Richardson, James Murray, Daniel Davis, Blossom CM Stephan, Louise Robinson, Carol Brayne, Linda Barnes, Stuart Parker, Avan A Sayer, Richard M Dodds, Louise Allan
May 13, 2021
BACKGROUND: Delirium is common, distressing, and associated with poor outcomes. Despite this, delirium remains poorly recognized, resulting in worse outcomes. There is an urgent need for methods to objectively assess for...
The Rockefeller Institute Review 1963, vol. 1, no. 4
The Rockefeller University
Jan 01, 0001
The Review is published six time a year by The Rockefeller Institute Press and is edited by Mr. John Maddox. Design and layout is by Mr. Reynard Biemiller. The cover photograph by Stephan Pischinger: Founder's Hall.
Published by: The Rockefeller Institute
The Rockefeller Institute Review 1963, vol. 1, no. 1
The Rockefeller University
Jan 01, 0001
The Review is published six time a year by The Rockefeller Institute Press and is edited by Mr. John Maddox. Design and layout is by Mr. Reynard Biemiller. The cover photograph by Stephan Pischinger: hanging stairway leading to...
Published by: The Rockefeller Institute
Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6.
Janice M Ranson, Timothy Rittman, Shabina Hayat, Carol Brayne, Frank Jessen, Kaj Blennow, Cornelia van Duijn, Frederik Barkhof, Eugene Tang, Catherine J Mummery, Blossom C M Stephan, Daniele Altomare, Giovanni B Frisoni, Federica Ribaldi, José Luis Molinuevo, Philip Scheltens, David J Llewellyn
Nov 22, 2021
We envisage the development of new Brain Health Services to achieve primary and secondary dementia prevention. These services will complement existing memory clinics by targeting cognitively unimpaired individuals, where the...
aging Prevention Alzheimer’s disease Dementia Risk Factors Public Health Risk profiling Brain Health Services
Published by: Alzheimer's research & therapy
Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6.
Janice M Ranson, Timothy Rittman, Shabina Hayat, Carol Brayne, Frank Jessen, Kaj Blennow, Cornelia van Duijn, Frederik Barkhof, Eugene Tang, Catherine J Mummery, Blossom CM Stephan, Daniele Altomare, Giovanni B Frisoni, Federica Ribaldi, José Luis Molinuevo, Philip Scheltens, David J Llewellyn, European Task Force for Brain Health Services
Nov 22, 2021
We envisage the development of new Brain Health Services to achieve primary and secondary dementia prevention. These services will complement existing memory clinics by targeting cognitively unimpaired individuals, where the...
The Ursinus Weekly, April 19, 1920
George P. Kehl
Jan 01, 0001
Student council dance held Saturday Girls' Glee Club returns from second trip Varsity loses at Swarthmore Tennis Ursinus loses in oratorical contest "Cherry blossom" cast selected Dr. Good to lecture Freeland freaks swamp...
Ursinus College Collegeville Pennsylvania newspaper James I. Good baseball YMCA YWCA tennis Zwinglian literary society Schaff literary society cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The Rockefeller Institute Review 1963, vol.1, no. 2
The Rockefeller University
Jan 01, 0001
The Review is published six time a year by The Rockefeller Institute Press and is edited by Mr. John Maddox. Design and layout is by Mr. Reynard Biemiller. The cover photograph by Stephan Pischinger: view of campus on south side...
Published by: The Rockefeller Institute
The Rockefeller Institute Review 1963, vol. 1, no. 3
The Rockefeller University
Jan 01, 0001
The Review is published six time a year by The Rockefeller Institute Press and is edited by Mr. John Maddox. Design and layout is by Mr. Reynard Biemiller. The cover photograph by Stephan Pischinger: the tree-shaded walk on...
Published by: The Rockefeller Institute
Education and Successful Aging Trajectories
As the population ages, interest is increasing in studying aging well. However, more refined means of examining predictors of biopsychosocial conceptualizations of successful aging (SA) are required. Existing evidence of the...
How has external knowledge contributed to lithium-ion batteries for the energy transition?
Innovation in clean-energy technologies is central toward a net-zero energy system. One key determinant of technological innovation is the integration of external knowledge, i.e., knowledge spillovers. However, extant work does...
Behavioural and psychological symptoms in the older population without dementia - Relationship with socio-demographics, health and cognition
Alzheimer's Disease Brain Disorders Mental Health Behavioral and Social Science Neurodegenerative Acquired Cognitive Impairment aging Dementia 2 Aetiology 2.3 Psychological social and economic factors Mental Health Neurological 3 Good Health and Well Being Aged Behavioral Symptoms Cognition Disorders Dementia Demography Female health status Humans Longitudinal Studies Male Neuropsychological Tests prevalence Psychotic Disorders United Kingdom
Learning Disease Causality Knowledge From the Web of Health Data
Health information becomes importantly valuable for protecting public health in the current coronavirus situation. Knowledge-based information systems can play a crucial role in helping individuals to practice risk assessment...
Published by: IGI Global Scientific Publishing
Dementia Research Fit for the Planet
Carol E Brayne, Linda E Barnes, Monique MB Breteler, Rachael L Brooks, Carole Dufouil, Chris Fox, Laura Fratiglioni, M Arfan Ikram, Rose A Kenny, Miia Kivipelto, Antonio Lobo, Massimo Musicco, Chengxuan Qiu, Edo Richard, Steffi G Riedel-Heller, Craig Ritchie, Ingmar Skoog, Blossom CM Stephan, Annalena Venneri, Fiona E Matthews
Feb 14, 2020
In recent years, a rapidly increasing collection of investigative methods in addition to changes in diagnostic criteria for dementia have followed "high-tech" trends in medicine, with the aim to better define the dementia...
Trends in the incidence of dementia
Lori B Chibnik, Frank J Wolters, Kristoffer Bäckman, Alexa Beiser, Claudine Berr, Joshua C Bis, Eric Boerwinkle, Daniel Bos, Carol Brayne, Jean-Francois Dartigues, Sirwan KL Darweesh, Stephanie Debette, Kendra L Davis-Plourde, Carole Dufouil, Myriam Fornage, Leslie Grasset, Vilmundur Gudnason, Christoforos Hadjichrysanthou, Catherine Helmer, M Arfan Ikram, M Kamran Ikram, Silke Kern, Lewis H Kuller, Lenore Launer, Oscar L Lopez, Fiona Matthews, Osorio Meirelles, Thomas Mosley, Alison Ower, Bruce M Psaty, Claudia L Satizabal, Sudha Seshadri, Ingmar Skoog, Blossom CM Stephan, Christophe Tzourio, Reem Waziry, Mei Mei Wong, Anna Zettergren, Albert Hofman
May 01, 2018
Several studies have reported a decline in incidence of dementia which may have large implications for the projected burden of disease, and provide important guidance to preventive efforts. However, reports are conflicting or...
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