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Results: 257
Investigating the Interaction Between PAM-1 and WEE-1.3 During Meiosis in C. elegans
Sophie Lear
Jan 01, 0001
PAM-1 is a puromycin sensitive aminopeptidase responsible for cleaving amino acids from the N-terminus of unknown target proteins. In our model system, a microscopic nematode known as C. elegans, functional PAM-1 is required for...
Published by: Ursinus College
The Relationship Between pam-1 and wee-1.3(lz5) in Mitosis of C. elegans
Sarah Bell
Jan 01, 0001
This research is focused on part of the cell cycle that involves the first cell division, otherwise known as mitosis. Regulation of mitosis is very important as mistakes can cause problems such as uncontrolled cell division...
Published by: Ursinus College
Does Using wee-1.3 as a Secondary Suppressor Restore Wildtype Timing of Meiosis and Oocyte Maturation in pam-1 C. elegans Mutants?
Caprice Eisele
Jan 01, 0001
The puromycin-sensitive aminopeptidase, PAM-1, is crucial for polarity establishment, pseudocleavage, and symmetric division, all of which are clear signs of viable development of one cell C. elegans embryos. We have found...
Published by: Ursinus College
Leucocyte subset-specific type 1 interferon signatures in SLE and other immune-mediated diseases.
Investigating Interactions Between Proteins PAM-1 and WEE-1.3 in Regulating the Cell Cycle in Caenorhabditis elegans
Nareen Babaian
Jan 01, 0001
In order to develop into mature organisms, fertilized embryos must go through growth, DNA replication, and cell division. These phases together make up the cell cycle, and movement through the phases is facilitated by many...
Published by: Ursinus College
Investigating the Effect of the wee-1.3 and pam-1 Mutations on Meiosis in C. elegans
PAM-1 is a puromycin sensitive aminopeptidase responsible for cleaving the amino acid from the N-terminus of unknown target proteins. In our model system, a microscopic nematode known as C. elegans, functional PAM-1 is required...
Published by: Ursinus College
Investigating the Interaction Between PAM-1 and WEE-1.3 During Meiosis in C. elegans
Sophie Lear
Jan 01, 0001
PAM-1 is a puromycin sensitive aminopeptidase responsible for cleaving the amino acid from the N-terminus of unknown target proteins. In our model system, a microscopic nematode known as C. elegans, functional PAM-1 is required...
Published by: Ursinus College
Does Using wee-1.3 as a Secondary Suppressor Restore Wildtype Timing of Meiosis and Oocyte Maturation in pam-1 C. elegans Mutants?
Caprice Eisele
Jan 01, 0001
I investigated the relationship between two developmental proteins, PAM-1 and WEE-1.3. WEE-1.3 is an inhibitory kinase that regulates a maturation promoting complex called CDK-1, and is responsible for timely oocyte development....
Published by: Ursinus College
SRSF3 maintains transcriptome integrity in oocytes by regulation of alternative splicing and transposable elements
Vinh Dang Do, Bernhard Strauss, Engin Cukuroglu, Iain Macaulay, Keng Boon Wee, Tim Xiamoming, Igor Ruiz De Los Mozos, Caroline Lee, Andrew Harrison, Richard Butler, Sabine Dietmann, Ule Jernej, John Marioni, Christopher WJ Smith, Jonathan Goke, Azim M Surani
Sep 05, 2018
The RNA-binding protein SRSF3 (also known as SRp20) has critical roles in the regulation of pre-mRNA splicing. Zygotic knockout of Srsf3 results in embryo arrest at the blastocyst stage.
However, SRSF3 is also present in...
Protein Interactions between PAM-1, CDC-25.1, and CDK-1 in C. elegans
Madison Smith
Jan 01, 0001
Caenorhabditis elegans are transparent nematodes used as model organisms for genetics research as their simple organ systems allow us to make and observe the effect of genetic mutations within the reproductive system to better...
Published by: Ursinus College
Genetic Interactions of PAM-1 & MPF in Developing Oocytes
Quaran Davis
Jan 01, 0001
Caenorhabditis elegans are microscopic worms that are a great model organism for examining genes and proteins involved in the reproductive system because of their fecundity, easy manipulation, and visible gonad. The Lyczak lab...
Published by: Ursinus College
Use of Bayesian statistics to calculate transient heat fluxes on compressor disks
Future gas turbine engines require improved understanding of the heat transfer between compressor disks and air in compressor cavities under transient operating conditions. Calculation of transient heat fluxes from...
/dk/atira/pure/subjectarea/asjc/2200/2206 name=Computational Mechanics /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2200/2211 name=Mechanics of Materials /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering /dk/atira/pure/subjectarea/asjc/1500/1507 name=Fluid Flow and Transfer Processes
Use of Bayesian statistics to calculate transient heat fluxes on compressor disks
Future gas turbine engines require improved understanding of the heat transfer between compressor disks and air in compressor cavities under transient operating conditions. Calculation of transient heat fluxes from...
/dk/atira/pure/subjectarea/asjc/2200/2206 name=Computational Mechanics /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2200/2211 name=Mechanics of Materials /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering /dk/atira/pure/subjectarea/asjc/1500/1507 name=Fluid Flow and Transfer Processes
Extending the Reach of Quality With CARF Accreditation
Brian Boon
Jan 01, 2022
Accreditation is a common method to assess quality and plan for improvements in the delivery of health and human services. CARF accreditation was established to create standards of quality for specialty programs in...
Published by: IGI Global Scientific Publishing
The Effect of Advance Care Planning on Heart Failure
Abstract: Background: Advance care planning is widely advocated to improve outcomes in end-of-life care for patients suffering from heart failure. But until now, there has been no systematic evaluation of the impact of advance...
Palliative and end-of-life care and junior doctors
BACKGROUND: Palliative and end-of-life care is a core competency for doctors and is increasingly recognised as a key clinical skill for junior doctors. There is a growing international movement to embed palliative care education...
Synergistic Activation of RD29A Via Integration of Salinity Stress and Abscisic Acid in Arabidopsis thaliana.
Plants perceive information from the surroundings and elicit appropriate molecular responses. How plants dynamically respond to combinations of external inputs is yet to be revealed, despite the detailed current knowledge of...
Combined stress Gene expression dynamics mathematical modeling Plant abiotic stresses Signaling cross-talk Abscisic Acid Arabidopsis Arabidopsis Proteins Computer Simulation Gene Expression Profiling Gene Expression Regulation Plant Models Biological Oligonucleotide Array Sequence Analysis Reproducibility of Results salinity Sodium Chloride Stress Physiological
Towards engineering hormone-binding globulins as drug delivery agents.
Amino Acid Sequence Biological Transport Crystallography X-Ray Drug Carriers Escherichia coli Fluoresceins Gene Expression Humans Hydrocortisone Leukocyte Elastase Models Molecular Molecular Sequence Data Molecular Targeted Therapy Mutation Prostate-specific antigen Protein Engineering Protein Structure Secondary Recombinant Proteins Thrombin Thyroxine Transcortin
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation.
Li Ren Kong, Richard Weijie Ong, Tuan Zea Tan, Nur Afiqah Binte Mohamed Salleh, Matan Thangavelu, Jane Vin Chan, Lie Yong Judice Koh, Giridharan Periyasamy, Jieying Amelia Lau, Thi Bich Uyen Le, Lingzhi Wang, MiYoung Lee, Srinivasaraghavan Kannan, Chandra S Verma, Chwee Ming Lim, Wee Joo Chng, David P Lane, Ashok Venkitaraman, Huynh The Hung, Chit Fang Cheok, Boon Cher Goh
May 15, 2020
Gain of function (GOF) DNA binding domain (DBD) mutations of TP53 upregulate chromatin regulatory genes that promote genome-wide histone methylation and acetylation. Here, we therapeutically exploit the oncogenic GOF mechanisms...
Acetylation Animals Antineoplastic Agents Apoptosis Caspase 3 Cell Line Tumor Cell Proliferation cisplatin Codon Epigenesis Genetic Gain of Function Mutation Gene Expression Regulation Neoplastic Humans Hydroxamic Acids Mice SCID Models Biological Mutant Proteins Mutation NF-kappa B Neoplasms Nucleotide Motifs Poly(ADP-ribose) Polymerases Protein Binding Protein Isoforms Sulfonamides Topotecan Tumor Suppressor Protein p53 Ubiquitin-Protein Ligases Xenograft Model Antitumor Assays
Social Media Marketing Strategies of Football Clubs
Sports organisations, including football clubs, are using social media to connect with spectators. The aim of this study is to examine whether social influence on social media can increase attendance at matches. In particular...
Published by: IGI Global Scientific Publishing
Identification of the lz5 Suppressor of pam-1 in C. elegans
Robin Alsher
Jan 01, 0001
RNA interference and western blotting were used to identify the lz5 suppressor mutation of pam-1 in the worm C. elegans. Preliminary data suggest that wee-1.3 is the most promising gene.
C. elegans pam-1 Cell Polarity Cell Division RNAi Biochemistry, Biophysics, and Structural Biology Life Sciences Molecular genetics
Published by: Ursinus College
Investigating Interactions Between PAM-1 and the Maturation Promoting Factor in Cell Cycle Regulation in Caenorhabditis elegans
Nareen Babaian
Jan 01, 0001
To develop into mature organisms, fertilized embryos must go through phases of growth, DNA replication, and cell division. The phases together make up the cell cycle, and movement through these phases is facilitated by many...
Published by: Ursinus College
Pathogenic viruses as a global commons
In light of the Covid-19 pandemic, the international community’s approach towards pathogenic viruses needs to be re-evaluated. This commentary notes that attempts to justify viral sovereignty, either under treaties or...
Tessa Sze-Myn Teo
Jun 18, 2021
Netrin Guides Spinal Commissural Axons to the Midline at Long Range Through the Receptors DCC and Neogenin
Sze Sing Shaun Teo
Jan 01, 0001
During neurodevelopment, commissural axons are guided to the ventral midline in a remarkably precise and stereotyped way. Netrin, a secreted laminin-related protein, provides the major attractive cue for midline guidance. It is...
Published by: Rockefeller University
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