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Robot seeks public library websites
UKOLN has been active recently analysing UK Public Library websites. Brian Kelly, Sarah Ormes and Ian Peacock report on their findings.
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Robot seeks public library websites
UKOLN has been active recently analysing UK Public Library websites. Brian Kelly, Sarah Ormes and Ian Peacock report on their findings.
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G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
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Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
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RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
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The Potential of the Josephson Energy
M. G. Blamire
Jun 28, 2021
Abstract: The concept of the Josephson energy emerges directly from the original predictions of Brian Josephson. Although it can be used to explain the behaviour of Josephson devices, the Josephson energy has no present...
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Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
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Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Published by:
Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

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Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

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Review of Richard Kearney and Brian Treanor (eds.), Carnal Hermeneutics, New York
Carnal Hermeneutics is a collection of essays published in 2015 in the “Perspectives in Continental Philosophy” series by Fordham University Press. The contributors fall into two categories: established French philosophers...
What Are Observables in Hamiltonian Einstein–Maxwell Theory?
J. Brian Pitts
Aug 05, 2020
Abstract: Is change missing in Hamiltonian Einstein–Maxwell theory? Given the most common definition of observables (having weakly vanishing Poisson bracket with each first-class constraint), observables are constants of the...
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