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New Scholarship Supports First-Generation College Students at Winthrop
Winthrop University
Jan 01, 0001
The Henry Brice Knox and Eunice Hood Knox Scholarship, established in honor of Warner's parents, will be endowed over a five-year period. Warner, a first-generation college student, credits her Winthrop experience and her...
Published by: Winthrop University
Winthrop's Think College Student Takes Home Scholarship From Star-Filled Event
Winthrop University
Jan 01, 0001
The 36th installment of UNCF An Evening of Stars, which will air on Sunday night, April 26, on BET, will feature singer Toni Braxton giving Winthrop's Terence Brice of Rock Hill his scholarship award as the national recipient. ...
Published by: Winthrop University
Design of a Blockchain-Based Smart Contract Model for Child Labor Alleviation
The achievements of west and central Africa in producing more than 60% of the world's cocoa, and sub-Saharan Africa's achievement in producing 13% of the world's cotton, hide child labor. These significant levels of production...
Published by: IGI Global Scientific Publishing
TAF6delta orchestrates an apoptotic transcriptome profile and interacts functionally with p53.
Emmanuelle Wilhelm, Mara Kornete, Brice Targat, Jimmy Vigneault-Edwards, Mattia Frontini, Laszlo Tora, Arndt Benecke, Brendan Bell
Sep 26, 2018
BACKGROUND: TFIID is a multiprotein complex that plays a pivotal role in the regulation of RNA polymerase II (Pol II) transcription owing to its core promoter recognition and co-activator functions. TAF6 is a core TFIID subunit...
Evaluating cognitive disturbances as treatment target and predictor of antidepressant action in major depressive disorder
Vibeke Høyrup Dam, Dea Siggaard Stenbæk, Kristin Köhler-Forsberg, Cheng Ip, Brice Ozenne, Barbara Jacquelyn Sahakian, Gitte Moos Knudsen, Martin Balslev Jørgensen, Vibe Gedsoe Frokjaer
Dec 09, 2022
Cognitive disturbances in major depressive disorder (MDD) constitute a critical treatment target and hold promise as an early predictor of antidepressant treatment response; yet their clinical relevance is not fully established....
Ovarian Yolk Sac Tumors; Does Age Matter?
Cecile Faure Conter, Caihong Xia, David Gershenson, Jean Hurteau, Al Covens, Farzana Pashankar, Mark Krailo, Deborah Billmire, Catherine Patte, Brice Fresneau, Furqan Shaikh, Sara Stoneham, James Nicholson, Matthew Murray, Anne Lindsay Frazier
Feb 15, 2019
BACKGROUND: Whereas among pediatric oncologists, ovarian yolk sac tumor (O-YST) is considered a chemosensitive tumor, it is often cited as an adverse prognostic factor in adult women with ovarian germ cell tumors. METHODS: The...
Temperate Earth-sized planets transiting a nearby ultracool dwarf star.
Michaël Gillon, Emmanuël Jehin, Susan M Lederer, Laetitia Delrez, Julien de Wit, Artem Burdanov, Valérie Van Grootel, Adam J Burgasser, Amaury HMJ Triaud, Cyrielle Opitom, Brice-Olivier Demory, Devendra K Sahu, Daniella Bardalez Gagliuffi, Pierre Magain, Didier Queloz
Jul 19, 2021
Star-like objects with effective temperatures of less than 2,700 kelvin are referred to as 'ultracool dwarfs'. This heterogeneous group includes stars of extremely low mass as well as brown dwarfs (substellar objects not massive...
Evaluating cognitive disturbances as treatment target and predictor of antidepressant action in major depressive disorder
Vibeke Høyrup Dam, Dea Siggaard Stenbæk, Kristin Köhler-Forsberg, Cheng Ip, Brice Ozenne, Barbara Jacquelyn Sahakian, Gitte Moos Knudsen, Martin Balslev Jørgensen, Vibe Gedsoe Frokjaer
Nov 09, 2022
Cognitive disturbances in major depressive disorder (MDD) constitute a critical treatment target and hold promise as an early predictor of antidepressant treatment response; yet their clinical relevance is not fully established....
A map of the large day-night temperature gradient of a super-Earth exoplanet.
Brice-Olivier Demory, Michael Gillon, Julien de Wit, Nikku Madhusudhan, Emeline Bolmont, Kevin Heng, Tiffany Kataria, Nikole Lewis, Renyu Hu, Jessica Krick, Vlada Stamenković, Björn Benneke, Stephen Kane, Didier Queloz
Mar 18, 2020
Over the past decade, observations of giant exoplanets (Jupiter-size) have provided key insights into their atmospheres, but the properties of lower-mass exoplanets (sub-Neptune) remain largely unconstrained because of the...
A C=O⋅⋅⋅Isothiouronium Interaction Dictates Enantiodiscrimination in Acylative Kinetic Resolutions of Tertiary Heterocyclic Alcohols
Mark D. Greenhalgh, Samuel M. Smith, Daniel M. Walden, James E. Taylor, Zamira Brice, Emily R.T. Robinson, Charlene Fallan, David B. Cordes, Alexandra M.Z. Slawin, H. Camille Richardson, Markas A. Grove, Paul Ha Yeon Cheong, Andrew D. Smith
Mar 07, 2018
A combination of experimental and computational studies have identified a C=O⋅⋅⋅isothiouronium interaction as key to efficient enantiodiscrimination in the kinetic resolution of tertiary heterocyclic alcohols bearing up to...
A C=O⋅⋅⋅Isothiouronium Interaction Dictates Enantiodiscrimination in Acylative Kinetic Resolutions of Tertiary Heterocyclic Alcohols
Mark D. Greenhalgh, Samuel M. Smith, Daniel M. Walden, James E. Taylor, Zamira Brice, Emily R.T. Robinson, Charlene Fallan, David B. Cordes, Alexandra M.Z. Slawin, H. Camille Richardson, Markas A. Grove, Paul Ha Yeon Cheong, Andrew D. Smith
Mar 07, 2018
A combination of experimental and computational studies have identified a C=O⋅⋅⋅isothiouronium interaction as key to efficient enantiodiscrimination in the kinetic resolution of tertiary heterocyclic alcohols bearing up to...
A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage.
Xueqing Zou, Gene Ching Chiek Koh, Arjun Scott Nanda, Andrea Degasperi, Katie Urgo, Theodoros I Roumeliotis, Chukwuma A Agu, Cherif Badja, Sophie Momen, Jamie Young, Tauanne Dias Amarante, Lucy Side, Glen Brice, Vanesa Perez-Alonso, Daniel Rueda, Celine Gomez, Wendy Bushell, Rebecca Harris, Jyoti S Choudhary, Genomics England Research Consortium, Josef Jiricny, William C Skarnes, Serena Nik-Zainal
Jul 28, 2021
Mutational signatures are imprints of pathophysiological processes arising through tumorigenesis. We generated isogenic CRISPR-Cas9 knockouts (Δ) of 43 genes in human induced pluripotent stem cells, cultured them in the absence...
Development of a Data Model and Data Commons for Germ Cell Tumors.
Bo Ci, Donghan M Yang, Mark Krailo, Caihong Xia, Bo Yao, Danni Luo, Qinbo Zhou, Guanghua Xiao, Lin Xu, Stephen X Skapek, Matthew M Murray, James F Amatruda, Lindsay Klosterkemper, Furqan Shaikh, Cecile Faure-Conter, Brice Fresneau, Samuel L Volchenboum, Sara Stoneham, Luiz Fernando Lopes, James Nicholson, A Lindsay Frazier, Yang Xie
Jul 06, 2020
Germ cell tumors (GCTs) are considered a rare disease but are the most common solid tumors in adolescents and young adults, accounting for 15% of all malignancies in this age group. The rarity of GCTs in some groups...
A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement.
Sylvie Bannwarth, Samira Ait-El-Mkadem, Annabelle Chaussenot, Emmanuelle C Genin, Sandra Lacas-Gervais, Konstantina Fragaki, Laetitia Berg-Alonso, Yusuke Kageyama, Valérie Serre, David G Moore, Annie Verschueren, Cécile Rouzier, Isabelle Le Ber, Gaëlle Augé, Charlotte Cochaud, Françoise Lespinasse, Karine N'Guyen, Anne de Septenville, Alexis Brice, Patrick Yu-Wai-Man, Hiromi Sesaki, Jean Pouget, Véronique Paquis-Flucklinger
Mar 18, 2019
Mitochondrial DNA instability disorders are responsible for a large clinical spectrum, among which amyotrophic lateral sclerosis-like symptoms and frontotemporal dementia are extremely rare. We report a large family with a...
CHCHD10 FTD-ALS mitochondrial DNA instability mitochondrial disorder Age of Onset Aged Alleles Amyotrophic Lateral Sclerosis DNA Mitochondrial Exome Female frontotemporal dementia HeLa Cells Humans Male Middle Aged Mitochondria Mitochondrial Diseases Mitochondrial Proteins Mutation Missense Pedigree Phenotype
Investigation of clinical characteristics and genome associations in the 'UK Lipoedema' cohort.
Dionysios Grigoriadis, Ege Sackey, Katie Riches, Malou van Zanten, Glen Brice, Ruth England, Mike Mills, Sara E Dobbins, Li Ling Lee, Lipoedema Consortium, Genomics England Research Consortium, Steve Jeffery, Liang Dong, David B Savage, Peter S Mortimer, Vaughan Keeley, Alan Pittman, Kristiana Gordon, Pia Ostergaard
Oct 13, 2022
Investigation of clinical characteristics and genome associations in the 'UK Lipoedema' cohort.
Dionysios Grigoriadis, Ege Sackey, Katie Riches, Malou van Zanten, Glen Brice, Ruth England, Mike Mills, Sara E Dobbins, Li Ling Lee, Lipoedema Consortium, Genomics England Research Consortium, Steve Jeffery, Liang Dong, David B Savage, Peter S Mortimer, Vaughan Keeley, Alan Pittman, Kristiana Gordon, Pia Ostergaard
Nov 16, 2022
Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's.
Ganqiang Liu, Brendon Boot, Joseph J Locascio, Iris E Jansen, Sophie Winder-Rhodes, Shirley Eberly, Alexis Elbaz, Alexis Brice, Bernard Ravina, Jacobus J van Hilten, Florence Cormier-Dequaire, Jean-Christophe Corvol, Roger A Barker, Peter Heutink, Johan Marinus, Caroline H Williams-Gray, Clemens R Scherzer, International Genetics of Parkinson Disease Progression (IGPP) Consortium
May 16, 2018
OBJECTIVE: We hypothesized that specific mutations in the β-glucocerebrosidase gene (GBA) causing neuropathic Gaucher's disease (GD) in homozygotes lead to aggressive cognitive decline in heterozygous Parkinson's disease (PD)...
Resolving the fibrotic niche of human liver cirrhosis at single-cell level.
P Ramachandran, R Dobie, JR Wilson-Kanamori, EF Dora, BEP Henderson, NT Luu, JR Portman, KP Matchett, M Brice, JA Marwick, RS Taylor, M Efremova, R Vento-Tormo, NO Carragher, TJ Kendall, JA Fallowfield, EM Harrison, DJ Mole, SJ Wigmore, PN Newsome, CJ Weston, JP Iredale, F Tacke, JW Pollard, CP Ponting, JC Marioni, SA Teichmann, NC Henderson
Dec 19, 2019
Animals Case-Control Studies Cell Lineage Duffy Blood-Group System Endothelial Cells Female Hepatic Stellate Cells Hepatocytes Humans Liver Liver Cirrhosis MACROPHAGES Male Membrane Glycoproteins Membrane Proteins Mice Phenotype Receptor Platelet-Derived Growth Factor alpha Receptors Cell Surface Receptors Immunologic Single-Cell Analysis Tetraspanin 29 Transcriptome Transendothelial and Transepithelial Migration
Prediction of cognition in Parkinson's disease with a clinical-genetic score
G Liu, JJ Locascio, J-C Corvol, B Boot, Z Liao, K Page, D Franco, K Burke, IE Jansen, A Trisini-Lipsanopoulos, S Winder-Rhodes, CM Tanner, AE Lang, S Eberly, A Elbaz, A Brice, G Mangone, B Ravina, I Shoulson, F Cormier-Dequaire, P Heutink, JJ van Hilten, RA Barker, CH Williams-Gray, J Marinus, CR Scherzer, HBS, CamPaIGN, PICNICS, PROPARK, PSG, DIGPD, PDBP
Sep 04, 2017
Differences in the Presentation and Progression of Parkinson's Disease by Sex.
Hirotaka Iwaki, Cornelis Blauwendraat, Hampton L Leonard, Mary B Makarious, Jonggeol J Kim, Ganqiang Liu, Jodi Maple-Grødem, Jean-Christophe Corvol, Lasse Pihlstrøm, Marlies van Nimwegen, Luba Smolensky, Ninad Amondikar, Samantha J Hutten, Mark Frasier, Khanh-Dung H Nguyen, Jacqueline Rick, Shirley Eberly, Faraz Faghri, Peggy Auinger, Kirsten M Scott, Ruwani Wijeyekoon, Vivianna M Van Deerlin, Dena G Hernandez, Raphael J Gibbs, Aaron G Day-Williams, Alexis Brice, Guido Alves, Alastair J Noyce, Ole-Bjørn Tysnes, Jonathan R Evans, David P Breen, Karol Estrada, Claire E Wegel, Fabrice Danjou, David K Simon, Ole A Andreassen, Bernard Ravina, Mathias Toft, Peter Heutink, Bastiaan R Bloem, Daniel Weintraub, Roger A Barker, Caroline H Williams-Gray, Bart P van de Warrenburg, Jacobus J van Hilten, Clemens R Scherzer, Andrew B Singleton, Mike A Nalls
Aug 11, 2020
Genetic risk of Parkinson disease and progression:
Hirotaka Iwaki, Cornelis Blauwendraat, Hampton L Leonard, Ganqiang Liu, Jodi Maple-Grødem, Jean-Christophe Corvol, Lasse Pihlstrøm, Marlies van Nimwegen, Samantha J Hutten, Khanh-Dung H Nguyen, Jacqueline Rick, Shirley Eberly, Faraz Faghri, Peggy Auinger, Kirsten M Scott, Ruwani Wijeyekoon, Vivianna M Van Deerlin, Dena G Hernandez, Aaron G Day-Williams, Alexis Brice, Guido Alves, Alastair J Noyce, Ole-Bjørn Tysnes, Jonathan R Evans, David P Breen, Karol Estrada, Claire E Wegel, Fabrice Danjou, David K Simon, Bernard Ravina, Mathias Toft, Peter Heutink, Bastiaan R Bloem, Daniel Weintraub, Roger A Barker, Caroline H Williams-Gray, Bart P van de Warrenburg, Jacobus J van Hilten, Clemens R Scherzer, Andrew B Singleton, Mike A Nalls
May 03, 2019
Deletions at 22q11.2 in idiopathic Parkinson's disease
Kin Y Mok, Una Sheerin, Javier Simón-Sánchez, Afnan Salaka, Lucy Chester, Valentina Escott-Price, Kiran Mantripragada, Karen M Doherty, Alastair J Noyce, Niccolo E Mencacci, Steven J Lubbe, International Parkinson's Disease Genomics Consortium (IPDGC), Caroline H Williams-Gray, Roger A Barker, Karin D van Dijk, Henk W Berendse, Peter Heutink, Jean-Christophe Corvol, Florence Cormier, Suzanne Lesage, Alexis Brice, Kathrin Brockmann, Claudia Schulte, Thomas Gasser, Thomas Foltynie, Patricia Limousin, Karen E Morrison, Carl E Clarke, Stephen Sawcer, Tom T Warner, Andrew J Lees, Huw R Morris, Mike A Nalls, Andrew B Singleton, John Hardy, Andrey Y Abramov, Vincent Plagnol, Nigel M Williams, Nicholas W Wood
Apr 05, 2016
Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.
Iris E Jansen, Hui Ye, Sasja Heetveld, Marie C Lechler, Helen Michels, Renée I Seinstra, Steven J Lubbe, Valérie Drouet, Suzanne Lesage, Elisa Majounie, J Raphael Gibbs, Mike A Nalls, Mina Ryten, Juan A Botia, Jana Vandrovcova, Javier Simon-Sanchez, Melissa Castillo-Lizardo, Patrizia Rizzu, Cornelis Blauwendraat, Amit K Chouhan, Yarong Li, Puja Yogi, Najaf Amin, Cornelia M van Duijn, International Parkinson’s Disease Genetics Consortium (IPGDC), Huw R Morris, Alexis Brice, Andrew B Singleton, Della C David, Ellen A Nollen, Shushant Jain, Joshua M Shulman, Peter Heutink
Nov 13, 2017
BACKGROUND: Whole-exome sequencing (WES) has been successful in identifying genes that cause familial Parkinson's disease (PD). However, until now this approach has not been deployed to study large cohorts of unrelated...
animal model Functional screening Genomics Loss-of-function Mitochondria Parkin Parkinson’s disease rare variants whole-exome sequencing α-synuclein Adolescent Adult Animals Animals Genetically Modified Caenorhabditis elegans Case-Control Studies Cells Cultured Child Disease Models Animal Drosophila melanogaster Exome Genetic Predisposition to Disease High-Throughput Nucleotide Sequencing Humans Middle Aged Parkinson Disease RNA Interference Sequence Analysis DNA Young Adult ALPHA-SYNUCLEIN
Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts.
Hirotaka Iwaki, Cornelis Blauwendraat, Hampton L Leonard, Jonggeol J Kim, Ganqiang Liu, Jodi Maple-Grødem, Jean-Christophe Corvol, Lasse Pihlstrøm, Marlies van Nimwegen, Samantha J Hutten, Khanh-Dung H Nguyen, Jacqueline Rick, Shirley Eberly, Faraz Faghri, Peggy Auinger, Kirsten M Scott, Ruwani Wijeyekoon, Vivianna M Van Deerlin, Dena G Hernandez, J Raphael Gibbs, International Parkinson's Disease Genomics Consortium, Kumaraswamy Naidu Chitrala, Aaron G Day-Williams, Alexis Brice, Guido Alves, Alastair J Noyce, Ole-Bjørn Tysnes, Jonathan R Evans, David P Breen, Karol Estrada, Claire E Wegel, Fabrice Danjou, David K Simon, Ole Andreassen, Bernard Ravina, Mathias Toft, Peter Heutink, Bastiaan R Bloem, Daniel Weintraub, Roger A Barker, Caroline H Williams-Gray, Bart P van de Warrenburg, Jacobus J van Hilten, Clemens R Scherzer, Andrew B Singleton, Mike A Nalls
Jul 29, 2019
Apolipoprotein E GBA Parkinson's Disease genomewide association study Adult Aged Aged 80 and over Antigens CD Biomarkers Cognitive Dysfunction Cohort Studies Cross-Sectional Studies Disease Progression Female Genome-Wide Association Study Glucosylceramidase Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Longitudinal Studies Male Middle Aged Organic Cation Transport Proteins Parkinson Disease Phenotype Risk Assessment
Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease.
Ganqiang Liu, Jiajie Peng, Zhixiang Liao, Joseph J Locascio, Jean-Christophe Corvol, Frank Zhu, Xianjun Dong, Jodi Maple-Grødem, Meghan C Campbell, Alexis Elbaz, Suzanne Lesage, Alexis Brice, Graziella Mangone, John H Growdon, Albert Y Hung, Michael A Schwarzschild, Michael T Hayes, Anne-Marie Wills, Todd M Herrington, Bernard Ravina, Ira Shoulson, Pille Taba, Sulev Kõks, Thomas G Beach, Florence Cormier-Dequaire, Guido Alves, Ole-Bjørn Tysnes, Joel S Perlmutter, Peter Heutink, Sami S Amr, Jacobus J van Hilten, Meike Kasten, Brit Mollenhauer, Claudia Trenkwalder, Christine Klein, Roger A Barker, Caroline H Williams-Gray, Johan Marinus, International Genetics of Parkinson Disease Progression (IGPP) Consortium, Clemens R Scherzer
Apr 19, 2022
A key driver of patients' well-being and clinical trials for Parkinson's disease (PD) is the course that the disease takes over time (progression and prognosis). To assess how genetic variation influences the progression of PD...
Apolipoprotein E4 Cognition Cognition Disorders Disease Progression Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Glucosylceramidase Humans Longitudinal Studies Multifactorial Inheritance Mutation Parkinson Disease Proportional Hazards Models Risk Factors Survival Analysis Synapses
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