Search
Results: 32
Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson's disease patients.
Gaia Meoni, Leonardo Tenori, Sebastian Schade, Cristina Licari, Chiara Pirazzini, Maria Giulia Bacalini, Paolo Garagnani, Paola Turano, PROPAG-AGEING consortium, Claudia Trenkwalder, Claudio Franceschi, Brit Mollenhauer, Claudio Luchinat
Feb 09, 2022
Parkinson's disease (PD) is the neurological disorder showing the greatest rise in prevalence from 1990 to 2016. Despite clinical definition criteria and a tremendous effort to develop objective biomarkers, precise diagnosis of...
Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients.
Luca Baldelli, Sebastian Schade, Silvia Jesús, Sebastian R Schreglmann, Luisa Sambati, Pilar Gómez-Garre, Claire Halsband, Giovanna Calandra-Buonaura, Astrid Daniela Adarmes-Gómez, Friederike Sixel-Döring, Corrado Zenesini, Chiara Pirazzini, Paolo Garagnani, Maria Giulia Bacalini, Kailash P Bhatia, Pietro Cortelli, Brit Mollenhauer, Claudio Franceschi, PROPAG-AGEING consortium, Pablo Mir, Claudia Trenkwalder, Federica Provini
Oct 08, 2021
A prodromal phase of Parkinson's disease (PD) may precede motor manifestations by decades. PD patients' siblings are at higher risk for PD, but the prevalence and distribution of prodromal symptoms are unknown. The study...
Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson's Disease.
Johannes Hertel, Amy C Harms, Almut Heinken, Federico Baldini, Cyrille C Thinnes, Enrico Glaab, Daniel A Vasco, Maik Pietzner, Isobel D Stewart, Nicholas J Wareham, Claudia Langenberg, Claudia Trenkwalder, Rejko Krüger, Thomas Hankemeier, Ronan MT Fleming, Brit Mollenhauer, Ines Thiele
Nov 25, 2019
Parkinson's disease (PD) exhibits systemic effects on the human metabolism, with emerging roles for the gut microbiome. Here, we integrate longitudinal metabolome data from 30 drug-naive, de novo PD patients and 30 matched...
The Crossroads of Digital Phenotyping
Brit Davidson
Feb 03, 2022
The term ‘Digital Phenotyping’ has started to appear with increasing regularity in medical research, especially within psychiatry. This aims to bring together digital traces (e.g., from smartphones), medical data (e.g....
The Crossroads of Digital Phenotyping
Brit Davidson
Feb 03, 2022
The term ‘Digital Phenotyping’ has started to appear with increasing regularity in medical research, especially within psychiatry. This aims to bring together digital traces (e.g., from smartphones), medical data (e.g....
Early downregulation of hsa-miR-144-3p in serum from drug-naïve Parkinson's disease patients.
Elisa Zago, Alessandra Dal Molin, Giovanna Maria Dimitri, Luciano Xumerle, Chiara Pirazzini, Maria Giulia Bacalini, Maria Giovanna Maturo, Tiago Azevedo, Simeon Spasov, Pilar Gómez-Garre, María Teresa Periñán, Silvia Jesús, Luca Baldelli, Luisa Sambati, Giovanna Calandra-Buonaura, Paolo Garagnani, Federica Provini, Pietro Cortelli, Pablo Mir, Claudia Trenkwalder, Brit Mollenhauer, Claudio Franceschi, Pietro Liò, Christine Nardini, PROPAG-AGEING consortium
Jan 28, 2022
Advanced age represents one of the major risk factors for Parkinson's Disease. Recent biomedical studies posit a role for microRNAs, also known to be remodelled during ageing. However, the relationship between microRNA...
A Systematic Review and Meta-Analysis of Discrepancies Between Logged and Self-Reported Digital Media Use
Douglas Parry, Brit Davidson, Craig Sewall, Jacob Fisher, Hannah Mieczkowski, Dan Quintana
Nov 30, 2021
There is widespread public and academic interest in understanding the uses and effects of digital media. Scholars primarily use self-report measures of the quantity or duration of media use as proxies for more objective...
Requirements for a Bespoke Intensive Care Unit Dashboard in Response to the COVID-19 Pandemic
Brit Davidson, Katiuska M.F. Portillo, Marceli Wac, Chris McWilliams, Chris Bourdeaux, Ian Craddock
Jun 30, 2022
Background: Intensive care units (ICUs) around the world are in high demand due to patients with COVID-19 requiring hospitalization. As researchers at the University of Bristol, we were approached to develop a bespoke data...
covid-19 ICU KEYWORDS intensive care Critical Care dashboard Design development disease monitoring eHealth human-centered design Interview Monitoring /dk/atira/pure/subjectarea/asjc/2700/2718 name=Health Informatics /dk/atira/pure/subjectarea/asjc/3300/3307 name=Human Factors and Ergonomics /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Measurement practices exacerbate the generalizability crisis
Psychology’s tendency to focus on confirmatory analyses before ensuring constructs are clearly defined and accurately measured is exacerbating the generalizability crisis. Our growing use of digital behaviors as predictors has...
Measurement practices exacerbate the generalizability crisis
Psychology’s tendency to focus on confirmatory analyses before ensuring constructs are clearly defined and accurately measured is exacerbating the generalizability crisis. Our growing use of digital behaviors as predictors has...
Social Media and Well-being
Due to the methodological challenges inherent in studying social media use (SMU), as well as the methodological choices that have shaped research into the effects of SMU on well-being, clear conclusions regarding...
A Systematic Review and Meta-Analysis of Discrepancies Between Logged and Self-Reported Digital Media Use
Douglas Parry, Brit Davidson, Craig Sewall, Jacob Fisher, Hannah Mieczkowski, Dan Quintana
Nov 30, 2021
There is widespread public and academic interest in understanding the uses and effects of digital media. Scholars primarily use self-report measures of the quantity or duration of media use as proxies for more objective...
Orienting to Student Sense-Making
This chapter reports on work from a decade-long project to develop and study the use of teaching simulations focused on the teaching practices of eliciting and interpreting student thinking to support preservice teachers'...
Teacher Education Education Teacher Education Social Sciences and Humanities Physical Sciences and Engineering
Published by: IGI Global Scientific Publishing
Requirements for a Bespoke Intensive Care Unit Dashboard in Response to the COVID-19 Pandemic
Brit Davidson, Katiuska M.F. Portillo, Marceli Wac, Chris McWilliams, Chris Bourdeaux, Ian Craddock
Jun 30, 2022
Background: Intensive care units (ICUs) around the world are in high demand due to patients with COVID-19 requiring hospitalization. As researchers at the University of Bristol, we were approached to develop a bespoke data...
covid-19 ICU KEYWORDS intensive care Critical Care dashboard Design development disease monitoring eHealth human-centered design Interview Monitoring /dk/atira/pure/subjectarea/asjc/2700/2718 name=Health Informatics /dk/atira/pure/subjectarea/asjc/3300/3307 name=Human Factors and Ergonomics /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Clinical diagnosis of progressive supranuclear palsy
Günter U Höglinger, Gesine Respondek, Maria Stamelou, Carolin Kurz, Keith A Josephs, Anthony E Lang, Brit Mollenhauer, Ulrich Müller, Christer Nilsson, Jennifer L Whitwell, Thomas Arzberger, Elisabet Englund, Ellen Gelpi, Armin Giese, David J Irwin, Wassilios G Meissner, Alexander Pantelyat, Alex Rajput, John C van Swieten, Claire Troakes, Angelo Antonini, Kailash P Bhatia, Yvette Bordelon, Yaroslau Compta, Jean-Christophe Corvol, Carlo Colosimo, Dennis W Dickson, Richard Dodel, Leslie Ferguson, Murray Grossman, Jan Kassubek, Florian Krismer, Johannes Levin, Stefan Lorenzl, Huw R Morris, Peter Nestor, Wolfgang H Oertel, Werner Poewe, Gil Rabinovici, James B Rowe, Gerard D Schellenberg, Klaus Seppi, Thilo van Eimeren, Gregor K Wenning, Adam L Boxer, Lawrence I Golbe, Irene Litvan, Movement Disorder Society-endorsed PSP Study Group
Jun 05, 2017
Social Media and Well-being
Due to the methodological challenges inherent in studying social media use (SMU), as well as the methodological choices that have shaped research into the effects of SMU on well-being, clear conclusions regarding...
The chronology of reindeer hunting on Norway's highest ice patches.
Lars Pilø, Espen Finstad, Christopher Bronk Ramsey, Julian Robert Post Martinsen, Atle Nesje, Brit Solli, Vivian Wangen, Martin Callanan, James H Barrett
Feb 21, 2018
The melting of perennial ice patches globally is uncovering a fragile record of alpine activity, especially hunting and the use of mountain passes. When rescued by systematic fieldwork (glacial archaeology), this evidence opens...
Platform-controlled social media APIs threaten Open Science
Brit Davidson, Darja Wischerath, Daniel Racek, Douglas A. Parry, Emily Godwin, Joanne Hinds, Dirk van der Linden, Jonathan F. Roscoe, Laura Ayravainen, Alicia Cork
Nov 02, 2023
Social media data enable insights into human behavior. Researchers can access these data via platform-provided Application Programming Interfaces (APIs), but these come with restrictive usage-terms that mean studies cannot be...
Rapid Atlantification along the Fram Strait at the beginning of the 20th century.
Tommaso Tesi, Francesco Muschitiello, Gesine Mollenhauer, Stefano Miserocchi, Leonardo Langone, Chiara Ceccarelli, Giuliana Panieri, Jacopo Chiggiato, Alessio Nogarotto, Jens Hefter, Gianmarco Ingrosso, Federico Giglio, Patrizia Giordano, Lucilla Capotondi
Jan 07, 2022
The recent expansion of Atlantic waters into the Arctic Ocean represents undisputable evidence of the rapid changes occurring in this region. Understanding the past variability of this “Atlantification” is thus crucial in...
Platform-controlled social media APIs threaten Open Science
Brit Davidson, Darja Wischerath, Daniel Racek, Douglas A. Parry, Emily Godwin, Joanne Hinds, Dirk van der Linden, Jonathan F. Roscoe, Laura Ayravainen, Alicia Cork
Nov 02, 2023
Social media data enable insights into human behavior. Researchers can access these data via platform-provided Application Programming Interfaces (APIs), but these come with restrictive usage-terms that mean studies cannot be...
Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease.
Ganqiang Liu, Jiajie Peng, Zhixiang Liao, Joseph J Locascio, Jean-Christophe Corvol, Frank Zhu, Xianjun Dong, Jodi Maple-Grødem, Meghan C Campbell, Alexis Elbaz, Suzanne Lesage, Alexis Brice, Graziella Mangone, John H Growdon, Albert Y Hung, Michael A Schwarzschild, Michael T Hayes, Anne-Marie Wills, Todd M Herrington, Bernard Ravina, Ira Shoulson, Pille Taba, Sulev Kõks, Thomas G Beach, Florence Cormier-Dequaire, Guido Alves, Ole-Bjørn Tysnes, Joel S Perlmutter, Peter Heutink, Sami S Amr, Jacobus J van Hilten, Meike Kasten, Brit Mollenhauer, Claudia Trenkwalder, Christine Klein, Roger A Barker, Caroline H Williams-Gray, Johan Marinus, International Genetics of Parkinson Disease Progression (IGPP) Consortium, Clemens R Scherzer
Apr 19, 2022
A key driver of patients' well-being and clinical trials for Parkinson's disease (PD) is the course that the disease takes over time (progression and prognosis). To assess how genetic variation influences the progression of PD...
Apolipoprotein E4 Cognition Cognition Disorders Disease Progression Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Glucosylceramidase Humans Longitudinal Studies Multifactorial Inheritance Mutation Parkinson Disease Proportional Hazards Models Risk Factors Survival Analysis Synapses
Which ante mortem clinical features predict progressive supranuclear palsy pathology?
Gesine Respondek, Carolin Kurz, Thomas Arzberger, Yaroslau Compta, Elisabet Englund, Leslie W Ferguson, Ellen Gelpi, Armin Giese, David J Irwin, Wassilios G Meissner, Christer Nilsson, Alexander Pantelyat, Alex Rajput, John C van Swieten, Claire Troakes, Keith A Josephs, Anthony E Lang, Brit Mollenhauer, Ulrich Müller, Jennifer L Whitwell, Angelo Antonini, Kailash P Bhatia, Yvette Bordelon, Jean-Christophe Corvol, Carlo Colosimo, Richard Dodel, Murray Grossman, Jan Kassubek, Florian Krismer, Johannes Levin, Stefan Lorenzl, Huw Morris, Peter Nestor, Wolfgang H Oertel, Gil D Rabinovici, James B Rowe, Thilo van Eimeren, Gregor K Wenning, Adam Boxer, Lawrence I Golbe, Irene Litvan, Maria Stamelou, Günter U Höglinger, Movement Disorder Society-endorsed PSP Study Group
Mar 22, 2018
BACKGROUND: Progressive supranuclear palsy (PSP) is a neuropathologically defined disease presenting with a broad spectrum of clinical phenotypes. OBJECTIVE: To identify clinical features and investigations that predict or...
|
|< |
< |
1 |